• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Structural basis for the cell-cell communication at the neuro-immune interface

Planned Research

Project AreaAnalysis and synthesis of multi-dimensional immune organ network
Project/Area Number 24111006
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionOsaka University

Principal Investigator

TAKAGI JUNICHI  大阪大学, たんぱく質研究所, 教授 (90212000)

Co-Investigator(Kenkyū-buntansha) 北郷 悠  大阪大学, たんぱく質研究所, 助教 (60507185)
Co-Investigator(Renkei-kenkyūsha) IWASAKI Kenji  大阪大学, 蛋白質研究所, 准教授 (20342751)
Project Period (FY) 2012-06-28 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥146,770,000 (Direct Cost: ¥112,900,000、Indirect Cost: ¥33,870,000)
Fiscal Year 2016: ¥28,080,000 (Direct Cost: ¥21,600,000、Indirect Cost: ¥6,480,000)
Fiscal Year 2015: ¥28,080,000 (Direct Cost: ¥21,600,000、Indirect Cost: ¥6,480,000)
Fiscal Year 2014: ¥28,210,000 (Direct Cost: ¥21,700,000、Indirect Cost: ¥6,510,000)
Fiscal Year 2013: ¥28,080,000 (Direct Cost: ¥21,600,000、Indirect Cost: ¥6,480,000)
Fiscal Year 2012: ¥34,320,000 (Direct Cost: ¥26,400,000、Indirect Cost: ¥7,920,000)
Keywords免疫-神経インターフェイス / X線結晶構造解析 / 電子顕微鏡イメージング / インテグリン / セマフォリン
Outline of Final Research Achievements

In this research I aimed at understanding the molecular mechanism of cellular signal reception from the immune organs via direct cell-cell attachments using structural methods. The major methods include x-ray crystallography and electron microscopy (EM). As a result, we determined for the first time the three dimensional structure of the laminin receptor α6β1 integrin at atomic resolution. We also deduced the signaling mechanism of plexins, the semaphorin receptors, by using EM imaging technique. Other accomplishments include the isolation of a macrocyclic peptide that modulates plexinB1 signaling via allosteric mechanism, together with the clarification of its mode of action by crystallography. We also discovered multiple key molecules on neuronal cells or stem cells implicated in the homeostasis, and performed biochemical as well as structural analyses to elucidate inter-cellular signaling mechanisms in a broad biological contexts.

Report

(6 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report

Research Products

(122 results)

All 2017 2016 2015 2014 2013 2012 Other

All Int'l Joint Research (8 results) Journal Article (38 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 27 results,  Open Access: 12 results,  Acknowledgement Compliant: 8 results) Presentation (68 results) (of which Int'l Joint Research: 7 results,  Invited: 35 results) Remarks (4 results) Patent(Industrial Property Rights) (4 results)

  • [Int'l Joint Research] Karlsruher Institute of Technology(ドイツ)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] University of Torino(イタリア)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Harvard Medical School(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Max Delbruck Center for Biomedicine(ドイツ)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Bnai-Zion Medical Center(イスラエル)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Hubrecht Institute(オランダ)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] University of Torino(イタリア)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Cornel University(米国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Conformational freedom of the LRP6 ectodomain is regulated by N-glycosylation and the binding of the Wnt antagonist Dkk1.2017

    • Author(s)
      Matoba K, Mihara E, Tamura-Kawakami K, Miyazaki N, Maeda S, Hirai H, Thompson S, Iwasaki K, and Takagi J.
    • Journal Title

      Cell Rep

      Volume: 18 Issue: 1 Pages: 32-40

    • DOI

      10.1016/j.celrep.2016.12.017

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 2D hybrid analysis: Approach for building three-dimensional atomic model by electron microscopy image matching.2017

    • Author(s)
      Matsumoto A, Miyazaki N, Takagi J, and Iwasaki K.
    • Journal Title

      Scientific Rep

      Volume: 7 Issue: 1 Pages: 377-377

    • DOI

      10.1038/s41598-017-00337-y

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The unique prodomain of T-cadherin plays a key role in adiponectin binding with the essential extracellular cadherin repeats 1 and 2.2017

    • Author(s)
      Fukuda S, Kita S, Obata Y, Fujishima Y, Nagao H, Masuda S, Tanaka Y, Nishizawa H, Funahashi T, Takagi J, Maeda N, and Shimomura I.
    • Journal Title

      J Biol Chem.

      Volume: 292 Issue: 19 Pages: 7840-7849

    • DOI

      10.1074/jbc.m117.780734

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tailored placement of a turn-forming PA tag into the structured domain of a protein to probe its conformational state.2016

    • Author(s)
      Fujii Y, Matsunaga Y, Arimori T, Kitago Y, Ogasawara S, Kaneko M, Kato Y, Takagi J
    • Journal Title

      J Cell Sci.

