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Development of biochemical methods to understand protein ubiquitylation

Planned Research

Project AreaNew aspect of the ubiquitin system : its enormous roles in protein regulation
Project/Area Number 24112008
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionTokyo Metropolitan Institute of Medical Science

Principal Investigator

SAEKI Yasushi  公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 副参事研究員 (80462779)

Project Period (FY) 2012-06-28 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥146,380,000 (Direct Cost: ¥112,600,000、Indirect Cost: ¥33,780,000)
Fiscal Year 2016: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2015: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2014: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Fiscal Year 2013: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2012: ¥93,730,000 (Direct Cost: ¥72,100,000、Indirect Cost: ¥21,630,000)
Keywords細胞内タンパク質分解 / ユビキチン / プロテアソーム / 質量分析計 / タンパク質分解 / 定量プロテオミクス / アフィニティープローブ / 生体分子 / 蛋白質 / 酵素 / プロテオーム
Outline of Final Research Achievements

Ubiquitylation is a post-translational modification that regulates numerous important cellular processes including proteasomal degradation, DNA repair, protein sorting, and signal transduction. The diverse functions of ubiquitin depend on the ubiquitin chain topology with eight linkage types, lengths, chemical modifications, and their combinations. To clarify the ubiquitin code, we developed an ultra-sensitive absolute quantification method of ubiquitin chains and a comprehensive identification method of ubiquitylated substrates using a high resolution mass spectrometry. Then, we applied them to the analysis of various important substrates found in the research group. In addition, we comprehensively analyzed ubiquitin chain type selectivity of yeast ubiquitin-binding proteins and found that proteasomal degradation is predominantly regulated by the Cdc48-Rad23/Dsk2 axis. Thus, we provided the first overall picture of the ubiquitin network via ubiquitin-binding proteins.

Report

(6 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report

Research Products

(58 results)

All 2018 2017 2016 2015 2014 2013 2012 Other

All Journal Article (25 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 24 results,  Acknowledgement Compliant: 18 results,  Open Access: 11 results) Presentation (20 results) (of which Invited: 16 results) Book (3 results) Remarks (7 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 1 results)

  • [Journal Article] Phosphorylated ubiquitin chain is the genuine Parkin receptor2018

    • Author(s)
      Okatsu, K., Koyano, F., Kimura, M., Kosako, H., Saeki, Y., Tanaka, K. * and Matsuda, N. * (*cocorespondences)
    • Journal Title

      J Pharm Biomed Anal.

      Volume: 209 Pages: 111-128

    • DOI

      10.1083/jcb.201410050

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] HTLV-1 Tax induces formation of the active macromolecular IKK complex by generating Lys63- and Metl-linked hybrid polyubiquitin chains.2017

    • Author(s)
      Shibata, Y., Tokunaga, F., Goto, E., Komatsu, G., Gohda, J., Saeki, Y., Tanaka, K., Takahashi, H., Sawasaki, T., Inoue, S., Oshiumi, H., Seya, T., Nakano, H., Tanaka, Y., Iwai, K., and Inoue, JI.
    • Journal Title

      PLoS Pathog.

      Volume: 13 Issue: 12

    • DOI

      10.1371/journal.ppat.1006162

    • NAID

      120005980879

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] In Vivo Ubiquitin Linkage-type Analysis Reveals that the Cdc48-Rad23/Dsk2 Axis Contributes to K48-linked Chain Specificity of the Proteasome.2017

    • Author(s)
      Tsuchiya, H., Ohtake, F., Arai, N., Kaiho, A., Yasuda, S., Tanaka, K., and Saeki, Y.
    • Journal Title

      Mol Cell

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Ubiquitin recognition by the proteasome.2017

    • Author(s)
      Saeki, Y.
    • Journal Title

      J. Biochem.

      Volume: 161 Pages: 113-124

    • DOI

      10.1093/jb/mvw091

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Mutations in the deubiquitinase gene USP8 cause Cushing's disease2017

    • Author(s)
      Reincke, M., Sbiera, S., Hayakawa, A., Theodoropoulou, M., Osswald, A., Beuschlein, F., Meitinger, T., Mizuno-Yamasaki, E., Kawaguchi, K., Saeki, Y., Tanaka, K., Wieland, T., Graf, E., Saeger, W., Ronchi, C. L., Allolio, B., Buchfelder, M., Strom, T. M., Fassnacht, M., and Komada M.
    • Journal Title

      Mol Cell Biol.

