• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Structural studies for specific recognition of ubiquitin signals

Planned Research

Project AreaNew aspect of the ubiquitin system : its enormous roles in protein regulation
Project/Area Number 24112009
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionUniversity of Hyogo

Principal Investigator

MIZUSHIMA TSUNEHIRO  兵庫県立大学, 生命理学研究科, 教授 (90362269)

Co-Investigator(Kenkyū-buntansha) 加藤 龍一  大学共同利用機関法人高エネルギー加速器研究機構, 物質構造科学研究所, 准教授 (50240833)
Research Collaborator KUWABARA Naoyuki  
TAKAGI Kenji  
Project Period (FY) 2012-06-28 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥116,610,000 (Direct Cost: ¥89,700,000、Indirect Cost: ¥26,910,000)
Fiscal Year 2016: ¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
Fiscal Year 2015: ¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
Fiscal Year 2014: ¥20,670,000 (Direct Cost: ¥15,900,000、Indirect Cost: ¥4,770,000)
Fiscal Year 2013: ¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
Fiscal Year 2012: ¥34,320,000 (Direct Cost: ¥26,400,000、Indirect Cost: ¥7,920,000)
Keywords蛋白質 / ユビキチン / 構造生物学 / 分子認識 / X線結晶構造解析 / タンパク質 / X線結晶構造解析 / X線化粧構造解析
Outline of Final Research Achievements

Ubiquitin modification controls various cellular processes, such as cell cycle control and protein quality control. This modification provides countless possibilities to assemble a specific polymer. Ubiquitin modification pathway is regulated by a variety of proteins including ubiquitin binding proteins, ubiquitin ligases and deubiquitinating enzymes. To elucidate the molecular mechanisms of ubiquitination pathway, we determined the crystal structures of ubiquitin binding protein, BAG6 and ubiquitin ligases, FBG3, HOIP and Keap1. Moreover, we have determined the structures of bacterial effectors, OspI and IpaH9.8 that manipulate the host ubiquitin pathway. These structures provide the substrate recognition and functional mechanisms.

Report

(6 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (73 results)

All 2017 2016 2015 2014 2013 2012 Other

All Int'l Joint Research (2 results) Journal Article (14 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 14 results,  Acknowledgement Compliant: 7 results,  Open Access: 10 results) Presentation (56 results) (of which Int'l Joint Research: 6 results,  Invited: 8 results) Book (1 results)

  • [Int'l Joint Research] ゲーテ大学(ドイツ)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] スタンフォード大学(米国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Crystal structure of the substrate-recognition domain of the Shigella E3 ligase IpaH9.82016

    • Author(s)
      K Takagi, et al
    • Journal Title

      Acta Cryst

      Volume: F72 Issue: 4 Pages: 269-275

    • DOI

      10.1107/s2053230x16002715

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] In-situ data collection at the photon factory macromolecular crystallography beamlines.2016

    • Author(s)
      Yamada, Y., Hiraki, M., Matsugaki, N., Kato, R., Senda, T.
    • Journal Title

      AIP Conf. Proc.

      Volume: 1741 Pages: 050023-050023

    • DOI

      10.1063/1.4952943

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming2016

    • Author(s)
      Saito T, Ichimura Y, Taguchi K, Suzuki T, Mizushima T, Takagi K, Hirose Y, Nagahashi M, Iso T, Fukutomi T, Ohishi M, Endo K, Uemura T, Nishito Y, Okuda S, Obata M, Kouno T, Imamura R, Tada Y, Obata R, Yasuda D, Takahashi K, Fujimura T, Pi J, Lee MS, Ueno T, Ohe T, Mashino T, Wakai T, Kojima H, Okabe T, Nagano T et al.
    • Journal Title

      Nature Commun

      Volume: 7 Issue: 1 Pages: 12030-12030

    • DOI

      10.1038/ncomms12030

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Structural analysis of a function-associated loop mutant of the substrate recognition domain of Fbs1 ubiquitin ligase.2016

    • Author(s)
      Nishio, K., Yoshida, Y., Tanaka, K., Mizushima, T.
    • Journal Title

      Acta Crystallographica Section F

      Volume: 72 Issue: 8 Pages: 619-626

    • DOI

      10.1107/s2053230x16011018

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A conserved island of BAG6/Scythe is related to ubiquitin domains and participates in short hydrophobicity recognition.2016

    • Author(s)
      Tanaka, H., Takahashi, T., Xie, Y., Minami, R., Yanagi, Y., Hayashishita, M., Suzuki, R., Yokota, N., Shimada, M., Mizushima, T., Kuwabara, N., Kato, R., Kawahara, H.
    • Journal Title

      FEBS J.

