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Epigenome dynamics and regulation in preimplantation embryos

Planned Research

Project AreaAnalyses and regulation of germline epigenome
Project/Area Number 25112006
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionNagahama Institute of Bio-Science and Technology

Principal Investigator

Nakamura Toshinobu  長浜バイオ大学, バイオサイエンス学部, 教授 (80403202)

Project Period (FY) 2013-06-28 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥79,690,000 (Direct Cost: ¥61,300,000、Indirect Cost: ¥18,390,000)
Fiscal Year 2017: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2016: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2015: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2014: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2013: ¥25,090,000 (Direct Cost: ¥19,300,000、Indirect Cost: ¥5,790,000)
Keywords着床前胚 / 全能性 / Klf17 / Btg4 / Trim61 / Pramef12 / Zfp92 / 全能性細胞 / リプログラミング / DNAメチル化 / 胚性遺伝子 / 母性RNA分解 / Rfpl4 / Zbed3 / Zc3h6 / 受精卵 / OGT / Tet3 / 5-メチル化シトシン / 5-ヒドロキシメチル化シトシン / ヒストンGlcNAc化 / ヒストン修飾
Outline of Final Research Achievements

In this study, we examined the function of totipotent-cell specific genes in vivo. We found that Klf17 and Btg4 are maternal effect genes required for preimplantation development. We also revealed that Klf17 and Btg4 are involved in zygotic gene activation and maternal RNA degradation, respectively. We also found that Trim61 possess E3 ubiquitin ligase activity, and is maternal-zygotic effect gene required for preimplantation development. In additoin, we revealed that Pramef12 plays important role in differentiation of male primordial germ cells, and is required for spermatogenesis. Furthermore, we defined culture condition for ESCs that leads to increases the population of totipotent cells.

Report

(6 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (81 results)

All 2018 2017 2016 2015 2014 2013 Other

All Journal Article (18 results) (of which Peer Reviewed: 18 results,  Open Access: 13 results,  Acknowledgement Compliant: 7 results) Presentation (48 results) (of which Int'l Joint Research: 6 results,  Invited: 11 results) Book (7 results) Remarks (8 results)

  • [Journal Article] Histone H3 Methylated at Arginine 17 Is Essential for Reprogramming the Paternal Genome in Zygotes.2017

    • Author(s)
      Hatanaka Y, Tsusaka T, Shimizu N, Morita K, Suzuki T, Machida S, Satoh M, Honda A, Hirose M, Kamimura S, Ogonuki N, Nakamura T, Inoue K, Hosoi Y, Dohmae N, Nakano T, Kurumizaka H, Matsumoto K, Shinkai Y, Ogura A.
    • Journal Title

      Cell Rep

      Volume: 20(12) Issue: 12 Pages: 2756-2765

    • DOI

      10.1016/j.celrep.2017.08.088

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] DNA hypomethylation circuit of mouse rDNA repeats in the germ cell lineage.2017

    • Author(s)
      Furuta A, Nakamura T.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 490(2) Issue: 2 Pages: 429-433

    • DOI

      10.1016/j.bbrc.2017.06.058

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of mild and severe vitamin B1 deficiencies on the meiotic maturation of mice oocytes.2017

    • Author(s)
      Tsuji A, Nakamura T, Shibata K
    • Journal Title

      Nutrition and Metabolic Insights

      Volume: 10 Pages: 1-9

    • DOI

      10.1177/1178638817693824

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Folic Acid Deficiency Does Not Adversely Affect Oocyte Meiosis in Mice2016

    • Author(s)
      Tsuji A, Noguchi R, Nakamura T, Shibata K
    • Journal Title

      Journal of Nutritional Science and Vitaminology

      Volume: 62 Issue: 6 Pages: 375-379

    • DOI

      10.3177/jnsv.62.375

    • NAID

      130005332258

    • ISSN
      0301-4800, 1881-7742
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reprogramming of germ cells into pluripotency2016

    • Author(s)
      Sekita Y, Nakamura T, Kimura T
    • Journal Title

      World J. Stem Cells

      Volume: 8 Issue: 8 Pages: 251-259

    • DOI

      10.4252/wjsc.v8.i8.251

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] High-affinity monoclonal IgA regulates gut microbiota and prevents colitis in mice.2016

