Investigations into psychoneuroimmunology-relevant microendophenotypes of psychiatric disorders

• Project Area: Unraveling micro-endophenotypes of psychiatric disorders at the molecular, cellular and circuit levels.
• Project/Area Number: 24116007
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Tohoku University
• Principal Investigator: Tomita Hiroaki 東北大学, 災害科学国際研究所, 教授 (90295064)
• Research Collaborator: YU Zhiqian 東北大学, 災害科学国際研究所, 助教 (60451639)
• Project Period (FY): 2012-06-28 – 2017-03-31
• Project Status: Completed(Fiscal Year 2016)
• Budget Amount: ¥78,130,000 (Direct Cost : ¥60,100,000、Indirect Cost : ¥18,030,000); Fiscal Year 2016 : ¥14,950,000 (Direct Cost : ¥11,500,000、Indirect Cost : ¥3,450,000); Fiscal Year 2015 : ¥14,950,000 (Direct Cost : ¥11,500,000、Indirect Cost : ¥3,450,000); Fiscal Year 2014 : ¥15,080,000 (Direct Cost : ¥11,600,000、Indirect Cost : ¥3,480,000); Fiscal Year 2013 : ¥14,950,000 (Direct Cost : ¥11,500,000、Indirect Cost : ¥3,450,000); Fiscal Year 2012 : ¥18,200,000 (Direct Cost : ¥14,000,000、Indirect Cost : ¥4,200,000)
• Keywords: 脳神経疾患 / 神経科学 / 遺伝子 / ストレス / 免疫学 / ミクログリア / サイトカイン / 心的外傷後ストレス障害 / マイクロアレイ / 次世代シークエンサー / トランスクリプトーム / メチローム / グリア細胞

Outline of Final Research Achievements

An intra-field collaborative research with Kida group (A03) has identified microglial cytokine production profiles as microendophenotypes of formation and maintenance of fear memory utilizing a mouse model of posttraumatic stress disorder. Also, a research with Hashimoto group (A02) has indicated altered methylation pattern of glial cell-related gene loci as the pathogeneses of schizophrenia caused by immune stress on maternal body during a fetal period. Furthermore, technologies to identify subpopulations of immune cells related to psychiatric disorders, and an immune-related microendophenotype relevant to the efficacy of a mood stabilizer were developed.

Research Products

• [Journal Article] The VEGF gene polymorphism impacts brain volume and arterial blood volume. (2017)
  • Author(s): Takeuchi H, Tomita H, Taki Y, Kikuchi Y, Ono C, Yu Z, Sekiguchi A, Nouchi R, Kotozaki Y, Nakagawa S, Miyauchi CM, Iizuka K, Yokoyama R, Shinada T, Yamamoto Y, Hanawa S, Araki T, Kunitoki K, Sassa Y, Kawashima R.
  • Journal Title: Hum Brain Mapp. Volume : in press
  • Peer Reviewed
• [Journal Article] Microglial production of TNF-alpha is a key element of sustained fear memory. (2017)
  • Author(s): Yu, Z., Fukushima, H., Ono, C., Sakai, M., Kasahara, Y., Kikuchi, Y., Gunawansa, N., Takahashi, Y., Matsuoka, H., Kida, S., Tomita, H.
  • Journal Title: Brain Behav. Immun. Volume : 59 Pages : 313-321
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Linking Activation of Microglia and Peripheral Monocytic Cells to the Pathophysiology of Psychiatric Disorders. (2016)
  • Author(s): Takahashi Y, Yu Z, Sakai M, Tomita H.
  • Journal Title: Front Cell Neurosci. Volume : 10 Pages : 144-144
  • Acknowledgement Compliant
• [Journal Article] Microglial gene expression alterations in the brains of patients with psychiatric disorders. (2016)
  • Author(s): Sakai M, Takahashi Y, Yu Z, Tomita H.
  • Journal Title: Advances in Neuroimmune Biology Volume : 6 Pages : 83-93
  • Acknowledgement Compliant
• [Journal Article] Effects of the BDNF Val66Met Polymorphism on Gray Matter Volume in Typically Developing Children and Adolescents. (2016)
  • Author(s): Hashimoto T, Fukui K, Takeuchi H, Yokota S, Kikuchi Y, Tomita H, Taki Y, Kawashima R.