      Volume: 12- Pages: 1512-1522

    • DOI

      10.1242/jcs.176685

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Structural basis of HGF-Met signaling2016

    • Author(s)
      海津正賢、高木淳一
    • Journal Title

      Japanese Journal of Thrombosis and Hemostasis

      Volume: 27 Issue: 1 Pages: 77-84

    • DOI

      10.2491/jjsth.27.77

    • NAID

      130005127665

    • ISSN
      0915-7441, 1880-8808
    • Related Report
      2016 Annual Research Report
  • [Journal Article] Structure of the plexin ectodomain bound by semaphorin-mimicking antibodies.2016

    • Author(s)
      Suzuki K, Tsunoda H, Omiya R, Matoba K, Baba T, Suzuki S, Segawa H, Kumanogoh A, Iwasaki K, Hattori K, Takagi J.
    • Journal Title

      PLoS One

      Volume: 11 Issue: 6 Pages: e0156719-e0156719

    • DOI

      10.1371/journal.pone.0156719

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Molecular Basis of the Ligand-binding Specificity of αvβ8 Integrin.2016

    • Author(s)
      Ozawa, A., Sato, Y., Imabayashi, T., Uemura, T., Takagi, J., and Sekiguchi, K.
    • Journal Title

      The Journal of Biological Chemisry

      Volume: 291 Issue: 22 Pages: 11551-11565

    • DOI

      10.1074/jbc.m116.719138

    • NAID

      120006585485

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structural basis for multi-specific peptide recognition by the anti-IDH1/2 monoclonal antibody, MsMab-1.2016

    • Author(s)
      Kitago Y, Kaneko MK, Ogasawara S, Kato Y, Takagi J.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 478 Issue: 3 Pages: 1274-1279

    • DOI

      10.1016/j.bbrc.2016.08.110

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Probing conformational and functional states of human hepatocyte growth factor by a panel of monoclonal antibodies.2016

    • Author(s)
      Umitsu M, Sakai K, Ogasawara S, Kaneko M, Asaki R, Tamura-Kawakami K, Kato Y, Matsumoto K, Takagi J.
    • Journal Title

      Sci Rep

      Volume: 9 Issue: 1 Pages: 33149-33149

    • DOI

      10.1038/srep33149

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The PA Tag: A Turn-forming Peptide Tag That Can Be Placed into the Structured Domain of a Protein in a Tailored Manner2016

    • Author(s)
      高木淳一
    • Journal Title

      Seibutsu Butsuri

      Volume: 56 Issue: 5 Pages: 284-287

    • DOI

      10.2142/biophys.56.284

    • NAID

      130005264852

    • ISSN
      0582-4052, 1347-4219
    • Related Report
      2016 Annual Research Report
  • [Journal Article] Redox-assisted regulation of Ca2+ homeostasis in the endoplasmic reticulum by disulfide reductase ERdj52016

    • Author(s)
      R. Ushioda, A. Miyamotod, M. Inoue, S. Watanabe, M. Okumurae, K. Maegawa, K. Uegaki, S. Fujii, Y. Fukuda, M. Umitsu, J. Takagi, K. Inaba, K. Mikoshibad, and K. Nagata
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 113(41) Issue: 41 Pages: 6055-6063

    • DOI

      10.1073/pnas.1605818113

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Allosteric inhibition of a semaphorin 4D receptor plexin B1 by a high-affinity macrocyclic peptide.2016

    • Author(s)
      Matsunaga Y, Bashiruddin NK, Kitago Y, Takagi J, Suga H.
    • Journal Title

      Cell Chem Biol

      Volume: 23 Issue: 11 Pages: 1341-1350

    • DOI

      10.1016/j.chembiol.2016.09.015

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural and biological function of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase.2016

    • Author(s)
      Morita J, Kano K, Kato K, Takita H, Skagami H, Yamamoto Y, Mihara E, Ueda H, Sato T, Tokuyama H, Arai H, Asou H, Takagi J, Ishitani R, Nishimasu H, Nureki O, Aoki J
    • Journal Title

      Sci Rep.

      Volume: 6 Issue: 1 Pages: 20995-20995

    • DOI

      10.1038/srep20995

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/α-albumin.2016

    • Author(s)
      Mihara, E., Hirai, H., Yamamoto, H., Tamura-Kawakami, K., Matano, M., Kikuchi, A., Sato, T., and Takagi, J.
    • Journal Title

      Elife

      Volume: 5 Pages: 1-19

    • DOI

      10.7554/elife.11621

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Interplay of endosomal pH and ligand occupancy in integrin α5β1 ubiquitination, endocytic sorting, and cell migration.2015

    • Author(s)
      Kharitidi D, Apaja PM, Manteghi S, Suzuki K, Malitskaya E, Roldan A, Gingras MC, Takagi J, Lukacs GL, Pause A
    • Journal Title

      Cell Rep.

