|Budget Amount *help
¥117,520,000 (Direct Cost: ¥90,400,000、Indirect Cost: ¥27,120,000)
Fiscal Year 2016: ¥22,620,000 (Direct Cost: ¥17,400,000、Indirect Cost: ¥5,220,000)
Fiscal Year 2015: ¥24,440,000 (Direct Cost: ¥18,800,000、Indirect Cost: ¥5,640,000)
Fiscal Year 2014: ¥24,570,000 (Direct Cost: ¥18,900,000、Indirect Cost: ¥5,670,000)
Fiscal Year 2013: ¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2012: ¥21,580,000 (Direct Cost: ¥16,600,000、Indirect Cost: ¥4,980,000)
|Outline of Final Research Achievements
Coevolution of anti-retroviral protein APOBEC3G (A3G) of humans and its inhibitor Vif of HIV-1 is mathematically modeled, and revealed the the conditions with which coevolution ends up with equilibrium or indefinite escalation of their expression levels. Intra-host dynamics of viruses with multiple tropism is also analyzed with the framework of network dynamics, and its R0-centrality analysis revealed the optimum intervention strategy that typically recommends extremely focussed intervention to the most amplifying tissue.
Comparing the time series data of the infection experiments that excluded cell-to-cell infection of HIV-1 and those with both cell-to-cell and cell-free infections, we quantified their relative contributions to the basic reproductive number of viruses. Infection experiments using polymorphic HIV restriction factor A3H reveals the roles of A3H restriction + type and this counteracting Vif type have played in the coevolutionary dynamism between human and HIV-1.