| Budget Amount *help |
¥131,300,000 (Direct Cost: ¥101,000,000、Indirect Cost: ¥30,300,000)
Fiscal Year 2017: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2016: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2015: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2014: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2013: ¥53,300,000 (Direct Cost: ¥41,000,000、Indirect Cost: ¥12,300,000)
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| Outline of Final Research Achievements |
In this project, we studied photoreceptive proteins such as rhodopsins and flavoproteins in view of discovery, conversion, and creation of functions. Through collaborations, we liked to know functional flexibility in these proteins. Consequently, we discovered light-driven inward proton pump, new channelrhodopsin, and an enzyme rhodopsin functioning as phosphodiesterase. We achieved several functional conversions for light-driven ion pumps and photolyases, while each functional conversion was asymmetric, and related to evolution. Based on the structure of a light-driven sodium pump KR2, we engineered light-driven potassium and cesium pumps. We published about 80 articles in Nature, Nat. Commun., Chem. Rev., JACS, Angew., PNAS, JPC Letters and JBC during the project period.
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