  • Journal Title: Cereb Cortex Volume : 26 Pages : 1795-1803
  • Peer Reviewed
• [Journal Article] The associations among the dopamine D2 receptor Taq1, emotional intelligence, creative potential measured by divergent thinking, and motivational state and these associations' sex differences. (2015)
  • Author(s): Takeuchi H, Tomita H, Taki Y, Kikuchi Y, Ono C, Yu Z, Sekiguchi A, Nouchi R, Kotozaki Y, Nakagawa S, Miyauchi CM, Iizuka K, Yokoyama R, Shinada T, Yamamoto Y, Hanawa S, Araki T, Hashizume H, Kunitoki K, Sassa Y, Kawashima R.
  • Journal Title: Front Psychol Volume : 6 Pages : 912-912
  • Peer Reviewed
• [Journal Article] Cognitive and neural correlates of the 5-repeat allele of the dopamine D4 receptor gene in a population lacking the 7-repeat allele (2015)
  • Author(s): Takeuchi H, Tomita H, Taki Y, Kikuchi Y, Ono C, Yu Z, Sekiguchi A, Nouchi R, Kotozaki Y, Nakagawa S, Miyauchi CM, Iizuka K, Yokoyama R, Shinada T, Yamamoto Y, Hanawa S, Araki T, Hashizume H, Kunitoki K, Sassa Y, Kawashima R
  • Journal Title: Neuroimage Volume : 110 Pages : 124-135
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Sex differences in the effects of adolescent social deprivation on alcohol consumption in µ-opioid receptor knockout mice (2015)
  • Author(s): Moriya Y, Kasahara Y, Hall FS, Sakakibara Y, Uhl GR, Tomita H, Sora I.
  • Journal Title: Psychopharmacology (Berl) Volume : 232 Pages : 1471-1482
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Therapeutic Concentration of Lithium Stimulates Complement C3 Production in Dendritic Cells and Microglia via GSK-3 Inhibition. (2015)
  • Author(s): Yu Z, Ono C, Aiba S, Kikuchi Y, Sora I, Matsuoka H, Tomita H
  • Journal Title: Glia Volume : 63 Pages : 257-270
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The Association Between Medical Treatment of Physical Diseases and Psychological Distress After the Great East Japan Earthquake: The Shichigahama Health Promotion Project. (2015)
  • Author(s): Nakaya N, Nakamura T, Tsuchiya N, Tsuji I, Hozawa A, Tomita H.
  • Journal Title: Disaster Med Public Health Prep. Volume : Epub ahead of print Pages : 1-8
  • Peer Reviewed
• [Journal Article] Fluorescently activated cell sorting followed by microarray profiling of helper T cell subtypes from human peripheral blood. (2014)
  • Author(s): Ono C, Yu Z, Kasahara Y, Kikuchi Y, Ishii N, Tomita H
  • Journal Title: Plos One Volume : 9
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 災害精神医学に関する研究の課題．東日本大震災からの復興に向けて ～災害精神医学・医療の課題と展望～ (2014)
  • Author(s): 富田博秋
  • Journal Title: 精神神経学雑誌 116(3), 231-236, 2014 Volume : 116 Pages : 231-236
• [Journal Article] 災害精神医学に関する研究の課題． 東日本大震災からの復興に向けて ～災害精神医学・医療の課題と展望～ (2014)
  • Author(s): 富田博秋
  • Journal Title: 精神神経学雑誌 Volume : 116(3) Pages : 231-236
• [Journal Article] G protein-linked signaling pathways in bipolar and major depressive disorders. (2013)
  • Author(s): Tomita H, Ziegler ME, Kim HB, Evans SJ, Choudary PV, Li JZ, Meng F, Dai M, Myers RM, Neal CR, Speed TP, Barchas JD, Schatzberg AF, Watson SJ, Akil H, Jones EG, Bunney WE, Vawter MP.
