| Budget Amount *help |
¥175,760,000 (Direct Cost: ¥135,200,000、Indirect Cost: ¥40,560,000)
Fiscal Year 2016: ¥32,760,000 (Direct Cost: ¥25,200,000、Indirect Cost: ¥7,560,000)
Fiscal Year 2015: ¥32,760,000 (Direct Cost: ¥25,200,000、Indirect Cost: ¥7,560,000)
Fiscal Year 2014: ¥32,890,000 (Direct Cost: ¥25,300,000、Indirect Cost: ¥7,590,000)
Fiscal Year 2013: ¥32,760,000 (Direct Cost: ¥25,200,000、Indirect Cost: ¥7,560,000)
Fiscal Year 2012: ¥44,590,000 (Direct Cost: ¥34,300,000、Indirect Cost: ¥10,290,000)
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| Outline of Final Research Achievements |
Ubiquitin system controls a variety of cellular processes. In this research, we try to clarify the new substrates and function of Cullin-type and TRIM-type E3s. Now we show that, in the Cullin type E3s, Ucc1, SSB4, ASB7 and Prame is related to the regulation of citric acid composition, signal transduction, spindle formation and transcription, respectively. Furthermore, we demonstrate that, in the TRIM-type E3s, TRIM45, TRIM23, TRIM29 and RNF207 controls tumor suppression, fat cell differentiation, DNA repair and glucose metabolism, respectively. Our findings shed the light on the new function of Cullin-type and TRIM-type E3s.
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