      Volume: 13 Issue: 3 Pages: 599-609

    • DOI

      10.1016/j.celrep.2015.09.024

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 電子顕微鏡技術の進展と相関解析2015

    • Author(s)
      岩崎憲治
    • Journal Title

      日本結晶学会誌

      Volume: Vol57, No1 Pages: 66-71

    • NAID

      130004799738

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 巨大受容体sorLAによるアミロイドβ分解の促進2015

    • Author(s)
      北郷 悠、高木 淳一
    • Journal Title

      医学のあゆみ(医歯薬出版)

      Volume: vol.252(9) Pages: 963-964

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Structural basis for amyloidogenic peptide recognition by sorLA.2015

    • Author(s)
      Kitago Y, Nagae M, Nakata Z, Yagi-Utsumi M, Takagi-Niidome S, Mihara E, Nogi T, Kato K, Takagi J.
    • Journal Title

      Nat Struct Mol Biol.

      Volume: 22 Issue: 3 Pages: 199-206

    • DOI

      10.1038/nsmb.2954

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ここまで進んだ3-D電顕2014

    • Author(s)
      岩崎憲治,宮崎直幸
    • Journal Title

      メディカル・ダイジェスト,ニューサイエンス,

      Volume: Vol40, No.9. Pages: 5-6

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 超高親和性を有する新規アフィニティータグシステム”PAタグシステム”2014

    • Author(s)
      藤井勇樹,金子美華,加藤幸成,高木淳一
    • Journal Title

      和光純薬時報

      Volume: 82, 4. Pages: 2-4

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Editorial overview: New constructs and expression of proteins: Making things better.2014

    • Author(s)
      Takagi, J. and Tate, CG.
    • Journal Title

      Curr Opin Struct Biol.

      Volume: 26 Pages: iv-vi

    • DOI

      10.1016/j.sbi.2014.05.001

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Expression, purification, crystallization and preliminary X-ray crystallographic analysis of Enpp62014

    • Author(s)
      Morita J, Kato K, Mihara E, Ishitani R, Takagi J, Nishimasu H, Aoki J, Nureki O
    • Journal Title

      Acta Crystallogr F Struct Biol Commun

      Volume: 70 Issue: 6 Pages: 794-799

    • DOI

      10.1107/s2053230x14008929

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Giant cadherins Fat and Dachsous self-bend to organize properly spaced intercellular junctions.2014

    • Author(s)
      Yoshikazu Tsukasaki, Naoyuki Miyazaki, Atsushi Matsumoto, Shigenori Nagae, Shigenobu Yonemura, Takuji Tanoue, Kenji Iwasaki, and Masatoshi Takeichi.
    • Journal Title

      Proc Natl Acad Science USA

      Volume: 111(45) Pages: 16011-16016

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystal structures of carbohydrate recognition domain of blood dendritic cell antigen-2 (BDCA2) reveal a common domain-swapped dimer.2014

    • Author(s)
      Nagae M, Ikeda A, Kitago Y, Matsumoto N, Yamamoto K, Yamaguchi Y.
    • Journal Title

      Proteins

      Volume: 82 Issue: 7 Pages: 1512-1518

    • DOI

      10.1002/prot.24504

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 新規アフィニティータグ“PA タグ”の利用法~蛋白質の精製および検出~2014

    • Author(s)
      藤井勇樹, 金子美華, 加藤幸成, 高木淳一
    • Journal Title

      蛋白質科学会アーカイブ

      Volume: 7

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A structure-based model of substrate discrimination by a non-canonical PDZ tandem in the intramembrane-cleaving protease RseP.2014

    • Author(s)
      檜作 洋平, 小田 隆, 田畑 早苗, 川上-田村 恵子, 大井 里香, 佐藤 衛, 高木 淳一, 秋山 芳展, 禾 晃和
    • Journal Title

      Structure

      Volume: 22 Issue: 2 Pages: 326-336

    • DOI

      10.1016/j.str.2013.12.003

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel role for SORLA/SORL1 as lysosomal sorting receptor for amyloid-b peptide is impaired by familial Alzheimer disease mutation2014

    • Author(s)
      Caglayan S, Takagi-Niidome S, Liao F, Carlo A-S, Schmidt V, Burgert T, Kitago Y, Fuchtbauer E-M, Fachtbauer A, Holtzman DM, Takagi J, and Wilnow TE
    • Journal Title

      Science Translational Medicine

      Volume: 6(223) Issue: 223

    • DOI

      10.1126/scitranslmed.3007747

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PA tag: a versatile protein tagging system using a super high affinity antibody against a dodecapeptide derived from human podoplanin2014

    • Author(s)
      Fujii Y, Kaneko M, Neyazaki M, Nogi T, Kato Y, Takagi J.
    • Journal Title

      Protein Expr Purif

      Volume: 95 Pages: 240-247

    • DOI

      10.1016/j.pep.2014.01.009

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A point mutation in Semaphorin 4A associates with defective endosomal sorting and causes retinal degeneration2013

