| Budget Amount *help |
¥208,780,000 (Direct Cost: ¥160,600,000、Indirect Cost: ¥48,180,000)
Fiscal Year 2016: ¥40,040,000 (Direct Cost: ¥30,800,000、Indirect Cost: ¥9,240,000)
Fiscal Year 2015: ¥40,040,000 (Direct Cost: ¥30,800,000、Indirect Cost: ¥9,240,000)
Fiscal Year 2014: ¥40,300,000 (Direct Cost: ¥31,000,000、Indirect Cost: ¥9,300,000)
Fiscal Year 2013: ¥40,040,000 (Direct Cost: ¥30,800,000、Indirect Cost: ¥9,240,000)
Fiscal Year 2012: ¥48,360,000 (Direct Cost: ¥37,200,000、Indirect Cost: ¥11,160,000)
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| Outline of Final Research Achievements |
This study revealed a novel aspect of positive selection, in which T cell antigen-receptor affinity for positively selecting peptides produced by cortical thymic epithelial cells (cTECs) determines the subsequent antigen responsiveness of mature T cells in the periphery. It was also found that cTEC expression of beta5t, which governs positive selection of CD8+ cytotoxic T cells, is directly promoted by transcription factor Foxn1. Moreover, this study identified that postnatal medullary thymic epithelial cells (mTECs), which establish self-tolerance in T cells, are derived from perinatal bipotent progenitors that exhibit cTEC-like gene expression profiles. Essential role of CCL21 expressed by a subpopulation of mTECs in the establishment of central self-tolerance in T cells was also described.
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