    • Author(s)
      Okai S, Usui F, Yokota S, Hori-I Y, Hasegawa M, Nakamura T, Kurosawa M, Okada S, Yamamoto K, Nishiyama E, Mori H, Yamada T, Kurokawa K, Matsumoto S, Nanno M, Naito T, Watanabe Y, Kato T, Miyauchi E, Ohno H, Shinkura R.
    • Journal Title

      Nature Microbiology

      Volume: 1 Issue: 9 Pages: 16103-16103

    • DOI

      10.1038/nmicrobiol.2016.103

    • NAID

      120005818448

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Trichostatin A specifically improves the aberrant expression of transcription factor genes in embryos produced by somatic cell nuclear transfer.2015

    • Author(s)
      Inoue K, Oikawa M, Kamimura S, Ogonuki N, Nakamura T, Nakano T, Abe K, Ogura A.
    • Journal Title

      Sci Rep

      Volume: 5 Issue: 1 Pages: 10127-10127

    • DOI

      10.1038/srep10127

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Human Dynactin-Associated Protein Transforms NIH3T3 Cells to Generate Highly Vascularized Tumors with Weak Cell-Cell Interaction.2015

    • Author(s)
      Kunoh T, Wang W, Kobayashi H, Matsuzaki D, Togo Y, Tokuyama M, Hosoi M, Koseki K, Wada S, Nagai N, Nakamura T, Nomura S, Hasegawa M, Sasaki R, Mizukami T.
    • Journal Title

      PLoS One.

      Volume: 10(8) Issue: 8 Pages: e0135836-e0135836

    • DOI

      10.1371/journal.pone.0135836

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Stella controls chromocenter formation through regulation of Daxx expression in 2-cell embryos.2015

    • Author(s)
      Arakawa, T., Nakatani, T., Oda, M., Kimura, Y., Sekita, Y., Kimura, T., Nakamura, T., and Nakano, T.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 466 Issue: 1 Pages: 60-60

    • DOI

      10.1016/j.bbrc.2015.08.106

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] De novo DNA methylation through the 5'-segment of the H19 ICR maintains its imprint during early embryogenesis2015

    • Author(s)
      Matsuzaki, H., Okamura, E., Takahashi, T., Ushiki, A., Nakamura, T., Nakano, T., Hata, K., Fukamizu, A., and Tanimoto, K.
    • Journal Title

      Development

      Volume: 142 Pages: 3833-3844

    • DOI

      10.1242/dev.126003

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Global DNA hypomethylation coupled to cellular transformation and metastatic ability.2015

    • Author(s)
      Funaki S, Nakamura T, Nakatani T, Umehara H, Nakashima H, Okumura M, Oboki K, Matsumoto K, Saito H, Nakano T.
    • Journal Title

      FEBS lett.

      Volume: 589 Issue: 24PartB Pages: 4053-60

    • DOI

      10.1016/j.febslet.2015.11.020

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Biotin-deficient diet induces chromosome misalignment and spindle defects in mouse oocytes.2015

    • Author(s)
      Tsuji A, Nakamura T, Shibata K.
    • Journal Title

      Biosci Biotechnol Biochem.

      Volume: 79 Issue: 2 Pages: 292-9

    • DOI

      10.1080/09168451.2014.968090

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dppa3 expression is critical for generation of fully-reprogrammed iPS cells and maintenance of Dlk1-Dio3 imprinting.2015

    • Author(s)
      Xu X et al.
    • Journal Title

      Nature Communications

      Volume: 6 Issue: 1 Pages: 6008-6008

    • DOI

      10.1038/ncomms7008

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Stella preserves maternal chromosome integrity by inhibiting 5hmC-dependent gammaH2AX accumulation.2015

    • Author(s)
      Nakatani et al.
    • Journal Title

      EMBO Reports

      Volume: 16 Issue: 5 Pages: 582-589

    • DOI

      10.15252/embr.201439427

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Trichostatin A specifically improves the aberrant expression of transcription factor genes in embryos produced by somatic cell nuclear transfer.2015

    • Author(s)
      Inoue K, Oikawa M, Kamimura S, Ogonuki N, Nakamura T, Nakano T, Abe K, Ogura A.
    • Journal Title

      Sci Rep

      Volume: 未定

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Inhibition of maintenance DNA methylation by Stella.2014

