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Systematization of the mechanism by which plasma irradiation causes cell growth and tumor cell death

Planned Research

Project AreaPlasma medical innovation
Project/Area Number 24108007
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionInternational University of Health and Welfare

Principal Investigator

SHIMIZU Nobuyuki  国際医療福祉大学, 臨床医学研究センター, 教授 (70262128)

Co-Investigator(Kenkyū-buntansha) 浜窪 隆雄  東京大学, 先端科学技術研究センター, 教授 (90198797)
張 京浩  東京大学, 医学部附属病院, 講師 (50302708)
山下 裕玄  東京大学, 医学部附属病院, 講師 (50599397)
Project Period (FY) 2012-06-28 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥72,670,000 (Direct Cost: ¥55,900,000、Indirect Cost: ¥16,770,000)
Fiscal Year 2016: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2015: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
Fiscal Year 2014: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Fiscal Year 2013: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
Fiscal Year 2012: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Keywordsプラズマ医療科学 / 動物モデル / 酸化ストレス / プロテオソーム / レドックスシグナリング / 低侵襲治療
Outline of Final Research Achievements

The application of the plasma into medical field is thought to be greatly useful, but the mechanism of plasma irradiation is still unclear. In our study, we performed cultured cell experiments and proved that hydrogen peroxide and nitrogen oxide played important roles of cell death.
The spread of the clinical applicability of plasma is expected. So, we established a mouse animal and a pig model to investigate the influence of plasma irradiation equipment, especially focusing on adhesion formation and inflammation.

Report

(6 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (97 results)

All 2017 2016 2015 2014 2013 2012 Other

All Journal Article (64 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 62 results,  Open Access: 30 results,  Acknowledgement Compliant: 6 results) Presentation (33 results) (of which Int'l Joint Research: 4 results,  Invited: 14 results)

  • [Journal Article] Optical inactivation of synaptic AMPA receptors erases fear memory.2017

    • Author(s)
      K. Takemoto, H. Iwanari, H. Tada, K. Suyama, A. Sano, T. Nagai, T. Hamakubo, T. Takahashi
    • Journal Title

      Nat Biotechnol

      Volume: 35 Issue: 1 Pages: 38-47

    • DOI

      10.1038/nbt.3710

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Plasma Irradiation Effects to Intra-Abdominal Organ Compared with Adhesion Mouse Model2017

    • Author(s)
      K. Soda, H. Yamashita, K. Chang, T. Kawamura, T. Hamakubo and N. Shimizu
    • Journal Title

      Plasma Medicine

      Volume: -

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Endoscopic gastric atrophy is strongly associated with gastric cancer development after Helicobacter pylori eradication2017

    • Author(s)
      O. Toyoshima, Y. Yamaji, S. Yoshida, S. Matsumoto, H. Yamashita, T. Kanazawa, K. Hata
    • Journal Title

      Surg Endosc

      Volume: 31 Issue: 5 Pages: 2140-2148

    • DOI

      10.1007/s00464-016-5211-4

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Randomized controlled clinical trial assessing the effects of oral nutritional supplements in postoperative gastric cancer patients2017

    • Author(s)
      Hatao F, Chen KY, Wu JM, Wang MY, Aikou S, Onoyama H, Shimizu N, Fukatsu K, Seto Y, Lin MT
    • Journal Title

      Langenbecks Arch Surg

      Volume: 402 Issue: 2 Pages: 203-211

    • DOI

      10.1007/s00423-016-1527-8

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxidation and interaction of DJ-1 with 20S proteasome in the erythrocytes of early stage Parkinson's disease patients.2016

    • Author(s)
      Y. Saito, Y. Akazawa-Ogawa, A. Matsumura, K. Saigoh, S. Itoh, K. Sutou, M. Kobayashi, Y. Mita, M. Shichiri, S. Hisahara, Y. Hara, H. Fujimura, H. Takamatsu, Y. Hagihara, Y. Yoshida, T. Hamakubo, S. Kusunoki, S. Shimohama, N. Noguchi
    • Journal Title

      Sci Rep

      Volume: 29 Issue: 1 Pages: 30793-30793

    • DOI

      10.1038/srep30793

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Coupling CDH17 and CLDN18 markers for comprehensive membrane-targeted detection of human gastric cancer.2016

    • Author(s)
      K. Matsusaka, T. Ushiku, M. Urabe, M. Fukuyo, H. Abe, S. Ishikawa, Y. Seto, H. Aburatani, T. Hamakubo, A. Kaneda, M. Fukayama
    • Journal Title

      Oncotarget

      Volume: 7 Issue: 39 Pages: 64168-64181

    • DOI

      10.18632/oncotarget.11638

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Short-term outcomes of robotic radical esophagectomy for esophageal cancer by a nontransthoracic approach compared with conventional transthoracic surgery.2016

    • Author(s)
      Mori K, Yamagata Y, Aikou S, Nishida M, Kiyokawa T, Yagi K, Yamashita H, Nomura S, Seto Y.
    • Journal Title

      Dis Esophagus

      Volume: in press Issue: 5 Pages: 429-434

    • DOI

      10.1111/dote.12345

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Safety and Effectiveness of Endovenous Laser Ablation Combined With Ligation for Severe Saphenous Varicose Veins in Japanese Patients2016

    • Author(s)
      Izumi M, Ikeda Y, Yamashita H, Asaoka Y, Fujishiro M, Shin M, Abo Y.
    • Journal Title

