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Regulation of endocytosis and lysosomal traffic by the ubiquitin conjugation system

Planned Research

Project AreaNew aspect of the ubiquitin system : its enormous roles in protein regulation
Project/Area Number 24112003
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionTokyo Institute of Technology

Principal Investigator

Komada Masayuki  東京工業大学, 科学技術創成研究院, 教授 (10225568)

Co-Investigator(Kenkyū-buntansha) 石戸 聡  昭和薬科大学, 薬学部, 教授 (10273781)
Project Period (FY) 2012-06-28 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥146,770,000 (Direct Cost: ¥112,900,000、Indirect Cost: ¥33,870,000)
Fiscal Year 2016: ¥28,080,000 (Direct Cost: ¥21,600,000、Indirect Cost: ¥6,480,000)
Fiscal Year 2015: ¥28,080,000 (Direct Cost: ¥21,600,000、Indirect Cost: ¥6,480,000)
Fiscal Year 2014: ¥28,210,000 (Direct Cost: ¥21,700,000、Indirect Cost: ¥6,510,000)
Fiscal Year 2013: ¥28,080,000 (Direct Cost: ¥21,600,000、Indirect Cost: ¥6,480,000)
Fiscal Year 2012: ¥34,320,000 (Direct Cost: ¥26,400,000、Indirect Cost: ¥7,920,000)
Keywordsユビキチン / ユビキチンリガーゼ / 脱ユビキチン化酵素 / エンドサイトーシス / エンドソーム / 受容体ダウンレギュレーション / 腫瘍 / 免疫 / ユビキチン結合モチーフ / ストレス顆粒 / 転写因子 / 免疫応答 / MHCクラスII分子 / 蛋白質 / 酵素 / 細胞・組織 / 癌 / 免疫学 / MHC class II / 樹状細胞 / 抗原提示 / タンパク質 / 細胞
Outline of Final Research Achievements

Cushing’s disease is an intractable endocrine disease caused by tumors of adrenocorticotropin-producing cells in the pituitary. The pathogenesis of Cushing’s disease has been unknown at a molecular level, which has prevented the development of effective drugs for this disease. In this study, we identified a hotspot mutation in the deubiquitinase gene USP8 in pituitary tumors of the patients with Cushing’s disease, and elucidated how an activating mutation in USP8 leads to the pathogenesis of the disease. This finding presents, for the first time, the molecular target for the treatment of Cushing’s disease.

Report

(6 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report

Research Products

(103 results)

All 2017 2016 2015 2014 2013 2012 Other

All Int'l Joint Research (11 results) Journal Article (37 results) (of which Int'l Joint Research: 12 results,  Peer Reviewed: 26 results,  Acknowledgement Compliant: 6 results,  Open Access: 3 results) Presentation (40 results) (of which Int'l Joint Research: 2 results,  Invited: 15 results) Book (1 results) Remarks (14 results)

  • [Int'l Joint Research] Ludwig-Maximilians-University Munich(ドイツ)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] National Institute of Health/University of California, San Francisco(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] McGill University/Universite de Montreal(カナダ)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] University of Rome Tor Vergata(イタリア)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] The University of Melbourne(オーストラリア)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Medizinische Klinik und Poliklinik IV/Ludwig-Maximilians-Universitat Munchen/Max Planck Institute of Psychiatry(ドイツ)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] National Institutes of Health/Oregon Health & Science University(米国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Queen Mary University of London(英国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Universite Paris Descartes(フランス)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Jiangsu Cancer Hospital(中国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2015 Annual Research Report
  • [Journal Article] USP15 attenuates IGF-I signaling by antagonizing Nedd4-induced IRS-2 ubiquitination.2017

    • Author(s)
      Fukushima T, Yoshihara H, Furuta H, Hakuno F, Iemura SI, Natsume T, Nakatsu Y, Kamata H, Asano T, Komada M, Takahashi SI.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 484 Issue: 3 Pages: 522-528

    • DOI

      10.1016/j.bbrc.2017.01.101

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tandem UIMs confer Lys48 ubiquitin chain substrate preference to deubiquitinase USP252017

    • Author(s)
      Kawaguchi K, Uo K, Tanaka T, Komada M
    • Journal Title

      Sci. Rep.

