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Investigations into psychoneuroimmunology-relevant microendophenotypes of psychiatric disorders

Planned Research

Project AreaUnraveling micro-endophenotypes of psychiatric disorders at the molecular, cellular and circuit levels.
Project/Area Number 24116007
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionTohoku University

Principal Investigator

Tomita Hiroaki  東北大学, 災害科学国際研究所, 教授 (90295064)

Research Collaborator YU Zhiqian  東北大学, 災害科学国際研究所, 助教 (60451639)
Project Period (FY) 2012-06-28 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥78,130,000 (Direct Cost: ¥60,100,000、Indirect Cost: ¥18,030,000)
Fiscal Year 2016: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2015: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2014: ¥15,080,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥3,480,000)
Fiscal Year 2013: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2012: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Keywords脳神経疾患 / 神経科学 / 遺伝子 / ストレス / 免疫学 / ミクログリア / サイトカイン / 心的外傷後ストレス障害 / マイクロアレイ / 次世代シークエンサー / トランスクリプトーム / メチローム / グリア細胞
Outline of Final Research Achievements

An intra-field collaborative research with Kida group (A03) has identified microglial cytokine production profiles as microendophenotypes of formation and maintenance of fear memory utilizing a mouse model of posttraumatic stress disorder. Also, a research with Hashimoto group (A02) has indicated altered methylation pattern of glial cell-related gene loci as the pathogeneses of schizophrenia caused by immune stress on maternal body during a fetal period. Furthermore, technologies to identify subpopulations of immune cells related to psychiatric disorders, and an immune-related microendophenotype relevant to the efficacy of a mood stabilizer were developed.

Report

(6 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report

Research Products

(61 results)

All 2017 2016 2015 2014 2013 2012 Other

All Journal Article (19 results) (of which Peer Reviewed: 13 results,  Acknowledgement Compliant: 7 results,  Open Access: 3 results) Presentation (39 results) (of which Int'l Joint Research: 3 results,  Invited: 17 results) Book (3 results)

  • [Journal Article] The VEGF gene polymorphism impacts brain volume and arterial blood volume.2017

    • Author(s)
      Takeuchi H, Tomita H, Taki Y, Kikuchi Y, Ono C, Yu Z, Sekiguchi A, Nouchi R, Kotozaki Y, Nakagawa S, Miyauchi CM, Iizuka K, Yokoyama R, Shinada T, Yamamoto Y, Hanawa S, Araki T, Kunitoki K, Sassa Y, Kawashima R.
    • Journal Title

      Hum Brain Mapp.

      Volume: in press

    • DOI

      10.1002/hbm.23606

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microglial production of TNF-alpha is a key element of sustained fear memory.2017

    • Author(s)
      Yu, Z., Fukushima, H., Ono, C., Sakai, M., Kasahara, Y., Kikuchi, Y., Gunawansa, N., Takahashi, Y., Matsuoka, H., Kida, S., Tomita, H.
    • Journal Title

      Brain, Behavior, and Immunity

      Volume: 59 Pages: 313-321

    • DOI

      10.1016/j.bbi.2016.08.011

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Linking Activation of Microglia and Peripheral Monocytic Cells to the Pathophysiology of Psychiatric Disorders.2016

    • Author(s)
      Takahashi Y, Yu Z, Sakai M, Tomita H.
    • Journal Title

      Front Cell Neurosci.

      Volume: 10 Pages: 144-144

    • DOI

      10.3389/fncel.2016.00144

    • Related Report
      2016 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] Microglial gene expression alterations in the brains of patients with psychiatric disorders.2016

    • Author(s)
      Sakai M, Takahashi Y, Yu Z, Tomita H.
    • Journal Title

      Advances in Neuroimmune Biology

      Volume: 6 Pages: 83-93

    • DOI

      10.3233/nib-160110

    • Related Report
      2016 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] Effects of the BDNF Val66Met Polymorphism on Gray Matter Volume in Typically Developing Children and Adolescents.2016