      Volume: 47 Pages: 195-195

    • DOI

      10.1038/ng.3166

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The ankrd13 family of ubiquitin-interacting motif-bearing proteins regulates valosin-containing protein/p97 protein-mediated lysosomal trafficking of caveolin 1.2016

    • Author(s)
      Burana, D., Yoshihara, H., Tanno, H., Yamamoto, A., Saeki, Y., Tanaka, K., and Komada, M.
    • Journal Title

      J Biol Chem.

      Volume: 291 Pages: 6218-6231

    • DOI

      10.1074/jbc.m115.710707

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The K48-K63 branched ubiquitin chain regulates NF-kappaB signaling2016

    • Author(s)
      Ohtake, F., Saeki, Y., Ishido, S., Kanno, J., and Tanaka, K.
    • Journal Title

      Molecular Cell

      Volume: 64 Pages: 251-266

    • DOI

      10.1016/j.molcel.2016.09.014

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 分子標的薬「プロテアソーム阻害剤」2016

    • Author(s)
      佐伯 泰
    • Journal Title

      腎臓内科・泌尿器科

      Volume: 4 Pages: 30-38

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Nedd4-induced mono-ubiquitination of IRS-2 enhances IGF-dependent signals and mitogenic activity2015

    • Author(s)
      Fukushima, T., Yoshihara, H., Furuta, H., Kamei, H., Hakuno, F., Luan, J., Duan, C., Saeki, Y., Tanaka, K., Iemura, S., Natsume, T., Chida, K., Nakatsu, Y., Kamata, H., Asano, T., and Takabashi, S-I
    • Journal Title

      Nature Commun.

      Volume: 6 Pages: 6780-6780

    • DOI

      10.1038/ncomms7780

    • NAID

      120006348510

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The E3 ubiquitin ligase TRIM23 regulates adipocyte differentiation via stabilization of the adipogenic activator PPARγ2015

    • Author(s)
      Watanabe, M., Takahashi, H., Saeki, Y., Ozaki, T., Itoh, S., Suzuki, M., Mizushima, W., Tanaka, K., and Hatakeyama, S.
    • Journal Title

      eLIfe

      Volume: 4

    • DOI

      10.7554/elife.05615

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Site-specific interaction mapping of phosphorylated ubiquitin to uncover parkin activation2015

    • Author(s)
      Yamano, K., Queliconi, B. B., Koyano, F., Saeki, Y., Hirokawa, T., Tanaka, K., and Matsuda, N.
    • Journal Title

      J Biol Chem.

      Volume: 290 Pages: 25199-211

    • DOI

      10.1074/jbc.m115.671446

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Liganded ERαstimulates the E3 ubiquitin ligase activity of UBE3C to facilitate cell proliferation2015

    • Author(s)
      Okada, M., Ohtake, F., Nishikawa, H., Wu, W., Saeki, Y., Tanaka, K., and Ohta, T.
    • Journal Title

      Mol Endocrinol.

      Volume: 29 Pages: 1646-1657

    • DOI

      10.1210/me.2015-1125

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] ユビキチンリガーゼ活性の簡便で効率的な検出方法2015

    • Author(s)
      吉田雪子, 佐伯 泰, 田中啓二
    • Journal Title

      実験医学

      Volume: 33 Pages: 3003-3007

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure, dynamics and functions of the proteasome2015

    • Author(s)
      佐伯泰
    • Journal Title

      生化学

      Volume: 87 Issue: 6 Pages: 705-722

    • DOI

      10.14952/SEIKAGAKU.2015.870705

    • NAID

      40020687379

    • ISSN
      0037-1017
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ubiquitn acetylation inhibits polyubiquitin chain elongation2015

    • Author(s)
      Ohtake, F., Saeki, Y., Sakamoto, K., Ohtake, K., Nishikawa, H., Tsuchiya, H., Ohta, T., Tanaka, K., and Kanno, J.
    • Journal Title

      EMBO Rep.

