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Generation and function of linear ubiquitin chains

Planned Research

Project AreaNew aspect of the ubiquitin system : its enormous roles in protein regulation
Project/Area Number 24112002
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKyoto University

Principal Investigator

IWAI Kazuhiro  京都大学, 医学研究科, 教授 (60252459)

Project Period (FY) 2012-06-28 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥203,060,000 (Direct Cost: ¥156,200,000、Indirect Cost: ¥46,860,000)
Fiscal Year 2016: ¥42,120,000 (Direct Cost: ¥32,400,000、Indirect Cost: ¥9,720,000)
Fiscal Year 2015: ¥42,120,000 (Direct Cost: ¥32,400,000、Indirect Cost: ¥9,720,000)
Fiscal Year 2014: ¥42,380,000 (Direct Cost: ¥32,600,000、Indirect Cost: ¥9,780,000)
Fiscal Year 2013: ¥42,120,000 (Direct Cost: ¥32,400,000、Indirect Cost: ¥9,720,000)
Fiscal Year 2012: ¥34,320,000 (Direct Cost: ¥26,400,000、Indirect Cost: ¥7,920,000)
Keywords直鎖状ユビキチン鎖 / ユビキチン / NF-kappaB / Bリンパ球 / B細胞リンパ腫 / アスペルギルス / 生体分子 / 直鎖状ポリユビキチン鎖 / 直鎖状ポリユビキチン鎖阻害剤 / B細胞
Outline of Final Research Achievements

The ubiquitin conjugation system is one of the most important reversible post-translational modification system that regulates functions of proteins in a wide variety of ways. This is one of the eight research projects of New aspect of the ubiquitin system : its enormous roles in protein regulation an research area of Grant-in-Aid for Scientific Research on Innovative Areas. Pathophysiological roles of the ligase that generate M1-linked chain and mechanism underlying M1-chain generation was studied. Then, I found that 1. M1-chains are essential for the function of B lymphocytes, 2.the ligase (LUBAC) and de ubiquitinating enzymes (OTULIN and CYLD) that are specific for M1-linked chains always form complex and tune strength of NF-kappaB activation elicited by M1-chains, M1-chains are involved in the oncogenesis of B cell lymphomas, and Aspergillus, an opportunistic pathogen for pneumonia, infects to lung by suppressing the generation of M1-chains.

Report

(6 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report

Research Products

(44 results)

All 2017 2016 2015 2014 2013 2012 Other

All Journal Article (26 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 25 results,  Acknowledgement Compliant: 1 results,  Open Access: 1 results) Presentation (17 results) (of which Int'l Joint Research: 5 results,  Invited: 12 results) Remarks (1 results)

  • [Journal Article] HTLV-1 Tax induces formation of the active macromolecular IKK complex by generating Lys63- and Met1-linked hybrid polyubiquitin chains.2017

    • Author(s)
      Shibata, Y., Tokunaga, F., Goto, E., Komatsu, G., Gohda, J., Saeki, Y., Tanaka, K., Takahashi, H., Sawasaki, T., Inoue, S., Oshiumi, H., Seya, T., Nakano, H., Tanaka, Y., Iwai, K., and Inoue, J.I.
    • Journal Title

      PLoS Pathog.

      Volume: 13 Pages: e1006162

    • DOI

      doi: 10.1371/journal.ppat.1006162

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis.2016

    • Author(s)
      Nakazawa, S., Oikawa, D., Ishii, R., Ayaki, T., Takahashi, H., Takeda, H., Ishitani, R., Kamei, K., Takeyoshi, I., Kawakami, H., Iwai, K., Hatada, I., Sawasaki, T., Ito, H., Nureki, O., and Tokunaga, F.
    • Journal Title

      Nat Commun.

      Volume: 7 Pages: 12547

    • DOI

      doi: 10.1038/ncomms12547

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Survival of mature T cells depends on signaling through HOIP.2016

    • Author(s)
      Okamura, K., Kitamura, A., Sasaki, Y., Chung, D.H., Kagami, S., Iwai, K., and Yasutomo, K.
    • Journal Title

      Sci. Rep.