    • Author(s)
      Nojima S, et al.
    • Journal Title

      Nat Commun

      Volume: 4 Issue: 1 Pages: 1406-1406

    • DOI

      10.1038/ncomms2420

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystal structure and enzymatic activity of an ADAMTS13 mutant with the East Asian-specific P475S polymorphism.2013

    • Author(s)
      Masashi Akiyama, Daisuke Nakayama, Soichi Takeda, Koichi Kokame, Junichi Takagi, and Toshiyuki Miyata.
    • Journal Title

      J. Thromb. Haemost.

      Volume: (In press) Issue: 7 Pages: 1399-1406

    • DOI

      10.1111/jth.12279

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correlative Light-electron Microscopy: The Synapse Adhesion Mechanism2013

    • Author(s)
      宮崎直幸;田中宏樹;禾 晃和;高木淳一;岩崎憲治.
    • Journal Title

      Seibutsu Butsuri

      Volume: 53 Issue: 4 Pages: 218-221

    • DOI

      10.2142/biophys.53.218

    • NAID

      10031178748

    • ISSN
      0582-4052, 1347-4219
    • Related Report
      2013 Annual Research Report
  • [Journal Article] 相関構造解析法による階層をまたがった生命機能の統合的解明2013

    • Author(s)
      高木淳一
    • Journal Title

      パリティ

      Volume: 28-07

    • Related Report
      2013 Annual Research Report
  • [Journal Article] セマフォリン関連分子群の立体構造2013

    • Author(s)
      松永 幸子
    • Journal Title

      実験医学

      Volume: 31 Pages: 523-530

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Expression, purification, crystallization and preliminary X-ray crystallographic analysis of Enpp12012

    • Author(s)
      Kato K, Nishimasu H, Mihara E, Ishitani R, Takagi J, Aoki J, Nureki O
    • Journal Title

      Acta Crystallogr

      Volume: F68 Issue: 7 Pages: 778-782

    • DOI

      10.1107/s1744309112019306

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Higher-order architecture of cell adhesion mediated by polymorphic synaptic adhesion molecules neurexin and neuroligin2012

    • Author(s)
      Tanaka, H., Miyazaki, N., Matoba, K., Nogi, T., Iwasaki, K., and Takagi, J
    • Journal Title

      Cell Reports

      Volume: 2(1) Issue: 1 Pages: 101-110

    • DOI

      10.1016/j.celrep.2012.06.009

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Schwann cell myelination requires integration of laminin activities2012

    • Author(s)
      Karen K. McKee
    • Journal Title

      Journal of Cell Science

      Volume: 125 Pages: 4609-4619

    • DOI

      10.1242/jcs.107995

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling2012

    • Author(s)
      Kato K, Nishimasu H, Okudaira S, Mihara E, Ishitani R, Takagi J, Aoki J, Nureki O
    • Journal Title

      Proc. Natl Acad. Sci. U. S. A.

      Volume: 109 Issue: 42 Pages: 16876-16881

    • DOI

      10.1073/pnas.1208017109

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LDL受容体ファミリーの構造と蛋白質間相互作用2012

    • Author(s)
      北郷 悠
    • Journal Title

      The Lipid

      Volume: 23 Pages: 56-62

    • Related Report
      2012 Annual Research Report
  • [Presentation] プロテアーゼ切断によるHGF活性化の構造的基盤2017

    • Author(s)
      高木淳一
    • Organizer
      金沢大学がん進展制御研究所 共同利用・共同研究拠点シンポジウム
    • Place of Presentation
      金沢大学(石川県、金沢市)
    • Year and Date
      2017-02-14
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 新規フラグメント抗体フォーマット“Fv-clasp”の開発2017

    • Author(s)
      有森貴夫
    • Organizer
      未来戦略機構第六部門(創薬基盤科学研究部門)シンポジウム
    • Place of Presentation
      大阪大学銀杏会館(大阪府、吹田市)
    • Year and Date
      2017-01-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Wnt蛋白質可溶化能をもつ血清蛋白質ヒトアファミンの結晶構造2016

    • Author(s)
      平井秀憲
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜市)
    • Year and Date
      2016-12-01
    • Related Report
      2016 Annual Research Report
  • [Presentation] Wnt結合活性をもつ血清蛋白質アファミンに対するモノクローナル抗体のエピトープ解析2016

    • Author(s)
      植田匠
    • Organizer
      第39回 日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜市)
    • Year and Date
      2016-12-01
    • Related Report
      2016 Annual Research Report
  • [Presentation] HGF/c-Metシグナリングの解明に向けた二本鎖HGFの構造決定2016

    • Author(s)
      海津 正賢
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] N型糖鎖によるWnt補助受容体LRP6細胞外領域のコンフォメーション制御2016

    • Author(s)
      的場京子
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 生物活性を保持したWnt蛋白質の新たな調製方法2016

    • Author(s)
      三原恵美子
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 「2Dハイブリッド解析による電子顕微鏡平均画像の成分解析(Component analysis of averaged EM images by 2D hybrid analysis)」2016