      Volume: 7 Issue: 1 Pages: 45037-45037

    • DOI

      10.1038/srep45037

    • NAID

      120006605589

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] MARCH1 E3 ubiquitin ligase dampens the innate inflammatory response by modulating monocyte functions in mice2017

    • Author(s)
      Galbas T, Raymond M, Sabourin A, Bourgeois-Daigneault MC, Guimont-Desrochers F, Yun TJ, Cailhier JF, Ishido S, Lesage S, Cheong C, Thibodeau J
    • Journal Title

      J. Immunol.

      Volume: 198 Issue: 2 Pages: 852-861

    • DOI

      10.4049/jimmunol.1601168

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Deficiency of X-linked protein kinase Nrk during pregnancy triggers breast tumor in mice2016

    • Author(s)
      Yanagawa T, Denda K, Inatani T, Fukushima T, Tanaka T, Kumaki N, Inagaki Y, Komada M
    • Journal Title

      Am. J. Pathol.

      Volume: 186 Issue: 10 Pages: 2751-2760

    • DOI

      10.1016/j.ajpath.2016.06.005

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The K48-K63 branched ubiquitin chain regulates NF-kappaB signaling2016

    • Author(s)
      Ohtake F, Saeki Y, Ishido S, Kanno J, Tanaka K
    • Journal Title

      Mol. Cell

      Volume: 64 Issue: 2 Pages: 251-266

    • DOI

      10.1016/j.molcel.2016.09.014

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thymic CD4 T cell selection requires attenuation of March8-mediated MHCII turnover in cortical epithelial cells through CD832016

    • Author(s)
      von Rohrscheidt J, Petrozziello E, Nedjic J, Federle C, Krzyzak L, Ploegh HL, Ishido S, Steinkasserer A, Klein L
    • Journal Title

      J. Exp. Med.

      Volume: 213 Issue: 9 Pages: 1685-1694

    • DOI

      10.1084/jem.20160316

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Ubiquitin ligase MARCH 8 cooperates with CD83 to control surface MHC II expression in thymic epithelium and CD4 T cell selection2016

    • Author(s)
      Liu H, Jain R, Guan J, Vuong V, Ishido S, La Gruta NL, Gray DH, Villadangos JA, Mintern JD
    • Journal Title

      J. Exp. Med.

      Volume: 213 Issue: 9 Pages: 1695-1703

    • DOI

      10.1084/jem.20160312

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Ubiquitin-mediated fluctuations in MHC class II facilitate efficient germinal center B cell responses2016

    • Author(s)
      Bannard O, McGowan SJ, Ersching J, Ishido S, Victora GD, Shin JS, Cyster JG
    • Journal Title

      J. Exp. Med.

      Volume: 213 Issue: 6 Pages: 993-1009

    • DOI

      10.1084/jem.20151682

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Ankrd13 family of ubiquitin-interacting motif-bearing proteins regulates VCP/p97-mediated lysosomal traffic of caveolin-1.2016

    • Author(s)
      Burana, D., Yoshihara, H., Tanno, H., Yamamoto, A., Saeki, Y., Tanaka, K., and Komada, M.
    • Journal Title

      J. Biol. Chem.

      Volume: 291 Issue: 12 Pages: 6218-6231

    • DOI

      10.1074/jbc.m115.710707

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The USP8 mutational status may predict drug susceptibility in corticotroph adenomas of Cushing's disease.2016

    • Author(s)
      Hayashi, K., Inoshita, N., Kawaguchi, K., Ardisasmita, A.I., Suzuki, H., Fukuhara, N., Okada, M., Nishioka, H., Takeuchi, Y., Komada, M., Takeshita, A., and Yamada, S.
    • Journal Title

      Eur. J. Endocrinol.

