| Budget Amount *help |
¥143,910,000 (Direct Cost: ¥110,700,000、Indirect Cost: ¥33,210,000)
Fiscal Year 2016: ¥28,080,000 (Direct Cost: ¥21,600,000、Indirect Cost: ¥6,480,000)
Fiscal Year 2015: ¥25,220,000 (Direct Cost: ¥19,400,000、Indirect Cost: ¥5,820,000)
Fiscal Year 2014: ¥28,210,000 (Direct Cost: ¥21,700,000、Indirect Cost: ¥6,510,000)
Fiscal Year 2013: ¥28,080,000 (Direct Cost: ¥21,600,000、Indirect Cost: ¥6,480,000)
Fiscal Year 2012: ¥34,320,000 (Direct Cost: ¥26,400,000、Indirect Cost: ¥7,920,000)
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| Outline of Final Research Achievements |
One of the goals of this study was to understand the molecular mechanism of the spatial control of the Wnt function in thymic stromal cells. Our results suggest that the Wnt signal promotes proliferation of epithelial cells in the margin of the thymus cortex. We also found that the variation of Wnt protein complexes and that of heparan sulfate proteoglycans in the extracellular space are involved in the regulation of the diffusion pattern of Wnt proteins in model systems. Another goal that we had was to understand the developmental mechanism of the thymus primordia. Our results suggest that the interaction between Ripply3 and several LIM domain proteins, which are known to be involved in adhesion to the extracellular matrix, is required for the proper morphogenesis of the pharyngeal epithelium, from which the thymus is generated.
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