  • Journal Title: Front Genet. Volume : 23(4) Pages : 1-12
  • Peer Reviewed
• [Journal Article] Missense mutations in the DNA-binding/dimerization domain of NFIX cause Sotos-like features (2012)
  • Author(s): Yoneda Y, Saitsu H, Touyama M, Makita Y, Miyamoto A, Hamada K, Kurotaki N, Tomita H, Nishiyama K, Tsurusaki Y, Doi H, Miyake N, Ogata K, Naritomi K, Matsumoto N
  • Journal Title: J Hum Genet Volume : 57巻 Pages : 207-211
  • Peer Reviewed
• [Journal Article] Mutations in PRRT2 responsible for paroxysmal kinesigenic dyskinesias also cause benign familialinfantile convulsions. (2012)
  • Author(s): Ono S, Yoshiura K , KinoshitaA, Kikuchi T, Nakane Y, Kato N,Sadamatsu M , Konishi T , Nagamitsu S , Matsuura M, Yasuda A, KomineM, Kanai K , Inoue T , Osamura T , Saito K , Hirose S, Koide H, Tomita H , Ozawa H , Niikawa N and Kurotaki N.
  • Journal Title: J Hum Genet Volume : 57 Pages : 1-4
  • Peer Reviewed
• [Journal Article] Expression analysis of a novel mRNA variant of the schizophrenia risk gene ZNF804A. (2012)
  • Author(s): Okada T, et al,
  • Journal Title: Schizophr Res, Volume : 141(2-3): Pages : 277-278
  • Peer Reviewed
• [Journal Article] 災害によるPTSDの疫学とリスクファクター (2012)
  • Author(s): 富田博秋
  • Journal Title: Pharma Medica Volume : 30 Pages : 13-17
• [Journal Article] うつ病の死後脳研究によるバイオマーカー探索 (2012)
  • Author(s): 富田博秋
  • Journal Title: 医学のあゆみ Volume : 244 Pages : 496-501
• [Presentation] Transcriptome responses to lithium in microglia and peripheral blood monocyte. (2016)
  • Author(s): Takahashi Y, Yu Z, Sakai M, Komatsu H, Ito F, Matsuoka H, Tomita H.
  • Organizer: The 13th International Congress of Human Genetics
  • Place of Presentation: 国立京都国際会館（京都府京都市）
  • Int'l Joint Research
• [Presentation] 心的外傷後ストレス障害病態形成における炎症性メカニズムの解明 (2016)
  • Author(s): 富田博秋
  • Organizer: 第46回日本神経精神薬理学会年会
  • Place of Presentation: COEXモール（韓国ソウル市）
  • Invited
• [Presentation] Pregnant mice exposure to extreme level of oxytocin influences emotional and social behaviors of the offsprings after growing up (2016)
  • Author(s): Kasahara Y, Suzuki S, Onouchi Y, Yoshida A, Ono C, Kikuchi Y, Yu Z, Tomita H
  • Organizer: 第30回国際神経精神薬理学会年会
  • Place of Presentation: COEXモール（韓国ソウル市）
  • Int'l Joint Research
• [Presentation] 恐怖記憶の持続におけるミクログリア由来TNF-αの発現 (2016)
  • Author(s): 兪志前、福島穂高、小野千晶、坂井舞、笠原好之、高橋雄太、松岡洋夫、喜田聡、富田博秋
  • Organizer: 第38回 日本生物学的精神医学会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
• [Presentation] Lithium stimulates complement component C3 production via GSK-3 inhibition in differentiated monocytic cells. (2015)
  • Author(s): Yu Z, Ono C, Aiba S, Sora I, Matsuoka H, Tomita H.
  • Organizer: NTNU-Tohoku Univ. Brain Science Exchange Meeting
  • Place of Presentation: Sendai, Japan
  • Year and Date: 2015-11-25
  • Invited
• [Presentation] Impact of the OLIG2 gene variant rs1059004 on white matter tract integrity and mean cerebral blood flow in healthy Japanese subjects. (2015)
  • Author(s): Komatsu H, Takeuchi H, Kikuchi Y, Kodaka A, Funakoshi S, Ono T, Kakuto Y, Kawashima R, Taki Y, Tomita H.
