| Budget Amount *help |
¥58,500,000 (Direct Cost : ¥45,000,000、Indirect Cost : ¥13,500,000)
Fiscal Year 2016 : ¥11,180,000 (Direct Cost : ¥8,600,000、Indirect Cost : ¥2,580,000)
Fiscal Year 2015 : ¥11,180,000 (Direct Cost : ¥8,600,000、Indirect Cost : ¥2,580,000)
Fiscal Year 2014 : ¥11,310,000 (Direct Cost : ¥8,700,000、Indirect Cost : ¥2,610,000)
Fiscal Year 2013 : ¥11,180,000 (Direct Cost : ¥8,600,000、Indirect Cost : ¥2,580,000)
Fiscal Year 2012 : ¥13,650,000 (Direct Cost : ¥10,500,000、Indirect Cost : ¥3,150,000)
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| Outline of Final Research Achievements |
We developed fluorescent probes for glutamate and acidic environment, and fluorescence labeling method for superresolution imaging for analyzing synaptic properties in psychiatric disease model animals. By using superresolution microscopy, we clarified transformation in size and number of nanoclusters formed by glutamate receptors in the hippocampus of Schnurri-2 knockout mice and dopaminergic receptors in striatum nucleus accumbens of DISC1 knockout mice, respectively. Further we revealed that the aberration of D2R nanocluster in DISC1 knockout mouse was ameliorated to the level of wild type by administration of antipsychotic drug clozapine. Our studies show that changes of nano-scale molecular assemblies could be a microendophenotype of psychiatric diseases.
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