| Budget Amount *help |
¥146,770,000 (Direct Cost: ¥112,900,000、Indirect Cost: ¥33,870,000)
Fiscal Year 2016: ¥28,080,000 (Direct Cost: ¥21,600,000、Indirect Cost: ¥6,480,000)
Fiscal Year 2015: ¥28,080,000 (Direct Cost: ¥21,600,000、Indirect Cost: ¥6,480,000)
Fiscal Year 2014: ¥28,210,000 (Direct Cost: ¥21,700,000、Indirect Cost: ¥6,510,000)
Fiscal Year 2013: ¥28,080,000 (Direct Cost: ¥21,600,000、Indirect Cost: ¥6,480,000)
Fiscal Year 2012: ¥34,320,000 (Direct Cost: ¥26,400,000、Indirect Cost: ¥7,920,000)
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| Outline of Final Research Achievements |
Cushing’s disease is an intractable endocrine disease caused by tumors of adrenocorticotropin-producing cells in the pituitary. The pathogenesis of Cushing’s disease has been unknown at a molecular level, which has prevented the development of effective drugs for this disease. In this study, we identified a hotspot mutation in the deubiquitinase gene USP8 in pituitary tumors of the patients with Cushing’s disease, and elucidated how an activating mutation in USP8 leads to the pathogenesis of the disease. This finding presents, for the first time, the molecular target for the treatment of Cushing’s disease.
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