Multidirectional evolution of mitochondria

• Project Area: "Matryoshka"-type evolution of eukaryotes
• Project/Area Number: 23117005
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: National Institute of Infectious Diseases
• Principal Investigator: Nozaki Tomoyoshi 国立感染症研究所, 寄生動物部, 部長 (60198588)
• Co-Investigator(Kenkyū-buntansha): ISHIKAWA Kaori 筑波大学, 生命環境系, 助教 (40734827) ; HASHIMOTO Tetsuo 筑波大学, 生命環境系, 教授 (50208451) ; KURODA Makoto 国立感染症研究所, 病原体ゲノム解析研究センター, センター長 (80317411)
• Project Period (FY): 2011-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥171,340,000 (Direct Cost: ¥131,800,000、Indirect Cost: ¥39,540,000); Fiscal Year 2015: ¥32,370,000 (Direct Cost: ¥24,900,000、Indirect Cost: ¥7,470,000); Fiscal Year 2014: ¥32,370,000 (Direct Cost: ¥24,900,000、Indirect Cost: ¥7,470,000); Fiscal Year 2013: ¥34,190,000 (Direct Cost: ¥26,300,000、Indirect Cost: ¥7,890,000); Fiscal Year 2012: ¥33,930,000 (Direct Cost: ¥26,100,000、Indirect Cost: ¥7,830,000); Fiscal Year 2011: ¥38,480,000 (Direct Cost: ¥29,600,000、Indirect Cost: ¥8,880,000)
• Keywords: 進化 / 共生 / オルガネラ / ミトコンドリア / 嫌気 / 寄生 / 内部共生 / 微生物 / 輸送 / 分裂

Outline of Final Research Achievements

We aimed at demonstration and elucidation of multidirectional evolution of mitochondria in eukaryotes, particularly in anaerobic protists. We mainly elucidated physiological functions, protein/metabolite transport mechanisms, quality control mechanisms, genomic and transcriptomic regulation of highly divergent mitochondrion-related organelles such as mitosomes and hydrogenosomes in protists. Our studies demonstrated the unique mechanisms that evolved under anaerobic and free living / parasitic conditions in detail, and gave insights into evolultionary constrains leading to such diversities.

Research Products

• [Int'l Joint Research] Dalhousie University(Canada)
• [Journal Article] Screening and discovery of lineage-specific mitosomal membrane proteins in Entamoeba histolytica. (2016)
  • Author(s): Santos, H. J., Imai, K., Hanadate, Y., Fukasawa, Y., Oda, T., Mi-ichi, F., and Nozaki, T.
  • Journal Title: Mol. Biochem. Parasitol Volume: ? Issue: 1-2 Pages: 10-17
  • DOI: 10.1016/j.molbiopara.2016.01.001
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Entamoeba thiol-based redox metabolism: a potential target for drug development. (2016)
  • Author(s): Jeelani, G. and Nozaki, T.
  • Journal Title: Mol. Biochem. Parasitol. Volume: ? Issue: 1-2 Pages: 39-45
  • DOI: 10.1016/j.molbiopara.2016.01.004
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Roles of acetyl-CoA synthetase (ADP-forming) and acetate kinase (PPi-forming) in ATP and PPi supply in Entamoeba histolytica. (2016)
  • Author(s): Pineda, E., Vázquez, C., Encalada, R., Nozaki, T., Sato, E., Hanadate, Y., Néquiz, M, Olivos-García, A., Moreno-Sánchez, R., Saavedra, E.
  • Journal Title: Biochim. Biophys. Acta Volume: 1860 Issue: 6 Pages: 1163-1172
  • DOI: 10.1016/j.bbagen.2016.02.010
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Endoplasmic reticulum-resident Rab8A GTPase is involved in phagocytosis in the protozoan parasite Entamoeba histolytica. (2016)
  • Author(s): Hanadate, Y., Saito-Nakano, Y., Nakada-Tsukui, K., and Nozaki, T.
  • Journal Title: Cell Microbiol Volume: ? Issue: 10 Pages: 1358-1373
  • DOI: 10.1111/cmi.12570
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Comparative genomics of mitochondria in chlorarachniophyte algae: endosymbiotic gene transfer and organellar genome dynamics. (2016)
  • Author(s): Goro Tanifuji, John M. Archibald, Tetsuo Hashimoto
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 21016-21016
  • DOI: 10.1038/srep21016
  • NAID: 120007129623
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Phenotypic and transcriptional profiling in Entamoeba histolytica reveal costs to fitness and adaptive responses associated with metronidazole resistance. (2015)
  • Author(s): Penuliar, G. M., Nakada-Tsukui, K., and Nozaki, T.
  • Journal Title: Front Microbiol Volume: 6 Pages: 354-354
  • DOI: 10.3389/fmicb.2015.00354
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Atg8 is involved in endosomal and phagosomal acidification in the parasitic protist Entamoeba histolytica. (2015)
  • Author(s): Picazarri, K., Nakada-Tsukui, K., Tsuboi, K., Miyamoto, E., Watanabe, N., Kawakami, E., and Nozaki, T.
  • Journal Title: Cell Microbiol Volume: 17 Issue: 10 Pages: 1510-1522
  • DOI: 10.1111/cmi.12453
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] The mitochondrial genomes of a myxozoan genus Kudoa are extremely divergent in Metazoa. (2015)
  • Author(s): Takeuchi F, Sekizuka T, Ogasawara Y, Yokoyama H, Kamikawa R, Inagaki Y, Nozaki T, Sugita-Konishi Y, Ohnishi T, Kuroda M.
  • Journal Title: PLoS One Volume: 10 Issue: 7 Pages: e0132030-e0132030
  • DOI: 10.1371/journal.pone.0132030
  • NAID: 120005763404
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Development of nucleotide sequence typing for Kudoa septempunctata, a flounder parasite causing foodborne disease. (2015)
  • Author(s): Takeuchi, F., Ogasawara, Y., Kato, K., Sekizuka, T., Nozaki, T., Sugita-Konishi, Y., Ohnishi, T., and Kuroda, M.
  • Journal Title: J Fish Dis Volume: 39 Issue: 6 Pages: 667-72
  • DOI: 10.1111/jfd.12395
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Identification of natural inhibitors of Entamoeba histolytica cysteine synthase from microbial secondary metabolites (2015)
  • Author(s): Mori, M., Jeelani, G., Masada, Y., Sakai, K., Tsukui, K., Waluyo, D., Watanabe, Y., Nonaka, K., Matsumoto, A., Omura, S., Nozaki, T., Shiomi, K.
