| Budget Amount *help |
¥30,420,000 (Direct Cost: ¥23,400,000、Indirect Cost: ¥7,020,000)
Fiscal Year 2014: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2013: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2012: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
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| Outline of Final Research Achievements |
For deep understanding the drug disposition at multi-levels from the molecular level to the whole organism level, this project was aimed to develop a methodology for implementing the extrapolation from the molecular to the whole organism level, and vice versa. We investigated the determination of the scaling factors for individual intrinsic processes in the overall hepatic elimination using PET, and absolute extrapolation method of the xenobiotic detoxification activity at the protein expression level using LC-MS/MS. As a physiological model, we constructed a detailed gastrointestinal absorption model (translocation model) that reflects the complex structure and dynamics in the digestive tract. Introducing a “Cluster Newton Method” enabled parameter estimation in complex models. These achievements are expected to contribute to the elaboration of the prediction of pharmacokinetics.
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