    • Author(s)
      松本淳
    • Organizer
      第55回日本生物物理年会
    • Place of Presentation
      つくば国際会議場(茨城県、つくば市)
    • Year and Date
      2016-11-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 新規フラグメント抗体Fv-claspの結晶化シャペロンとしての応用2016

    • Author(s)
      有森貴夫
    • Organizer
      日本結晶学会平成28年度年会
    • Place of Presentation
      茨城県立県民文化センター(茨城県、茨城市)
    • Year and Date
      2016-11-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] Fv-clasp化抗体の結晶化シャペロンとしての有用性2016

    • Author(s)
      高木淳一
    • Organizer
      蛋白研セミナー「抗体創薬の最前線:バイオ医薬品開発の鍵となる分子設計技術」
    • Place of Presentation
      九州大学(福岡県、福岡市)
    • Year and Date
      2016-11-01
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Understanding the signal transduction mechanism of single-pass membrane receptors via structural analysis2016

    • Author(s)
      高木淳一
    • Organizer
      第89回日本生化学会大会シンポジウム「Making the most out of structures -Critical role of structural information in modern life science research-」
    • Place of Presentation
      仙台国際会議場(宮城県、仙台市)
    • Year and Date
      2016-09-27
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Crystal structure of human Afamin, a serum glycoprotein that solubilize lipidated Wnt proteins2016

    • Author(s)
      Hidenori Hirai
    • Organizer
      EMBO conferernce Wnt Meeting 2016
    • Place of Presentation
      Brno, Czech Republic
    • Year and Date
      2016-09-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Antibody-based technology to aid structural study of cell surface receptors.2016

    • Author(s)
      Junichi Takagi
    • Organizer
      Department Seminar, Langone Medical Center, New York University
    • Place of Presentation
      New York, USA
    • Year and Date
      2016-08-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The “PA-tag toolbox”: Purification, detection, and biophysical manipulation of high-value target proteins.2016

    • Author(s)
      Junichi Takagi
    • Organizer
      The Bioprocessing Summit "Advances in Purification Technologies"
    • Place of Presentation
      Westin Boston Waterfront, Boston, USA
    • Year and Date
      2016-08-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Antibodies and macrocyclic peptide binders to aid protein crystallization, receptor functional analysis, and lead discovery.2016

    • Author(s)
      Junichi Takagi
    • Organizer
      Program in Cellular and Melecular Medicine Seminar, Boston Children’s Hospital / Harvard Medical School
    • Place of Presentation
      Boston, USA
    • Year and Date
      2016-08-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] New format antibody drives the crystallization of sorLA Vps10p domain2016

    • Author(s)
      Kitago Y
    • Organizer
      Gordon Research Conference, Diffraction Methods in Structural Biology
    • Place of Presentation
      Bates College, Lewston ME, USA
    • Year and Date
      2016-07-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 特異抗体FabによるSorLA Vps10pドメインの結晶化促進2016

    • Author(s)
      北郷 悠
    • Organizer
      第16回日本蛋白質科学会年会
    • Place of Presentation
      福岡国際センター(福岡県、福岡市)
    • Year and Date
      2016-06-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] PAタグのループへの挿入による蛋白質の構造変化評価システム2016

    • Author(s)
      藤井勇樹
    • Organizer
      第16回 日本蛋白質科学会年会
    • Place of Presentation
      福岡国際センター(福岡県、福岡市)
    • Year and Date
      2016-06-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] Wnt結合能を有するヒトAfaminの構造解析2016

    • Author(s)
      平井秀憲
    • Organizer
      第16回日本蛋白質科学会年会
    • Place of Presentation
      福岡国際センター(福岡県、福岡市)
    • Year and Date
      2016-06-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] SLE患者由来抗DNA抗体の結晶構造解析2016

    • Author(s)
      有森貴夫
    • Organizer
      第16回 日本蛋白質科学会年会
    • Place of Presentation
      福岡国際センター(福岡県、福岡市)
    • Year and Date
      2016-06-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] 難溶性分泌タンパク質Wnt3aの発現精製・保存法の開発とその再生医療へのインパクト2016

    • Author(s)
      高木淳一
    • Organizer
      第16回日本蛋白質科学会年会 ワークショップ「最新の蛋白質科学を支えるサンプル調製」
    • Place of Presentation
      福岡国際センター(福岡県、福岡市)
    • Year and Date
      2016-06-07
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 神経ガイダンス因子セマフォリン4D受容体であるプレキシンB1に対するアロステリック阻害環状ペプチドP6の構造機能解析2016

    • Author(s)
      松永幸子
    • Organizer
      第16回日本蛋白質科学会年会
    • Place of Presentation
      福岡国際会議場(福岡県、福岡市)
    • Year and Date
      2016-06-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] プロテアーゼ切断によるHGF活性化の構造的基盤2016