  • Journal Title: Frontiers in Microbiology Volume: 6 Pages: 962-962
  • DOI: 10.3389/fmicb.2015.00962
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Discovery of PPi-type Phosphoenolpyruvate carboxykinase genes in eukaryotes and bacteria. (2015)
  • Author(s): Chiba Y, Kamikawa R, Nakada-Tsukui K, Saito-Nakano Y, Nozaki T
  • Journal Title: Journal of Biological Chemistry Volume: 290 Issue: 39 Pages: 23960-23970
  • DOI: 10.1074/jbc.m115.672907
  • NAID: 120007136108
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Evidence that Entamoeba histolytica mitochondrial carrier family links mitosomal and cytosolic pathways through exchange of PAPS and ATP. (2015)
  • Author(s): Mi-ichi, F., Nozawa, A., Yoshida, H., Tozawa, Y., Nozaki, T.
  • Journal Title: Eukaryot Cell Volume: 14 Issue: 11 Pages: 1144-1150
  • DOI: 10.1128/ec.00130-15
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Metabolic capacity of mitochondrion-related organelles in the free-living anaerobic stramenopile Cantina marsupialis (2015)
  • Author(s): Fumiya Noguchi, Shigeru Shimamura, Takuro Nakayama, Euki Yazaki, Akinori Yabuki, Tetsuo Hashimoto, Yuji Inagaki, Katsunori Fujikura, Kiyotaka Takishita
  • Journal Title: Protist Volume: 166 Issue: 5 Pages: 534-550
  • DOI: 10.1016/j.protis.2015.08.002
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Phylogeny and evolution of apicoplasts and apicomplexan parasites (2015)
  • Author(s): Arisue N, Hashimoto T
  • Journal Title: Parasitology International Volume: 64 Issue: 3 Pages: 254-259
  • DOI: 10.1016/j.parint.2014.10.005
  • Peer Reviewed
• [Journal Article] G7731A mutation in mouse mitochondrial tRNALys regulates late-onset disorders in transmitochondrial mice. (2015)
  • Author(s): Shimizu A, Mito T, Hashizume O, Yonekawa H, Ishikawa K, Nakada K, Hayashi J-I
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 459 Issue: 1 Pages: 66-70
  • DOI: 10.1016/j.bbrc.2015.02.070
  • Peer Reviewed / Open Access
• [Journal Article] Mouse somatic mutation orthologous to MELAS A3302G mutation in the mitochondrial tRNA(Leu(UUR)) gene confers respiration defects. (2015)
  • Author(s): Shimizu A, Enoki S, Ishikawa K, Mito T, Obata K, Nagashima R, Yonekawa H, Nakada K, Hayashi J.
  • Journal Title: Biochem Biophys Res Commun. Volume: 467 Issue: 4 Pages: 1097-102
  • DOI: 10.1016/j.bbrc.2015.09.072
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects (2015)
  • Author(s): Hashizume O, Ohnishi S, Mito T, Shimizu A, Ishikawa K, Nakada K, Soda M, Mano H, Togayachi S, Miyoshi H, Okita K, Hayashi J
  • Journal Title: Sci Rep Volume: 5 Issue: 1 Pages: 10434-10434
  • DOI: 10.1038/srep10434
  • NAID: 120005819481
  • Peer Reviewed / Open Access
• [Journal Article] Small GTPase Rab21 mediates fibronectin induced actin reorganization in Entamoeba histolytica: implications in pathogen invasion. (2015)
  • Author(s): Emmanuel M, Nakano YS, Nozaki T, Datta S.
  • Journal Title: PLoS Pathog Volume: 11 Issue: 3 Pages: e1004666-e1004666
  • DOI: 10.1371/journal.ppat.1004666
  • Peer Reviewed / Open Access
• [Journal Article] A novel Mitosomal beta-barrel Outer Membrane Protein in Entamoeba (2015)
  • Author(s): Santos HJ, Imai K, Makiuchi T, Tomii K, Horton P, Nozawa A, Ibrahim M, Tozawa Y, *Nozaki T.
  • Journal Title: Sci Rep Volume: 5 Issue: 1 Pages: 8545-8545
  • DOI: 10.1038/srep08545
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Complete Genome Sequence of a Novel GV.2 Sapovirus Strain, NGY-1, Detected from a Suspected Foodborne Gastroenteritis Outbreak. (2015)
  • Author(s): Shibata S, Sekizuka T, Kodaira A, Kuroda M, Haga K, Doan YH, Takai-Todaka R, Katayama K, Wakita T, Oka T, Hirata H
  • Journal Title: Genome Announc Volume: 3 Issue: 1
  • DOI: 10.1128/genomea.01553-14
  • Peer Reviewed
• [Journal Article] A Mutant H3N2 Influenza Virus Uses an Alternative Activation Mechanism in TMPRSS2 Knockout Mice by Loss of an Oligosaccharide in the Hemagglutinin Stalk Region (2015)
  • Author(s): Sakai K, Sekizuka T, Ami Y, Nakajima N, Kitazawa M, Sato Y, Nakajima K, Anraku M, Kubota T, Komase K, Takehara K, Hasegawa H, Odagiri T, Tashiro M, Kuroda M, Takeda M
  • Journal Title: J Virol Volume: 89 Issue: 9 Pages: 5154-5158
  • DOI: 10.1128/jvi.00124-15
  • Peer Reviewed / Open Access
• [Journal Article] Extensive amplification of GI-VII-6, a multidrug resistance genomic island of Salmonella enterica serovar Typhimurium, increases resistance to extended-spectrum cephalosporins. (2015)
  • Author(s): Lee K, Kusumoto M, Sekizuka T, Kuroda M, Uchida I, Iwata T, Okamoto S, Yabe K, Inaoka T, Akiba M
  • Journal Title: Front Microbiol Volume: 6 Pages: 78-78
  • DOI: 10.3389/fmicb.2015.00078
  • Peer Reviewed / Open Access
• [Journal Article] Molecular evolution of the VP1, VP2, and VP3 genes in human rhinovirus species C. (2015)
  • Author(s): Kuroda M, Niwa S, Sekizuka T, Tsukagoshi H, Yokoyama M, Ryo A, Sato H, Kiyota N, Noda M, Kozawa K, Shirabe K, Kusaka T, Shimojo N, Hasegawa S, Sugai K, Obuchi M, Tashiro M, Oishi K, Ishii H, Kimura H et al.