      International Heart Journal

      Volume: 57 Issue: 1 Pages: 87-90

    • DOI

      10.1536/ihj.15-282

    • NAID

      130005120984

    • ISSN
      1349-2365, 1349-3299
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pretreatment Neutrophil to Lymphocyte Ratio Independently Predicts Disease-specific Survival in Patients With Resectable Gastroesophageal Junction and Gastric Cancer2016

    • Author(s)
      M. Urabe, H. Yamashita, Y. Seto
    • Journal Title

      Ann Surg

      Volume: - Issue: 6 Pages: e76-e77

    • DOI

      10.1097/sla.0000000000001596

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glucose metabolism in gastric cancer: The cutting-edge.2016

    • Author(s)
      Yuan LW, Yamashita H, Seto Y.
    • Journal Title

      World J Gastroenterol.

      Volume: 22 Issue: 6 Pages: 2046-2059

    • DOI

      10.3748/wjg.v22.i6.2046

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] In Epstein-Barr virus-associated gastric carcinoma a high density of CD66b-positive tumor-associated neutrophils is associated with intestinal-type histology and low frequency of lymph node metastasis2016

    • Author(s)
      H. Abe, T. Morikawa, R. Saito, H. Yamashita, Y. Seto, M. Fukayama
    • Journal Title

      Virchows Arch

      Volume: 468 Issue: 5 Pages: 539-548

    • DOI

      10.1007/s00428-016-1915-z

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early endoscopic management for early bowel obstruction after gastrectomy: a case report2016

    • Author(s)
      K. Higashizono, S. Aikou, K. Yagi, K. Mori, H. Yamashita, S. Nomura, Y. Seto
    • Journal Title

      Surg Case Rep

      Volume: 2 Issue: 1 Pages: 35-35

    • DOI

      10.1186/s40792-016-0164-3

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Low density of CD204-positive M2-type tumor-associated macrophages in Epstein-Barr virus-associated gastric cancer: a clinicopathologic study with digital image analysis2016

    • Author(s)
      T. Ichimura, H. Abe, T. Morikawa, H. Yamashita, S. Ishikawa, T. Ushiku, Y. Seto, M. Fukayama
    • Journal Title

      Hum Pathol

      Volume: 56 Pages: 74-80

    • DOI

      10.1016/j.humpath.2016.06.002

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Galectin expression in healing wounded skin treated with low-temperature plasma:Comparison with treatment by electronical coagulation.2016

    • Author(s)
      Akimoto Y, Ikehara S, Yamaguchi T, Kim J, Hayato Kawakami, Nobuyuki Shimizu, Masaru Hori, Hajime Sakakita, Ikehara Y.
    • Journal Title

      Archives of Biochemistry and Biophysics

      Volume: 印刷中 Pages: 86-94

    • DOI

      10.1016/j.abb.2016.01.012

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Is the transthoracic approach no longer a viable option for Siewert type II esophagogastric junction carcinoma?2016

    • Author(s)
      H.Yamashita, Y. Seto
    • Journal Title

      Transl Gastroenterol Hepatol

      Volume: 1 Pages: 14-14

    • DOI

      10.21037/tgh.2016.03.07

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 連続411例に行った単孔式腹腔鏡下胆嚢摘出術(USIDT,臍部2トロカー法)における手術成績の検討.2016

    • Author(s)
      渡邊五朗、清水伸幸、辻塚一幸、高尾良彦、奥田誠、菊池潔、橋本雅司、進藤潤一、佐々木一成
    • Journal Title

      胆と膵

      Volume: 37 Pages: 769-773

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 低侵襲プラズマ止血機器の開発2016

    • Author(s)
      榊田創、池原譲、清水伸幸、山田大将、清水一男
    • Journal Title

      機械の研究

      Volume: 68 Pages: 319-321

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Suppression of Slit2/ROBO1 mediated HUVEC migration by Robo42016

    • Author(s)
      Enomoto S, Mitsui K, Kawamura T, Iwanari H, Daigo K, Horiuchi K, Minami T, Kodama T, Hamakubo T.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 469 Issue: 4 Pages: 797-802

    • DOI

      10.1016/j.bbrc.2015.12.075

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pretreatment neutrophil to lymphocyte ratio independently predicts disease-specific survival in patients with resectable gastroesophageal junction and gastric cancer.2016

    • Author(s)
      Urabe M, Yamashita H, Seto Y.
    • Journal Title

      Ann Surg

      Volume: in press

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure and mechanism of the mammalian fructose transporter GLUT52015

    • Author(s)
      Nomura N, Verdon G, Kang HJ, Shimamura T, Nomura Y, Sonoda Y, Hussien SA, Qureshi AA, Coincon M, Sato Y, Abe H, Nakada-Nakura Y, Hino T, Arakawa T, Kusano-Arai O, Iwanari H, Murata T, Kobayashi T, Hamakubo T, Kasahara M, Iwata S, Drew D
    • Journal Title

      Nature

      Volume: 526 Issue: 7573 Pages: 397-401

    • DOI

      10.1038/nature14909

    • NAID

      120005657713

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Severely exacerbated neuromyelitis optica rat model with extensive astrocytopathy by high affinity anti-aquaporin-4 monoclonal antibody.2015

    • Author(s)
      Kurosawa K, Misu T, Takai Y, Sato DK, Takahashi T, Abe Y, Iwanari H, Ogawa R, Nakashima I, Fujihara K, Hamakubo T, Yasui M, Aoki M.
    • Journal Title