      Volume: 174 Issue: 2 Pages: 213-226

    • DOI

      10.1530/eje-15-0689

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Ubiquitin-mediated fluctuations in MHC class II facilitate efficient germinal center B cell responses2016

    • Author(s)
      Bannard, O., McGowan S.J., Ersching, J., Ishido, S., Victora, G.D., Shin, J.S., and Cyster, J.G.
    • Journal Title

      J. Exp. Med.

      Volume: 213

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] クッシング病の原因遺伝子と発症機構2016

    • Author(s)
      川口紘平、駒田雅之
    • Journal Title

      Annual Review 2016 糖尿病・代謝・内分泌

      Volume: なし Pages: 180-186

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 脱ユビキチン化酵素によるエンドサイトーシス制御と遺伝子疾患2016

    • Author(s)
      川口紘平、駒田雅之
    • Journal Title

      医学のあゆみ

      Volume: 256 Pages: 861-867

    • Related Report
      2015 Annual Research Report
  • [Journal Article] The gene of the ubiquitin-specific protease 8 is frequently mutated in adenomas causing Cushing's disease.2015

    • Author(s)
      Perez-Rivas, L.G.,
    • Journal Title

      J. Clin. Endocrinol. Metab.

      Volume: 100 Issue: 7 Pages: E997-E1004

    • DOI

      10.1210/jc.2015-1453

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Decoding the genetic basis of Cushing's disease: USP8 in the spotlight.2015

    • Author(s)
      Theodoropoulou, M., Reincke, M., Fassnacht, M., and *Komada, M. (*co-correspondence)
    • Journal Title

      Eur. J. Endocrinol.

      Volume: 173 Issue: 4 Pages: M73-M83

    • DOI

      10.1530/eje-15-0320

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc2015

    • Author(s)
      Sun XX, He X, Yin L, Komada M, Sears RC & Dai MS
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 112 Issue: 12 Pages: 3734-3739

    • DOI

      10.1073/pnas.1411713112

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ubiquitination by March-I prevents MHC Class II recycling and promotes MHC Class II turnover in antigen presenting cells2015

    • Author(s)
      Cho, K.J., Walseng, E., Ishido, S., and Roche, P.A.
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 112 Issue: 33 Pages: 10449-10454

    • DOI

      10.1073/pnas.1507981112

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] IL-10 mediated immunosuppression: March-I induction regulates antigen presentation by macrophages but not dendritic cells2015

    • Author(s)
      Mittal, S.K., Cho, K.J., Ishido, S., and Roche, P.A.
    • Journal Title

      J. Biol. Chem.

      Volume: 290 Issue: 45 Pages: 27158-27167

    • DOI

      10.1074/jbc.m115.682708

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 脱ユビキチン化酵素USP8の機能獲得型変異はCushing病をひき起こす.2015

    • Author(s)
      駒田 雅之
    • Journal Title

      ライフサイエンス新着論文レビュー ”First Author's"

      Volume: なし

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 見えてきたユビキチンを介した核小体の多彩な機能.2015

    • Author(s)
      川口紘平、駒田雅之
    • Journal Title

      ファルマシア

      Volume: 51 Pages: 300-304

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 難病 ”クッシング病” 発症の分子メカニズム.2015

    • Author(s)
      川口紘平、駒田雅之
    • Journal Title

      バイオサイエンスとインダストリー

      Volume: 73 Pages: 300-301

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 脱ユビキチン化酵素USP8の機能獲得型変異がクッシング病を引き起こす.2015

    • Author(s)
      駒田 雅之
    • Journal Title

      ACTH Related Peptides

      Volume: 26 Pages: 56-58

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 脱ユビキチン化酵素USP8変異とCushing病.2015

    • Author(s)
      駒田 雅之
    • Journal Title

      クッシング症候群診療マニュアル

      Volume: なし Pages: 259-260

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Mutations in the deubiquitinase gene USP8 cause Cushing’s disease2015

    • Author(s)
      Reincke M, Sbiera S, Hayakawa A, Theodoropoulou M, Osswald A, Beuschlein F, Meitinger T, Mizuno-Yamasaki E, Kawaguchi K, Saeki Y, Tanaka K, Wieland T, Graf E, Saeger W, Ronchi CL, Allolio B, Buchfelder M, Strom TM, Fassnacht M & Komada M
    • Journal Title

      Nat. Genet.