  • Journal Title: Sci Rep Volume: 5 Issue: 1 Pages: 8185-8185
  • DOI: 10.1038/srep08185
  • Peer Reviewed
• [Journal Article] Outbreak of henipavirus infection, Philippines (2015)
  • Author(s): Ching PK, de los Reyes VC, Sucaldito MN, Tayag E, Columna-Vingno AB, Malbas FF Jr, Bolo GC Jr, Sejvar JJ, Eagles D, Playford G, Dueger E, Kaku Y, Morikawa S, Kuroda M, Marsh GA, McCullough S, Foxwell AR.
  • Journal Title: Emerg Infect Dis Volume: 21 Issue: 2 Pages: 328-331
  • DOI: 10.3201/eid2102.141433
  • Peer Reviewed
• [Journal Article] A Global Core Genome SNP Analysis for Bacillus anthracis (2015)
  • Author(s): Yamashita A, Sekizuka T, *Kuroda M. GcoGSA-BA
  • Journal Title: Health Secur Volume: 13 Pages: 64-68
  • Peer Reviewed
• [Journal Article] New Validated Rapid Screening Methods for Identifying <i>Kudoa septempunctata</i> in Olive Flounder (<i>Paralichthys olivaceus</i>) (2015)
  • Author(s): Sugita-Konishi Y, Fukuda Y, Mori K, Mekata T, Namba T, Kuroda M, Yamazaki A, Ohnishi T.
  • Journal Title: Japanese Journal of Infectious Diseases Volume: 68 Issue: 2 Pages: 145-147
  • DOI: 10.7883/yoken.JJID.2014.133
  • NAID: 130004757133
  • ISSN: 1344-6304, 1884-2836
  • Peer Reviewed / Open Access
• [Journal Article] Isolation and Characterization of an Huh.7.5.1-Derived Cell Clone Highly Permissive to Hepatitis C Virus (2015)
  • Author(s): Shirasago Y, Sekizuka T, Saito K, Suzuki T, Wakita T, Hanada K, Kuroda M, Abe R, Fukasawa M.
  • Journal Title: Japanese Journal of Infectious Diseases Volume: 68 Issue: 2 Pages: 81-88
  • DOI: 10.7883/yoken.JJID.2014.231
  • NAID: 130004716751
  • ISSN: 1344-6304, 1884-2836
  • Peer Reviewed / Open Access
• [Journal Article] MePIC, metagenomic pathogen identification for clinical specimens. (2015)
  • Author(s): Takeuchi F, Sekizuka T, Yamashita A, Ogasawara Y, Mizuta K, *Kuroda M.
  • Journal Title: Jpn J Infect Dis Volume: 67 Pages: 62-65
  • NAID: 130003399236
  • Peer Reviewed
• [Journal Article] Transmitochondrial mito-miceΔ and mtDNA mutator mice, but not aged mice, share the same spectrum of musculoskeletal disorders. (2015)
  • Author(s): Mito T, Ishizaki H, Suzuki M, Morishima H, Ota A, Ishikawa K, Nakada K, Maeno A, Shiroishi T, Hayashi J-I
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 456 Issue: 4 Pages: 933-937
  • DOI: 10.1016/j.bbrc.2014.12.009
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Mass spectrometric analysis of L-cysteine metabolism: physiological role and fate of L-cysteine in the enteric protozoan parasite Entamoeba histolytica. (2014)
  • Author(s): Jeelani G, Sato D, Soga T, Watanabe H and Nozaki T.
  • Journal Title: MBio Volume: 5 Issue: 6
  • DOI: 10.1128/mbio.01995-14
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Interaction between Nbp35 and Cfd1 proteins of cytosolic Fe-S cluster assembly reveals a stable complex formation in Entamoeba histolytica. (2014)
  • Author(s): Anwar S, Dikhit MR, Singh KP, Kar RK, Zaidi A, Sahoo GC, Roy AK, Nozaki T, Das P, Ali V.
  • Journal Title: PLoS One Volume: 9 Issue: 10 Pages: e108971-e108971
  • DOI: 10.1371/journal.pone.0108971
  • Peer Reviewed / Open Access
• [Journal Article] Proteomic analysis of Entamoeba histolytica in vivo assembled pre-mRNA splicing complexes. (2014)
  • Author(s): Valdes J, Nozaki T, Sato E, Chiba Y, Nakada-Tsukui K, Villegas-Sepulveda N, Winkler R, Azuara-Liceaga E, Mendoza-Figueroa MS, Watanabe N, Santos HJ, Saito-Nakano Y, Galindo-Rosales JM.
  • Journal Title: J Proteomics Volume: 111 Pages: 30-45
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Metabolomic analysis of Entamoeba: applications and implications. (2014)
  • Author(s): Jeelani G, *Nozaki T
  • Journal Title: Curr Opin Microbiol Volume: 20 Pages: 118-124
  • DOI: 10.1016/j.mib.2014.05.016
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Ligand heterogeneity of the cysteine protease binding protein family in the parasitic protist Entamoeba histolytica (2014)
  • Author(s): Marumo K, Nakada-Tsukui K, Tomii K, *Nozaki T
  • Journal Title: Int J Parasitol Volume: 44 Issue: 9 Pages: 625-635
  • DOI: 10.1016/j.ijpara.2014.04.008
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Selection of rodent species appropriate for mtDNA transfer to generate transmitochondrial mito-mice expressing mitochondrial respiration defects (2014)
  • Author(s): Enoki S, Shimizu A, Hayashi C, Imanishi H, Hashizume O, Mekada K, Suzuki H, Hashimoto T, Nakada K, Hayashi J.
