| Budget Amount *help |
¥81,510,000 (Direct Cost: ¥62,700,000、Indirect Cost: ¥18,810,000)
Fiscal Year 2016: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2015: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2014: ¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000)
Fiscal Year 2013: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2012: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
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| Outline of Final Research Achievements |
All immune cells are generated from hematopoietic stem cells (HSCs) in the bone marrow. HSCs are in contact with and maintained by restricted microenvironments, termed niches; however, the identity of cells creating HSC niches has been a subject of longstanding debate. We identified a population of mesenchymal cells, termed CXCL12-abundant reticular (CAR) cells and revealed that CAR cells create a critical niche for HSCs and lympho-hematopoiesis. In this study, we found that the transcription factor Foxc1 was preferentially expressed in CAR cells in bone marrow and was essential for development and maintenance of the niche for lympho-hematopoiesis. In addition, there are numerous empty HSC niches available for engraftment and proliferation of HSCs in bone marrow, supporting the idea that CAR cells with long processes function as niches for lympho-hematopoiesis.
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