      Volume: 6 Pages: 36135

    • DOI

      doi: 10.1038/srep36135

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential involvement of the NZF domains of SHARPIN and HOIL-1L in LUBAC-mediated cell death protection.2016

    • Author(s)
      Shimizu, S., Fujita, H., Sasaki, Y., Tsuruyama, T., Fukuda, K., and Iwai, K.
    • Journal Title

      Mol. Cell. Biol.

      Volume: 36 Pages: 1569-1583

    • DOI

      doi:10.1128/MCB.01049-15

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LUBAC Formation Is Impaired in the Livers of Mice with MCD-Dependent Nonalcoholic Steatohepatitis.2015

    • Author(s)
      Matsunaga, Y., Nakatsu, Y., Fukushima, T., Okubo, H., Iwashita, M., Sakoda, H., Fujishiro, M., Yamamotoya, T., Kushiyama, A., Takahashi, S., Tsuchiya, Y., Kamata, H., Tokunaga, F., Iwai, K., and Asano, T.
    • Journal Title

      Mediators Inflamm.

      Volume: 1 Pages: 125380

    • DOI

      doi: 10.1155/2015/125380.

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CYLD and the NEMO zinc finger regulate tumor necrosis factor signaling and early embryogenesis.2015

    • Author(s)
      Zhao, Y., Ma, C. A., Wu, L., Iwai, K., Ashwell, J. D., Oltz, E. M., Ballard, D. W., and Jain, A.
    • Journal Title

      J. Biol. Chem.

      Volume: 290 Pages: 22076-22084

    • DOI

      doi: 10.1074/jbc.M115.658096

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The Structural differences between a glycoprotein specific F-Box protein Fbs1 and its homologous protein FBG3.2015

    • Author(s)
      Kumanomidou, T., Nishio, K., Takagi, K., Nakagawa, T., Suzuki, A., Yamane, T., Tokunaga, F., Iwai, K., Murakami, A., Yoshida, Y., Tanaka, K., and Mizushima, T.
    • Journal Title

      PLoS One

      Volume: 10 Pages: e0140366

    • DOI

      doi: 10.1371/journal.pone.0140366

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Posttranslational Modification of HOIP Blocks Toll-Like Receptor 4-Mediated Linear-Ubiquitin-Chain Formation.2015

    • Author(s)
      Bowman, J., Rodgers, M.A., Shi, M., Amatya, R., Hostager, B., Iwai, K., Gao, S.J., and Jung, J.U.
    • Journal Title

      MBio.

      Volume: 6 Pages: e01777-15

    • DOI

      doi: 10.1128/mBio.01777-15

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Roles of linear ubiquitinylation, a crucial regulator of NF-κB and cell death, in the immune system.2015

    • Author(s)
      Sasaki, K. and Iwai, K.
    • Journal Title

      Immunol. Rev.

      Volume: 393 Pages: 175-189

    • DOI

      doi: 10.1111/imr.12308.

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The unexpected role of polyubiquitin chains in the formation of fibrillar aggregates.2015

    • Author(s)
      Morimoto, D., Walinda, E., Fukada, H., Sou, Y. S., Kageyama, S., Hoshino, M., Fujii, T., Tsuchiya, H., Saeki, Y., Arita, K., Ariyoshi, M., Tochio, H., Iwai, K., Namba, K., Komatsu, M., Tanaka, K., Shirakawa, M.
    • Journal Title

      Nat. Commun

      Volume: 6 Pages: 6116

    • DOI

      10.1038/ncomms7116

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gliotoxin suppresses NF-κB activation by selectively inhibiting linear ubiquitin chain assembly complex (LUBAC).2015

    • Author(s)
      Sakamoto, H., Egashira, S., Saito, N., Kirisako, T., Miller, S., Sasaki, Y., Matsumoto, T., Shimonishi, M., Komatsu, T., Terai, T., Ueno, T., Hanaoka, K., Kojima, H., Okabe, T., Wakatsuki, S., Iwai, K., (corresponding author) and Nagano, T.
    • Journal Title

      ACS Chem. Biol.