  • Journal Title: Exp Anim Volume: 63 Pages: 21-30
  • NAID: 130003391604
  • Peer Reviewed
• [Journal Article] An outbreak of acute respiratory infections due to human respiratory syncytial virus in a nursing home for the elderly in Ibaraki, Japan, 2014. (2014)
  • Author(s): Doi I, Nagata N, Tsukagoshi H, Komori H, Motoya T, Watanabe M, Keta T, Kawakami M, Tsukano T, Honda M, Ishioka T, Takeda M, Ryo A, Kuroda M, Oishi K, Kimura H
  • Journal Title: Jpn J Infect Dis Volume: 67 Pages: 326-328
  • NAID: 130004757108
  • Peer Reviewed
• [Journal Article] Complete genome sequence and comparative genomic analysis of Mycobacterium massiliense JCM 15300 in the Mycobacterium abscessus group reveal a conserved genomic island MmGI-1 related to putative lipid metabolism (2014)
  • Author(s): Sekizuka T, Kai M, Nakanaga K, Nakata N, Kazumi Y, Maeda S, Makino M, Hoshino Y, Kuroda M
  • Journal Title: PLoS One Volume: 9 Issue: 12 Pages: e114848-e114848
  • DOI: 10.1371/journal.pone.0114848
  • Peer Reviewed / Open Access
• [Journal Article] Draft genome sequence of Rhodococcus erythropolis JCM 6824, an aurachin RE antibiotic producer. (2014)
  • Author(s): Kitagawa, W., Hata, M., Sekizuka, T., Kuroda, M., and Ishikawa, J.
  • Journal Title: Genome Announcement Volume: 2 Issue: 5
  • DOI: 10.1128/genomea.01026-14
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Molecular evolution of human respiratory syncytial virus attachment glycoprotein (G) gene of new genotype ON1 and ancestor NA1 (2014)
  • Author(s): Hirano E, Kobayashi M, Tsukagoshi H, Yoshida LM, Kuroda M, Noda M, Ishioka T, Kozawa K, Ishii H, Yoshida A, Oishi K, Ryo A, Kimura H
  • Journal Title: Infect Genet Evol Volume: 28 Pages: 183-191
  • DOI: 10.1016/j.meegid.2014.09.030
  • Peer Reviewed
• [Journal Article] The genome landscape of the African green monkey kidney-derived Vero cell line. (2014)
  • Author(s): Osada N, Kohara A, Yamaji T, Hirayama N, Kasai F, Sekizuka T, Kuroda M, Hanada K
  • Journal Title: DNA Res. Volume: 21 Issue: 6 Pages: 673-683
  • DOI: 10.1093/dnares/dsu029
  • Peer Reviewed / Open Access
• [Journal Article] Characterization of blaTEM-52-carrying plasmids of extended-spectrum-beta-lactamase-producing Salmonella enterica isolates from chicken meat with a common supplier in Japan (2014)
  • Author(s): Matsumoto Y, Izumiya H, Sekizuka T, Kuroda M, Ohnishi M
  • Journal Title: Antimicrob Agents Chemother Volume: 58 Issue: 12 Pages: 7545-7547
  • DOI: 10.1128/aac.02731-14
  • Peer Reviewed
• [Journal Article] Genetic characterization and comparison of Clostridium botulinum isolates from botulism cases in Japan between 2006 and 2011 (2014)
  • Author(s): Kenri T, Sekizuka T, Yamamoto A, Iwaki M, Komiya T, Hatakeyama T, Nakajima H, Takahashi M, Kuroda M, Shibayama K.
  • Journal Title: Appl Environ Microbiol Volume: 80 Issue: 22 Pages: 6954-6964
  • DOI: 10.1128/aem.02134-14
  • Peer Reviewed
• [Journal Article] A food-borne outbreak of gastroenteritis due to genotype G1P[8] rotavirus among adolescents in Japan (2014)
  • Author(s): Mizukoshi F, Kuroda M, Tsukagoshi H, Sekizuka T, Funatogawa K, Morita Y, Noda M, Katayama K, Kimura H
  • Journal Title: Microbiol Immunol Volume: 58 Issue: 9 Pages: 536-539
  • DOI: 10.1111/1348-0421.12176
  • NAID: 40020207382
  • Peer Reviewed
• [Journal Article] Whole-Genome Sequence of CMY-2 beta-Lactamase-Producing Salmonella enterica Serovar Typhimurium Strain L-3553 (2014)
  • Author(s): Sekizuka T, Lee K, Kuroda M, Kusumoto M, Iwata T, Uchida I, Tanaka K, Tamamura Y, Akiba M
  • Journal Title: Genome Announc Volume: 2 Issue: 4
  • DOI: 10.1128/genomea.00711-14
  • Peer Reviewed / Open Access
• [Journal Article] Characterization of Antimicrobial Resistance Dissemination across Plasmid Communities Classified by Network Analysis (2014)
  • Author(s): Tsuzuki S, Fukumoto H, Mine S, Sato N, Mochizuki M, Hasegawa H, Sekizuka T, Kuroda M, Matsushita T, Katano H
  • Journal Title: Pathogens Volume: 3 Issue: 2 Pages: 356-376
  • DOI: 10.3390/pathogens3020356
  • Peer Reviewed
• [Journal Article] Morphological and molecular evidence support the recognition of Champia lubrica sp. nov. (Champiaceae, Rhodophyta) from Japan (2014)
  • Author(s): Suzuki M, Hashimoto T, Kitayama T, Nozaki H
  • Journal Title: Phycologia Volume: 53
  • Peer Reviewed
• [Journal Article] Secondary loss of a cis-spliced intron during the divergence of Giardia intestinalis assemblages (2014)
  • Author(s): Ryoma Kamikawa, Yuji Inagaki and Tetsuo Hashimoto
  • Journal Title: BMC Research Notes Volume: 7 Issue: 1 Pages: 413-413
  • DOI: 10.1186/1756-0500-7-413
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Gene-content evolution in discobid mitochondria deduced from the phylogenetic position and complete mitochondrial genome of Tsukubamonas globosa. (2014)
  • Author(s): Kamikawa R, Kolisko M, Nishimura Y, Yabuki A, rown MW, Sohta A. Ishikawa, Ishida K, Roger AJ, Hashimoto T, Inagaki Y
  • Journal Title: Genome Biology and Evolution Volume: 第6巻2号 Issue: 2 Pages: 306-315
  • DOI: 10.1093/gbe/evu015
  • Peer Reviewed
• [Journal Article] The Host Protease TMPRSS2 Plays a Major Role in In Vivo Replication of Emerging H7N9 and Seasonal Influenza Viruses (2014)