    • Author(s)
      Hashimoto T, Fukui K, Takeuchi H, Yokota S, Kikuchi Y, Tomita H, Taki Y, Kawashima R.
    • Journal Title

      Cereb Cortex

      Volume: 26 Pages: 1795-1803

    • DOI

      10.1093/cercor/bhw020

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The associations among the dopamine D2 receptor Taq1, emotional intelligence, creative potential measured by divergent thinking, and motivational state and these associations' sex differences.2015

    • Author(s)
      Takeuchi H, Tomita H, Taki Y, Kikuchi Y, Ono C, Yu Z, Sekiguchi A, Nouchi R, Kotozaki Y, Nakagawa S, Miyauchi CM, Iizuka K, Yokoyama R, Shinada T, Yamamoto Y, Hanawa S, Araki T, Hashizume H, Kunitoki K, Sassa Y, Kawashima R.
    • Journal Title

      Front Psychol

      Volume: 6 Pages: 912-912

    • DOI

      10.3389/fpsyg.2015.00912

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cognitive and neural correlates of the 5-repeat allele of the dopamine D4 receptor gene in a population lacking the 7-repeat allele2015

    • Author(s)
      Takeuchi H, Tomita H, Taki Y, Kikuchi Y, Ono C, Yu Z, Sekiguchi A, Nouchi R, Kotozaki Y, Nakagawa S, Miyauchi CM, Iizuka K, Yokoyama R, Shinada T, Yamamoto Y, Hanawa S, Araki T, Hashizume H, Kunitoki K, Sassa Y, Kawashima R
    • Journal Title

      Neuroimage

      Volume: 110 Pages: 124-135

    • DOI

      10.1016/j.neuroimage.2015.01.053

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Sex differences in the effects of adolescent social deprivation on alcohol consumption in μ-opioid receptor knockout mice.2015

    • Author(s)
      Yuki Moriya, Yoshiyuki Kasahara, F. Scott Hall, Yasufumi Sakakibara, George R. Uhl, Hiroaki Tomita, Ichiro Sora.
    • Journal Title

      Psychopharmacology (Berl)

      Volume: 232(8) Pages: 1471-1482

    • DOI

      10.1007/s00213-014-3784-y

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Therapeutic Concentration of Lithium Stimulates Complement C3 Production in Dendritic Cells and Microglia via GSK-3 Inhibition.2015

    • Author(s)
      Yu Z, Ono C, Aiba S, Kikuchi Y, Sora I, Matsuoka H, Tomita H
    • Journal Title

      Glia

      Volume: 63 Pages: 257-270

    • DOI

      10.1002/glia.22749

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The Association Between Medical Treatment of Physical Diseases and Psychological Distress After the Great East Japan Earthquake: The Shichigahama Health Promotion Project.2015

    • Author(s)
      Nakaya N, Nakamura T, Tsuchiya N, Tsuji I, Hozawa A, Tomita H.
    • Journal Title

      Disaster Med Public Health Prep.

      Volume: Epub ahead of print Pages: 1-8

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fluorescently activated cell sorting followed by microarray profiling of helper T cell subtypes from human peripheral blood.2014

    • Author(s)
      Ono C, Yu Z, Kasahara Y, Kikuchi Y, Ishii N, Tomita H
    • Journal Title

      PLoS ONE

      Volume: 9

    • DOI

      10.1371/journal.pone.0111405

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 災害精神医学に関する研究の課題.東日本大震災からの復興に向けて ~災害精神医学・医療の課題と展望~2014

    • Author(s)
      富田博秋
    • Journal Title

      精神神経学雑誌 116(3), 231-236, 2014

      Volume: 116 Pages: 231-236

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 災害精神医学に関する研究の課題. 東日本大震災からの復興に向けて  ~災害精神医学・医療の課題と展望~2014

    • Author(s)
      富田博秋
    • Journal Title

      精神神経学雑誌

      Volume: 116(3) Pages: 231-236

    • Related Report
      2013 Annual Research Report
  • [Journal Article] G protein-linked signaling pathways in bipolar and major depressive disorders.2013

    • Author(s)
      Tomita H, Ziegler ME, Kim HB, Evans SJ, Choudary PV, Li JZ, Meng F, Dai M, Myers RM, Neal CR, Speed TP, Barchas JD, Schatzberg AF, Watson SJ, Akil H, Jones EG, Bunney WE, Vawter MP.
    • Journal Title

      Front Genet.