      Volume: 283 Issue: 4 Pages: 662-677

    • DOI

      10.1111/febs.13618

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A novel mode of ubiquitin recognition by the ubiquitin-binding zinc finger domain of WRNIP12016

    • Author(s)
      Suzuki, N., Rohaim, A., Kato, R., Dikic, I., Wakatsuki, S., Kawasaki, M.
    • Journal Title

      FEBS Letters

      Volume: 印刷中 Issue: 11 Pages: 2004-2017

    • DOI

      10.1111/febs.13734

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Structure of a BAG6 (Bcl-2-associated Athanogene 6)-Ubl4a (Ubiquitin-like Protein 4a) Complex Reveals a Novel Binding Interface That Functions in Tail-anchored Protein Biogenesis.2015

    • Author(s)
      Kuwabara N, Minami R, Yokota N, Matsumoto H, Senda T, Kawahara H, Kato R.
    • Journal Title

      J. Biol. Chem.

      Volume: 290 Issue: 15 Pages: 9387-9398

    • DOI

      10.1074/jbc.m114.631804

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Conserved Mode of Interaction between Yeast Bro1 Family V Domains and YP(X)nL Motif-Containing Target Proteins2015

    • Author(s)
      Yoko Kimura, Mirai Tanigawa, Junko Kawawaki, Kenji Takagi, Tsunehiro Mizushima, Tatsuya Maeda, Keiji Tanaka
    • Journal Title

      Eukaryotic Cell

      Volume: 14 Issue: 10 Pages: 976-982

    • DOI

      10.1128/ec.00091-15

    • NAID

      120005671359

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The Structural Differences between a Glycoprotein Specific F-Box Protein Fbs1 and Its Homologous Protein FBG3.2015

    • Author(s)
      Kumanomidou T, Nishio K, Takagi K, Nakagawa T, Suzuki A, Yamane T, Tokunaga F, Iwai K, Murakami A, Yoshida Y, Tanaka K, Mizushima T.
    • Journal Title

      PLoS One.

      Volume: 10 Issue: 10 Pages: e0140366-e0140366

    • DOI

      10.1371/journal.pone.0140366

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Kinetic, Thermodynamic and Structural Characterizations of Association between Nrf2-DLGex Degron and Keap1.2014

    • Author(s)
      Fukutomi, T., Takagi, K., Mizushima, T., Ohuchi, N., and Yamamoto, M.
    • Journal Title

      Moll Cell Biol.

      Volume: 34 Issue: 5 Pages: 832-846

    • DOI

      10.1128/mcb.01191-13

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Bacterial Effectors and Their Functions in the Ubiquitin-Proteasome System: Insight from the Modes of Substrate Recognition2014

    • Author(s)
      Kim M et. al
    • Journal Title

      Cells

      Volume: 3 Issue: 3 Pages: 848-864

    • DOI

      10.3390/cells3030848

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Mechanism underlying IKK activation mediated by the linear ubiquitin chain assembly complex (LUBAC).2014

    • Author(s)
      Fujita, H., Rahighi, S., Akita, M., Kato, R., Sasaki, Y., Wakatsuki, S., and Iwai, K.
    • Journal Title

      Mol. Cell. Biol.

      Volume: 34 Issue: 7 Pages: 1322-1335

    • DOI

      10.1128/mcb.01538-13

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Structural basis for the recognition of Ubcl3 by the Shigell a flexneri effector OspI2013

    • Author(s)
      Nishide A, et. al
    • Journal Title

      J Mol Bio.