  • Author(s): Sakai K, Ami Y, Tahara M, Kubota T, Anraku M, Abe M, Nakajima N, Sekizuka T, Shirato K, Suzaki Y, Ainai A, Nakatsu Y, Kanou K, Nakamura K, Suzuki T, Komase K, Nobusawa E, Maenaka K, Kuroda M, Hasegawa H et al
  • Journal Title: J Virol Volume: 88 Issue: 10 Pages: 5608-5616
  • DOI: 10.1128/jvi.03677-13
  • Peer Reviewed / Open Access
• [Journal Article] The Entamoeba histolytica Dnmt2 homolog (Ehmeth) confers resistance to nitrosative stress (2014)
  • Author(s): Hertz R, Tovy A, Kirschenbaum M, Geffen M, Nozaki T, Adir N, Ankri S
  • Journal Title: Eukaryot Cell Volume: 13 Issue: 4 Pages: 494-503
  • DOI: 10.1128/ec.00031-14
  • Peer Reviewed
• [Journal Article] Role of pathogenicity determinant protein C (PdpC) in determining the virulence of the Francisella tularensis subspecies tularensis SCHU (2014)
  • Author(s): Uda A, Sekizuka T, Tanabayashi K, Fujita O, Kuroda M, Hotta A, Sugiura N, Sharma N, Morikawa S, Yamada A
  • Journal Title: PLoS One Volume: 9 Issue: 2 Pages: e89075-e89075
  • DOI: 10.1371/journal.pone.0089075
  • Peer Reviewed
• [Journal Article] Insights into the GTP/GDP cycle of RabX3, a novel GTPase from Entamoeba histolytica with tandem G-domainsistry (2014)
  • Author(s): Chandra M, Mukherjee M, Srivastava VK, Saito-Nakano Y, Nozaki T, Datta S
  • Journal Title: Biochem Volume: 53 Issue: 7 Pages: 1191-1205
  • DOI: 10.1021/bi401428f
  • Peer Reviewed / Open Access
• [Journal Article] Highly divergent mitochondrion-related organelles in anaerobic parasitic protozoa (2014)
  • Author(s): Makiuchi T, Nozaki T
  • Journal Title: Biochimie Volume: 100 Pages: 3-17
  • DOI: 10.1016/j.biochi.2013.11.018
  • Peer Reviewed
• [Journal Article] Discrimination of Mycobacterium abscessus subsp. massiliense from Mycobacterium abscessus subsp. abscessus in clinical isolates by multiplex PCR (2014)
  • Author(s): Nakanaga K, Sekizuka T, Fukano H, Sakakibara Y, Takeuchi F, Wada S, Ishii N, Makino M, Kuroda M, Hoshino Y
  • Journal Title: J Clin Microbiol Volume: 52 Issue: 1 Pages: 251-259
  • DOI: 10.1128/jcm.01327-13
  • Peer Reviewed
• [Journal Article] The V protein of canine distemper virus is required for virus replication in human epithelial cells (2013)
  • Author(s): Otsuki N, Nakatsu Y, Kubota T, Sekizuka T, Seki F, Sakai K, Kuroda M, Yamaguchi R, Takeda M
  • Journal Title: PLoS One Volume: 8 Issue: 12 Pages: e82343-e82343
  • DOI: 10.1371/journal.pone.0082343
  • Peer Reviewed
• [Journal Article] Genetic variation of human papillomavirus type 16 in individual clinical specimens revealed by deep sequencing (2013)
  • Author(s): Kukimoto I, Maehama T, Sekizuka T, Ogasawara Y, Kondo K, Kusumoto-Matsuo R, Mori S, Ishii Y, Takeuchi T, Yamaji T, Takeuchi F, Hanada K, Kuroda M
  • Journal Title: PLoS One Volume: 8 Issue: 11 Pages: e80583-e80583
  • DOI: 10.1371/journal.pone.0080583
  • Peer Reviewed
• [Journal Article] Transcriptome analysis of encystation in Entamoeba invadens (2013)
  • Author(s): De Cadiz AE, Jeelani G, Nakada-Tsukui K, Caler E, Nozaki T
  • Journal Title: PLoS One Volume: 8 Issue: 9 Pages: e74840-e74840
  • DOI: 10.1371/journal.pone.0074840
  • Peer Reviewed
• [Journal Article] Genetic analysis of attachment glycoprotein (G) gene in new genotype ON1 of human respiratory syncytial virus detected in Japan (2013)
  • Author(s): Tsukagoshi H, Yokoi H, Kobayashi M, Kushibuchi I, Okamoto-Nakagawa R, Yoshida A, Morita Y, Noda M, Yamamoto N, Sugai K, Oishi K, Kozawa K, Kuroda M, Shirabe K, Kimura H
  • Journal Title: Microbiol Immunol Volume: 57 Issue: 9 Pages: 655-659
  • DOI: 10.1111/1348-0421.12075
  • Peer Reviewed
• [Journal Article] Differential potential for envelope gycoprotein-mediated steric shielding of host cell surface proteins among filoviruses (2013)
  • Author(s): Noyori Osamu
  • Journal Title: Virology Volume: 446 Issue: 1-2 Pages: 152-161
  • DOI: 10.1016/j.virol.2013.07.029
  • Peer Reviewed
• [Journal Article] Parallel re-modeling of EF-la function in eukaryotic evolution : Divergent, low-expressed EF-1α genes co-occur with EFL genes in diverse distantly related eukaryotes. (2013)
  • Author(s): Kamikawa R, Brown MW, Nishimura Y, Sako Y, Heiss AA, Yubuki N, Gawryluk R, Simpson AGB, Roger AJ, Hashimoto T, Inagaki Y
  • Journal Title: BMC Evolutionary Biology Volume: 13 Issue: 1 Pages: 131-131
  • DOI: 10.1186/1471-2148-13-131
  • Peer Reviewed
• [Journal Article] Epidemic myalgia associated with human parechovirus type 3 infection among adults occurs during an outbreak among children: findings from Yamagata, Japan,in 2011 (2013)
  • Author(s): Mizuta K, Yamakawa T, Nagasawa H, Itagaki T, Katsushima F, Katsushima Y, Shimizu Y, Ito S, Aoki Y, Ikeda T, Abiko C, Kuroda M, Noda M, Kimura H, Ahiko T
  • Journal Title: J Clin Virol Volume: 58 Issue: 1 Pages: 188-193
  • DOI: 10.1016/j.jcv.2013.05.019
  • Peer Reviewed
• [Journal Article] Molecular evolution of attachment glycoprotein (G) gene in human respiratory syncytial virus detected in Japan (2013)
  • Author(s): Kushibuchi I, Kobayashi M, Kusaka T, Tsukagoshi H, Ryo A, Yoshida A, Ishii H, Saraya T, Kurai D, Yamamoto N, Kanou K, Saitoh M, Noda M, Kuroda M, Morita Y, Kozawa K, Oishi K, Tashiro M, Kimura H