  • Organizer: World Congress of Psychiatric Genetics 2015
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2015-10-18
  • Int'l Joint Research
• [Presentation] リチウム療法奏功機序へのミクログリアの関与 (2015)
  • Author(s): 富田 博秋、兪志前
  • Organizer: 第25回日本臨床精神神経薬理学会
  • Place of Presentation: 東京都
  • Year and Date: 2015-10-10
  • Invited
• [Presentation] 精神疾患と精神神経免疫相関～その細胞分子生物学的基盤～ (2015)
  • Author(s): 富田博秋
  • Organizer: 平成27 年度生理学研究所研究会
  • Place of Presentation: 岡崎市
  • Year and Date: 2015-10-08
  • Invited
• [Presentation] Microglial involvement in regulation of mood and fear memory. (2015)
  • Author(s): Tomita H.
  • Organizer: Neuroscience 2015.
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2015-07-28
  • Invited
• [Presentation] PTSDの生物学的基盤に基づく治療戦略 (2015)
  • Author(s): 富田博秋
  • Organizer: 第111回日本精神神経学会学術総会
  • Place of Presentation: 大阪市
  • Year and Date: 2015-06-04
  • Invited
• [Presentation] Biological researches into neuropsychiatric conditions at post-disaster settings. (2015)
  • Author(s): Tomita H.
  • Organizer: 2015 HeKKSaGOn Presidents’ Conference
  • Place of Presentation: Sendai, Japan
  • Year and Date: 2015-04-17
  • Invited
• [Presentation] 精神神経免疫相関が関与する精神疾患病態のマイクロエンドフェノタイプの解明 (2014)
  • Author(s): 富田博秋
  • Organizer: 平成26年度包括脳ネットワーク冬のシンポジウム
  • Place of Presentation: 東京都
  • Year and Date: 2014-12-11
  • Invited
• [Presentation] Maternal infection in mice leads different DNA methylation and gene expression between male and female offspring (2014)
  • Author(s): Yu Z, Funayama R, Ueno K, Nariai N, Kojima K, Ono C, Kasahara Y, Kikuchi Y, Nagasaki M, Nakayama K, Tomita H.
  • Organizer: Society for Neuroscience 2014
  • Place of Presentation: Washington DC, United States
  • Year and Date: 2014-11-10
• [Presentation] Differences in responsiveness between methamphetamine and mMethylphenidate, may reflect the specific developmental characteristics in juvenile DAT KO mice. (2014)
  • Author(s): Kubo Y; Kasahara Y; Arime Y; Hall FS; Ikeda K; Uhl GR; Sora I; Tomita H
  • Organizer: Society for Neuroscience 2014
  • Place of Presentation: Washington DC, United States
  • Year and Date: 2014-11-10
• [Presentation] Sex differences in the effects of adolescent social deprivation on alcohol consumption in μ-opioid receptor knockout mice. (2014)
  • Author(s): Moriya Y, Kasahara Y, Hall FS, Uhl GR, Tomita H, Sora I
  • Organizer: Society for Neuroscience 2014
  • Place of Presentation: Washington DC, United States
  • Year and Date: 2014-11-10
• [Presentation] Glial involvement in the mechanism of action of mood stabilizers and the pathophysiology of bipolar disorder. (2014)
  • Author(s): Tomita H
  • Organizer: The 2nd Annual Molecular Psychiatry Meeting
  • Place of Presentation: San Francisco , United States.
  • Year and Date: 2014-11-08
  • Invited
• [Presentation] Psychosocial impact of Great East Japan Earthquake on the elderly and the neuroimmune bases of PTSR. (2014)
  • Author(s): Tomita H
  • Organizer: Joint Congress of 19th Japan Congress of Neuropsychiatry and 14th International College of Geriatric Psychoneuropharmacology.