      Volume: 47 Issue: 1 Pages: 31-38

    • DOI

      10.1038/ng.3166

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 見えてきたユビキチンを介する核小体の多彩な機能2015

    • Author(s)
      川口紘平、駒田雅之
    • Journal Title

      ファルマシア

      Volume: 51 Pages: 300-304

    • NAID

      130007448051

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 難病“クッシング病”発症の分子メカニズム2015

    • Author(s)
      川口紘平、駒田雅之
    • Journal Title

      バイオサイエンスとインダストリー

      Volume: 73

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Ubiquitin-interacting motifs confer full catalytic activity, but not ubiquitin chain substrate specificity, to deubiquitinating enzyme USP372014

    • Author(s)
      Tanno, H., Shigematsu, T., Nishikawa, S., Hayakawa, A., Denda, K., Tanaka, T., and Komada, M.
    • Journal Title

      J. Biol. Chem.

      Volume: 289 Issue: 4 Pages: 2415-2423

    • DOI

      10.1074/jbc.m113.528372

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Loss of MHC II ubiquitination inhibits the activation and differentiation of CD4 T cells2014

    • Author(s)
      Ishikawa, R., Kajikawa, M., and Ishido, S.
    • Journal Title

      Int. Immunol.

      Volume: 未定 Issue: 5 Pages: 283-289

    • DOI

      10.1093/intimm/dxt066

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ERK-dependent downregulation of Skp2 reduces Myc activity with HGF, leading to inhibition of cell proliferation through a decrease in Id1 expression2013

    • Author(s)
      Li, X., Bian, Y., Takizawa, Y., Hashimoto, T., Ikoma, T., Tanaka, J., Kitamura, N., Inagaki, Y., Komada, M., and Tanaka, T.
    • Journal Title

      Mol. Cancer Res.

      Volume: 11 Issue: 11 Pages: 1437-1447

    • DOI

      10.1158/1541-7786.mcr-12-0718

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo assembly of the axon initial segment in motor neurons2013

    • Author(s)
      Le Bras, B., Freal, A., Czarnecki, A., Legendre, P., Bullier, E., Komada, M., Brophy, P.J., Davenne, M., and Couraud, F
    • Journal Title

      Brain Struct. Funct

      Volume: 未定 Issue: 4 Pages: 1433-1450

    • DOI

      10.1007/s00429-013-0578-7

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of Src in the membrane skeletal complex, MPP6-4.1G, in Schmidt-Lanterman incisures of mouse myelinated nerve fibers in PNS2013

    • Author(s)
      Terada, N., Saitoh, Y., Ohno, N., Komada, M., Yamauchi, J., and Ohno, S.
    • Journal Title

      Histochem. Cell Biol

      Volume: 139 Issue: 2 Pages: 213-222

    • DOI

      10.1007/s00418-012-1073-6

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The ubiquitin code and its decoding machinery in the endocytic pathway.2013

    • Author(s)
      Tanno, H.
    • Journal Title

      J. Biochem.

      Volume: 153 Issue: 6 Pages: 497-504

    • DOI

      10.1093/jb/mvt028

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ユビキチン化によるFrizzledのリソソーム分解を介した Wntシグナル強度の制御2013

    • Author(s)
      Daocharad Burana, 後藤聡, 駒田雅之
    • Journal Title

      細胞工学

      Volume: 32 Pages: 396-400

    • Related Report
      2013 Annual Research Report
  • [Journal Article] MITOL regulates endoplasmic reticulum-mitochondria contacts via Mitofusin2.2013

    • Author(s)
      Sugiura, A., Nagashima, S., Tokuyama, T., Amo, T., Matsuki, Y., Ishido, S., Kudo, Y., McBride, H.M., Fukuda, T., Matsushita, T., Inatome, R., and C Yanagi, S.
    • Journal Title