  • Journal Title: Infect Genet Evol Volume: 18 Pages: 168-173
  • DOI: 10.1016/j.meegid.2013.05.010
  • Peer Reviewed
• [Journal Article] Cysteine protease-binding protein family 6 mediates the trafficking of amylases to phagosomes in the enteric protozoan Entamoeba histolytica. (2013)
  • Author(s): A. Furukawa, K. Nakada-Tsukui, T. Nozaki
  • Journal Title: Infection and Immunity Volume: 81 Issue: 5 Pages: 1820-1829
  • DOI: 10.1128/iai.00915-12
  • Peer Reviewed
• [Journal Article] Iron sulfur clusters, their biosythesis and biological functions in protozoan parasites (2013)
  • Author(s): Ali, V. and Nozaki, T
  • Journal Title: Adv. Parasiol Volume: in press
  • Peer Reviewed
• [Journal Article] Novel TPR-containing subunit of TOM complex functions as cytosolic receptor for Entamoeba mitosomal transport (2013)
  • Author(s): Makiuchi T, Mi-Ichi F, Nakada-Tsukui K, Nozaki T
  • Journal Title: Sci Rep Volume: 3 Issue: 1 Pages: 1129-1129
  • DOI: 10.1038/srep01129
  • Peer Reviewed
• [Journal Article] Biochemical and functional characterization of novel NADH kinase in the enteric protozoan parasite Entamoeba histolytica. Biochimie (2013)
  • Author(s): Jeelani, G., Husain, A., Sato, D., Soga, T., Suematsu, M., Nozaki, T
  • Journal Title: Biochimie Volume: 2013 95 Issue: 2 Pages: 309-319
  • DOI: 10.1016/j.biochi.2012.09.034
  • Peer Reviewed
• [Journal Article] Canine distemper virus with the intact C protein has the potential to replicate in human epithelial cells by using human nectin4 as a receptor (2012)
  • Author(s): Otsuki N, Sekizuka T, Seki F, Sakai K, Kubota T, Nakatsu Y, Chen S, Fukuhara H, Maenaka K, Yamaguchi R, Kuroda M, Takeda M
  • Journal Title: Virology Volume: 435(2) Issue: 2 Pages: 485-92
  • DOI: 10.1016/j.virol.2012.10.033
  • Peer Reviewed
• [Journal Article] Genetic analysis of non-hydrogen sulfide-producing Salmonella enterica serovar Typhimurium and Infantis isolates in Japan (2012)
  • Author(s): Sakano C, Kuroda M, Sekizuka T, Ishioka T, Morita Y, Ryo A, Tsukagoshi H, Kawai Y, Inoue N, Takada H, Ogaswara Y, Nishina A, Shimoda MA, Kozawa K, Oishi K, Kimura H
  • Journal Title: J Clin Microbiol Volume: vol. 51 no. 1 Issue: 1 Pages: 328-330
  • DOI: 10.1128/jcm.02225-12
  • Peer Reviewed
• [Journal Article] Epidemic myalgia in adults associated with human parechovirus type 3 infection, yamagata, Japan, 2008 (2012)
  • Author(s): Mizuta K., Kuroda M., Kurimura M., Yahata Y., Sekizuka T., Aoki Y., Ikeda T., Abiko C., Noda M., Kimura H., Mizutani T., Kato T., Kawanami T., Ahiko T.
  • Journal Title: Emerging Infectious Diseases Volume: 18 Issue: 11 Pages: 1787-1793
  • DOI: 10.3201/eid1811.111570
  • Peer Reviewed
• [Journal Article] Pathogenic characterization of a cervical lymph node derived from a patient with Kawasaki disease (2012)
  • Author(s): Katano H, Sato S, Sekizuka T, Kinumaki A, Fukumoto H, Sato Y, Hasegawa H, Morikawa S, Saijo M, Mizutani T, *Kuroda M
  • Journal Title: Int J Clin Exp Pathol Volume: 5 Pages: 814-823
  • Peer Reviewed
• [Journal Article] Dramatic increase in glycerol biosynthesis upon oxidative stress in the anaerobic protozoan parasite Entamoeba histolytica (2012)
  • Author(s): Husain, A., Sato, D., Jeelani, G., Soga, T., and Nozaki, T
  • Journal Title: PLoS Negl. Trop. Dis Volume: 6 Issue: 9 Pages: e1831-e1831
  • DOI: 10.1371/journal.pntd.0001831
  • Peer Reviewed
• [Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy (2012)
  • Author(s): Klionsky DJ et al
  • Journal Title: Autophagy Volume: 8 Pages: 445-544
  • Peer Reviewed
• [Journal Article] RY-coding and non-homogeneous models ameliorate the maximum-likelihood inferences from nucleotide sequence data with parallel compositional heterogeneity. (2012)
  • Author(s): Ishikawa SA, Inagaki Y, Hashimoto T.
  • Journal Title: Evolutionary Bioinformatics Volume: 8 Pages: 357-371
  • DOI: 10.4137/ebo.s9017
  • Peer Reviewed
• [Journal Article] Metabolic profiling of the protozoan parasite Entamoeba revealed activation of unpredicted pathway during encystation (2012)
  • Author(s): Jeelani, G,, Sato, S., Husain, A., Escueta-de Cadiza, A., Sugimoto, M., Soga, T., Suematsu, M., and Nozaki, T
  • Journal Title: PLoS ONE Volume: 7 Issue: 5 Pages: e37740-e37740
  • DOI: 10.1371/journal.pone.0037740
  • Peer Reviewed
• [Journal Article] Separate origins of group I introns in two mitochondrial genes of the katablepharid Leucocryptos marina. (2012)
  • Author(s): Nishimura Y, Kamikawa R, Hashimoto T, Inagaki Y.
  • Journal Title: PLoS One Volume: 7 Issue: 5 Pages: e37307-e37307
  • DOI: 10.1371/journal.pone.0037307
  • Peer Reviewed
• [Journal Article] Corynebacterium ulcerans 0102 carries the gene encoding diphtheria toxin on a prophage different from the C. diphtheriae NCTC 13129 prophage (2012)
  • Author(s): Sekizuka T, Yamamoto A, Komiya T, Kenri T, Takeuchi F, Shibayama K, Takahashi M, Kuroda M, Iwaki M
  • Journal Title: BMC Microbiol Volume: 12 Issue: 1 Pages: 72-72
  • DOI: 10.1186/1471-2180-12-72
  • Peer Reviewed
• [Journal Article] A novel class of cysteine protease receptors that mediate lysosomal transport (2012)
  • Author(s): Nakada-Tsukui K, Tsuboi K, Furukawa A, Yamada Y, *Nozaki T.
