|Budget Amount *help
¥105,430,000 (Direct Cost: ¥81,100,000、Indirect Cost: ¥24,330,000)
Fiscal Year 2017: ¥23,660,000 (Direct Cost: ¥18,200,000、Indirect Cost: ¥5,460,000)
Fiscal Year 2016: ¥20,930,000 (Direct Cost: ¥16,100,000、Indirect Cost: ¥4,830,000)
Fiscal Year 2015: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2014: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2013: ¥23,530,000 (Direct Cost: ¥18,100,000、Indirect Cost: ¥5,430,000)
|Outline of Final Research Achievements
According to mutation screening of the WDR45 gene responsible for SENDA, we identified high prevalence of the disease in patients with characteristic phenotype.
We revealed that Dynactin mutant, with pathogenic mutant of Perry syndrome, one of the parkinsonian disorders, has inhibiting effect on autophagic flux by decreased autophagosome-lysosome fusion step, resulting in apoptosis. Also, CHCHD2, a novel gene responsible for autosomal dominant Parkinson's disease, was identified and now its molecular function is investigated within the mitochondria. Using TH neurons selective autophagy deficient mice, intraneuronal inclusions have been detected in the affected lesions.