      Acta Neuropathol Commun

      Volume: 4 Issue: 1 Pages: 783-783

    • DOI

      10.1186/s40478-015-0259-2

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Crystal structure of the anion exchanger domain of human erythrocyte band 32015

    • Author(s)
      Arakawa T, Kobayashi-Yurugi T, Alguel Y, Iwanari H, Hatae H, Iwata M, Abe Y, Hino T, Ikeda-Suno C, Kuma H, Kang D, Murata T, Hamakubo T, Cameron AD, Kobayashi T, Hamasaki N, Iwata S
    • Journal Title

      Science

      Volume: 350 Issue: 6261 Pages: 680-684

    • DOI

      10.1126/science.aaa4335

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Copper Transport Protein Antioxidant-1 Promotes Inflammatory Neovascularization via Chaperone and Transcription Factor Function2015

    • Author(s)
      Gin-Fu Chen, Varadarajan Sudhahar, Seock-Won Youn, Archita Das, Jaehyung Cho, Tetsuro Kamiya, Norifumi Urao, Ronald D. McKinney, Bayasgalan Surenkhuu, Takao Hamakubo, Hiroko Iwanari, Senlin Li, John W. Christman, Saran Shantikumar, Gianni D. Angelini, Costanza Emanueli, Masuko Ushio-Fukai, Tohru Fukai
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 14780-14780

    • DOI

      10.1038/srep14780

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] MicroRNA-153 Regulates the Acquisition of Gliogenic Competence by Neural Stem Cells.2015

    • Author(s)
      Tsuyama J, Bunt J, Richards LJ, Iwanari H, Mochizuki Y, Hamakubo T, Shimazaki T, Okano H.
    • Journal Title

      Stem Cell Reports.

      Volume: 5 Pages: 365-377

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 90Y-Labeled Anti-ROBO1 Monoclonal Antibody Exhibits Antitumor Activity against Small Cell Lung Cancer Xenografts.2015

    • Author(s)
      Fujiwara K, Koyama K, Suga K, Ikemura M, Saito Y, Hino A, Iwanari H, Kusano-Arai O, Mitsui K, Kasahara H, Fukayama M, Kodama T, Hamakubo T, Momose T.
    • Journal Title

      PLoS One.

      Volume: 10

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lysophosphatidylcholine promotes SREBP-2 activation via rapid cholesterol efflux and SREBP-2-independent cytokine release in human endothelial cells2015

    • Author(s)
      Morita M, Sekine A, Urano Y, Nishimura T, Takabe W, Arai H, Hamakubo T, Kodama T, Noguchi N.
    • Journal Title

      J Biochem.

      Volume: 158 Issue: 4 Pages: 331

    • DOI

      10.1093/jb/mvv044

    • NAID

      40020615439

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Factor H-related protein 5 interacts with pentraxin 3 and the extracellular matrix and modulates complement activation.2015

    • Author(s)
      Csincsi ÁI, Kopp A, Zöldi M, Bánlaki Z, Uzonyi B, Hebecker M, Caesar JJ, Pickering MC, Daigo K, Hamakubo T, Lea SM, Goicoechea de Jorge E, Józsi M.
    • Journal Title

      J Immunol.

      Volume: 194 Issue: 10 Pages: 4963-4973

    • DOI

      10.4049/jimmunol.1403121

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Solitary fibrous tumor of the greater omentum, mimicking gastrointestinal stromal tumor of the small intestine: a case report.2015

    • Author(s)
      Urabe M, Yamagata Y, Aikou S, Mori K, Yamashita H, Nomura S, Shibahara J, Fukayama M, Seto Y.
    • Journal Title

      Int Surg.

      Volume: 100 Issue: 5 Pages: 836-840

    • DOI

      10.9738/intsurg-d-14-00141.1

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphatidylserine-specific phospholipase A1 (PS-PLA1) expression in colorectal cancer correlates with tumor invasion and hematogenous metastasis.2015

    • Author(s)
      Iida Y, Sunami E, Yamashita H, Hiyoshi M, Ishihara S, Yamaguchi H, Inoue A, Makide K, Tsuno NH, Aoki J, Kitayama J, Watanabe T.
    • Journal Title

      Anticancer Res.

      Volume: 35 Pages: 1459-64

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of 18F-FDG uptake for detecting lymph node metastasis of gastric cancer: a prospective pilot study for one-to-one comparison of radiation dose and pathological findings.2015

    • Author(s)
      Okumura Y, Aikou S, Onoyama H, Jinbo K, Yamagata Y, Mori K, Yamashita H, Nomura S, Takahashi M, Koyama K, Momose T, Abe H, Matsusaka K, Ushiku T, Fukayama M, Seto Y.
    • Journal Title

      World J Surg Oncol.