  • Journal Title: Cell Microbiol Volume: 14 Issue: 8 Pages: 1299-1317
  • DOI: 10.1111/j.1462-5822.2012.01800.x
  • Peer Reviewed
• [Journal Article] The Plasmodium apicoplast genome : conserved structure and close relationship of P.ovale to rodent malaria parasites (2012)
  • Author(s): Arisue N, Hashimoto T, 他8名
  • Journal Title: Molecular Biology and Evolution Volume: (In press) Issue: 9 Pages: 2095-9
  • DOI: 10.1093/molbev/mss082
  • Peer Reviewed
• [Journal Article] Novel protein-protein interactions between Entamoeba histolyticad-phosphoglycerate dehydrogenase and phosphoserine aminotransferase (2012)
  • Author(s): Mishra V, Kumar A, Ali V, Nozaki T, Zhang KY, Bhakuni V
  • Journal Title: Biochimie Volume: 94 Issue: 8 Pages: 1676-1686
  • DOI: 10.1016/j.biochi.2012.02.028
  • Peer Reviewed
• [Journal Article] Novel transmembrane receptor involved in phagosome transport of lysozymes and β-hexosaminidase in the enteric protozoan Entamoeba histolytica (2012)
  • Author(s): Furukawa A, Nakada-Tsukui K, Nozaki T
  • Journal Title: PLoS Pathog Volume: 8 Issue: 2 Pages: e1002539-e1002539
  • DOI: 10.1371/journal.ppat.1002539
  • Peer Reviewed
• [Journal Article] Multisite performance evaluation of an enzyme-linked immunosorbent assay for detection of Giardia, Cryptosporidium, and Entamoeba histolytica antigens in human stool (2012)
  • Author(s): Christy NC, Hencke JD, Escueta-De Cadiz A, Nazib F, von Thien H, Yagita K, Ligaba S, Haque R, Nozaki T, Tannich E, Herbein JF, Petri WA Jr
  • Journal Title: J Clin Microbiol Volume: 50 Pages: 1762-1763
  • Peer Reviewed
• [Journal Article] Multigene phylogenies of diverse Carpediemonas-like organisms identify the closest relatives of 'amitochndriate' diplomonads and retortamonads (2012)
  • Author(s): Takishita K, Kolisko M, Komatsuzaki H, Yabuki A, Inagaki Y, Cepicka I, Smejkalova P, Silberman JD, Hashimoto T, Roger AJ, Simpson AGB.
  • Journal Title: Protist Volume: 163 Issue: 3 Pages: 344-355
  • DOI: 10.1016/j.protis.2011.12.007
  • Peer Reviewed
• [Journal Article] Detection of a possible bioterrorism agent, Francisella sp., in a clinical specimen by use of next-generation direct DNA sequencing (2012)
  • Author(s): Kuroda M, Sekizuka T, Shinya F, Takeuchi F, Kanno T, Sata T, Asano S
  • Journal Title: J Clin Microbiol Volume: 50 Issue: 5 Pages: 1810-1812
  • DOI: 10.1128/jcm.06715-11
  • Peer Reviewed
• [Journal Article] Identification of Kudoa septempunctata as the causative agent of novel food poisoning outbreaks in Japan by consumption of Paralichthys olivaceus in raw fish (2012)
  • Author(s): Kawai T, Sekizuka T, Yahata Y, Kuroda M, Kumeda Y, Iijima Y, Kamata Y, Sugita-Konishi Y, Ohnishi T
  • Journal Title: Clin Infect Dis Volume: 54 Issue: 8 Pages: 1046-1052
  • DOI: 10.1093/cid/cir1040
  • Peer Reviewed
• [Journal Article] Transcriptional and functional analysis of trifluoromethionine resistance in Entamoeba histolytica (2012)
  • Author(s): Penuliar GM, Furukawa A, Nakada-Tsukui K, Husain A, Sato D, *Nozaki T.
  • Journal Title: J Antimicrob Chemother Volume: 67, Issue: 2 Pages: 375-386
  • DOI: 10.1093/jac/dkr484
  • Peer Reviewed
• [Journal Article] Glu-108 is essential for subunit assembly and dimer stability of D-phosphoglycerate dehydrogenase from Entamoeba histolytica (2012)
  • Author(s): Mishra V, Kumar A, Ali V, Nozaki T, Zhang KY, Bhakuni V
  • Journal Title: Mol Biochem Parasitol Volume: 181 Issue: 2 Pages: 117-124
  • DOI: 10.1016/j.molbiopara.2011.10.008
  • Peer Reviewed
• [Journal Article] Role of conserved active site tryptophan-101 in functional activity and stability of phosphoserine aminotransferase from an enteric human parasite (2012)
  • Author(s): Mishra V, Kumar A, Ali V, Nozaki T, Zhang KY, Bhakuni V
  • Journal Title: Amino Acids Volume: 43 Issue: 1 Pages: 483-491
  • DOI: 10.1007/s00726-011-1105-x
  • Peer Reviewed
• [Journal Article] Transcriptional and functional analysis of trifluoromethionine resistance in Entamoeba histolytica (2012)
  • Author(s): Penuliar, G.M., Furukawa, A.,Nakada-Tsukui, K., Husain, A., Sato, D., Nozaki, T.
  • Journal Title: J.Antimicrob.Chemother. Volume: 67 Pages: 375-386
  • Peer Reviewed
• [Journal Article] Sulfate activation in mitosomes plays a crucial role in the proliferation of Entamoeba histolytica (2012)
  • Author(s): Furukawa, A., Nakada-Tsukui, K., Nozaki, T.Novel, transmembrane receptor involved in phagosome transport of lysozymes and ss-hexosaminidase in the enteric protozoan Entamoeba histolytica. (2) : doi : ./journal. ppat. 1002539, 2012
  • Journal Title: PLoS Pathogens Volume: 8
  • Peer Reviewed
• [Journal Article] Global Analysis of gene expression in response to L-cysteine deprivation in the anaerobic protozoan parasite Entamoeba histolytica (2011)
  • Author(s): Husain, A., Jeelani, G., Sato, D., Nozaki, T.