      Volume: 10 Pages: 675-681

    • DOI

      10.1021/cb500653y

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phenotypic complementation of genetic immunodeficiency by chronic herpesvirus infection.2015

    • Author(s)
      MacDuff, D. A., Reese, T. A,, Kimmey, J. M., Weiss, L. A., Song, C., Zhang, X., Kambal, A., Duan, E., Carrero, J. A., Boisson, B., Laplantine, E., Israel, A., Picard, C., Colonna, M., Edelson, B. T., Sibley, L. D., Stallings, C. L., Casanova, J. L., Iwai, K., Virgin, H. W.
    • Journal Title

      eLife

      Volume: 4 Pages: e04494

    • DOI

      10.7554/eLife.04494

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IFN-γ or IFN-α ameliorates chronic proliferative dermatitis by inducing expression of linear ubiquitin chain assembly complex.2014

    • Author(s)
      Tamiya H, Terao M, Takiuchi T, Nakahara M, Sasaki Y, Katayama I, Yoshikawa H, and Iwai K.
    • Journal Title

      J. Immunol.

      Volume: 192 Pages: 3793-3804

    • DOI

      10.4049/jimmunol.1302308

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation.2014

    • Author(s)
      Rodgers, M. A., Bowman, J., Fujita, H., Orazio, N., Shi, M., Liang, Q., Amatya, R., Kelly, T. J., Iwai, K., Ting, J., and Jung, J. U.
    • Journal Title

      J. Exp. Med.

      Volume: 211 Pages: 1333-1347

    • DOI

      10.1084/jem.20132486

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HOIL-1L Functions as the PKCζ Ubiquitin Ligase to Promote Lung Tumor Growth.2014

    • Author(s)
      Queisser, M. A., Dada, L. A., Deiss-Yehiely, N., Angulo, M., Zhou, G., Kouri, F. M., Knab, L. M., Liu, J., Stegh, A. H., DeCamp, M. M., Budinger, G. R., Chandel, N. S., Ciechanover, A., Iwai, K., and Sznajder, J. I.
    • Journal Title

      Am. J. Respir. Crit. Care Med.

      Volume: 190 Pages: 688-698

    • DOI

      10.1164/rccm.201403-0463OC

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Linear ubiquitin chains: NF-κB signalling, cell death, and beyond.2014

    • Author(s)
      Iwai, K., Fujita, H., and Sasaki, Y.
    • Journal Title

      Nature Rev. Mol. Cell Biol.

      Volume: 15 Pages: 503-508

    • DOI

      10.1038/nrm3836

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ubiquitin chain elongation: An intriguing strategy.2014

    • Author(s)
      Iwai, K. and Tanaka, K.
    • Journal Title

      Molecular Cell

      Volume: 56 Pages: 189–191

    • DOI

      10.1016/j.molcel.2014.10.009

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Suppression of LUBAC-mediated linear ubiquitination by a specific interaction between LUBAC and the deubiquitinases CYLD and OTULIN2014

    • Author(s)
      Takiuchi, T., Nakagawa, T., Tamiya, H., Fujita, H., Sasaki, Y., Saeki, Y., Takeda, H., Sawasaki, T., Buchberger, A., Kimura, T., and Iwai. K.
    • Journal Title

      Genes Cells.

      Volume: 19 Pages: 254-272

    • DOI

      doi: 10.1111/gtc.12128.

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanism underlying IKK activation mediated by the linear ubiquitin chain assembly complex (LUBAC).2014

    • Author(s)
      Fujita, H., Rahighi, S., Akita, M., Kato, R., Sasaki, Y., Wakatsuki, S., and Iwai, K.
    • Journal Title

      Mol. Cell. Biol.

      Volume: 34 Pages: 1322-1335

    • DOI

      doi: 10.1128/MCB.01538-13.

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Essential role of the linear ubiquitin chain assembly complex in lymphoma revealed by rare germline polymorphisms.2014

    • Author(s)
      Yang Y, Schmitz R, Mitala JJJr, Whiting A, Xiao W, Ceribelli M, Wright GW, Zhao H, Yang Y, Xu W, Rosenwald A, Ott G, Gascoyne RD, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Wiestner A, Kruhlak MJ, Iwai K, Bernal F, Staudt LM
    • Journal Title

      Cancer Discov.