    • Author(s)
      Funaki S, Nakamura T, Nakatani T, Umehara H, Nakashima H, Nakano T.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 453 Issue: 3 Pages: 455-60

    • DOI

      10.1016/j.bbrc.2014.09.101

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Effects of Dppa3 on DNA methylation dynamics during primordial germ cell development2013

    • Author(s)
      Nakashima H, Kimura T, Kaga Y. Nakatani T, Seki Y, Nakamura T, Nakano T
    • Journal Title

      Biol Rep

      Volume: 88 Issue: 5 Pages: 1-9

    • DOI

      10.1095/biolreprod.112.105932

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GPAT2, a Mitochondrial Outer Membrane Protein in piRNA Biogenesis in Germline Stem Cells2013

    • Author(s)
      Shiromoto Y, Kuramochi-Miyagawa S, Daiba A, Chuma S, Katanaya A, Nishimura K, Ohtaka M, Nakanishi M, Nakamura T, Yoshinaga K, Asada N, Nakamura S, Yasunaga T, Kojima-Kita K, Itou D, Kimura T, Nakano T
    • Journal Title

      RNA

      Volume: 19 Issue: 6 Pages: 803-810

    • DOI

      10.1261/rna.038521.113

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] マウスES細胞由来胚様体の金属メッシュデバイスによるサイズ分画と心筋分化の検討2018

    • Author(s)
      木村 七海、井上 有香、水上 民夫、細井 美穂、土田 美江、中村 肇伸、神波 誠治、近藤 孝志、長谷川 慎
    • Organizer
      第17回日本再生医療学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] エピゲノム制御による胚性遺伝子の活性化機構2018

    • Author(s)
      中村 肇伸、仲野 徹
    • Organizer
      AMED-CREST研究開発領域「エピゲノム研究に基づく診断・治療に向けた新技術の創出」平成29年度領域会議
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ビタミン欠乏が卵母細胞の質におよぼす影響2017

    • Author(s)
      辻 愛、中村 肇伸、柴田 克己
    • Organizer
      日本農芸化学会2017年大会
    • Place of Presentation
      京都
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] 金属メッシュデバイスによるマウスES細胞由来胚様体のサイズ分画法の検討2017

    • Author(s)
      長谷川 慎 、木村 七海、井上 有香、水上 民夫、佐々木 隆造、土田 美江、中村 肇伸、古田 明日香、三浦 佳子、神波 誠治、近藤 孝志
    • Organizer
      第16回日本再生医療学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] エピゲノム成立の分子メカニズムの解明と制御2017

    • Author(s)
      仲野 徹、中村 肇伸
    • Organizer
      CREST「エピゲノム研究に基づく診断・治療へ向けた新技術の創出」研究領域 第6回領域会議
    • Place of Presentation
      東京
    • Year and Date
      2017-02-03
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Tet3とOGTが胚性遺伝子の活性化に及ぼす影響2017

    • Author(s)
      中村 肇伸、古田 明日香、仲野 徹
    • Organizer
      CREST「エピゲノム研究に基づく診断・治療へ向けた新技術の創出」研究領域 第6回領域会議
    • Place of Presentation
      東京
    • Year and Date
      2017-02-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] 全能性細胞で特異的に発現する遺伝子群の機能解析2017

    • Author(s)
      中村 肇伸
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 全能性細胞特異的遺伝子を用いた高品質iPS細胞の作製2017

    • Author(s)
      原口 大生、中村 肇伸
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ES細胞に含まれる全能性細胞のエネルギー代謝経路2017

    • Author(s)
      古田 明日香、中村 肇伸
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ES細胞に含まれる全能性細胞の誘導と解析2017

    • Author(s)
      中村 肇伸
    • Organizer
      文部科学省科学研究費補助金 新学術領域研究「生殖細胞のエピゲノムダイナミクスとその制御」第4回公開シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Induction and characterization of totipotent fraction in ES culture2017

    • Author(s)
      Asuka Furuta, Toshinobu Nakamura
    • Organizer
      World Congress of Reproductive Biology 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of Akt signaling on totipotent cells within ES cell culture2017

    • Author(s)
      Ayaka Kakihara, Asuka Furuta, Ayaka Mori, Toshinobu Nakamura
    • Organizer
      World Congress of Reproductive Biology 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Induction of totipotent fraction in ES cell culture2017