    • Author(s)
      海津 正賢
    • Organizer
      第16回日本蛋白質科学学会
    • Place of Presentation
      福岡国際会議場(福岡県、福岡市)
    • Year and Date
      2016-06-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] Revisiting the structure-activity relationship of semaphorin 3A2016

    • Author(s)
      高木淳一
    • Organizer
      第89回日本薬理学会年会シンポジウム「創薬ターゲットとしてのセマフォリン」
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-03-09
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 新規エピトープタグ開発と分子イメージングへの応用2016

    • Author(s)
      高木淳一
    • Organizer
      第370回CBI学会研究講演会「分子イメージングと創薬」
    • Place of Presentation
      東京大学山上会館(東京都文京区)
    • Year and Date
      2016-03-03
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 高難度創薬ターゲット蛋白質の生産技術革新とそのインパクト2015

    • Author(s)
      高木淳一
    • Organizer
      BMB2015ワークショップ「分子生物学と構造生命科学による創薬への挑戦」
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 抗ペプチド抗体を用いたカスタムアフィニティータグシステムの開発とその応用2015

    • Author(s)
      高木淳一
    • Organizer
      第25回WSフォーラム「蛋白質・ペプチド研究の現状と展望」
    • Place of Presentation
      九州大学(福岡県福岡市)
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 糖鎖工学・タンパク質工学を駆使して高付加価値抗体を創成する!2015

    • Author(s)
      高木淳一
    • Organizer
      第3回創薬等支援技術基盤プラットフォーム公開シンポジウム
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] A versatile protein tagging system for recombinant protein production, isolation, and detection in mammalian cells.2015

    • Author(s)
      高木淳一
    • Organizer
      HUPO 2015 Wako Pure Chemical Industries, Ltd. Industry Seminar
    • Place of Presentation
      バンクーバー(カナダ)
    • Year and Date
      2015-09-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Use of custom-made epitope tagging system to facilitate structural biology on mammalian receptors,2015

    • Author(s)
      高木淳一
    • Organizer
      The First Trilateral Workshop for Frontier Protein Studies
    • Place of Presentation
      北京(中国)
    • Year and Date
      2015-04-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 脳内アミロイドペプチド受容体sorLAの立体構造2015

    • Author(s)
      高木淳一
    • Organizer
      第三回物構研サイエンスフェスタ
    • Place of Presentation
      エポカルつくば
    • Year and Date
      2015-03-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Boosting the protein production pipeline by the use of custom-made epitope tagging system.2015

    • Author(s)
      高木淳一
    • Organizer
      WINTech 2015 “Innovation by Synergy of Computational & Synchrotron Radiation Sciences"
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 動物細胞発現系を用いた高品質受容体タンパク質生産とカスタムアフィニティータグシステムの開発2015

    • Author(s)
      海津 正賢
    • Organizer
      大阪大学未来戦略機構国際シンポジウム
    • Place of Presentation
      大阪(梅田)
    • Year and Date
      2015-03-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] 創薬ターゲットの高品質生産の技術と応用2015

    • Author(s)
      高木淳一
    • Organizer
      PDIS最先端セミナー「創薬につなぐ日本の創薬基盤技術」
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2015-02-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ヒト疾患関連受容体の構造生物学研究における高品質タンパク質生産技術の重要性-「技術開発」と「基礎研究」は車の両輪-2015

    • Author(s)
      高木淳一
    • Organizer
      創薬等PF特別セミナー
    • Place of Presentation
      東北大学
    • Year and Date
      2015-01-16
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Immunological tools to aid recombinant protein production and analysis2014

    • Author(s)
      高木淳一
    • Organizer
      第43回日本免疫学会学術集会 テクニカルセミナー
    • Place of Presentation
      京都国際会館
    • Year and Date
      2014-12-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 創薬ターゲット蛋白質の生産におけるカスタムアフィニティータグシステム利用の威力2014

    • Author(s)
      高木淳一
    • Organizer
      第37回日本分子生物学会年会 バイオテクノロジーセミナー
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 構造解析に向けたc-Metレセプター細胞外蛋白質の高効率生産2014

    • Author(s)
      海津 正賢
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Structural analysis can lead to a discovery of novel biological function -a case with neuronal lipoprotein receptor sorLA-2014

    • Author(s)
      Junichi Takagi
    • Organizer
      Seminar on Structural Neuroscience
    • Place of Presentation
      Peking University, China
    • Year and Date
      2014-10-31
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Crystal structure of full-length ApoER2 ectodomain in complex with its ligand reelin2014

    • Author(s)
      Hidenori Hirai
    • Organizer
      Cold Spring Harbor Asia Conference (Mechanism of Transmembrane Signaling).
    • Place of Presentation
      Suzhou, China
    • Year and Date
      2014-10-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] Use of custom-made epitope tagging system to facilitate receptor structural biology.2014

    • Author(s)
      Junichi Takagi
    • Organizer
      Cold Spring Harbor Asia Conference (Mechanism of Transmembrane Signaling).
    • Place of Presentation
      Suzhou, China
    • Year and Date
      2014-10-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Efficient production of receptor ectodomains for structural analysis2014