      Volume: 425 Issue: 15 Pages: 2623-2631

    • DOI

      10.1016/j.jmb.2013.02.037

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.2013

    • Author(s)
      Ichimura, Y., Waguri, S., Sou, Y., Kageyama, S., Hasegawa, J., Ishimura, R., Saito, T., Yang, Y., Kouno, T., Fukutomi, T., Hoshii, T., Atsushi, H., Takagi, K., Mizushima, T., Motohashi, H., Lee, M-S., Yoshimori, T., Tanaka, K., Yamamoto, M., and Komatsu, K.
    • Journal Title

      Mol Cell

      Volume: 51 Issue: 5 Pages: 618-631

    • DOI

      10.1016/j.molcel.2013.08.003

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Structural basis for the recognition of citrate synthase, Cit2 by F-box protein Ucc12017

    • Author(s)
      Kazuya Nishio, Syu Moriyama, Kunio Nakatsukasa, Takumi Kamura and Tsunehiro Mizushima
    • Organizer
      The Annual Evaluation Conference of the Leading Program, University of Hyogo for school year of 2016
    • Place of Presentation
      兵庫県立先端科学技術支援センター (兵庫県・赤穂郡上郡町)
    • Year and Date
      2017-03-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] ユビキチン-プロテアソーム経路による生命制御の分子メカニズム2017

    • Author(s)
      水島恒裕
    • Organizer
      徳島大学薬学部講演会
    • Place of Presentation
      徳島大学薬学部 (徳島県・徳島市)
    • Year and Date
      2017-03-01
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] バクテリアの感染戦略:エフェクターによる宿主防御経路の阻害機構2017

    • Author(s)
      水島恒裕
    • Organizer
      第4回県立健康生活科学研究所・理学部合同研究発表会
    • Place of Presentation
      兵庫県立大学 (兵庫県・赤穂郡上郡町)
    • Year and Date
      2017-02-10
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 病原細菌エフェクターによる宿主防御経路阻害の分子メカニズム2017

    • Author(s)
      水島恒裕
    • Organizer
      神戸大学/兵庫県立大学間交流セミナー
    • Place of Presentation
      兵庫県立先端科学技術支援センター (兵庫県・赤穂郡上郡町)
    • Year and Date
      2017-01-06
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 構造学的手法を用いた赤痢菌エフェクター IpaH ファミリーの反応機構の解析2016

    • Author(s)
      西出旭, Kim Minsoo, 桑原直之, 加藤龍一, 笹川千尋, 水島恒裕
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜 (神奈川県・横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] クエン酸合成酵素Cit2およびリガンド複合体の結晶構造解析2016

    • Author(s)
      森山 周, 西尾 和也, 中務 邦雄, 嘉村 巧, 水島 恒裕
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜 (神奈川県・横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] F-boxタンパク質Ucc1によるクエン酸合成酵素Cit2の認識機構2016

    • Author(s)
      西尾 和也, 森山 周, 中務 邦雄, 嘉村 巧, 水島 恒裕
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜 (神奈川県・横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 「放射光X線を用いたユビキチン修飾に関わるタンパク質の構造解析2016

    • Author(s)
      加藤龍一
    • Organizer
      科学研究費補助金 新学術領域「ユビキチンネオバイオロジー」平成28年度 領域班会議
    • Place of Presentation
      シャトレーゼガトーキングダムサッポロ (北海道・札幌市)
    • Year and Date
      2016-11-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] ユビキチンリガーゼによる基質認識と反応機構の構造解析2016

    • Author(s)
      水島恒裕
    • Organizer
      科学研究費補助金 新学術領域「ユビキチンネオバイオロジー」平成28年度 領域班会議
    • Place of Presentation
      シャトレーゼガトーキングダムサッポロ (北海道・札幌市)
    • Year and Date
      2016-11-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] 赤痢菌エフェクター IpaH1880 反応機構の解析2016

    • Author(s)
      西出旭, Kim Minsoo, 水島恒裕
    • Organizer
      科学研究費補助金 新学術領域「ユビキチンネオバイオロジー」平成28年度 領域班会議
    • Place of Presentation
      シャトレーゼガトーキングダムサッポロ (北海道・札幌市)
    • Year and Date
      2016-11-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] 赤痢菌エフェクターOspIによるTRAF6阻害機構の構造生物学解析2016

    • Author(s)
      高木賢治, 西出旭, Kim Minsoo, 笹川千尋, 水島恒裕
    • Organizer
      科学研究費補助金 新学術領域「ユビキチンネオバイオロジー」平成28年度 領域班会議
    • Place of Presentation
      シャトレーゼガトーキングダムサッポロ (北海道・札幌市)
    • Year and Date
      2016-11-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] MD-SAXS相関構造解析による蛋白質の溶液構造解析2016