      Volume: 13 Issue: 1 Pages: 327-327

    • DOI

      10.1186/s12957-015-0743-y

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 酵素処理などにより軟化した摂食回復支援食の胃癌術後食としての応用―初期安全性評価研究―2015

    • Author(s)
      清水伸幸、畑尾史彦、深柄和彦、大谷幸子、関根里恵、朝倉比都美、岡本智子、稲葉毅、柴田近、福島亮治、佐々木巌、瀬戸泰之
    • Journal Title

      外科と代謝

      Volume: 49 Pages: 169-176

    • NAID

      130005128178

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemical corrector treatment ameliorates increased seizure susceptibility in a mouse model of familial temporal lobe epilepsy.2015

    • Author(s)
      Yokoi N, Fukata Y, Kase D, Miyazaki T, Jaegle M, Ohkawa T, Takahashi N, Iwanari H, Mochizuki Y, Hamakubo T, Imoto K, Meijer D, Watanabe M, Fukata M
    • Journal Title

      Nat Med

      Volume: 21 Issue: 1 Pages: 19-26

    • DOI

      10.1038/nm.3759

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Structural features of interfacial tyrosine residue in ROBO1 fibronectin domain-antibody complex: Crystallographic, thermodynamic, and molecular dynamic analyses.2015

    • Author(s)
      Nakayama T, Mizohata E, Yamashita T, Nagatoishi S, Nakakido M, Iwanari H, Mochizuki Y, Kado Y, Yokota Y, Satoh R, Tsumoto K, Fujitani H, Kodama T, Hamakubo T, Inoue T.
    • Journal Title

      Protein Sci

      Volume: 24 Issue: 3 Pages: 328-340

    • DOI

      10.1002/pro.2619

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential expression of pentraxin 3 in neutrophils.2015

    • Author(s)
      Razvina O, Jiang S, Matsubara K, Ohashi R, Hasegawa G, Aoyama T, Daigo K, Kodama T, Hamakubo T, Naito M.
    • Journal Title

      Exp Mol Pathol

      Volume: 98 Issue: 1 Pages: 33-40

    • DOI

      10.1016/j.yexmp.2014.11.009

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma.2014

    • Author(s)
      Kakiuchi M, Nishizawa T, Ueda H, Gotoh K, Tanaka A, Hayashi A, Yamamoto S, Tatsuno K, Katoh H, Watanabe Y, Ichimura T, Ushiku T, Funahashi S, Tateishi K, Wada I, Shimizu N, Nomura S, Koike K, Seto Y, Fukayama M, Aburatani H, Ishikawa S
    • Journal Title

      Nat Genet.

      Volume: 46(6) Issue: 6 Pages: 583-7

    • DOI

      10.1038/ng.2984

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Landiolol hydrochloride for early postoperative tachycardia after transthoracic esophagectomy.2014

    • Author(s)
      Mori K, Yamada K, Fukuda T, Mitsui T, Kitamura T, Yamaguchi D, Ando J, Wada I, Nomura S, Shimizu N, Seto Y
    • Journal Title

      Surg Today

      Volume: 44 Issue: 5 Pages: 848-854

    • DOI

      10.1007/s00595-013-0615-4

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Non-exposed endoscopic wall-inversion surgery as a novel partial gastrectomy technique.2014

    • Author(s)
      Mitsui T, Niimi K, Yamashita H, Goto O, Aikou S, Hatao F, Wada I, Shimizu N, Fujishiro M, Koike K, Seto Y
    • Journal Title

      Gastric Cancer

      Volume: 17 Issue: 3 Pages: 594-599

    • DOI

      10.1007/s10120-013-0291-5

    • NAID

      40020216231

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intraperitoneal injection of in vitro expanded Vγ9Vδ2 T cells together with zoledronate for the treatment of malignant ascites due to gastric cancer.2014

    • Author(s)
      Wada I, Matsushita H, Noji S, Mori K, Yamashita H, Nomura S, Shimizu N, Seto Y, Kakimi K
    • Journal Title

      Cancer Med

      Volume: 3 Issue: 2 Pages: 362-375

    • DOI

      10.1002/cam4.196

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A two-stage operation for thoracic esophageal cancer: esophagectomy and subsequent reconstruction by a free jejunal flap.2014

    • Author(s)
      Okumura Y, Mori K, Yamagata Y, Fukuda T, Wada I, Shimizu N, Nomura S, Iida T, Mihara M, Seto Y.
    • Journal Title

      Surg Today

      Volume: 44 Issue: 2 Pages: 395-398

    • DOI

      10.1007/s00595-013-0797-9

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Esophageal intramucosal hematoma after peripheral blood stem cell transplantation: case report and review of literature.2014

    • Author(s)
      Kobayashi T, Seo S, Morita S, Goto A, Masuda A, Shimizu N, Nishida M, Nunobe S, Ichikawa M, Takazawa Y, Seto Y, Fukayama M, Kurokawa M
    • Journal Title

      Int J Clin Exp Pathol.

      Volume: 7 Pages: 2690-2694

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p652014

    • Author(s)
      Shinozaki S, Chang K, Sakai M, Shimizu N, Yamada M, Tanaka T, Nakazawa H,Ichinose F, Yamada Y, Ishigami A, Ito H, Ouchi Y, Starr ME, Saito H, Shimokado K,Stamler JS, Kaneki M
    • Journal Title

      Sci Signal

      Volume: 7 Issue: 351

    • DOI

      10.1126/scisignal.2005375

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] G protein-dependent basal and evoked endothelial cell vWF secretion.2014

    • Author(s)
      Rusu L, Andreeva A, Visintine DJ, Kim K, Vogel SM, Stojanovic-Terpo A, Chernaya O, Liu G, Bakhshi FR, Haberichter SL, Iwanari H, Kusano-Arai O, Suzuki N, Hamakubo T, Kozasa T, Cho J, Du X, Minshall RD.
    • Journal Title

      Blood

      Volume: 123 Issue: 3 Pages: 442-450

    • DOI

      10.1182/blood-2013-03-489351

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification and Characterization of the X-Dimer of Human P-Cadherin : Implications for Homophilic Cell Adhesion2014