      Volume: 23(4) Pages: 1-12

    • DOI

      10.3389/fgene.2013.00297

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Missense mutations in the DNA-binding/dimerization domain of NFIX cause Sotos-like features2012

    • Author(s)
      Yoneda Y, Saitsu H, Touyama M, Makita Y, Miyamoto A, Hamada K, Kurotaki N, Tomita H, Nishiyama K, Tsurusaki Y, Doi H, Miyake N, Ogata K, Naritomi K, Matsumoto N
    • Journal Title

      J. Hum. Genet.

      Volume: 57巻 Pages: 207-11

    • DOI

      10.1038/jhg.2012.7

    • NAID

      10030712151

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutations in PRRT2 responsible for paroxysmal kinesigenic dyskinesias also cause benign familialinfantile convulsions.2012

    • Author(s)
      Ono S, Yoshiura K , KinoshitaA, Kikuchi T, Nakane Y, Kato N,Sadamatsu M , Konishi T , Nagamitsu S , Matsuura M, Yasuda A, KomineM, Kanai K , Inoue T , Osamura T , Saito K , Hirose S, Koide H, Tomita H , Ozawa H , Niikawa N and Kurotaki N.
    • Journal Title

      J Hum Genet,

      Volume: 57 Pages: 281-287

    • DOI

      10.1038/jhg.2012.23

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression analysis of a novel mRNA variant of the schizophrenia risk gene ZNF804A.2012

    • Author(s)
      Okada T, et al,
    • Journal Title

      Schizophr Res.

      Volume: 141(2-3): Pages: 277-278

    • DOI

      10.1016/j.schres.2012.08.015

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 災害によるPTSDの疫学とリスクファクター2012

    • Author(s)
      富田博秋
    • Journal Title

      Pharma Medica

      Volume: 30 Pages: 13-17

    • Related Report
      2012 Annual Research Report
  • [Journal Article] うつ病の死後脳研究によるバイオマーカー探索2012

    • Author(s)
      富田博秋
    • Journal Title

      医学のあゆみ

      Volume: 244 Pages: 496-501

    • Related Report
      2012 Annual Research Report
  • [Presentation] Transcriptome responses to lithium in microglia and peripheral blood monocyte.2016

    • Author(s)
      Takahashi Y, Yu Z, Sakai M, Komatsu H, Ito F, Matsuoka H, Tomita H.
    • Organizer
      The 13th International Congress of Human Genetics
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 心的外傷後ストレス障害病態形成における炎症性メカニズムの解明2016

    • Author(s)
      富田博秋
    • Organizer
      第46回日本神経精神薬理学会年会
    • Place of Presentation
      COEXモール(韓国ソウル市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Pregnant mice exposure to extreme level of oxytocin influences emotional and social behaviors of the offsprings after growing up2016

    • Author(s)
      Kasahara Y, Suzuki S, Onouchi Y, Yoshida A, Ono C, Kikuchi Y, Yu Z, Tomita H
    • Organizer
      第30回国際神経精神薬理学会年会
    • Place of Presentation
      COEXモール(韓国ソウル市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 恐怖記憶の持続におけるミクログリア由来TNF-αの発現2016

    • Author(s)
      兪志前、福島穂高、小野千晶、坂井舞、笠原好之、高橋雄太、松岡洋夫、喜田聡、富田博秋
    • Organizer
      第38回 日本生物学的精神医学会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Lithium stimulates complement component C3 production via GSK-3 inhibition in differentiated monocytic cells.2015

    • Author(s)
      Yu Z, Ono C, Aiba S, Sora I, Matsuoka H, Tomita H.
    • Organizer
      NTNU-Tohoku Univ. Brain Science Exchange Meeting
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2015-11-25
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Impact of the OLIG2 gene variant rs1059004 on white matter tract integrity and mean cerebral blood flow in healthy Japanese subjects.2015