    • Author(s)
      浴本亨、池口満徳
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター (宮城県・仙台市)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] p62を介したKeap1、LC3複合体状態の解析2016

    • Author(s)
      高木賢治, 水島恒裕
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター (宮城県・仙台市)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] Keap1-Nrf2ストレス応答系制御の構造生物学解析2016

    • Author(s)
      高木賢治
    • Organizer
      生命科学研究科研究発表会
    • Place of Presentation
      兵庫県立大学 (兵庫県・赤穂郡上郡町)
    • Year and Date
      2016-07-11
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 赤痢菌エフェクターOspI触媒機構の解明2016

    • Author(s)
      西出旭, Kim Minsoo, 高木賢治, 古田徹郎, 笹川千尋, 水島恒裕
    • Organizer
      日本蛋白質科学会年会
    • Place of Presentation
      福岡国際会議場 (福岡県・福岡市)
    • Year and Date
      2016-06-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 赤痢菌エフェクターIpaH9.8によるNEMO認識機構の解析2016

    • Author(s)
      高木賢治, 大津彩織, Kim Minsoo, 水島恒裕
    • Organizer
      日本蛋白質科学会年会
    • Place of Presentation
      福岡国際会議場 (福岡県・福岡市)
    • Year and Date
      2016-06-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] Structural basis for the recognition of phospholylated USP8 by 14-3-3 epsilon2016

    • Author(s)
      Nishio, K., Suzuki, E., Komada, M., Mizushima, T.
    • Organizer
      The Annual Evaluation Conference of the Leading Program, University of Hyogo for the School Year of 2015
    • Place of Presentation
      先端支援センター (兵庫・赤穂郡上郡町)
    • Year and Date
      2016-03-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] Structure and substrate recognition mechanism of IpaH9.8 LRR.2016

    • Author(s)
      Takagi, K., Kim, M., Sasakawa, C., Mizushima, T.
    • Organizer
      The Annual Evaluation Conference of the Leading Program, University of Hyogo for the School Year of 2015
    • Place of Presentation
      先端支援センター (兵庫・赤穂郡上郡町)
    • Year and Date
      2016-03-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] Structural Analysis of Reaction Mechanism of Shigella flexneri effector OspI2016

    • Author(s)
      Nishide, A., Kim, M., Takagi, K., Sasakawa, C., Mizushima, T.
    • Organizer
      The Annual Evaluation Conference of the Leading Program, University of Hyogo for the School Year of 2015
    • Place of Presentation
      先端支援センター (兵庫・赤穂郡上郡町)
    • Year and Date
      2016-03-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] 赤痢菌エフェクターIpaH9.8によるNEMO認識機構の解析2015

    • Author(s)
      高木賢治、Kim Minsoo、水島恒裕
    • Organizer
      科研費新学術領域研究「ユビキチンネオバイオロジー」領域班会議
    • Place of Presentation
      南房総富浦ロイヤルホテル(千葉・南房総市)
    • Year and Date
      2015-12-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 脱ユビキチン化酵素USP37のユビキチン結合モチーフの機能解析2015

    • Author(s)
      西川周平、桑原直之、伝田公紀、川崎政人、駒田雅之、加藤龍一
    • Organizer
      科研費新学術領域研究「ユビキチンネオバイオロジー」領域班会議
    • Place of Presentation
      南房総富浦ロイヤルホテル(千葉・南房総市)
    • Year and Date
      2015-12-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] Structure of a BAG6*Ubl4a complex reveals a nobel binding interface that functions in tail-anchored protein biogenesis2015

    • Author(s)
      桑原直之、横田直人、川原裕之、加藤龍一
    • Organizer
      科研費新学術領域研究「ユビキチンネオバイオロジー」領域班会議
    • Place of Presentation
      南房総富浦ロイヤルホテル(千葉・南房総市)
    • Year and Date
      2015-12-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 赤痢菌OpaH1880とIpaH3のMD-SAXS相関構造解析2015

    • Author(s)
      浴本亨、西出旭、桑原直之、Kim minsoo、加藤龍一、水島恒裕、池口満徳
    • Organizer
      科研費新学術領域研究「ユビキチンネオバイオロジー」領域班会議
    • Place of Presentation
      南房総富浦ロイヤルホテル(千葉・南房総市)
    • Year and Date
      2015-12-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 赤痢菌エフェクターによる宿主防御阻害機構の解析2015