    • Author(s)
      Shota Kudo, Jose M. M. Caaveiro, Shuichiro Goda, Satoru Nagatoishi, Keisuke Ishii, Tadashi Matsuura, Yukio Sudou, Tatsuhiko Kodama, Takao Hamakubo, and Kouhei Tsumoto
    • Journal Title

      Biochemistry

      Volume: 53(11) Issue: 11 Pages: 1742-1752

    • DOI

      10.1021/bi401341g

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Conjugation-free, visual, and quantitative evaluation of inhibitors on protein tyrosine kinases and phosphatases with a luminescent Tb(III) complex2014

    • Author(s)
      Hiroki Akiba, Jun Sumaoka, Takao Hamakubo, Makoto Komiyama
    • Journal Title

      Analytical and Bioanalytical Chemistry

      Volume: 406 Issue: 12 Pages: 2957-2964

    • DOI

      10.1007/s00216-014-7707-x

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A 90Y-labelled anti-ROBO1 monoclonal antibody exhibits antitumour activity against hepatocellular carcinoma xenografts during ROBO1-targeted radioimmunotherapy.2014

    • Author(s)
      Fujiwara K, Koyama K, Suga K, Ikemura M, Saito Y, Hino A, Iwanari H, Kusano-Arai O, Mitsui K, Kasahara H, Fukayama M, Kodama T, Hamakubo T, Momose T.
    • Journal Title

      EJNMMI Research

      Volume: 4 Issue: 1 Pages: 29-29

    • DOI

      10.1186/s13550-014-0029-3

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gα13/PDZ-RhoGEF/RhoA signaling is essential for gastrin-releasing peptide receptor-mediated colon cancer cell migration.2014

    • Author(s)
      Patel M, Kawano T, Suzuki N, Hamakubo T, Karginov AV, Kozasa T.
    • Journal Title

      Mol Pharmacol

      Volume: 86 Issue: 3 Pages: 252-262

    • DOI

      10.1124/mol.114.093914

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] PPARβ/δ activation of CD300a controls intestinal immunity.2014

    • Author(s)
      Tanaka T, Tahara-Hanaoka S, Nabekura T, Ikeda K, Jiang S, Tsutsumi S, Inagaki T, Magoori K, Higurashi T, Takahashi H, Tachibana K, Tsurutani Y, Raza S, Anai M, Minami T, Wada Y, Yokote K, Doi T, Hamakubo T, Auwerx J, Gonzalez FJ, Nakajima A, Aburatani H, Naito M, Shibuya A, Kodama T, Sakai J.
    • Journal Title

      Sci Rep

      Volume: 4 Issue: 1 Pages: 5412-5412

    • DOI

      10.1038/srep05412

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immunostaining of oxidized DJ-1 in human and mouse brains.2014

    • Author(s)
      Saito, Y., T. Miyasaka, H. Hatsuta, K. Takahashi-Niki, K. Hayashi, Y. Mita, O. Kusano-Arai, H. Iwanari, H. Ariga, T. Hamakubo, Y. Yoshida, E. Niki, S. Murayama, Y. Ihara and N. Noguchi
    • Journal Title

      J Neuropathol Exp Neurol

      Volume: 73 Issue: 7 Pages: 714-728

    • DOI

      10.1097/nen.0000000000000087

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical initiatives linking Japanese and Swedish healthcare resources on cancer studies utilizing Biobank Repositories.2014

    • Author(s)
      Nishimura T, Kawamura T, Sugihara Y, Bando Y, Sakamoto S, Nomura M, Ikeda N, Ohira T, Fujimoto J, Tojo H, Hamakubo T, Kodama T, Andersson R, Fehniger TE, Kato H, Marko-Varga G.
    • Journal Title

      Clin Transl Med.

      Volume: 3 Issue: 1 Pages: 61-61

    • DOI

      10.1186/s40169-014-0038-x

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protective effect of the long pentraxin PTX3 against histone-mediated endothelial cell cytotoxicity in sepsis.2014

    • Author(s)
      Daigo K, Nakakido M, Ohashi R, Fukuda R, Matsubara K, Minami T, Yamaguchi N, Inoue K, Jiang S, Naito M, Tsumoto K, Hamakubo T.
    • Journal Title

      Sci Signal

      Volume: 7 Issue: 343

    • DOI

      10.1126/scisignal.2005522

    • NAID

      120005537769

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Proteoliposome-based selection of a recombinant antibody fragment against the human M2 muscarinic acetylcholine receptor.2014

    • Author(s)
      Suharni, Nomura Y, Arakawa T, Hino T, Abe H, Nakada-Nakura Y, Sato Y, Iwanari H, Shiroishi M, Asada H, Shimamura T, Murata T, Kobayashi T, Hamakubo T, Iwata S, Nomura N.
    • Journal Title

      Monoclon Antib Immunodiagn Immunother

      Volume: 33 Issue: 6 Pages: 378-385

    • DOI

      10.1089/mab.2014.0041

    • NAID

      120005530933

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Laboratory-size three-dimensional x-ray microscope with Wolter type I mirror optics and an electron-impact water window x-ray source.2014

    • Author(s)
      Ohsuka S, Ohba A, Onoda S, Nakamoto K, Nakano T, Miyoshi M, Soda K, Hamakubo T.
    • Journal Title