    • Author(s)
      Masataka Umitsu
    • Organizer
      Cold Spring Harbor Asia Conference (Mechanism of Transmembrane Signaling).
    • Place of Presentation
      Suzhou, China
    • Year and Date
      2014-10-27 – 2014-10-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] 新規アフィニティータグ「PA tag」のループへの挿入による効果的な利用法2014

    • Author(s)
      藤井勇樹
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都国際会館
    • Year and Date
      2014-10-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] 2D hybrid analysis: A new approach to build 3D atomic model from 2D EM image2014

    • Author(s)
      岩崎憲治
    • Organizer
      第52回日本生物物理学会年会
    • Place of Presentation
      札幌コンベンションセンター, 札幌
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] “PA tag”, a versatile affinity tag system that enables one-step affinity purification and high sensitive detection of recombinant proteins from dilute sample2014

    • Author(s)
      藤井勇樹
    • Organizer
      The 28th Annual Symposium of The Protein Society
    • Place of Presentation
      Manchester Grand Hyatt, San Diego
    • Year and Date
      2014-07-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 創薬ターゲット蛋白質の生産におけるカスタムアフィニティータグシステム利用の威力2014

    • Author(s)
      高木淳一
    • Organizer
      第14回日本蛋白質科学会年会 ランチョンセミナー
    • Place of Presentation
      ワークピア横浜/横浜産貿ホール マリネリア
    • Year and Date
      2014-06-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 電子顕微鏡単粒子解析を用いたDkk1-LRP6複合体の構造解析2014

    • Author(s)
      的場 京子
    • Organizer
      第14回日本蛋白質科学会年会
    • Place of Presentation
      ワークピア横浜/横浜産貿ホール マリネリア
    • Year and Date
      2014-06-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] セマフォリン-プレキシン複合体の電子顕微鏡による解析2014

    • Author(s)
      鈴木慶
    • Organizer
      第14回日本蛋白質科学会年会
    • Place of Presentation
      ワークピア横浜/横浜産貿ホール マリネリア
    • Year and Date
      2014-06-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] ApoER2細胞外領域-リガンド複合体が明らかにするLDLRファミリーのリガンド認識メカニズム2014

    • Author(s)
      平井秀憲
    • Organizer
      第14回日本蛋白質科学会年会
    • Place of Presentation
      ワークピア横浜/横浜産貿ホール マリネリア
    • Year and Date
      2014-06-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 電子顕微鏡画像からの原子モデル構造の構築2014

    • Author(s)
      岩崎憲治
    • Organizer
      第14回日本蛋白質科学会年会
    • Place of Presentation
      ワークピア横浜 / 横浜産貿ホール マリネリア, 横浜
    • Year and Date
      2014-06-25 – 2014-06-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] コイルドコイル融合による新規Fvフラグメント抗体の開発2014

    • Author(s)
      有森貴夫
    • Organizer
      第14回日本蛋白質科学会年会
    • Place of Presentation
      ワークピア横浜/横浜産貿ホール マリネリア
    • Year and Date
      2014-06-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] 抗PAタグペプチド抗体NZ-1の特異性の改変2014

    • Author(s)
      藤井勇樹
    • Organizer
      第14回日本蛋白質科学会年会
    • Place of Presentation
      ワークピア横浜/横浜産貿ホール マリネリア
    • Year and Date
      2014-06-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] ハイブリッドアプローチによる電顕画像からの情報抽出2014

    • Author(s)
      岩崎憲治
    • Organizer
      日本顕微鏡学会第70回記念学術講演会
    • Place of Presentation
      日本顕微鏡学会第70回記念学術講演会
    • Year and Date
      2014-05-11 – 2014-05-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Multi-faceted approach to analyze structure and function of integrins2013

    • Author(s)
      Junichi Takagi
    • Organizer
      Gordon Research Conference (Fibronectin, Integrins, Related molecules)
    • Place of Presentation
      Ventura Beach Marriott, USA
    • Year and Date
      2013-02-14
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 二次元EMイメージングへの原子構造のフィッティング2013

    • Author(s)
      岩崎 憲治
    • Organizer
      日本顕微鏡学会第68回学術講演会
    • Place of Presentation
      ホテル阪急エキスポパーク
    • Related Report
      2013 Annual Research Report
  • [Presentation] アルツハイマー病発症におけるSorLAの役割2013

    • Author(s)
      新留 穏香
    • Organizer
      第12回日本蛋白質科学会年会
    • Place of Presentation
      とりぎん文化会館(鳥取県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Higher-order Architecture of Cell Adhesion Mediated by Polymorphic Synaptic Adhesion Molecules Neurexin and Neuroligin2012

    • Author(s)
      Junichi Takagi
    • Organizer
      第35回日本分子生物学会大会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2012-12-13
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 免疫学研究における構造生物学のインパクト2012