      Volume: 16 Pages: 192-201

    • DOI

      10.15252/embr.201439152

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The unexpected role of polyubiquitin chains in the formation of fibrillar aggregates2015

    • Author(s)
      Morimoto, D., Walinda, E. Fukada, H., Sou, Y. S., Kageyama, S., Hoshino, M., Fujii, T., Tsuchiya, H., Saeki, Y., Arita, K., Ariyoshi, M., Tochio, H., Iwai, K., Namba, K., Komatsu, M., Tanaka, K., and Shirakawa M.
    • Journal Title

      Nat Commun.

      Volume: 6 Pages: 000-000

    • DOI

      10.1038/ncomms7116

    • NAID

      120005528125

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A comprehensive method for detecting ubiquitinated substrates using TR-TUBE2015

    • Author(s)
      Yoshida, Y., Yasushi Saeki, Y., Murakami, A., Kawawaki, J., Tsuchiya, H., Yoshibara, H., Shindo, M., and Tanaka, K.
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 112 Pages: 4630-4635

    • DOI

      10.1073/pnas.1422313112

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Ubiquitin is phosphorylated by PINK1 to activate parkin.2014

    • Author(s)
      Koyano, F., Okatsu, K., Kosako, H., Tamura, Y., Go, E., Kimura, M., Kimura, Y., Tsuchiya, H., Yoshihara, H., Hirokawa, T., Endo, T., Fon. E. A., Trempe, J. F., Saeki, Y., Tanaka, K., and Matsuda, N.
    • Journal Title

      Nature

      Volume: 510(in press) Pages: 162-166

    • DOI

      10.1038/nature13392

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Pba3-Pba4 heterodimer acts as a molecular matchmaker in proteasome α-ring formation2014

    • Author(s)
      Takagi, K., Saeki, Y., Yashiroda, H., Yagi, H., Kaiho, A., Murata, S., Yamane, T., Tanaka, K., Mizushima, T. and Kato, K.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 450 Pages: 1110-1114

    • DOI

      10.1016/j.bbrc.2014.06.119

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Suppression of LUBAC-mediated linear ubiquitination by a specific interaction between LUBAC and the deubiquitinases CYLD and OTULIN.2014

    • Author(s)
      Takiuchi, T., Nakagawa, T., Tamiya, H., Fujita, H., Sasaki, Y., Saeki, Y., Takeda, H., Sawasaki, T., Buchberger, A., Kimura, T., and Iwai. K.
    • Journal Title

      Genes Cells

      Volume: 19 Pages: 254-272

    • DOI

      10.1111/gtc.12128

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Quantitative live-cell imaging reveals spatio-temporal dynamics and cytoplasmic assembly of the 26S proteasome2014

    • Author(s)
      Pack, CG., Yukii, H., Toh-e, A., Kudo, T., Tsuchiya, H., Kaiho, A., Sakata, E., Murata, S., Sako, Y., Baumeister, W., Tanaka, K., and Saeki, Y.
    • Journal Title

      Nat Commun

      Volume: 5 Pages: 3396-3396

    • DOI

      10.1038/ncomms4396

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural Basis for Proteasome Formation Controlled by an Assembly Chaperone Nas22014

    • Author(s)
      Satoh T, Saeki Y, Hiromoto T, Wang YH, Uekusa Y, Yagi H, Yoshihara H, Yagi-Utsumi M, Mizushima T, Tanaka K, Kato K
    • Journal Title

      Structure

      Volume: (掲載確定) Pages: 731-743

    • DOI

      10.1016/j.str.2014.02.014

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Ubiquitin is phosphorylated by PINK1 to activate Parkin2014

    • Author(s)
      Koyano, F., Okatsu, K., Kosako, H., Tamura, Y., Go, E., Kimura, M., Kimura, Y., Tsuchiya, H., Yoshihara, H., Hirokawa, T., Endo, T., Fon, E.A., Trempe, J., Saeki, Y., Tanaka, K. and Matsuda, N.
    • Journal Title

      Nature

      Volume: 印刷中

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A multi-purpose fusion tag derived from an unstructured and hyper-acidic region of the amyloid precursor protein.2013

    • Author(s)
      Sangawa, T., Tabata, S., Suzuki, K., Saeki, Y., Tanaka, K., and Takagi, J.
    • Journal Title

      Protein Sci.