      Rev Sci Instrum

      Volume: 85 Issue: 9 Pages: 093701-093701

    • DOI

      10.1063/1.4894468

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation of antibodies against membrane proteins.2014

    • Author(s)
      Hamakubo T, Kusano-Arai O, Iwanari H.
    • Journal Title

      Biochim Biophys Acta

      Volume: 1844 Issue: 11 Pages: 1920-1924

    • DOI

      10.1016/j.bbapap.2014.08.007

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD90(+)CD45(-) intraperitoneal mesothelial-like cells inhibit T cell activation by production of arginase I.2014

    • Author(s)
      Kitayama J, Emoto S, Yamaguchi H, Ishigami H, Yamashita H, Seto Y, Matsuzaki K, Watanabe T.
    • Journal Title

      Cell Immunol

      Volume: 288 Issue: 1-2 Pages: 8-14

    • DOI

      10.1016/j.cellimm.2014.01.008

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Endoscopic trimming of a migrated gastroduodenal stent using a loop cutter and a two-channel endoscope.2014

    • Author(s)
      Sasaki T, Isayama H, Yoshida S, Nakai Y, Yamashita H, Seto Y, Koike K.
    • Journal Title

      Endoscopy

      Volume: 46 Issue: S 01 Pages: E462-E463

    • DOI

      10.1055/s-0034-1377552

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Salvage gastrectomy after intravenous and intraperitoneal paclitaxel (PTX) administration with oral S-1 for peritoneal dissemination of advanced gastric cancer with malignant ascites.2014

    • Author(s)
      Kitayama J, Ishigami H, Yamaguchi H, Yamashita H, Emoto S, Kaisaki S, Watanabe T.
    • Journal Title

      Ann Surg Oncol.

      Volume: 21 Issue: 2 Pages: 539-46

    • DOI

      10.1245/s10434-013-3208-y

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] HER2 expression in carcinomas of the true cardia (siewert type II esophagogastric junction carcinoma)2014

    • Author(s)
      Katai H, Ishida M, Yamashita H, Ohashi M, Morita S, Katayama H, Fukagawa T, Kushima R.
    • Journal Title

      World J Surg

      Volume: 38 Issue: 2 Pages: 426

    • DOI

      10.1007/s00268-013-2256-6

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Flow cytometric quantification of intraperitoneal free tumor cells in patients with peritoneal metastasis.2014

    • Author(s)
      Kitayama J, Emoto S, Yamaguchi H, Ishigami H, Kamei T, Yamashita H, Seto Y, Matsuzaki K, Watanabe T.
    • Journal Title

      Cytometry B Clin Cytom

      Volume: 86 Issue: 1 Pages: 56-62

    • DOI

      10.1002/cyto.b.21126

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] NOによる蛋白修飾と細胞保護作用2013

    • Author(s)
      張京浩
    • Journal Title

      Journal of Medical Gases

      Volume: 15 Pages: 13-19

    • NAID

      130007708688

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Formation of Membrane-like Structures in Clotted Blood by Mild Plasma Treatment during Hemostasis.2013

    • Author(s)
      Ikehara Y., Sakakita H, Shimizu N, Ikehara S, Nakanishi H
    • Journal Title

      J Photopol Sci Tech

      Volume: 26 Pages: 555-557

    • NAID

      130004833534

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Wilms' tumor 1-associating protein complex and its role in alternative splicing and the cell cycle.2013

    • Author(s)
      Horiuchi K, Kawamura T, Iwanari H, Ohashi R, Naito M, Kodama T, Hamakubo T
    • Journal Title

      J Biol Chem

      Volume: 288 Issue: 46 Pages: 33292-33302

    • DOI

      10.1074/jbc.m113.500397

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Host-protective effect of circulating pentraxin 3 (PTX3) and complex formation with neutrophil extracellular traps2012

    • Author(s)
      Daigo K, Hamakubo T
    • Journal Title

      Front Immunol

      Volume: 3:378 Pages: 378-378

    • DOI

      10.3389/fimmu.2012.00378

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The proteomic profile of circulating pentraxin 3 (PTX3) complex in sepsis demonstrates the interaction with azurocidin 1 and other components of neutrophil extracellular traps2012

    • Author(s)
      Daigo K, Yamaguchi N, Kawamura T, Matsubara K, Jiang S, Ohashi R, Sudou Y, Kodama T, Naito M, Inoue K, Hamakubo T
    • Journal Title

      Mol Cell Proteomics

      Volume: 11(6) Issue: 6 Pages: M111.015073-M111.015073

    • DOI

      10.1074/mcp.m111.015073

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of cytotoxicity induced by proinflammatory cytokines in the human alveolar epithelial cell line A549.2012

    • Author(s)
      Muroya M, Chang K, Uchida K, Bougaki M, Yamada Y.
    • Journal Title

      Biosci Trends

      Volume: 6 Pages: 70-80

    • NAID

      130004572568

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Protective Effects of PTX3 Against Histone Cytotoxicity2015

    • Author(s)
      Keita Soda, Takao Hamakubo
    • Organizer
      第44回日本免疫学会
    • Place of Presentation
      札幌
    • Year and Date
      2015-12-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] PETイメージングのための小分子化抗体プローブ作製2015

    • Author(s)
      浜窪隆雄
    • Organizer
      日本薬物動態学会第30回年会
    • Place of Presentation
      東京
    • Year and Date
      2015-11-12
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Soluble Proteins Form Film by the Treatment of Low Temperature Plasma.2015