    • Author(s)
      Asuka Furuta, Toshinobu Nakamura
    • Organizer
      International Society for Stem Cell Research (ISSCR) 2017 Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ES細胞に含まれる全能性細胞の可視化とその制御2017

    • Author(s)
      古田 明日香、中村 肇伸
    • Organizer
      文部科学省科学研究費補助金 新学術領域研究「生殖細胞のエピゲノムダイナミクスとその制御」「ステムセルエイジングから解明する疾患原理」「動的クロマチン構造と機能」合同若手勉強会2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] ES細胞に含まれる全能性細胞の可視化とその制御2016

    • Author(s)
      古田 明日香、中村 肇伸
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 全能性細胞で高発現するPramef12の機能解析2016

    • Author(s)
      中村 肇伸
    • Organizer
      文部科学省科学研究費補助金 新学術領域研究「生殖細胞のエピゲノムダイナミクスとその制御」第4回公開シンポジウム
    • Place of Presentation
      静岡
    • Year and Date
      2016-11-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] Induction of totipotent fraction in ES cell culture2016

    • Author(s)
      Asuka Furuta, Toshinobu Nakamura
    • Organizer
      Cold Spring Harbor Laboratory Meeting Germ Cells
    • Place of Presentation
      NY, USA
    • Year and Date
      2016-10-04
    • Related Report
      2016 Annual Research Report
  • [Presentation] ES細胞に含まれる全能性細胞の可視化とその制御2016

    • Author(s)
      古田 明日香、中村 肇伸
    • Organizer
      文部科学省科学研究費補助金 新学術領域研究「生殖細胞のエピゲノムダイナミクスとその制御」第4回若手勉強会
    • Place of Presentation
      大分
    • Year and Date
      2016-07-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] Critical function of Klf17 for the zygotic genome activation in mice2016

    • Author(s)
      Yui Goto, Asuka Furuta, Kenji Suzuki, Takashi Kohda, Masahito Ikawa, Toshinobu Nakamura
    • Organizer
      International Symposium on “Epigenome dynamics and regulation in germ cells”
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2016-02-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 全能性細胞で特異的に発現するKlf17の初期発生における必要性2015

    • Author(s)
      後藤 悠比、鈴木 健士、古田 明日香、幸田 尚、伊川 正人、中村 肇伸
    • Organizer
      BMB2015(第38回日本分子生物学会年会・第88回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] High-affinity, poly-reactive IgA is required for gut homeostatic maintenance to prevent colitis in mice2015

    • Author(s)
      Shinsaku Okai, Fumihito Usui, Makoto Hasegawa, Toshinobu Nakamura, Kazuya Yamamoto, Eri Nishiyama, Hiroshi Mori, Takuji Yamada, Ken Kurokawa, Tamotsu Kato, Eiji Miyauchi, Hiroshi Ohno, Reiko Shinkura
    • Organizer
      BMB2015(第38回日本分子生物学会年会・第88回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] High-affinity, poly-reactive IgA is required for gut homeostatic maintenance to prevent colitis in mice2015

    • Author(s)
      Shinsaku Okai, Fumihito Usui, Makoto Hasegawa, Toshinobu Nakamura, Kazuya Yamamoto, Eri Nishiyama, Hiroshi Mori, Takuji Yamada, Ken Kurokawa, Tamotsu Kato, Eiji Miyauchi, Hiroshi Ohno, Reiko Shinkura
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2015-11-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] 全能性細胞で特異的に発現する遺伝子群の機能解析2015

    • Author(s)
      中村 肇伸
    • Organizer
      神戸大学農学部 第33回インターゲノミクスセミナー
    • Place of Presentation
      神戸
    • Year and Date
      2015-11-13
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Vitamin B1栄養が卵子の質におよぼす影響2015

    • Author(s)
      辻 愛、中村 肇伸、柴田 克己
    • Organizer
      第54回 日本栄養食糧学会 近畿支部大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-10-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] Critical functions of totipotent-cell specific genes Klf17 and Btg4 in zygotic reprogramming2015

    • Author(s)
      Kenji Suzuki, Yui Goto, Asuka Furuta, Takashi Kohda, Masahito Ikawa, Toshinobu Nakamura
    • Organizer
      The 40th Naito Conference Epigenetics "From Histone Code to Therapeutic Strategy"
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      2015-09-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 全能性細胞で高発現するBtg4の初期発生における必要性2015