    • Author(s)
      Komatsu H, Takeuchi H, Kikuchi Y, Kodaka A, Funakoshi S, Ono T, Kakuto Y, Kawashima R, Taki Y, Tomita H.
    • Organizer
      World Congress of Psychiatric Genetics 2015
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2015-10-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] リチウム療法奏功機序へのミクログリアの関与2015

    • Author(s)
      富田 博秋、兪志前
    • Organizer
      第25回日本臨床精神神経薬理学会
    • Place of Presentation
      東京都
    • Year and Date
      2015-10-10
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 精神疾患と精神神経免疫相関~その細胞分子生物学的基盤~2015

    • Author(s)
      富田博秋
    • Organizer
      平成27 年度生理学研究所研究会
    • Place of Presentation
      岡崎市
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Microglial involvement in regulation of mood and fear memory.2015

    • Author(s)
      Tomita H.
    • Organizer
      Neuroscience 2015.
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] PTSDの生物学的基盤に基づく治療戦略2015

    • Author(s)
      富田博秋
    • Organizer
      第111回日本精神神経学会学術総会
    • Place of Presentation
      大阪市
    • Year and Date
      2015-06-04
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Biological researches into neuropsychiatric conditions at post-disaster settings.2015

    • Author(s)
      Tomita H.
    • Organizer
      2015 HeKKSaGOn Presidents’ Conference
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2015-04-17
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 精神神経免疫相関が関与する精神疾患病態のマイクロエンドフェノタイプの解明2014

    • Author(s)
      富田博秋
    • Organizer
      平成26年度包括脳ネットワーク冬のシンポジウム
    • Place of Presentation
      東京都
    • Year and Date
      2014-12-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Maternal infection in mice leads different DNA methylation and gene expression between male and female offspring2014

    • Author(s)
      Yu Z, Funayama R, Ueno K, Nariai N, Kojima K, Ono C, Kasahara Y, Kikuchi Y, Nagasaki M, Nakayama K, Tomita H.
    • Organizer
      Society for Neuroscience 2014
    • Place of Presentation
      Washington DC, United States
    • Year and Date
      2014-11-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] Differences in responsiveness between methamphetamine and mMethylphenidate, may reflect the specific developmental characteristics in juvenile DAT KO mice.2014

    • Author(s)
      Kubo Y; Kasahara Y; Arime Y; Hall FS; Ikeda K; Uhl GR; Sora I; Tomita H
    • Organizer
      Society for Neuroscience 2014
    • Place of Presentation
      Washington DC, United States
    • Year and Date
      2014-11-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] Sex differences in the effects of adolescent social deprivation on alcohol consumption in μ-opioid receptor knockout mice.2014

    • Author(s)
      Moriya Y, Kasahara Y, Hall FS, Uhl GR, Tomita H, Sora I
    • Organizer
      Society for Neuroscience 2014
    • Place of Presentation
      Washington DC, United States
    • Year and Date
      2014-11-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] Glial involvement in the mechanism of action of mood stabilizers and the pathophysiology of bipolar disorder.2014

    • Author(s)
      Tomita H
    • Organizer
      The 2nd Annual Molecular Psychiatry Meeting
    • Place of Presentation
      San Francisco , United States.
    • Year and Date
      2014-11-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Psychosocial impact of Great East Japan Earthquake on the elderly and the neuroimmune bases of PTSR.2014

    • Author(s)
      Tomita H
    • Organizer
      Joint Congress of 19th Japan Congress of Neuropsychiatry and 14th International College of Geriatric Psychoneuropharmacology.
    • Place of Presentation
      Tsukuba, Japan
    • Year and Date
      2014-10-03
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 早期社会的隔離ストレスにおけるアルコール摂取量変化へのμオピオイド受容体の関与.2014