  • Journal Title: BMC Genomics Volume: 12 Pages: 275-275
  • Peer Reviewed
• [Journal Article] Sulfate activation in mitosomes plays a crucial role in the proliferation of Entamoeba histolytica (2011)
  • Author(s): Mi-ichi, F., Makiuchi, T., Furukawa, A., Sato, D., Nozaki, T.
  • Journal Title: PLoS Negl.Trop.Dis. Volume: 5
  • Peer Reviewed
• [Journal Article] Amebiasis in HIV-1-Infected Japanese Men : Clinical Features and Response to Therapy (2011)
  • Author(s): Watanabe, K., Gatanaga, H., de Cadiz, A.E., Tanuma, J., Nozaki, T., Oka, S.
  • Journal Title: PLoS Negl.Trop.Dis.
  • Peer Reviewed
• [Journal Article] Mechanism of trifluoromethionine resistance in Entamoeba histolytica (2011)
  • Author(s): Penuliar, G.M., Furukawa, A., Sato, D., Nozaki, T.
  • Journal Title: J.Antimicrob.Chemother. Volume: 66 Pages: 2045-2052
  • Peer Reviewed
• [Presentation] Metabolism, pathogenesis, and unique organelles in the enteric protozoon Entamoeba histolytica. (2015)
  • Author(s): Nozaki, T.
  • Organizer: The 44th Annual Convention and Scientific Meeting of the Philippine Society for Microbiology.
  • Place of Presentation: Pasay City, The Philippines.
  • Year and Date: 2015-07-16
  • Int'l Joint Research / Invited
• [Presentation] ミトコンドリア・ダイナミクスの破綻が突然変異型mtDNAの組織内含有率に及ぼす影響 (2014)
  • Author(s): 石川香、堅田俊、石原孝也、櫻澤遼太、小笠原絵美、林純一、三原勝芳、石原直忠、中田和人
  • Organizer: 第14回日本ミトコンドリア学会年会
  • Place of Presentation: 福岡
  • Year and Date: 2014-12-03
• [Presentation] Unique evolution of metabolism, pathogenesis, and organelles in the enteric protozoon Entamoeba histolytica (2014)
  • Author(s): Nozaki, T
  • Organizer: International Conference of Parasitology XIII
  • Place of Presentation: Mexico City, Mexico
  • Year and Date: 2014-08-10 – 2014-08-15
  • Invited
• [Presentation] Novel lysosome transport mechanisms of the enteric protozoon Entamoeba (2014)
  • Author(s): Nozaki, T
  • Organizer: International Conference of Parasitology XIII
  • Place of Presentation: Mexico City, Mexico
  • Year and Date: 2014-08-10 – 2014-08-15
  • Invited
• [Presentation] Divergent evolution of protein and metabolite transport in the anaerobic protozoon Entamoeba histolytica (2014)
  • Author(s): Nozaki, T
  • Organizer: CIFAR meeting
  • Place of Presentation: Praque, Czec Republic
  • Year and Date: 2014-06-25 – 2014-06-28
• [Presentation] A novel beta barrel transporter in the mitosome of Entamoeba histolytica (2013)
  • Author(s): Nozaki, T
  • Organizer: XVII Seminar on Amebiasis 2013
  • Place of Presentation: Merida, Mexico
  • Year and Date: 2013-03-01
• [Presentation] 寄生生物ミトコンドリアの特性～嫌気環境下における多様化 (2012)
  • Author(s): 野崎智義
  • Organizer: J-mit, “Mitochondrial Diversity: shall we find out her multiple faces” (日本ミトコンドリア学会)
  • Place of Presentation: Tsukuba, Ibaraki
  • Year and Date: 2012-12-19
• [Presentation] Evolution of the mitochondria under anaerobic conditions: Function and import machinery of the highly divergent mitochondrion-related organelle in Entamoeba histolytica (2012)
  • Author(s): Nozaki, T
  • Organizer: Joint International Tropical Medicine Meeting
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2012-12-12
• [Presentation] Evolution of the mitochondria under anaerobic conditions: Function and import machinery of the highly divergent mitochondrion-related organelle in the parasitic protozoan Entamoeba histolytica (2012)
  • Author(s): Nozaki, T
  • Organizer: The 11th Awaji International Forum on Infection and Immunity
  • Place of Presentation: Awaji, Japan
  • Year and Date: 2012-09-11
• [Presentation] Mitosomal transport system in Entamoeba histolytica (2012)
  • Author(s): Nozaki, T
  • Organizer: Protist 2012, International Society of Evolutionary Protistology Meeting
  • Place of Presentation: Oslo, Norway
  • Year and Date: 2012-07-29
• [Presentation] Evolution of function and import machinery of the mitochondria under anaerobic conditions: Highly divergent mitochondrion-related organelles in the parasitic protozoan Entamoeba histolytica (2012)
  • Author(s): Nozaki, T
  • Organizer: Mito 21012
  • Place of Presentation: Heraklion, Greece
  • Year and Date: 2012-05-09
• [Book] Metabolomic analysis of Entamoeba biology. In "Amebiasis: Biology and Pathogenesis of Entamoeba" (2015)
  • Author(s): Ghulam Jeelani, Dan Sato, and Tomoyoshi Nozaki.
  • Total Pages: 581
  • Publisher: Springer
• [Book] Mitosomes in Entamoeba histolytica. In "Amebiasis: Biology and Pathogenesis of Entamoeba" (2015)
  • Author(s): Takashi Makiuchi, Fumika Mi-ichi, and Tomoyoshi Nozaki.
  • Total Pages: 581
  • Publisher: Springer
• [Book] Molecular basis of the trafficking of cysteine proteases and other soluble lysosomal proteins in Entamoeba histolytica. In "Amebiasis: Biology and Pathogenesis of Entamoeba" (2015)
  • Author(s): Kumiko Nakada-Tsukui, and Tomoyoshi Nozaki.
  • Total Pages: 581
  • Publisher: Springer
• [Remarks] http://www.matryoshka-evolution.jp/
• [Remarks] マトリョーシカ型進化原理
  • URL: http://www.matryoshka-evolution.jp/
• [Remarks] マトリョーシカ型進化原理
  • URL: http://www.matryoshka-evolution.jp/
• [Remarks] 国立感染症研究所寄生動物部
  • URL: http://www.nih.go.jp/niid/ja/from-para.html
• [Remarks]
  • URL: http://www.matryoshka-evolution.jp/
• [Remarks]
  • URL: http://www.nih.go.jp/niid/ja/2011-05-26-00-03-52.html