  • Place of Presentation: Tsukuba, Japan
  • Year and Date: 2014-10-03
  • Invited
• [Presentation] 早期社会的隔離ストレスにおけるアルコール摂取量変化へのμオピオイド受容体の関与． (2014)
  • Author(s): 森屋由紀, 笠原好之, 曽良一郎, 富田博秋．
  • Organizer: 第36回日本生物学的精神医学会/第57回日本神経化学会大会合同年会
  • Place of Presentation: 奈良市
  • Year and Date: 2014-09-30
• [Presentation] ドーパミントランスポーター欠損マウスのADHD様行動における発達段階特異的な薬剤応答性 (2014)
  • Author(s): 久保有美子、笠原好之、有銘預世布、曽良一郎、富田博秋．
  • Organizer: 第36回日本生物学的精神医学会/第57回日本神経化学会大会合同年会
  • Place of Presentation: 奈良市
  • Year and Date: 2014-09-30
• [Presentation] 胎生期免疫ストレスがエピゲノムを介して精神行動に及ぼす影響の特定． (2014)
  • Author(s): 兪 志前, 舟山 亮, 植野 和子, 成相 直樹, 小島 要, 小野 千晶, 笠原 好之, 菊地 淑恵, 長崎 正朗, 中山 啓子, 富田 博秋
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-09-12
• [Presentation] アポリポプロテインE4の健常青少年海馬の体積への影響． (2014)
  • Author(s): 國時 景子, 橋本 照男, 横田 晋務, 橋爪 寛, 井上 健太郎, 竹内 光, 関口 敦, 荒井 啓行, 富田 博秋 , 川島 龍太, 瀧 靖之
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-09-12
• [Presentation] 早期社会的孤立ストレスによるμ-オピオイド受容体欠損マウスのアルコール摂取量変化への関与． (2014)
  • Author(s): 森屋 由紀, 笠原 好之, F. Scott Hall, George R. Uhl, 富田 博秋, 曽良 一郎
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-09-12
• [Presentation] メチルフェニデートによるドーパミントランスポーター欠損マウスのADHD様行動の改善は発達段階によって異なる． (2014)
  • Author(s): 久保 有美子, 笠原 好之, 富田 博秋, 有銘 預世布, 高松 幸雄, 池田 和隆, 曽良 一郎．
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-09-12
• [Presentation] Multi-faceted approaches to identify social, psychological, and biological factors involved in disaster-related mental health problems. (2012)
  • Author(s): Tomita H, Ono C, Yu Z, Suzuki D, Tsukida M, Ueda Y, Hozawa A, Tsuji I
  • Organizer: 8th APRU Research Symposium on Multi-hazards around the Pacific Rim
  • Place of Presentation: Sendai, Japan
• [Presentation] 精神神経免疫相関が関与する精神疾患病態のマイクロエンドフェノタイプの解明． (2012)
  • Author(s): 富田博秋
  • Organizer: 新学術領域研究「マイクロエンドフェノタイプによる精神病態学の創出」キックオフシンポジウム
  • Place of Presentation: 名古屋
  • Invited
• [Presentation] The influence of pH and RNA integrity on postmortem brain gene expression profiles. (2012)
  • Author(s): Yu Z, Ono C, Kunii Y, Wada A, Mastumoto J, Hino M, Ikemoto K, Niwa S, Tomita H
  • Organizer: 第34回日本生物学的精神医学会
  • Place of Presentation: 神戸
• [Presentation] Therapeutic concentration of lithium stimulates immune related gene expressions in differentiated monocytic cells． (2012)
  • Author(s): Yu Z, Ono C, Aiba S, Sora I, Tomita H．
  • Organizer: 第22回日本臨床精神神経薬理学会/第42回日本神経精神薬理学会・合同年会．
  • Place of Presentation: 宇都宮
• [Presentation] Gene expression profiling of specific immune cells in peripheral blood samples as a tool for neuropsychoimmunological bases of traumatic stress-related diseases. (2012)
  • Author(s): Ono C, Yu Z, Ishii N, Tomita H
  • Organizer: International Society for Traumatic Stress Studies 28th Annual Meeting
  • Place of Presentation: Los Angeles, United States
  • Year and Date: 2012-10-31
• [Presentation] The influence of individual physical-social characteristics on mental health among the Great East Japan Earthquake victims. (2012)