      Volume: 4 Pages: 480-493

    • DOI

      doi:10.1158/2159-8290. CD-13-0915

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Defective immune responses in mice lacking LUBAC-mediated linear ubiquitination in B cells.2013

    • Author(s)
      Sasaki, Y., Sano, S., Nakahara, M., Murata, S., Kometani, K., Aiba, Y., Sakamoto, S., Watanabe, Y., Tanaka, K., Kurosaki, K. and Iwai, K.
    • Journal Title

      EMBO J.

      Volume: 32 Pages: 2463-2476

    • DOI

      doi:10.1038/emboj.2013.184

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin.2013

    • Author(s)
      Fujita, N., Morita, E., Itoh, T., Tanaka, A., Nakaoka, M., Osada, Y., Umemoto, T., Saitoh, T., Nakatogawa, H., Kobayashi, S., Haraguchi, T., Guan, J.L., Iwai, K., Tokunaga, F., Saito, K., Ishibashi, K., Akira, S., Fukuda, M., Noda, T., and Yoshimori, T.
    • Journal Title

      J. Cell Biol.

      Volume: 203 Pages: 115-128

    • DOI

      doi: 10.1083/jcb.201304188.

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of nuclear factor-κB (NF-κB) essential modulator (NEMO) binding to linear and lysine-linked ubiquitin chains and its role in the activation of NF-κB.2012

    • Author(s)
      Kensche, T.
    • Journal Title

      J. Biol. Chem.

      Volume: 287 Pages: 641-652

    • DOI

      doi: 10.1074/jbc.M112.347195.

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Linear ubiquitination of NEMO negatively regulates the interferon antiviral response through disruption of the MAVS-TRAF3 complex.2012

    • Author(s)
      Belgnaoui, SM.
    • Journal Title

      Cell Host Microbe.

      Volume: 12 Pages: 211-222

    • DOI

      doi: 10.1016/j.chom.2012.06.009.

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation.2012

    • Author(s)
      Tokunaga, F.
    • Journal Title

      EMBO J.

      Volume: 31 Pages: 3856-3870

    • DOI

      doi: 10.1038/emboj.2012.241.

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diverse ubiquitin signaling in NF-κB activation.2012

    • Author(s)
      Iwai, K.
    • Journal Title

      Trends Cell Biol.

      Volume: 22 Pages: 355-364

    • DOI

      doi: 10.1016/j.tcb.2012.04.001.

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Pathophysiology of the atypical linear ubiquitin chain2016

    • Author(s)
      Iwai, K
    • Organizer
      Diverse functions of Ubiquitin : Degradation, Signaling, and Beyond
    • Place of Presentation
      Kyoto Japan
    • Year and Date
      2016-12-06 – 2016-12-06
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Differential involvement of subunits of LUBAC ubiquitin ligase in signalling and cell death.2015

    • Author(s)
      Shimizu, S., Fujita, H., Sasaki, Y., and Iwai, K.
    • Organizer
      EMBO Conference “Ubiquitin and ubiquitin-like modifiers: From molecular mechanisms to human diseases”
    • Place of Presentation
      Cavtat, Croatia
    • Year and Date
      2015-09-18 – 2015-09-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Linear ubiquitin chains: NF-kappaB activation, cell death, and cancer.2015

    • Author(s)
      Iwai, K.
    • Organizer
      International Symposium on Ubiquitin and Diseases.
    • Place of Presentation
      Zhangjiajie, China
    • Year and Date
      2015-06-14 – 2015-06-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Linear ubiquitin chains: a new regulator of NF-kappaB activation and cell death signaling.2015

    • Author(s)
      Iwai, K.
    • Organizer
      1st SPS International Symposium Xiamen University
    • Place of Presentation
      Xiamen, China
    • Year and Date
      2015-06-13 – 2015-06-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] LUBAC-mediated linear ubiquitination by a virulence factor of Aspergillus, gliotoxin.2015

    • Author(s)
      Sakamoto, H., Egashira, S., Okabe, T., Nagano, T., and Iwai, K.
    • Organizer
      Cold Spring Harbor Laboratory meeting “The Ubiquitin Family”
    • Place of Presentation
      Cold Spring Harbor, NY, USA
    • Year and Date
      2015-04-21 – 2015-04-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Increased redox-active iron induces mitochondrial damage that recruits Parkin.2014