    • Author(s)
      鈴木 健士、後藤 悠比、古田 明日香、伊川 正人、中村 肇伸
    • Organizer
      文部科学省科学研究費補助金 新学術領域研究「生殖細胞のエピゲ ノムダイナミクスとその制御」第3回若手勉強会
    • Place of Presentation
      静岡県
    • Year and Date
      2015-07-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] 初期胚のクロマチン再構成におけるヒストンシャペロンの役割 ~DNA脱メチル化制御因子Stella欠損 胚をモデルとして~2015

    • Author(s)
      荒川 達彦、中谷 庸寿、小田 昌朗、木村 康義、関田 洋一、木村 透、中村 肇 伸、仲野 徹
    • Organizer
      文部科学省科学研究費補助金 新学術領域研究「生殖細胞のエピゲ ノムダイナミクスとその制御」第3回若手勉強会
    • Place of Presentation
      静岡県
    • Year and Date
      2015-07-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] マウス受精卵におけるStellaの雌性ゲノム保護とその初期胚発生への重要性2015

    • Author(s)
      中谷 庸寿、山縣 一夫、木村 透、小田 昌朗、中島 啓行、堀 真由子、関田 洋 一、荒川 達彦、中村 肇伸、仲野 徹
    • Organizer
      第9回日本エピジェネティクス研究会年会
    • Place of Presentation
      東京
    • Year and Date
      2015-05-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] Biotin-deficient diet induces abnormal oocyte in mouse2015

    • Author(s)
      Ai Tsuji, Toshinobu Nakamura, Katsumi Shibata
    • Organizer
      12th Asian Congress of Nutrition
    • Place of Presentation
      Yokohama
    • Year and Date
      2015-05-14 – 2015-05-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Biotin-deficient diet induces abnormal oocyte in mouse2015

    • Author(s)
      Ai Tsuji, Toshinobu Nakamura, Katsumi Shibata
    • Organizer
      12th Asian Congress of Nutrition
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2015-05-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 全能性細胞で高発現する遺伝子群の機能解析2015

    • Author(s)
      中村 肇伸、仲野 徹
    • Organizer
      CREST「エピゲノム研究に基づく診断・治療へ向けた新技術の創出」研究領域 第4回領域会議
    • Place of Presentation
      大阪
    • Year and Date
      2015-02-21 – 2015-02-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] エピゲノム成立の分子メカニズムの解明と制御2015

    • Author(s)
      仲野 徹、中村 肇伸
    • Organizer
      CREST「エピゲノム研究に基づく診断・治療へ向けた新技術の創出」研究領域 第4回領域会議
    • Place of Presentation
      大阪
    • Year and Date
      2015-02-21 – 2015-02-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] マウスにおけるビオチン欠乏は卵子の質を劣化させる2014

    • Author(s)
      辻 愛、中村 肇伸、柴田 克己
    • Organizer
      第13回日本栄養改善学会近畿支部学術総会
    • Place of Presentation
      京都
    • Year and Date
      2014-12-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] Asymmetry in histone H2B O-GlcNAcylation between paternal and maternal chromatin of mouse zygotes2014

    • Author(s)
      中村 肇伸、鈴木 健士、後藤 悠比、中谷 庸寿、関田 洋一、仲野 徹
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 腸炎モデルマウスに対する腸管IgA抗体の作用機序の解明2014

    • Author(s)
      岡井 晋作、臼井 文人、野村 慎太郎、中村 肇伸、山本 和也、西山 依里、森 宙史、山田 拓司、黒川 顕、加藤 保、大野 博司、新蔵 礼子
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 初期胚のクロマチン再構成におけるヒストンシャペロンの役割 ~DNA脱メチル化制御因子Stellaの欠損胚をモデルとして~2014

    • Author(s)
      荒川 達彦、中谷 庸寿、関田 洋一、木村 透、中村 肇伸、小田 昌朗、仲野 徹
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 受精卵における胚性遺伝子の活性化機構の解明2014