    • Author(s)
      Sanae IKEHARA, Hajime SAKAKITA, Kenji ISHIKAWA, Yoshihiro AKIMOTO, Hayao NAKANISHI, Nobuyuki SHIMIZU, Masaru HORI, Yuzuru IKEHARA.
    • Organizer
      9th International Conference on Reactive Plasma / 68th Gaseous Electronics Conference.
    • Place of Presentation
      Hawaii Convention Center, Honolulu, Hawaii, USA
    • Year and Date
      2015-10-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Measurements of Striation Phenomena in Low Energy Atmospheric Pressure Plasma Using the Optical Emission Spectoscopy.2015

    • Author(s)
      Hiromasa YAMADA, Hajime SAKAKITA, Yutaka FUJIWARA, Yuzuru IKEHARA, Jaeho KIM, Satoru KIYAMA, Susumu KATO, Masanori FUJIWARA, Hirotomo ITAGAKI, Tomonori HATTA, Hayao NAKANISHI, Nobuyuki SHIMIZU.
    • Organizer
      9th International Conference on Reactive Plasma / 68th Gaseous Electronics Conference.
    • Place of Presentation
      Hawaii Convention Center, Honolulu, Hawaii, USA
    • Year and Date
      2015-10-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Systematization of the mechanism by which plasma irradiation causes cell growth and tumor cell death.2015

    • Author(s)
      Nobuyuki Shimizu
    • Organizer
      9th International Conference on Reactive Plasma / 68th Gaseous Electronics Conference.
    • Place of Presentation
      Hawaii Convention Center, Honolulu, Hawaii, USA
    • Year and Date
      2015-10-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] プラズマ医療応用の為の、マウス腹腔内癒着モデルの確立2015

    • Author(s)
      早田敬太、山下裕玄、張京浩、清水伸幸、浜窪隆雄
    • Organizer
      新学術領域研究合同公開シンポジウム
    • Place of Presentation
      名古屋大学 野依記念学術交流館 名古屋
    • Year and Date
      2015-08-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] Protective Effect of Pentraxin 3 in Animal Models of Sepsis.2015

    • Author(s)
      Takao Hamakubo, Rie Fukuda, Hiroko Iwanari, Keita Soda, Kenji Daigo.
    • Organizer
      Targeting Ebola
    • Place of Presentation
      Paris
    • Year and Date
      2015-05-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 分子生物学的解析に基づくプラズマ誘起細胞増殖・腫瘍細胞死誘起メカニズムの体系化2015

    • Author(s)
      清水伸幸
    • Organizer
      新学術領域研究「プラズマ医療科学の創成」キックオフミーティング
    • Place of Presentation
      九州大学医学部キャンパス医学部基礎研究B棟2階 講義室、福岡
    • Year and Date
      2015-05-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 膜タンパク質抗体の作製とドラッグデザイン2015

    • Author(s)
      浜窪 隆雄
    • Organizer
      日本薬学会 第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] プラズマ臨床応用に向けての分子メカニズム解析2015

    • Author(s)
      浜窪 隆雄、早田敬太、張京浩、山下裕玄、清水伸幸
    • Organizer
      新学術領域研究「プラズマ医療科学の創成」全体会議
    • Place of Presentation
      名古屋大学ES館1階ESホール
    • Year and Date
      2015-03-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Visible and Near-Infrared Spectroscopic Measurements of Reactive Species Produced by Low Temperature Atmospheric Pressure Plasma.2015

    • Author(s)
      Yamada H, Sakakita H, Ikehara Y, Kim J, Kiyama S, Fujiwara M, Itagaki H, Okazaki T, Ikehara S, Nakanishi H, Shimizu N
    • Organizer
      The 2nd International Workshop on Plasma for Cancer Treatment
    • Place of Presentation
      ES Hall, Nagoya University
    • Year and Date
      2015-03-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] A Feasibility and the Spreading Effect of Plasma Coagulation Technology to Improve the Current Approaches against Pancreatic Cancer.2015

    • Author(s)
      Ikehara Y, Sakakita H, Ikehara S, Shimizu N, Yamaguchi T, Yamagishi M, Kim J, Nakanishi H, Akimoto Y
    • Organizer
      2nd International Workshop on Plasma for Cancer Treatment
    • Place of Presentation
      ES Hall, Nagoya University
    • Year and Date
      2015-03-16
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] The Establishment of Peritoneal Adhesion Mouse Model For The Plasma Medicine.2015

    • Author(s)
      Soda K, Yamashita H, Chang K, Shimizu N, Hamakubo T
    • Organizer
      The 2nd international Workshop on Plasma for Cancer Treatment
    • Place of Presentation
      ES Hall, Nagoya University
    • Year and Date
      2015-03-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] 胃切除後早期経口摂取開始による在院日数短縮の可能性 ―全国アンケート調査結果から―2015

    • Author(s)
      清水伸幸
    • Organizer
      第87回日本胃癌学会総会
    • Place of Presentation
      メルパルク広島
    • Year and Date
      2015-03-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] Pentraxin 3 in Coronary Artery Lesions in Kawasaki Disease、2015

    • Author(s)
      Kitoh T, Kitagawa Y, Kaneko A, Shimizu M, Yachie A, Kume N, Hamakubo T.
    • Organizer
      11th International Kawasaki Disease Symposium
    • Place of Presentation
      Hawaii
    • Year and Date
      2015-02-03 – 2015-02-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 胃がん転移のPET イメージングのための小分子化抗体のプローブ作製分子イメージングによる次世代がん研究と抗がん創薬・治療の推進2015