    • Author(s)
      森屋由紀, 笠原好之, 曽良一郎, 富田博秋.
    • Organizer
      第36回日本生物学的精神医学会/第57回日本神経化学会大会合同年会
    • Place of Presentation
      奈良市
    • Year and Date
      2014-09-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] ドーパミントランスポーター欠損マウスのADHD様行動における発達段階特異的な薬剤応答性2014

    • Author(s)
      久保有美子、笠原好之、有銘預世布、曽良一郎、富田博秋.
    • Organizer
      第36回日本生物学的精神医学会/第57回日本神経化学会大会合同年会
    • Place of Presentation
      奈良市
    • Year and Date
      2014-09-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 胎生期免疫ストレスがエピゲノムを介して精神行動に及ぼす影響の特定.2014

    • Author(s)
      兪 志前, 舟山 亮, 植野 和子, 成相 直樹, 小島 要, 小野 千晶, 笠原 好之, 菊地 淑恵, 長崎 正朗, 中山 啓子, 富田 博秋
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] アポリポプロテインE4の健常青少年海馬の体積への影響.2014

    • Author(s)
      國時 景子, 橋本 照男, 横田 晋務, 橋爪 寛, 井上 健太郎, 竹内 光, 関口 敦, 荒井 啓行, 富田 博秋 , 川島 龍太, 瀧 靖之
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 早期社会的孤立ストレスによるμ-オピオイド受容体欠損マウスのアルコール摂取量変化への関与.2014

    • Author(s)
      森屋 由紀, 笠原 好之, F. Scott Hall, George R. Uhl, 富田 博秋, 曽良 一郎
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] メチルフェニデートによるドーパミントランスポーター欠損マウスのADHD様行動の改善は発達段階によって異なる.2014

    • Author(s)
      久保 有美子, 笠原 好之, 富田 博秋, 有銘 預世布, 高松 幸雄, 池田 和隆, 曽良 一郎.
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Gene expression profiling of specific immune cells in peripheral blood samples as a tool for neuropsychoimmunological bases of traumatic stress-related diseases.2012

    • Author(s)
      Ono C, Yu Z, Ishii N, Tomita H
    • Organizer
      International Society for Traumatic Stress Studies 28th Annual Meeting
    • Place of Presentation
      Los Angeles, United States
    • Year and Date
      2012-10-31
    • Related Report
      2012 Annual Research Report
  • [Presentation] The influence of individual physical-social characteristics on mental health among the Great East Japan Earthquake victims.2012

    • Author(s)
      Ueda Y, Suzuki D, Tsukida M, Kim Y, Tsuji I, Tomita H
    • Organizer
      International Society for Traumatic Stress Studies 28th Annual Meeting
    • Place of Presentation
      Los Angeles, United States
    • Year and Date
      2012-10-31
    • Related Report
      2012 Annual Research Report
  • [Presentation] Habits of Alcohol Use and Cigarette Smoking in Disaster Victims Relate to Mental Health.2012

    • Author(s)
      Suzuki D, Tsukida M, Ueda Y, Kim Y, Tsuji I, Tomita H
    • Organizer
      International Society for Traumatic Stress Studies 28th Annual Meeting
    • Place of Presentation
      Los Angeles, United States
    • Year and Date
      2012-10-31
    • Related Report
      2012 Annual Research Report
  • [Presentation] Social network and mental health conditions among the Great East Japan Earthquake victims.2012

    • Author(s)
      Tsukida M, Ueda Y, Suzuki D, Kim Y, Tsuji I, Tomita H
    • Organizer
      International Society for Traumatic Stress Studies 28th Annual Meeting
    • Place of Presentation
      Los Angeles, United States
    • Year and Date
      2012-10-31
    • Related Report
      2012 Annual Research Report
  • [Presentation] Multi-faceted approaches to identify social, psychological, and biological factors involved in disaster-related mental health problems.2012

    • Author(s)
      Tomita H, Ono C, Yu Z, Suzuki D, Tsukida M, Ueda Y, Hozawa A, Tsuji I
    • Organizer
      8th APRU Research Symposium on Multi-hazards around the Pacific Rim
    • Place of Presentation
      Sendai, Japan
    • Related Report
      2012 Annual Research Report
  • [Presentation] 精神神経免疫相関が関与する精神疾患病態のマイクロエンドフェノタイプの解明.2012