      Mol. Cell

      Volume: 51 Issue: 1 Pages: 1-15

    • DOI

      10.1016/j.molcel.2013.04.023

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ユビキチン化によるFrizzledのリソソーム分解を介したWntシグナル強度の制御2013

    • Author(s)
      Burana, D.
    • Journal Title

      細胞工学

      Volume: 32 Pages: 396-400

    • Related Report
      2012 Annual Research Report
  • [Journal Article] The Ankrd 13 family of UIM-bearing proteins regulates EGF receptor endocytosis from the plasma membrane2012

    • Author(s)
      Tanno, H.
    • Journal Title

      Mol.Biol.Cell

      Volume: 23 Issue: 7 Pages: 1343-1353

    • DOI

      10.1091/mbc.e11-09-0817

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Balanced ubiquitination determines cellular responsiveness to extracellular stimuli.2012

    • Author(s)
      Mukai, A.
    • Journal Title

      Cell. Mol. Life Sci.

      Volume: 69 Issue: 23 Pages: 4007-4016

    • DOI

      10.1007/s00018-012-1084-4

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] クッシング病において脱ユビキチン化酵素USP8変異体を活性化するプロテアーゼの解析2017

    • Author(s)
      浅水謙吾、川口紘平、遠藤彬則、福嶋俊明、金丸周司、駒田雅之
    • Organizer
      第28回 間脳・下垂体・副腎系研究会
    • Place of Presentation
      ロシュ・ダイアグノスティックス 本社ビル(東京都港区)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 遺伝子変異による脱ユビキチン化酵素USP8の細胞質から核への局在変化とCushing病2016

    • Author(s)
      駒田雅之
    • Organizer
      第39回 日本分子生物学会大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 母性Cyclin E-DNMT1新規複合体によるツメガエル尾部形成のエピジェネティックな制御2016

    • Author(s)
      田中利明、駒田雅之
    • Organizer
      第39回 日本分子生物学会大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] クッシング病で見られる脱ユビキチン化酵素USP8の変異はバソプレシン受容体V1bの安定化を引き起こす2016

    • Author(s)
      福嶋俊明、川口紘平、遠藤彬則、駒田雅之
    • Organizer
      第39回 日本分子生物学会大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 脱ユビキチン化酵素USP28はSnailを安定化し、がん細胞の浸潤に寄与する2016

    • Author(s)
      佐藤晃一、井上靖道、伊藤友香、駒田雅之、林秀敏
    • Organizer
      第39回 日本分子生物学会大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] Deubiquitinase USP5 is required for the disassembly of heat-induced stress granules2016

    • Author(s)
      Xuan Xie, Shunsuke Matsumoto, Masayuki Komada
    • Organizer
      第39回 日本分子生物学会大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 脱ユビキチン化酵素USP25のユビキチン結合モチーフはK48ユビキチン鎖に対する切断特異性を規定する2016

    • Author(s)
      川口紘平、卯尾和音、田中利明、駒田雅之
    • Organizer
      第39回 日本分子生物学会大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] Cushing病におけるUSP8インタラクトーム解析2016

    • Author(s)
      駒田雅之
    • Organizer
      第43回 日本神経内分泌学会学術集会
    • Place of Presentation
      アクトシティ浜松コングレスセンター(静岡県浜松市)
    • Year and Date
      2016-10-14
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] USP8 interactome in Cushing’s disease2016

    • Author(s)
      Masayuki Komada
    • Organizer
      IMPROCUSH-2 (Improving Outcome of Cushing’s Syndrome Symposium 2)
    • Place of Presentation
      Carl Friedrich von Siemens Stiftung (Munich, Germany)
    • Year and Date
      2016-06-23
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 脱ユビキチン化酵素USP25におけるユビキチン結合モチーフUIMの機能2015

    • Author(s)
      卯尾和音、田中利明、駒田雅之
    • Organizer
      第38回 日本分子生物学会/第88回日本生化学会・合同大会 BMB2015
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2015-12-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] 脱ユビキチン化酵素USP37におけるユビキチン結合モチーフUIMの機能2015