    • Author(s)
      浜窪 隆雄
    • Organizer
      招待講演
    • Place of Presentation
      一橋講堂
    • Year and Date
      2015-01-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 敗血症におけるペントラキシン3の血管内皮細胞保護効果について2014

    • Author(s)
      浜窪 隆雄
    • Organizer
      第20回エンドトキシン・自然免疫研究会
    • Place of Presentation
      順天堂大学
    • Year and Date
      2014-12-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 診断・治療のための小分子化抗体の設計について2014

    • Author(s)
      浜窪 隆雄
    • Organizer
      次世代バイオ医薬品創出の向けた設計・基盤技術最前線
    • Place of Presentation
      ソラシティカンファレンスセンターお茶の水
    • Year and Date
      2014-10-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 抗原ペプチドへの蛋白質融合が抗原-抗体相互作用に及ぼす影響の熱力学的評価2014

    • Author(s)
      宮鍋 一紘、秋葉 宏樹、中木戸 誠、新井 修、岩成 宏子、浜窪 隆雄、津本 浩平
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] バキュロウイルスディスプレイを用いた膜タンパク質抗体親和性測定法2014

    • Author(s)
      草野-新井 修、福田 理絵、神谷 若菜、遠藤 康弘、岩成 宏子、 浜窪 隆雄
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] 難溶性蛋白質KAP8.1の溶液状態と粉末状態の多面的な解析による特徴付け2014

    • Author(s)
      Ganbat Javkhlan、松長 遼、秋葉 宏樹、下村 裕、新井 修、岩成 宏子、浜窪 隆雄、津本 浩平
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] 日本内視鏡外科学会主導のE-ラーニングによせる期待―内視鏡外科の立ち上げを経験して―2014

    • Author(s)
      清水伸幸
    • Organizer
      第27回日本内視鏡外科学会総会
    • Place of Presentation
      ホテルメトロポリタン盛岡
    • Year and Date
      2014-10-03
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] プラズマ臨床応用に向けての分子メカニズム解析― Plasma-activated medium で活性化される細胞障害性シグナルと創傷治癒における炎症反応の検討 ―2014

    • Author(s)
      清水伸幸、浜窪隆雄、早田敬太、張京浩、山下裕玄
    • Organizer
      合同公開シンポジウム「新学術の最前線~プラズマと生物と医療の協奏曲~」
    • Place of Presentation
      名古屋大学ES館1階ESホール
    • Year and Date
      2014-08-09
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Plasma-activated medium(PAM)で活性化される細胞障害性シグナルの検討2014

    • Author(s)
      清水伸幸、浜窪隆雄、早田敬太、張京浩、山下裕玄
    • Organizer
      プラズマが拓く新学術領域と今後の展開
    • Place of Presentation
      名古屋大学東山キャンパスIB電子情報館
    • Year and Date
      2014-06-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] 炎症細胞で活性化される細胞障害性シグナルの検討

    • Author(s)
      張京浩、清水伸幸
    • Organizer
      プラズマ医療科学の創世-新学術領域研究公開シンポジウム
    • Place of Presentation
      名古屋大学IB電子情報館大講義室
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Introduction of Medical Plasma Equipment for the Minimally Invasive Treatment

    • Author(s)
      Sakakita H, Ikehara Y, Kim J, Shimizu N, Ikehara S, Nakanishi H, Yamada H, Yamagishi Y, Kiyama S, Kubota A, Ichinose M, Niwa T
    • Organizer
      10th International Conference on Flow Dynamics (ICFD)
    • Place of Presentation
      Sendai International Center
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] iNOS (inducible nitric oxide synthase) and NO donor induce S-nitrosylation and inactivation of Sirt1, a key regulator of cell fate and metabolism

    • Author(s)
      Chang K, Shimizu N, Kaneki M.
    • Organizer
      17th Biennial Meeting of Society for Free Radical Research International
    • Place of Presentation
      Kyoto International Conference Center
    • Related Report
      2013 Annual Research Report
  • [Presentation] マイルドプラズマを用いた新規止血デバイスの開発

    • Author(s)
      清水伸幸
    • Organizer
      第113回日本外科学会総会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2013 Annual Research Report
  • [Presentation] 炎症性サイトカインで惹起される細胞障害性シグナルの検討

    • Author(s)
      張京浩、山田芳嗣
    • Organizer
      日本麻酔科学会
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] 分子生物学的解析に基づくプラズマ誘起細胞増殖・腫瘍細胞死誘起メカニズムの体系化

    • Author(s)
      清水伸幸
    • Organizer
      プラズマ医療科学の創世-新学術領域研究公開シンポジウム
    • Place of Presentation
      弘済会館ビル(四谷)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Surgical Treatment for Gastric Cancer: What should we research on?

    • Author(s)
      Shimizu N
    • Organizer
      Research conference of Division of Gastrointestinal Surgery
    • Place of Presentation
      Seoul National University Hospital
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 走化性におけるリガンド刺激依存的Gタンパク質活性変化と細胞膜伸長の解析

    • Author(s)
      増 一之、浜窪隆雄
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] NOによる蛋白修飾と細胞保護作用

    • Author(s)
      張京浩
    • Organizer
      第16回日本医療ガス学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report

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Published: 2012-11-27   Modified: 2019-07-29  

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