    • Author(s)
      水島恒裕
    • Organizer
      科研費新学術領域研究「ユビキチンネオバイオロジー」領域班会議
    • Place of Presentation
      南房総富浦ロイヤルホテル(千葉・南房総市)
    • Year and Date
      2015-12-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] X線結晶構造解析とそれと相補的な測定方法によるユビキチン関連タンパク質の研究2015

    • Author(s)
      加藤龍一
    • Organizer
      科研費新学術領域研究「ユビキチンネオバイオロジー」領域班会議
    • Place of Presentation
      南房総富浦ロイヤルホテル(千葉・南房総市)
    • Year and Date
      2015-12-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] Structural differences between sugar-recognizing F-box protein Fbs1 and homologous protein FBG32015

    • Author(s)
      K. Nishio, Y. Yoshida, K. Tanaka, T. Mizushima
    • Organizer
      3rd International Picobiology Institute Symposium Structural and biological studies on pathogenic and therapeutic targets
    • Place of Presentation
      先端支援センター (兵庫・赤穂郡上郡町)
    • Year and Date
      2015-12-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Structure and substrate recognition mechanism of IpaH9.8 LRR2015

    • Author(s)
      Takagi, K., Kim, M.., Mizushima, T.
    • Organizer
      3rd International Picobiology Institute Symposium Structural and biological studies on pathogenic and therapeutic targets
    • Place of Presentation
      先端支援センター (兵庫・赤穂郡上郡町)
    • Year and Date
      2015-12-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Structural Analysis of Reaction Mechanism of Shigella flexneri effector OspI2015

    • Author(s)
      Nishide, A., Kim, M., Takagi, K., Sasakawa, C., Mizushima, T.
    • Organizer
      3rd International Picobiology Institute Symposium Structural and biological studies on pathogenic and therapeutic targets
    • Place of Presentation
      先端支援センター (兵庫・赤穂郡上郡町)
    • Year and Date
      2015-12-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Structural analysis of the recognition mechanism of NEMO by shigella effector IpaH9.82015

    • Author(s)
      Otsu, S., Takagi, K., Kim, M., Mizushima, T.
    • Organizer
      3rd International Picobiology Institute Symposium Structural and biological studies on pathogenic and therapeutic targets
    • Place of Presentation
      先端支援センター (兵庫・赤穂郡上郡町)
    • Year and Date
      2015-12-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Structural analysis of the recognition mechanism of phospholylated USP8 by 14-3-3 epsilon2015

    • Author(s)
      E. Suzuki, K. Nishio, M. Komada, T. Mizushima
    • Organizer
      3rd International Picobiology Institute Symposium Structural and biological studies on pathogenic and therapeutic targets
    • Place of Presentation
      先端支援センター (兵庫・赤穂郡上郡町)
    • Year and Date
      2015-12-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脱ユビキチン化酵素USP37におけるユビキチン結合モチーフUIMの機能解析2015

    • Author(s)
      西川周平、桑原直之、伝田公紀、川崎政人、駒田雅之、加藤龍一
    • Organizer
      BMB2015(分子生物学会・生化学会 合同年会)
    • Place of Presentation
      神戸ポートアイランド(兵庫・神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 14-3-3蛋白質における脱ユビキチン化酵素USP8の機能制御機構の構造基盤2015

    • Author(s)
      西尾和也, 鈴木恵利奈, 駒田雅之, 水島恒裕
    • Organizer
      日本結晶学会年会
    • Place of Presentation
      大阪府立大学 (大阪・堺市)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] 赤痢菌エフェクタータンパク質IpaH9.8によるNEMOの認識機構の解析2015

    • Author(s)
      大津彩織,高木賢治, Kim Minsoo, 水島恒裕
    • Organizer
      日本結晶学会年会
    • Place of Presentation
      大阪府立大学 (大阪・堺市)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] 赤痢菌エフェクターOspI触媒機構の解明2015

    • Author(s)
      西出旭,高木賢治, Kim Minsoo, 水島恒裕
    • Organizer
      日本結晶学会年会
    • Place of Presentation
      大阪府立大学 (大阪・堺市)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] 赤痢菌エフェクターOspIによる 免疫阻害機構の解析2015

    • Author(s)
      水島恒裕
    • Organizer
      大阪大学蛋白質研究所セミナー
    • Place of Presentation
      大阪大学蛋白研(大阪・吹田市)
    • Year and Date
      2015-08-27
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Crystal structure of Shigella effector IpaH9.8 substrate recognition domain2015

    • Author(s)
      Kenji Takagi
    • Organizer
      新学術領域研究「ユビキチンネオバイオロジー」 平成27年度若手ワークショップ
    • Place of Presentation
      アピカルイン京都(京都府・京都市)
    • Year and Date
      2015-07-02
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 赤痢菌エフェクターIpaH9.8基質認識ドメインのX線結晶構造解析2015

    • Author(s)
      高木賢治、Kim Minsoo、水島恒裕
    • Organizer
      第15回 日本蛋白質科学会年会
    • Place of Presentation
      あわぎんホール(徳島・徳島市)
    • Year and Date
      2015-06-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] 新生タンパク質の品質管理に関与するBAG6-Ubl4a複合体の構造機能解析2015

    • Author(s)
      桑原直之、横田直人、千田俊哉、川原裕之、加藤龍一
    • Organizer
      第3回物構研サイエンスフェスタ
    • Place of Presentation
      つくば国際会議場 (茨城県つくば市)
    • Year and Date
      2015-03-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Structural Basis for the Recognition of Ubc13 by the Shigella flexneri Effector OspI2015

    • Author(s)
      Nishide, A., Kim, M., Takagi, K., Himeno, A., Sanada, T., Sasakawa, C., Mizushima, T.
    • Organizer
      The Annual Evaluation Conference of the Leading Program, University of Hyogo
    • Place of Presentation
      先端科学技術支援センター (兵庫・赤穂郡上郡町)
    • Year and Date
      2015-03-16 – 2015-03-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Structural basis for the formation of sugar-recognizing site of ubiquitin ligase SCFFbs12015

    • Author(s)
      Nishio, K. Yoshida, Y. Tanaka, K. Mizushima T.
    • Organizer
      The Annual Evaluation Conference of the Leading Program, University of Hyogo
    • Place of Presentation
      先端科学技術支援センター (兵庫・赤穂郡上郡町)
    • Year and Date
      2015-03-16 – 2015-03-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] 赤痢菌エフェクターIpaH9.8基質認識ドメインのX線結晶構造解析2014

    • Author(s)
      高木賢治、Kim Minsoo、笹川千尋、水島恒裕
    • Organizer
      新学術領域研究「ユビキチンネオバイオロジー」平成26年度領域班会議
    • Place of Presentation
      ホテルたつき(愛知・蒲郡市)
    • Year and Date
      2014-12-03 – 2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 赤痢菌エフェクターIpaH1880の結晶化と構造解析2014

    • Author(s)
      西出旭、KimMinsoo、笹川千尋、水島恒裕
    • Organizer
      新学術領域研究「ユビキチンネオバイオロジー」平成26年度領域班会議
    • Place of Presentation
      ホテルたつき(愛知・蒲郡市)
    • Year and Date
      2014-12-03 – 2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 新生タンパク質の品質管理に関与するBAG6-UBL4A複合体の構造機能解析2014

    • Author(s)
      桑原直之、横田直人、川原裕之、加藤龍一
    • Organizer
      新学術領域研究「ユビキチンネオバイオロジー」平成26年度領域班会議
    • Place of Presentation
      ホテルたつき(愛知・蒲郡市)
    • Year and Date
      2014-12-03 – 2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Structure and substrate recognition mechanism of IpaH9.8 LRR2014

    • Author(s)
      Takagi, K., Nishide, A., Mizushima, T.
    • Organizer
      Symposium for young ubiquitin researchers in Japan “New Era in the Ubiquitin Research
    • Place of Presentation
      国際高等研究所(京都・木津川市)
    • Year and Date
      2014-11-11 – 2014-11-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Structural Basis for the Recognition of Ubc13 by the Shigella flexneri Effector OspI2014