    • Author(s)
      Iwai, K. and Takeda, Y.
    • Organizer
      The 17th Biennial Meeting of Society for Free Radical Research International. Symposium “Redox-Active Iron in Disease Pathology and Treatment”
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      20140323-20140326
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Phenotypical difference between mice lacking subunits of LUBAC ubiquitin ligase.2014

    • Author(s)
      Iwai, K.
    • Organizer
      1st International Symposium for New Aspects of the Ubiquitin Research
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2014-11-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Mechanism underlying linear ubiquitin-mediated NF-κB activation.2014

    • Author(s)
      Iwai, K.
    • Organizer
      Benzon Symposium Nuclear regulation by ubiquitin
    • Place of Presentation
      Copenhagen, Denmark
    • Year and Date
      2014-08-18 – 2014-08-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] Linear ubiquitination : a new regulator of NF-κB and cell death signaling.2014

    • Author(s)
      Iwai, K.
    • Organizer
      2014 International Conference on Protein Metabolism & Diseases
    • Place of Presentation
      Yangyang, Korea
    • Year and Date
      2014-07-09 – 2014-07-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Molecular mechanism and regulation of linear chain-mediated NF-κB activation.2014

    • Author(s)
      Fujita, H., Takiuchi, T., and Iwai, K.
    • Organizer
      Cold Spring Harbor Asia Conference “ Protein Modifications & Homeostasis”
    • Place of Presentation
      Suzhou, China
    • Year and Date
      2014-06-16 – 2014-06-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Linear Polyubiquitination: a Crucial Regulator of NF-κB Activation.2014

    • Author(s)
      Iwai, K.
    • Organizer
      THE UEHARA MEMORIAL FOUNDATION SYMPOSIUM 2014, Innovative Medicine : Basic Research and Development.
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2014-06-14 – 2014-06-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Differential requirement of LUBAC-mediated linear polyubiquitination in CD40- or BCR-mediated canonical NF-κB activation in B cells.2013

    • Author(s)
      Sasaki, Y., Fujita, H., and Iwai, K.
    • Organizer
      The EMBO Conference “Ubiquitin and Ubiquitin-like Proteins: From structure to function”
    • Place of Presentation
      Riva del Garda, Italy.
    • Year and Date
      20131001-20131005
    • Related Report
      2013 Annual Research Report
  • [Presentation] Linear polyubiquitination: a new regulator of NF-κB activation2013

    • Author(s)
      Iwai, K.
    • Organizer
      The 35th Naito Conference “The Ubiquitin-Proteasome System: From Basic Mechanisms to Pathophysiological Roles”
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      20130709-20130712
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Linear polyubiquitination: a new regulator of NF-κB activation.2013

    • Author(s)
      Iwai, K.
    • Organizer
      he 38th FEBS congress
    • Place of Presentation
      St. Petersburg, Russia
    • Year and Date
      20130706-20130712
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Linear polyubiquitination : A crucial regulator of NF-kB signaling.2012

    • Author(s)
      Iwai, K.
    • Organizer
      The 3rd International Symposium "Signaling and Regulation in the Immune and Nervous Systems“
    • Place of Presentation
      Magdeburg, Germany
    • Year and Date
      2012-11-22 – 2012-11-23
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Linear polyubiquitination: A crucial regulator of NF-κB signalling2012

    • Author(s)
      Fujita, H.
    • Organizer
      ZOMESVII conference
    • Place of Presentation
      Munich Germany
    • Year and Date
      2012-09-18 – 2012-09-22
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Mechanism underlying generation of linear polyubiquitin chains.2012

    • Author(s)
      Iwai, K.
    • Organizer
      4th Annual Ubiquitin Drug Discovery Diagnostics Conference 2012
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2012-07-23 – 2012-07-25
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Remarks] 京都大学・大学院医学研究科・細胞機能制御学

    • URL

      http://www.mcp.med.kyoto-u.ac.jp/

    • Related Report
      2014 Annual Research Report 2012 Annual Research Report

URL: 

Published: 2012-11-27   Modified: 2019-07-29  

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