    • Author(s)
      高木淳一
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2012-12-07
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] “構造神経科学”のすすめ-立体構造情報を使いこなすクールなニューロサイエンティストになろう-2012

    • Author(s)
      高木淳一
    • Organizer
      第35回日本神経科学会大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2012-09-21
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Correlation technology to fill the gap between X-ray crystallography and microscopic imaging2012

    • Author(s)
      Junichi Takagi
    • Organizer
      "International Integrin Signaling Meeting"
    • Place of Presentation
      Universitaetszentrum Obergurgl, Tirol - Austria
    • Year and Date
      2012-09-16
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Expanding the Structural Genomics to Structural Life Science: Not just to answer, but to ask new biological questions

    • Author(s)
      Junichi Takagi
    • Organizer
      International Conference on Structural Genomics 2013 - Structural Life Science
    • Place of Presentation
      札幌京王プラザホテル(北海道)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Resolution, dynamics, and heterogeneity -In what detail do we need to know protein structures for answering biological questions?

    • Author(s)
      Junichi Takagi
    • Organizer
      Gordon Research Conference (X-ray Science)
    • Place of Presentation
      Stonehill Colledge, USA
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Analyzing higher-order architecture of synaptic adhesion machinery: Correlation technologies to fill the gap between different imaging methods

    • Author(s)
      Junichi Takagi
    • Organizer
      11th International Conference on Biology and Synchrotron Radiation
    • Place of Presentation
      Humberg, Germany
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] アミロイドクリアランス受容体sorLAの構造

    • Author(s)
      高木 淳一
    • Organizer
      千里ライフサイエンスセミナー
    • Place of Presentation
      千里ライフサイエンスセンター(大阪府)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] アミロイドクリアランス受容体sorLA/LR11の構造

    • Author(s)
      高木 淳一
    • Organizer
      蛋白研セミナー「第4回神経科学と構造生物学の融合研究会」
    • Place of Presentation
      岡崎コンファレンスセンター(愛知県)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] SorLA Vps10pドメインのAβペプチド認識機構

    • Author(s)
      北郷 悠
    • Organizer
      第13回日本蛋白質科学会年会、ワークショップ
    • Place of Presentation
      とりぎん文化会館(鳥取県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Molecular basis of peptide ligand recognition by SorLA Vps10p domain

    • Author(s)
      Yu Kitago
    • Organizer
      International Conference on Structural Genomics 2013 - Structural Life Science
    • Place of Presentation
      札幌京王プラザホテル(北海道)
    • Related Report
      2013 Annual Research Report
  • [Presentation] "PA tag", a novel affinity tag system that enables one-step affinity purification of recombinant proteins from dilute sample

    • Author(s)
      Yuki Fujii
    • Organizer
      International Conference on Structural Genomics 2013 - Structural Life ScienceInternational Conference on Structural Genomics 2013 - Structural Life Science
    • Place of Presentation
      札幌京王プラザホテル(北海道)
    • Related Report
      2013 Annual Research Report
  • [Remarks] 研究室HP

    • URL

      http://www.protein.osaka-u.ac.jp/rcsfp/synthesis/index.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] アルツハイマー病の原因物質を「掃除」するタンパク質の立体構造を解明

    • URL

      http://www.protein.osaka-u.ac.jp/achievement/papers/sorla-2/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 光学顕微鏡と電子顕微鏡で同じ細胞を見ることに成功

    • URL

      http://www.protein.osaka-u.ac.jp/jpn/achievement/prof.takagi.pressrelease.pdf

    • Related Report
      2012 Annual Research Report
  • [Remarks] フィブロネクチン受容体α5β1インテグリンの結晶構造

    • URL

      http://www.protein.osaka-u.ac.jp/jpn/achievement/papers/crystal-structure-of-51-integr.php

    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] プレキシンの結合調節剤2016

    • Inventor(s)
      菅裕明、バシルディン ナセル、高木淳一、松永幸子
    • Industrial Property Rights Holder
      菅裕明、バシルディン ナセル、高木淳一、松永幸子
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-120226
    • Filing Date
      2016-06-16
    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] フラグメント抗体及び当該フラグメント抗体を用いるタンパク質の結晶化法2016

    • Inventor(s)
      高木淳一
    • Industrial Property Rights Holder
      高木淳一
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-218631
    • Filing Date
      2016-11-09
    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] 細胞培養培地、培養方法、およびオルガノイド2016

    • Inventor(s)
      佐藤俊朗、股野麻未、高木淳一
    • Industrial Property Rights Holder
      佐藤俊朗、股野麻未、高木淳一
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-029060
    • Filing Date
      2016-02-18
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] Wntタンパク質の安定な製造法および保存法2014

    • Inventor(s)
      高木淳一
    • Industrial Property Rights Holder
      高木淳一
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-260792
    • Filing Date
      2014-12-24
    • Related Report
      2014 Annual Research Report

URL: 

Published: 2012-11-27   Modified: 2022-01-28  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi