KOBAYASHI Kyosuke 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 主任研究員
NAGATA Noriyo 国立感染症研究所, 感染病理部, 室長
STAEHELI Peter University of Freiburg, University Medical Center Freiburg,Institute of Virology, Department of Medical Viroloty and Hygiene, Professor
Wong Kum Thong Malaya University, Department of Pathology, Professor
|Budget Amount *help
¥59,280,000 (Direct Cost: ¥45,600,000、Indirect Cost: ¥13,680,000)
Fiscal Year 2016: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
Fiscal Year 2015: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Fiscal Year 2014: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Fiscal Year 2013: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
Fiscal Year 2012: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
|Outline of Final Research Achievements
Viruses infect preferentially in their target tissues. The target tissues are determined by competition between the viruses and the host factors. Host factors that support virus replication such as viral receptors and those that inhibit virus replication such as interferon (IFN) system are considered to be most important factors.
Using poliovirus receptor transgenic mice and IFN-lambda receptor knockout mice, we have shown that IFN-lambda plays an important role in protection of poliovirus infection in the alimentary tract. Scavenger receptor B2 (SCARB2) and heparan sulfate-proteoglycan (HS-PG) are known as receptors for enterovirus 71 (EV71). We have shown that SCARB2 determines the host range specificity of EV71 by producing SCARB2 transgenic mice. On the other hannd, HS-PG reduced the viral replication and pathogenicity in SCARB2tg mice.