      Volume: 22 Pages: 840-850

    • DOI

      10.1002/pro.2254

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The parallel reaction monitoring method contributes to a highly sensitive polyubiquitin chain quantification.2013

    • Author(s)
      Tsuchiya, H.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: XXX

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] ユビキチン修飾の全容解明を目指して:Parallel Reaction Monitoring法によるユビキチン鎖の超高感度絶対定量法の開発と応用2016

    • Author(s)
      佐伯 泰、土屋 光、大竹史明、田中啓二
    • Organizer
      日本プロテオーム学会2016年大会
    • Place of Presentation
      北里大学(東京都港区)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Cdc48/p97-Rad23軸がプロテアソーム分解の主要経路である2016

    • Author(s)
      佐伯 泰
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ユビキチンネットワークの全容解明を目指して2015

    • Author(s)
      佐伯 泰
    • Organizer
      平成27年度日本生化学会関東支部例会
    • Place of Presentation
      新潟日報メディアシップ(新潟県新潟市)
    • Year and Date
      2015-06-20
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ユビキチンコードの全容解明を目指して2015

    • Author(s)
      佐伯 泰
    • Organizer
      日本農芸化学会2015大会シンポジウム
    • Place of Presentation
      岡山大学(岡山)
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Elucidating the proteasome dynamics and cellular ubiquitin code2014

    • Author(s)
      Yasushi Saeki
    • Organizer
      The 5th International Symposium on Life Science in Toyama
    • Place of Presentation
      富山大学(富山)
    • Year and Date
      2014-12-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] A comprehensive analysis of ubiquitin linkages and length specificities of ubiquitin-binding proteins2014

    • Author(s)
      Yasushi Saeki
    • Organizer
      1st International Meeting for New Aspects of the Ubiquitin Research
    • Place of Presentation
      国際高等研究所レクチャーホール(京都)
    • Year and Date
      2014-11-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 質量分析計を用いたユビキチン修飾の解析2013

    • Author(s)
      佐伯 泰
    • Organizer
      新学術領域研究「ユビキチンネオバイオロジー:拡大するタンパク質制御システム」第1回班会議
    • Place of Presentation
      淡路
    • Year and Date
      2013-01-29
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Ub-ProT: A novel method to determine the chain length of the polyubiquitylated proteins.2013

    • Author(s)
      Yasushi Saeki, Hikaru Tsuchiya, Ai Kaiho, and Keiji Tanaka
    • Organizer
      4th IGAKUKEN International Symposium on“Cutting-edge of the Ubiquitin Proteasome System”
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] A method to determine the chain length of the polyubiqutinated proteins2013

    • Author(s)
      Hikaru Tscuchiya, Yasushi Saeki, Ai Kaiho, Keiji Tanaka, and Tetsu Akiyama
    • Organizer
      The 35th Natio Conference “The Ubiquitin-Proteasome System: From Basic Mechanisms to Pathophysiological Roles”
    • Place of Presentation
      Sapporo, Japan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ユビキチンコード解析法とプロテアソーム研究の最前線2013

    • Author(s)
      佐伯 泰
    • Organizer
      東京工業大学フロンティア研究機構セミナー
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ユビキチンコード解析法の開発2013

    • Author(s)
      佐伯 泰、土屋 光、田中啓二
    • Organizer
      酵母遺伝学フォーラム第46回研究報告会
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
  • [Presentation] ユビキチンコード解析法の開発2013

    • Author(s)
      佐伯 泰、土屋 光、田中啓二
    • Organizer
      第86回 日本生化学会大会シンポジウム
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Absolute quantification of ubiquitin-linkages and ubiquitin-binding proteins by parallel reaction monitoring from biological complex samples2013

    • Author(s)
      Yasushi Saeki
    • Organizer
      HUPO2013
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] A method to determine the chain length of the polyubiqutinated proteins2013

    • Author(s)
      Hikaru Tsuchia, Keiji Tanaka, and Yasushi Saeki
    • Organizer
      EMBO Conference on Ubiquitin and ubiquitin-like proteins “From structure to function”
    • Place of Presentation
      Riva der Garda, Italy
    • Related Report
      2013 Annual Research Report
  • [Presentation] 細胞内ポリユビキチン化タンパク質の鎖長制御機構2013

    • Author(s)
      佐伯 泰、土屋 光、吉原英人、田中啓二
    • Organizer
      第36回 日本分子生物学会年会ワークショップ
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Structure and dynamics of the 26S proteasome2012