    • Author(s)
      西川周平、桑原直之、伝田公紀、川崎政人、駒田雅之、加藤龍一
    • Organizer
      第38回 日本分子生物学会/第88回 日本生化学会・合同大会 BMB2015
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2015-12-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] 脳下垂体の腫瘍性疾患クッシング病における脱ユビキチン化酵素USP8の活性化変異2015

    • Author(s)
      駒田雅之、川口紘平、Arif Ibrahim Ardisasmita、福嶋俊明
    • Organizer
      第38回 日本分子生物学会/第88回 日本生化学会・合同大会 BMB2015
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Somatic gain-of-function mutations in deubiquitinase USP8 in pituitary tumors causing Cushing's disease2015

    • Author(s)
      駒田雅之
    • Organizer
      EMBO Conference on “Ubiquitin and Ub-like modifiers”
    • Place of Presentation
      Hotel Croatia(クロアチア・ツァブタット)
    • Year and Date
      2015-09-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脱ユビキチン化酵素USP8の機能獲得型変異がクッシング病を引き起こす2015

    • Author(s)
      駒田雅之
    • Organizer
      第26回 間脳・下垂体・副腎系研究会・教育講演
    • Place of Presentation
      ロシュ・ダイアグノスティックス 本社(東京都)
    • Year and Date
      2015-03-14
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 脱ユビキチン化酵素の機能獲得型変異によるヒト腫瘍の発症機構2014

    • Author(s)
      Martin Reincke、Silviu Sbiera、早川哲、Marily Theodoropoulou、Andrea Osswald、Felix Beuschlein、Thomas Meitinger、水野-山崎英美、佐伯泰、田中啓二、Thomas Wieland、 Elisabeth Graf、Wolfgang Saeger、Cristina Ronchi、Bruno Allolio、Michael Buchfelder、Tim Strom、Martin Fassnachat、駒田雅之
    • Organizer
      第37回 日本分子生物学会大会・一般ポスター発表
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 核小体ストレス応答における分解性及び非分解性ユビキチン化修飾の機能解析2014

    • Author(s)
      川口紘平、齊藤尚吾、早川哲、田中利明、山本章嗣、駒田雅之
    • Organizer
      第37回 日本分子生物学会大会・ワークショップ
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2014-11-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Ankrd13 family of ubiquitin-binding proteins regulates VCP function in endosomal sorting of caveolin-12014

    • Author(s)
      Burana Daocharad、丹野秀崇、駒田雅之
    • Organizer
      第37回 日本分子生物学会大会・一般ポスター発表
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2014-11-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Impairment of ubiquitination-dependent receptor downregulation in human tumor2014

    • Author(s)
      Masayuki Komada
    • Organizer
      新学術領域「ユビキチン制御」第1回 国際シンポジウム
    • Place of Presentation
      国際高等研究所(京都府)
    • Year and Date
      2014-11-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ヒト腫瘍におけるユビキチン化依存的な増殖因子受容体ダウンレギュレーションの破綻2014

    • Author(s)
      駒田雅之、早川哲、水野-山崎英美
    • Organizer
      第87回 日本生化学会大会・シンポジウム
    • Place of Presentation
      京都国際会館(京都府)
    • Year and Date
      2014-10-16
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 核小体ストレス応答における分解性及び非分解性ユビキチン化修飾の機能解析2014

    • Author(s)
      川口紘平、齊藤尚吾、早川哲、田中利明、山本章嗣、駒田雅之
    • Organizer
      第87回 日本生化学会大会・一般口頭発表
    • Place of Presentation
      京都国際会館(京都府)
    • Year and Date
      2014-10-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Impaired receptor downregulation in Cushing’s disease2014

    • Author(s)
      Masayuki Komada
    • Organizer
      Improving Outcome of Cushing´s Syndrome Symposium “IMPROCUSH”
    • Place of Presentation
      Carl Friedrich von Siemens Stiftung(ドイツ・ミュンヘン)
    • Year and Date
      2014-10-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Loss of MHC II ubiquitination induces negative consequence to dendritic cells2014