  • Author(s): Ueda Y, Suzuki D, Tsukida M, Kim Y, Tsuji I, Tomita H
  • Organizer: International Society for Traumatic Stress Studies 28th Annual Meeting
  • Place of Presentation: Los Angeles, United States
  • Year and Date: 2012-10-31
• [Presentation] Habits of Alcohol Use and Cigarette Smoking in Disaster Victims Relate to Mental Health. (2012)
  • Author(s): Suzuki D, Tsukida M, Ueda Y, Kim Y, Tsuji I, Tomita H
  • Organizer: International Society for Traumatic Stress Studies 28th Annual Meeting
  • Place of Presentation: Los Angeles, United States
  • Year and Date: 2012-10-31
• [Presentation] Social network and mental health conditions among the Great East Japan Earthquake victims. (2012)
  • Author(s): Tsukida M, Ueda Y, Suzuki D, Kim Y, Tsuji I, Tomita H
  • Organizer: International Society for Traumatic Stress Studies 28th Annual Meeting
  • Place of Presentation: Los Angeles, United States
  • Year and Date: 2012-10-31
• [Presentation] Multi-faceted basic and clinical research approaches to the Great East Japan Earthquake. Symposium “Perspectives in neurobiology of PTSD and disaster-related psychiatric disorders”
  • Author(s): Tomita H
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: Kyoto, Japan
  • Invited
• [Presentation] Closing remarks: Future direction in brain banking in Japan. Symposium “Twenty first century brain banking: Management and research application”.
  • Author(s): Tomita H
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: Kyoto, Japan
  • Invited
• [Presentation] Lithium stimulates chemokine production in monocytic cells via GSK-3 inhibition.
  • Author(s): Yu Z, Ono C, Aiba S, Sora I, Tomita H.
  • Organizer: Society for Neuroscience 2013
  • Place of Presentation: San Diego, United States
• [Presentation] 死後脳研究におけるpH 評価の方法論の検討．
  • Author(s): 兪志前、小野千晶、國井泰人、 和田明、松本純也、日野瑞城、 池本桂子、丹羽真一、富田博秋．
  • Organizer: 第54回 日本神経病理学会総会学術研究会．
  • Place of Presentation: 東京
• [Presentation] 災害による心的外傷後ストレス反応の生物学的研究．シンポジウムD-3「トラウマの生物学的研究の現在と将来」
  • Author(s): 富田博秋
  • Organizer: 第12回トラウマティック・ストレス学会
  • Place of Presentation: 東京
  • Invited
• [Presentation] 災害精神医学に関する研究の課題．シンポジウム18「災害関連精神医学・医療の展望と課題」
  • Author(s): 富田博秋
  • Organizer: 第109回日本精神神経学会学術総会
  • Place of Presentation: 福岡
  • Invited
• [Presentation] 心的外傷後ストレス反応形成メカニズム解明に向けた生物学的研究の動向．合同シンポジウム3 「PTSDの神経生物学的メカニズムと治療薬開発の可能性」
  • Author(s): 富田博秋
  • Organizer: 第23回日本臨床精神神経薬理学会・第43回日本神経精神薬理学会 合同年会
  • Place of Presentation: 宜野湾市
  • Invited
• [Presentation] Biological Approaches to Posttraumatic Stress Reactions after Disaster. Symposium “Biology of PTSD”.
  • Author(s): Tomita H
  • Organizer: 6th Annual Meeting of Anxiety Disorder Association.
  • Place of Presentation: Tokyo, Japan
  • Invited
• [Book] 遺伝子－環境相関－PTSDに関する双生児研究と遺伝子研究－． PTSDハンドブック－科学と実践． (2014)
  • Author(s): 富田博秋
  • Publisher: 金剛出版
• [Book] メンタル医療 ～原因解明と診断、治療の最前線～ (2013)
  • Author(s): 富田博秋
  • Publisher: シーエムシー出版
• [Book] 東日本大震災を分析する． (2013)
  • Author(s): 富田博秋
  • Publisher: 明石書店