    • Author(s)
      中村 肇伸
    • Organizer
      文部科学省科学研究費補助金 新学術領域研究「生殖細胞のエピゲノムダイナミクスとその制御」第2回公開シンポジウム
    • Place of Presentation
      福岡
    • Year and Date
      2014-10-31 – 2014-11-01
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Asymmetry in histone H2B O-GlcNAcylation between paternal and maternal chromatin of mouse zygotes2014

    • Author(s)
      Toshinobu Nakamura, Kenji Suzuki, Yui gotou, Tsunetoshi Nakatani, Yoichi Sekita, Toru Nakano
    • Organizer
      Cold Spring Harbor Laboratory meeting EPIGENETICS & CHROMATIN
    • Place of Presentation
      New York, USA
    • Year and Date
      2014-09-09 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Stella preserves maternal chromosome integrity by inhibiting 5hmC-dependent γH2AX accumulation.2014

    • Author(s)
      Tsunetoshi Nakatani, Kazuo Yamagata, Tohru Kimura, Masaaki Oda, Hiroyuki Nakashima, Mayuko Hori, Yoichi Sekita, Tatsuhiko Arakawa, Toshinobu Nakamura, Toru Nakano
    • Organizer
      Cold Spring Harbor Laboratory meeting EPIGENETICS & CHROMATIN
    • Place of Presentation
      New York, USA
    • Year and Date
      2014-09-09 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] トリコスタチンA処理による体細胞核移植クローン胚の転写因子関連遺伝子発現の改善について2014

    • Author(s)
      井上 貴美子、及川 真実、上村 悟氏、越後貫 成美、中村 肇伸、仲野 徹、小倉 淳郎
    • Organizer
      第107回日本繁殖生物学会大会
    • Place of Presentation
      帯広
    • Year and Date
      2014-08-21 – 2014-08-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] 初期胚のクロマチン再構成におけるヒストンシャペロンの役割 ~DNA脱メチル化制御因子Stellaの欠損胚をモデルとして~2014

    • Author(s)
      荒川 達彦、中谷 庸寿、関田 洋一、木村 透、中村 肇伸、小田 昌朗、仲野 徹
    • Organizer
      第3回大阪大学医学系研究科若手研究フォーラム
    • Place of Presentation
      大阪
    • Year and Date
      2014-07-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 全能性細胞で高発現するBtg4の機能解析2014

    • Author(s)
      鈴木 健士、後藤 悠比、中村 肇伸
    • Organizer
      文部科学省科学研究費補助金 新学術領域研究「生殖細胞のエピゲノムダイナミクスとその制御」第2回若手勉強会
    • Place of Presentation
      つくば
    • Year and Date
      2014-07-16 – 2014-07-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 着床前胚におけるKlf17の重要な役割2014

    • Author(s)
      後藤 悠比、鈴木 健士、中村 肇伸
    • Organizer
      文部科学省科学研究費補助金 新学術領域研究「生殖細胞のエピゲノムダイナミクスとその制御」第2回若手勉強会
    • Place of Presentation
      つくば
    • Year and Date
      2014-07-16 – 2014-07-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 受精卵におけるヒストンH2BのN-アセチルグルコサミン修飾2014

    • Author(s)
      中村 肇伸、鈴木 健士、後藤 悠比、中谷 庸寿、関田 洋一、仲野 徹
    • Organizer
      第8回日本エピジェネティクス研究会年会
    • Place of Presentation
      東京
    • Year and Date
      2014-05-25 – 2014-05-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 受精卵におけるヒストンH2BのN-アセチルグルコサミン修飾とその意義2013

    • Author(s)
      中村 肇伸
    • Organizer
      文部科学省科学研究費補助金 新学術領域研究「生殖細胞のエピゲノムダイナミクスとその制御」第1回公開シンポジウム
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 全能性細胞で高発現するKlf17の機能解析2013

    • Author(s)
      後藤 悠比、鈴木 健士、中村 肇伸
    • Organizer
      文部科学省科学研究費補助金 新学術領域研究「生殖細胞のエピゲノムダイナミクスとその制御」第1回若手勉強会
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] 全能性細胞で高発現するBtg4の機能解析2013

    • Author(s)
      鈴木 健士、後藤 悠比、中村 肇伸
    • Organizer
      文部科学省科学研究費補助金 新学術領域研究「生殖細胞のエピゲノムダイナミクスとその制御」第1回若手勉強会
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] 受精卵における能動的DNA脱メチル化の制御機構の解明2013