    • Author(s)
      Satoshi Ishido
    • Organizer
      8th International Workshop on Antigen Processing & Presentation
    • Place of Presentation
      フィラデルフィア(アメリカ合衆国)
    • Year and Date
      2014-06-10 – 2014-06-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] タイトル未定2013

    • Author(s)
      駒田 雅之
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Year and Date
      2013-12-03
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] タイトル未定2013

    • Author(s)
      駒田 雅之
    • Organizer
      第86回日本生化学会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2013-09-11
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Recognition of K63-linked ubiquitin chains by the Ankrd13 family of UIM-bearing proteins regulates endocytosis of plasma membrane proteins.2013

    • Author(s)
      駒田 雅之
    • Organizer
      第35回内藤コンファレンス
    • Place of Presentation
      シャトレーゼ ガトーキングダム サッポロ(北海道)
    • Year and Date
      2013-07-09
    • Related Report
      2012 Annual Research Report
  • [Presentation] ユビキチン化と脱ユビキチン化によるストレス顆粒の制御2013

    • Author(s)
      駒田 雅之
    • Organizer
      第65回日本細胞生物学会
    • Place of Presentation
      ウインク愛知(愛知県)
    • Year and Date
      2013-06-19
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ユビキチン化と脱ユビキチン化によるストレス顆粒の制御2013

    • Author(s)
      松本俊介、解玄、駒田雅之
    • Organizer
      第65回 日本細胞生物学会大会
    • Place of Presentation
      ウインクあいち(愛知県)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Roles of the Ankrd13 family of ubiquitin-binding proteins in the endocytic pathway2013

    • Author(s)
      駒田雅之、丹野秀崇、Daocharad Burana、奥谷幸平
    • Organizer
      第86回 日本生化学会大会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Endosomal interaction of VCP/p97 with Ankrd13 family of ubiquitin-binding proteins2013

    • Author(s)
      駒田雅之
    • Organizer
      第36回 日本分子生物学会大会
    • Place of Presentation
      神戸国際会議場(兵庫)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Interaction of Ankrd13 family of ubiquitin-binding proteins with VCP/p97 is implicated in endosomal sorting of caveolin-12013

    • Author(s)
      Daocharad Burana、丹野秀崇、駒田雅之
    • Organizer
      第36回 日本分子生物学会大会
    • Place of Presentation
      神戸国際会議場(兵庫)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 脱ユビキチン化酵素USP36の核小体局在を阻害する化合物の同定と解析2013

    • Author(s)
      齊藤尚吾、川口紘平、本田香織、近藤恭光、斎藤臣雄、長田裕之、駒田雅之
    • Organizer
      第36回 日本分子生物学会大会
    • Place of Presentation
      神戸国際会議場(兵庫)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 脱ユビキチン化酵素USP37の活性にはたすユビキチン結合モチーフUIMの役割2013

    • Author(s)
      重松壮、西川周平、丹野秀崇、駒田雅之
    • Organizer
      第36回 日本分子生物学会大会
    • Place of Presentation
      神戸国際会議場(兵庫)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Negative regulation of mammary epithelial cell proliferation by protein kinase Nrk2013

    • Author(s)
      柳川享世、稲谷卓也、伝田公紀、駒田雅之
    • Organizer
      第36回 日本分子生物学会大会
    • Place of Presentation
      神戸国際会議場(兵庫)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 分娩発来をもたらす胎盤特異的なプロテインキナーゼNrkが与るシグナル伝達2013

    • Author(s)
      伝田公紀、井田加奈子、廣崎賢、岡本直樹、柳川享世、林宣宏、駒田雅之
    • Organizer
      第36回 日本分子生物学会大会
    • Place of Presentation
      神戸国際会議場(兵庫)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ツメガエル初期胚の尾部形成における母性Cyclin Eタンパク質分解とエピジェネティック制御の関係2013