    • Author(s)
      富田博秋
    • Organizer
      新学術領域研究「マイクロエンドフェノタイプによる精神病態学の創出」キックオフシンポジウム
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] The influence of pH and RNA integrity on postmortem brain gene expression profiles.2012

    • Author(s)
      Yu Z, Ono C, Kunii Y, Wada A, Mastumoto J, Hino M, Ikemoto K, Niwa S, Tomita H
    • Organizer
      第34回日本生物学的精神医学会
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] Therapeutic concentration of lithium stimulates immune related gene expressions in differentiated monocytic cells.2012

    • Author(s)
      Yu Z, Ono C, Aiba S, Sora I, Tomita H.
    • Organizer
      第22回日本臨床精神神経薬理学会/第42回日本神経精神薬理学会・合同年会.
    • Place of Presentation
      宇都宮
    • Related Report
      2012 Annual Research Report
  • [Presentation] Multi-faceted basic and clinical research approaches to the Great East Japan Earthquake. Symposium “Perspectives in neurobiology of PTSD and disaster-related psychiatric disorders”

    • Author(s)
      Tomita H
    • Organizer
      11th World Congress of Biological Psychiatry
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Closing remarks: Future direction in brain banking in Japan. Symposium “Twenty first century brain banking: Management and research application”.

    • Author(s)
      Tomita H
    • Organizer
      11th World Congress of Biological Psychiatry
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Lithium stimulates chemokine production in monocytic cells via GSK-3 inhibition.

    • Author(s)
      Yu Z, Ono C, Aiba S, Sora I, Tomita H.
    • Organizer
      Society for Neuroscience 2013
    • Place of Presentation
      San Diego, United States
    • Related Report
      2013 Annual Research Report
  • [Presentation] 死後脳研究におけるpH 評価の方法論の検討.

    • Author(s)
      兪志前、小野千晶、國井泰人、 和田明、松本純也、日野瑞城、 池本桂子、丹羽真一、富田博秋.
    • Organizer
      第54回 日本神経病理学会総会学術研究会.
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 災害による心的外傷後ストレス反応の生物学的研究.シンポジウムD-3「トラウマの生物学的研究の現在と将来」

    • Author(s)
      富田博秋
    • Organizer
      第12回トラウマティック・ストレス学会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 災害精神医学に関する研究の課題.シンポジウム18「災害関連精神医学・医療の展望と課題」

    • Author(s)
      富田博秋
    • Organizer
      第109回日本精神神経学会学術総会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 心的外傷後ストレス反応形成メカニズム解明に向けた生物学的研究の動向.合同シンポジウム3 「PTSDの神経生物学的メカニズムと治療薬開発の可能性」

    • Author(s)
      富田博秋
    • Organizer
      第23回日本臨床精神神経薬理学会・第43回日本神経精神薬理学会 合同年会
    • Place of Presentation
      宜野湾市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Biological Approaches to Posttraumatic Stress Reactions after Disaster. Symposium “Biology of PTSD”.

    • Author(s)
      Tomita H
    • Organizer
      6th Annual Meeting of Anxiety Disorder Association.
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] 遺伝子-環境相関-PTSDに関する双生児研究と遺伝子研究-. PTSDハンドブック-科学と実践.2014

    • Author(s)
      富田博秋
    • Publisher
      金剛出版
    • Related Report
      2014 Annual Research Report
  • [Book] メンタル医療 ~原因解明と診断、治療の最前線~2013

    • Author(s)
      富田博秋
    • Publisher
      シーエムシー出版
    • Related Report
      2013 Annual Research Report
  • [Book] 東日本大震災を分析する.2013

    • Author(s)
      富田博秋
    • Publisher
      明石書店
    • Related Report
      2012 Annual Research Report

URL: 

Published: 2012-11-27   Modified: 2019-07-29  

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