    • Author(s)
      Nishide, A., Kim, M., Takagi, K., Himeno, A., Sanada, T., Sasakawa, C., Mizushima, T.
    • Organizer
      Symposium for young ubiquitin researchers in Japan “New Era in the Ubiquitin Research
    • Place of Presentation
      国際高等研究所(京都・木津川市)
    • Year and Date
      2014-11-11 – 2014-11-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 赤痢菌エフェクターIpaH9.8基質認識ドメインのX線結晶構造解析2014

    • Author(s)
      高木賢治、水島恒裕
    • Organizer
      日本結晶学会
    • Place of Presentation
      東京大学(東京)
    • Year and Date
      2014-11-01 – 2014-11-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] Structural analyses of bacterial effectors and their mechanisms of infection in the ubiquitin-proteasome system2014

    • Author(s)
      Mizushima T.
    • Organizer
      2nd International Picobiology Institute Symposium Development & Destruction
    • Place of Presentation
      先端科学技術支援センター (兵庫・赤穂郡上郡町)
    • Year and Date
      2014-10-09 – 2014-10-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Structural basis for sugar-recognizing mechanism of ubiquitin ligase SCFFbs12014

    • Author(s)
      Nishio, K. Yoshida, Y. Tanaka, K. Mizushima T.
    • Organizer
      2nd International Picobiology Institute Symposium Development & Destruction
    • Place of Presentation
      先端科学技術支援センター (兵庫・赤穂郡上郡町)
    • Year and Date
      2014-10-09 – 2014-10-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] 赤痢菌エフェクターOspIの結晶構造解析による感染機構の解明2014

    • Author(s)
      西出旭、水島恒裕
    • Organizer
      兵庫県立大学 知の交流シンポジウム
    • Place of Presentation
      姫路商工会議所 (兵庫・姫路市)
    • Year and Date
      2014-09-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] Structural basis for sugar-recognizing mechanism of ubiquitin ligase SCFFbs12014

    • Author(s)
      Nishio K., Yoshida Y., Tanaka K., Mizushima T.
    • Organizer
      1st International Picobiology Institute Symposium Picometer- to Micrometer-Level Structural Analyses for Studies on Functional Mechanisms of Proteins
    • Place of Presentation
      RIKEN HARIMA (兵庫県佐用郡)
    • Related Report
      2013 Annual Research Report
  • [Presentation] OspI-Ubc13複合体構造解析による赤痢菌エフェクタータンパク質のE2酵素認識機構2013

    • Author(s)
      西出旭、Minsoo Kim、高木賢治、真田貴人、笹川千尋、水島恒裕
    • Organizer
      第13回日本蛋白質科学会年会
    • Place of Presentation
      とりぎん文化会館(鳥取県鳥取市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Structural basis for the recognition of Ubc13 by the Shigella flexneri effector OspI2013

    • Author(s)
      Nishide A., Kim M., Takagi K., Himeno A., Sanada T., Sasakawa C., Mizushima T.
    • Organizer
      The 35th Naito Conference
    • Place of Presentation
      シャトレーゼガトーキングダム(北海道札幌市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ユビキチンリガーゼSCFFbs1の糖鎖認識機構の構造基盤2013

    • Author(s)
      西尾和也、吉田雪子、田中啓二、水島恒裕
    • Organizer
      日本結晶学会年会
    • Place of Presentation
      熊本大学(熊本県熊本市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] プロテアソーム複合体構造とシャペロンによる形成機構2012

    • Author(s)
      水島恒裕
    • Organizer
      第85回 日本生化学会大会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 創薬等支援基盤プラットフォームによるフォトンファクトリーにおける構造生物学研究の支援と高度化2012

    • Author(s)
      加藤龍一 他
    • Organizer
      日本分子生物学会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Related Report
      2012 Annual Research Report
  • [Presentation] PF構造生物学研究センターにおける創薬等支援基盤プラットフォームによる構造生物学研究の支援と高度化2012

    • Author(s)
      山田悠介 他
    • Organizer
      第85回 日本生化学会大会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Related Report
      2012 Annual Research Report
  • [Book] in "Photon Factory Activity Report 2011, Part A, Highlights and Facility Report" Structural Biology Research Center2012

    • Author(s)
      S. Kishimoto ed.
    • Total Pages
      195
    • Publisher
      高エネルギー加速器研究機構図書館
    • Related Report
      2012 Annual Research Report

URL: 

Published: 2012-11-27   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi