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Neural mechanism underlying the auditory memory in fruit flies

Planned Research

Project AreaPrinciples of memory dynamism elucidated from a diversity of learning systems
Project/Area Number 25115007
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionNagoya University

Principal Investigator

Kamikouchi Azusa  名古屋大学, 理学研究科, 教授 (00525264)

Project Period (FY) 2013-06-28 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥90,480,000 (Direct Cost: ¥69,600,000、Indirect Cost: ¥20,880,000)
Fiscal Year 2017: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2016: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2015: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2014: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2013: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Keywords聴覚学習 / 神経回路機構 / 歌学習 / 聴覚可塑性 / 記憶 / 神経科学 / 神経回路地図 / 行動可塑性 / 行動制御
Outline of Final Research Achievements

Many animals use the courtship sound in their mating behaviors. The courtship sound emitted by the sender gradually affects the receiver’s mating drive, which finally leads to its rejection of acceptance. We studied how the courtship sound is accumulated in the receiver’s brain and evokes an appropriate mating decision. Firstly, we mapped the auditory neural circuits in the fly brain by identifying interneurons that project to the primary auditory center. Secondly, we identified the feed-forward circuit that tunes the selectivity for a species-specific rhythm in the courtship sound. Finally, we found that an experience of hearing the conspecific song as a young adult sharpens the song preference and mate selection as a breeding adult. Together, we revealed a mechanism underlying the information processing and memory formation of the courtship sound in the fruit-fly brain.

Report

(6 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (30 results)

All 2018 2017 2016 2015 2014 Other

All Int'l Joint Research (1 results) Journal Article (7 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 7 results,  Open Access: 5 results,  Acknowledgement Compliant: 2 results) Presentation (15 results) (of which Int'l Joint Research: 5 results,  Invited: 8 results) Book (5 results) Remarks (2 results)

  • [Int'l Joint Research] Janelia Research Campus(米国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Auditory experience controls the maturation of song discrimination and sexual response in Drosophila2018

    • Author(s)
      Xiaodong Li, Hiroshi Ishimoto, Azusa Kamikouchi
    • Journal Title

      eLife

      Volume: 7

    • DOI

      10.7554/elife.34348

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] GABAergic local interneurons shape female fruit fly response to mating songs2018

    • Author(s)
      Daichi Yamada, Hiroshi Ishimoto, Xiaodong Li, Tsunehiko Kohashi, Yuki Ishikawa, Azusa Kamikouchi
    • Journal Title

      The Journal of Neuroscience

      Volume: 印刷中 Issue: 18 Pages: 4329-4347

    • DOI

      10.1523/jneurosci.3644-17.2018

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Anatomic and Physiologic Heterogeneity of Subgroup-A Auditory Sensory Neurons in Fruit Flies2017

    • Author(s)
      Ishikawa Yuki、Okamoto Natsuki、Nakamura Mizuki、Kim Hyunsoo、Kamikouchi Azusa
    • Journal Title

      Frontiers in Neural Circuits

      Volume: 11 Pages: 46-46

    • DOI

      10.3389/fncir.2017.00046

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Organization of projection neurons and local neurons of the primary auditory center in the fruit fly Drosophila melanogaster.2016

    • Author(s)
      Matsuo E, Seki H, Asai T, Morimoto T, Miyakawa H, Ito K, Kamikouchi A
    • Journal Title

      The Journal of comparative neurology

      Volume: 524 Issue: 6 Pages: 1099-1164

    • DOI

      10.1002/cne.23972

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The Nutrient-Responsive Hormone CCHamide-2 Controls Growth by Regulating Insulin-like Peptides in the Brain of Drosophila melanogaster.2015

    • Author(s)
      Sano H, Nakamura A, Texada MJ, Truman JW, Ishimoto H, Kamikouchi A, Nibu Y, Kume K, Ida T, Kojima M
    • Journal Title

      PLoS genetics

      Volume: 11 Issue: 9 Pages: e1005481-e1005481

    • DOI

      10.1371/journal.pgen.1005481

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Auditory system of fruit flies2015

    • Author(s)
      Ishikawa Y, Kamikouchi A
    • Journal Title

      Hearing research

      Volume: In Press Pages: 1-8

    • DOI

      10.1016/j.heares.2015.10.017

    • NAID

      120005868241

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of novel vibration- and deflection-sensitive neuronal subgroups in Johnston’s organ of the fruit fly.2014

    • Author(s)
      Matsuo E, Yamada D, Ishikawa Y, Asai T, Ishimoto H, Kamikouchi A
    • Journal Title

      Frontiers in Physiology

      Volume: 5 Pages: 179-179

    • DOI

      10.3389/fphys.2014.00179

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] ショウジョウバエ聴覚系の神経解剖学2018

    • Author(s)
      上川内あづさ
    • Organizer
      第123回日本解剖学会総会・日本学術総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Experience-dependent tuning of the auditory behavior in Drosophila2017

    • Author(s)
      Li Xiaodong, Azusa Kamikouchi
    • Organizer
      The 4th Asia-Pacific Dorosophila Research Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 求愛歌受容を担うショウジョウバエの聴覚システム2017

    • Author(s)
      上川内あづさ
    • Organizer
      第89回日本遺伝学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Early auditory experience shapes the auditory response in fruit flies (Drosophila melanogaster)2017

    • Author(s)
      上川内あづさ
    • Organizer
      日本比較生理生化学会第39回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Auditory neural circuits in the fly brain2017

    • Author(s)
      上川内あづさ
    • Organizer
      From sender to receiver: physics and sensory ecology of hearing in insects and vertebrates
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Plasticity in the auditory behavior of fruit flies2016

    • Author(s)
      N. Morimoto, A. Kamikouchi
    • Organizer
      2016 Association for Research in Otolaryngology MidWinter Meeting
    • Place of Presentation
      San Diego,CA,USA
    • Year and Date
      2016-02-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The central auditory pathways of fruit flies2015

    • Author(s)
      Kamikouchi A
    • Organizer
      H27年度新学術領域研究国際シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2015-11-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Auditory neural circuit in the fruit-fly brain2015

    • Author(s)
      E. Matsuo, H. Seki, T. Asai, T. Morimoto, H. Miyakawa, K. Ito, A. Kamikouchi
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] ショウジョウバエ聴覚系の神経回路ーショウジョウバエを使った研究から聴覚システムの動作原理を探るー2015

    • Author(s)
      上川内あづさ
    • Organizer
      聴覚研究会
    • Place of Presentation
      豊橋技術科学大学
    • Year and Date
      2015-05-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] Auditory neural pathways in the fly brain2015

    • Author(s)
      Kamikouchi A
    • Organizer
      3rd Asia-Pacific Drosophila Research Conference(APDRC)
    • Place of Presentation
      Beijing, China
    • Year and Date
      2015-05-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The organization of auditory neural circuits in the fruit-fly brain2015

    • Author(s)
      Azusa Kamikouchi
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-03-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Auditory plasticity induced by long-term sound exposure in Drosophila2015

    • Author(s)
      Xiaodong Li, Hiroshi Ishimoto, Azusa Kamikouchi
    • Organizer
      Systems Neurobiology Spring School 2015
    • Place of Presentation
      京都
    • Year and Date
      2015-03-06
    • Related Report
      2013 Annual Research Report
  • [Presentation] Neuronal encoding of sound and gravity in the fruit fly2015

    • Author(s)
      Azusa Kamikouchi
    • Organizer
      2015 ARO Midwinter Meeting
    • Place of Presentation
      Baltimore
    • Year and Date
      2015-02-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ハエの「求愛歌」がコードする情報を脳はどのように読み解くのか?2014

    • Author(s)
      上川内あづさ
    • Organizer
      生命情報科学若手の会
    • Place of Presentation
      神戸
    • Year and Date
      2014-10-29
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Identification of a novel vibration and deflection center2014

    • Author(s)
      Daichi Yamada, Eriko Matsuo, Yuki Ishikawa, Hiroshi Ishimoto, Azusa Kamikouchi
    • Organizer
      The 37th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Book] Insect Hearing (Springer Handbook of Auditory Research)2016

    • Author(s)
      Azusa Kamikouchi, Yuki Ishikawa
    • Total Pages
      262
    • Publisher
      Springer
    • Related Report
      2016 Annual Research Report
  • [Book] Insect Hearing (Springer Handbook of Auditory Research)2016

    • Author(s)
      Daniel F. Eberl, Azusa Kamikouchi, Joerg T. Albert
    • Total Pages
      262
    • Publisher
      Springer
    • Related Report
      2016 Annual Research Report
  • [Book] 研究者が教える動物実験 第1巻―感覚― 第3章(1)音への応答行動を測る:求愛歌は効果あり?(キイロショウジョウバエ)2015

    • Author(s)
      石元広志、上川内あづさ
    • Total Pages
      212
    • Publisher
      共立出版
    • Related Report
      2015 Annual Research Report
  • [Book] 研究者が教える動物実験 第1巻―感覚― 第3章(2)重力への応答行動を測る:ショウジョウバエは上に逃げる?2015

    • Author(s)
      松尾恵倫子、上川内あづさ
    • Total Pages
      212
    • Publisher
      共立出版
    • Related Report
      2015 Annual Research Report
  • [Book] 動物行動の分子生物学 (新・生命科学シリーズ)2014

    • Author(s)
      久保健雄、上川内あづさ、竹内秀明、奥山輝大
    • Total Pages
      180
    • Publisher
      裳華房
    • Related Report
      2014 Annual Research Report
  • [Remarks] ハエだって聞きなれた歌が好き♪ ~ヒトの言語学習のメカニズム解明につながる可能性も~

    • URL

      http://www.nagoya-u.ac.jp/about-nu/public-relations/researchinfo/upload_images/20180320_sci_1.pdf

    • Related Report
      2017 Annual Research Report
  • [Remarks] わずかなリズムの違いを聞き分ける脳のしくみを発見♪

    • URL

      http://www.bio.nagoya-u.ac.jp/files/topics/180417_Kamikouchi.pdf

    • Related Report
      2017 Annual Research Report

URL: 

Published: 2013-07-10   Modified: 2022-01-28  

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