    • Author(s)
      中村 肇伸
    • Organizer
      大阪大学蛋白質研究所セミナー「DNAメチル化の制御機構-メチル化模様形成、維持と消去」
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] バイオテクノロジー入門2016

    • Author(s)
      高畑京也・蔡晃植・齊藤修・今村綾・宇佐美昭二・尾山廣・数岡孝幸・河内浩行・佐々壽浩・髙村岳樹・田中直子・永井信夫・仲亀誠司・中村肇伸・徳田宏晴・殿山泰弘・濱田博喜・室伏誠・若生豊
    • Total Pages
      168
    • Publisher
      建帛社
    • Related Report
      2016 Annual Research Report
  • [Book] 生体の科学「着床前胚と始原生殖細胞におけるDNAメチル化リプログラミング」2015

    • Author(s)
      中村 肇伸
    • Total Pages
      7
    • Publisher
      医学書院
    • Related Report
      2015 Annual Research Report
  • [Book] 細胞工学「母性因子を用いたiPS細胞の樹立効率と質の改善」2015

    • Author(s)
      中村 肇伸
    • Total Pages
      8
    • Publisher
      学研メディカル秀潤社
    • Related Report
      2015 Annual Research Report
  • [Book] 細胞工学; 母性因子を用いたiPS細胞の樹立効率と質の改善2015

    • Author(s)
      中村 肇伸
    • Publisher
      学研メディカル秀潤社
    • Related Report
      2014 Annual Research Report
  • [Book] 生体の科学; 着床前胚と始原生殖細胞におけるDNAメチル化リプログラミング2015

    • Author(s)
      中村 肇伸
    • Publisher
      医学書院
    • Related Report
      2014 Annual Research Report
  • [Book] Stella and zygotic reprogramming; In “Epigenetic Mechanisms in Cellular Reprogramming”, Epigenetics and Human Health series2015

    • Author(s)
      Nakamura T, Nakano T.
    • Total Pages
      12
    • Publisher
      Springer
    • Related Report
      2014 Annual Research Report
  • [Book] 細胞工学「受精後のエピジェネティック制御」2014

    • Author(s)
      中村 肇伸
    • Total Pages
      6
    • Publisher
      学研メディカル秀潤社
    • Related Report
      2013 Annual Research Report
  • [Remarks] マウス受精卵における精子ゲノムの再構築にMettl23が重要であることを発見

    • URL

      http://www.nagahama-i-bio.ac.jp/research/

    • Related Report
      2017 Annual Research Report
  • [Remarks] rDNAのプロモーター領域が低メチル化状態に維持されていることを発見

    • URL

      http://www.nagahama-i-bio.ac.jp/research/

    • Related Report
      2017 Annual Research Report
  • [Remarks] iPS細胞の質を高める研究で再生医療の躍進に貢献する

    • URL

      http://www.nagahama-i-bio.ac.jp/research/%E5%90%9B%E3%82%82%E5%AD%A6%E3%81%B9%E3%82%8B%EF%BC%81%E6%9C%80%E5%85%88%E7%AB%AF%E3%81%AE%E7%A0%94%E7%A9%B6/#01

    • Related Report
      2016 Annual Research Report
  • [Remarks] 中村肇伸准教授らの共同研究が『Nature communications』に掲載されました

    • URL

      http://www.nagahama-i-bio.ac.jp/research/

    • Related Report
      2015 Annual Research Report
  • [Remarks] [プレスリリース]中村肇伸准教授らの共同研究について

    • URL

      http://www.nagahama-i-bio.ac.jp/research/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 中村肇伸准教授らの共同研究が『Nature communications』に掲載されました

    • URL

      http://www.nagahama-i-bio.ac.jp/others/

    • Related Report
      2014 Annual Research Report
  • [Remarks] Nature communicationsに掲載された論文が新聞で報道されました

    • URL

      http://b-lab.nagahama-i-bio.ac.jp/?page_id=203

    • Related Report
      2014 Annual Research Report
  • [Remarks] 中村肇伸講師が文部科学大臣表彰若手科学者賞を受賞しました

    • URL

      http://www.nagahama-i-bio.ac.jp/news/news/2013/04/post_233.html

    • Related Report
      2013 Annual Research Report

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Published: 2013-07-10   Modified: 2019-07-29  

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