    • Author(s)
      Yasushi Saeki
    • Organizer
      熊本大学発生医学研究所リエゾンラボ研究会
    • Place of Presentation
      熊本
    • Year and Date
      2012-12-19
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 新規ユビキチン鎖長決定法の開発2012

    • Author(s)
      土屋 光
    • Organizer
      第35回分子生物学会ワークショップ
    • Place of Presentation
      博多
    • Year and Date
      2012-12-14
    • Related Report
      2012 Annual Research Report
  • [Presentation] 選択的なポリユビキチン鎖の検出・定量法の開発2012

    • Author(s)
      佐伯 泰
    • Organizer
      新学術領域研究「ユビキチンネオバイオロジー:拡大するタンパク質制御システム」kick-off シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2012-09-26
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 新規ユビキチン鎖長決定法の開発2012

    • Author(s)
      土屋 光
    • Organizer
      酵母遺伝学フォーラム第45回研究報告会
    • Place of Presentation
      宇治
    • Year and Date
      2012-09-05
    • Related Report
      2012 Annual Research Report
  • [Presentation] Regulation by ubiquitin-proteasome system.2012

    • Author(s)
      Yasushi Saeki
    • Organizer
      Core-to-Core Project sponsored by JSPS International Seminar,
    • Place of Presentation
      東京
    • Year and Date
      2012-08-25
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] 実験医学・増刊号「構造生命科学-構造を使う研究を目指す新しいライフサイエンス」2014

    • Author(s)
      佐伯 泰、水島恒裕
    • Total Pages
      7
    • Publisher
      羊土社
    • Related Report
      2013 Annual Research Report
  • [Book] 細胞工学Hot Press2014

    • Author(s)
      佐伯 泰、白 燦基
    • Total Pages
      2
    • Publisher
      秀潤社
    • Related Report
      2013 Annual Research Report
  • [Book] 「特集/蛋白構造-機能連関解析と治療薬開発への応用」内分泌・糖尿病・代謝内科2012

    • Author(s)
      佐伯 泰
    • Total Pages
      10
    • Publisher
      科学評論社
    • Related Report
      2012 Annual Research Report
  • [Remarks] 公益財団法人東京都医学総合研究所蛋白質代謝研究室ホームページ

    • URL

      http://www.igakuken.or.jp/pro-meta/

    • Related Report
      2016 Annual Research Report
  • [Remarks] ライフサイエンス新着論文レビュー「K48/K63分岐型のユビキチン鎖はNF-κBシグナルを制御する」

    • URL

      http://first.lifesciencedb.jp/archives/14798

    • Related Report
      2016 Annual Research Report
  • [Remarks] 蛋白質代謝研究室ホームページ

    • URL

      http://www.igakuken.or.jp/pro-meta/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 研究室ホームページ

    • URL

      http://www.igakuken.or.jp/pro-meta/

    • Related Report
      2014 Annual Research Report
  • [Remarks] ユビキチン化基質の効率的な同定法の開発

    • URL

      http://www.igakuken.or.jp/topics/2015/0331.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 難病"クッシング病"の原因遺伝子と発症機構を解明

    • URL

      http://www.igakuken.or.jp/topics/2014/1209.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 公益財団法人東京都医学総合研究所蛋白質代謝研究室

    • URL

      http://www.igakuken.or.jp/pro-meta/

    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] A method for determining Ubiquitin chain length2014

    • Inventor(s)
      Yasushi Saeki et al
    • Industrial Property Rights Holder
      Yasushi Saeki et al
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-11-05
    • Related Report
      2014 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] パーキンソン病のバイオマーカーおよびその利用2014

    • Inventor(s)
      松田憲之、小谷野史香、尾勝圭、呉越、木村まゆみ、佐伯泰
    • Industrial Property Rights Holder
      松田憲之、小谷野史香、尾勝圭、呉越、木村まゆみ、佐伯泰
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-02-18
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] ポリユビキチン化基質の同定方法2013

    • Inventor(s)
      吉田雪子、佐伯 泰、土屋 光、村上有沙、田中啓二
    • Industrial Property Rights Holder
      吉田雪子、佐伯 泰、土屋 光、村上有沙、田中啓二
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-11-15
    • Related Report
      2013 Annual Research Report

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Published: 2012-11-27   Modified: 2019-07-29  

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