    • Author(s)
      田中利明、駒田雅之
    • Organizer
      第36回 日本分子生物学会大会
    • Place of Presentation
      神戸国際会議場(兵庫)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Roles of Ankrd13, a family of UIM-bearing proteins, in the endocytic pathway2013

    • Author(s)
      駒田雅之
    • Organizer
      第35回 内藤コンファレンス
    • Place of Presentation
      シャトレーゼ ガトーキングダム(北海道)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Loss of MHC class II ubiquitination negatively regulates dendritic cells2013

    • Author(s)
      石戸聡
    • Organizer
      第35回 内藤コンファレンス
    • Place of Presentation
      シャトレーゼ ガトーキングダム(北海道)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 脱ユビキチン化酵素による細胞のストレス応答の制御2012

    • Author(s)
      駒田 雅之
    • Organizer
      第85回日本生化学会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2012-12-14
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 脱ユビキチン化酵素USP13によるストレス顆粒の制御2012

    • Author(s)
      松本 俊介
    • Organizer
      第85回日本生化学会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2012-12-14
    • Related Report
      2012 Annual Research Report
  • [Presentation] 脱ユビキチン化酵素USP18はユビキチン化された変性タンパク質によるアグリソーム形成に関与する2012

    • Author(s)
      Bolotbyek Avliush
    • Organizer
      第85回日本生化学会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2012-12-14
    • Related Report
      2012 Annual Research Report
  • [Book] Encyclopedia of Signaling Molecules, 2nd Edition2017

    • Author(s)
      Komada M, Reincke M, Theodoropoulou M
    • Total Pages
      4700
    • Publisher
      Springer
    • Related Report
      2016 Annual Research Report
  • [Remarks] 東京工業大学・駒田研究室 ホームページ

    • URL

      http://www.komada-lab.bio.titech.ac.jp

    • Related Report
      2016 Annual Research Report
  • [Remarks] 東京工業大学・細胞制御工学研究センター ホームページ

    • URL

      http://www.rcb.iir.titech.ac.jp

    • Related Report
      2016 Annual Research Report
  • [Remarks] 東京工業大学・科学技術創成研究院 ホームページ

    • URL

      http://www.iir.titech.ac.jp

    • Related Report
      2016 Annual Research Report
  • [Remarks] 東京工業大学・生命理工学院 ホームページ

    • URL

      http://www.educ.titech.ac.jp/bio/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 兵庫医科大学・石戸研究室 ホームページ

    • URL

      http://www.hyo-med.ac.jp/faculty/course/microbiology.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 東京工業大学 科学技術創成研究院 駒田研究室 ホームページ

    • URL

      http://www.komada-lab.bio.titech.ac.jp

    • Related Report
      2015 Annual Research Report
  • [Remarks] 科研費 新学術領域 ユビキチン制御 ホームページ

    • URL

      http://www.ubiquitin.jp

    • Related Report
      2015 Annual Research Report
  • [Remarks] 東京工業大学ホームページ「研究最前線」

    • URL

      http://www.titech.ac.jp/news/2014/029324.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 駒田研究室ホームページ

    • URL

      http://www.komada-lab.bio.titech.ac.jp

    • Related Report
      2014 Annual Research Report
  • [Remarks] 駒田研究室ホームページ

    • URL

      http://www.bio.titech.ac.jp/laboratory/komada/index.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 石戸研究室ホームページ

    • URL

      http://www.shoyaku.ac.jp/labosite/kansen/index.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 東京工業大学 大学院生命理工学研究科 駒田研究室 ホームページ

    • URL

      http://www.komada-lab.bio.titech.ac.jp

    • Related Report
      2013 Annual Research Report
  • [Remarks] 昭和薬科大学 薬学部 統合感染免疫学研究室 ホームページ

    • URL

      http://www.shoyaku.ac.jp/labosite/kansen/index.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 東京工業大学 大学院生命理工学研究科 駒田研究室

    • URL

      http://www.komada-lab.bio.titech.ac.jp

    • Related Report
      2012 Annual Research Report

URL: 

Published: 2012-11-27   Modified: 2022-02-07  

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