• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

In vitro reconstitution and structural studies for chromatin

Planned Research

Project AreaDynamic chromatin structure and function
Project/Area Number 25116002
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionWaseda University

Principal Investigator

Kurumizaka Hitoshi  早稲田大学, 理工学術院, 教授 (80300870)

Co-Investigator(Kenkyū-buntansha) 堀 哲也  大阪大学, 生命機能研究科, 准教授 (70550078)
Project Period (FY) 2013-06-28 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥232,700,000 (Direct Cost: ¥179,000,000、Indirect Cost: ¥53,700,000)
Fiscal Year 2017: ¥39,130,000 (Direct Cost: ¥30,100,000、Indirect Cost: ¥9,030,000)
Fiscal Year 2016: ¥39,130,000 (Direct Cost: ¥30,100,000、Indirect Cost: ¥9,030,000)
Fiscal Year 2015: ¥37,180,000 (Direct Cost: ¥28,600,000、Indirect Cost: ¥8,580,000)
Fiscal Year 2014: ¥39,130,000 (Direct Cost: ¥30,100,000、Indirect Cost: ¥9,030,000)
Fiscal Year 2013: ¥78,130,000 (Direct Cost: ¥60,100,000、Indirect Cost: ¥18,030,000)
Keywordsエピジェネティクス / ゲノム機能 / 染色体構築・機能・分配 / ゲノム多様性 / 生体高分子構造・機能ゲノム進化・再編 / 遺伝情報複製・再編 / ゲノム維持修復 / ゲノム進化・再編 / 活性発現の分子機構 / 生体高分子構造・機能 / 構造活性相関 / クロマチン / ゲノム / 遺伝子 / 染色体
Outline of Final Research Achievements

In eukaryotes, genomic DNA is compacted as chromatin, which is formed as the higher ordered protein-DNA complex. Recent evidences suggested that versatility of the structures and dynamics of chromatin is essential for gene regulation. However, the mechanism by which the chromatin dynamics regulates eukaryotic genes has not been elucidated yet. The purpose of this study is to elucidate the structures and dynamics of fundamental unites of chromatin. To do so, we have established in vitro methods for chromatin reconstitution. We then performed X-ray crystallography, X-ray and neutron scattering, and cryogenic electron microscopy with the reconstituted chromatin samples. We also performed the biochemical, cell biological, and genomics approaches. We then revealed many important aspects of chromatin to understand the molecular mechanism for genomic DNA function in eukaryotes.

Report

(6 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (206 results)

All 2018 2017 2016 2015 2014 2013 Other

All Int'l Joint Research (8 results) Journal Article (70 results) (of which Int'l Joint Research: 10 results,  Peer Reviewed: 69 results,  Open Access: 49 results,  Acknowledgement Compliant: 30 results) Presentation (115 results) (of which Int'l Joint Research: 14 results,  Invited: 41 results) Book (9 results) Remarks (4 results)

  • [Int'l Joint Research] 国立環境衛生科学研究所/ロチェスター大学(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] ヴュルツブルク大学(ドイツ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] グルノーブル大学/IGBMC/リヨン第1大学(フランス)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Institute for Advanced Bioscience(フランス)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] フリードリッヒ・ミーシャ研究所(スイス)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] NIH/University of Colorado, Aurora/University of Colorado, Boulder(米国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Friedrich Miescher Institute(スイス)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Laval University/McGill University(カナダ)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] LC-MS/MS-based quantitative study of the acyl group- and site-selectivity of human sirtuins to acylated nucleosomes2018

    • Author(s)
      Tanabe Kana、Liu Jiaan、Kato Daiki、Kurumizaka Hitoshi、Yamatsugu Kenzo、Kanai Motomu、Kawashima Shigehiro A.
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 2656-2656

    • DOI

      10.1038/s41598-018-21060-2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structural Basis of Heterochromatin Formation by Human HP12018

    • Author(s)
      Machida Shinichi、Takizawa Yoshimasa、Ishimaru Masakazu、Sugita Yukihiko、Sekine Satoshi、Nakayama Jun-ichi、Wolf Matthias、Kurumizaka Hitoshi
    • Journal Title

      Molecular Cell

      Volume: 69 Issue: 3 Pages: 385-397

    • DOI

      10.1016/j.molcel.2017.12.011

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural Basis of Homology-Directed DNA Repair Mediated by RAD522018

    • Author(s)
      Saotome, M., Saito, K., Yasuda, T., Ohtomo, H., Sugiyama, S., Nishimura, Y., Kurumizaka, H., Kagawa, W.
    • Journal Title

      iScience

      Volume: 3 Pages: 50-62

    • DOI

      10.1016/j.isci.2018.04.005

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cryo-EM structure of the nucleosome containing the ALB1 enhancer DNA sequence2018

    • Author(s)
      Takizawa Yoshimasa、Tanaka Hiroki、Machida Shinichi、Koyama Masako、Maehara Kazumitsu、Ohkawa Yasuyuki、Wade Paul A.、Wolf Matthias、Kurumizaka Hitoshi
    • Journal Title

      Open Biology

      Volume: 8 Issue: 3 Pages: 170255-170255

    • DOI

      10.1098/rsob.170255

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Replication stress induces accumulation of FANCD2 at central region of large fragile genes.2018

    • Author(s)
      Okamoto Y, Iwasaki WM, Kugou K, Takahashi KK, Oda A, Sato K, Kobayashi W, Kawai H, Sakasai R, Takaori-Kondo A, Yamamoto T, Kanemaki MT, Taoka M, Isobe T, Kurumizaka H, Innan H, Ohta K, Ishiai M, Takata M.
    • Journal Title

      Nucleic Acids Res.

      Volume: 46(6) Issue: 6 Pages: 2932-2944

    • DOI

      10.1093/nar/gky058

    • NAID

      120006488604

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Parallel mapping with site-directed hydroxyl radicals and micrococcal nuclease reveals structural features of positioned nucleosomes in vivo.2017

    • Author(s)
      Fuse T, Katsumata K, Morohoshi K, Mukai Y, Ichikawa Y, Kurumizaka H, Yanagida A, Urano T, Kato H, Shimizu M.
    • Journal Title

      PLoS One

      Volume: 12 Issue: 10 Pages: e0186974-e0186974

    • DOI

      10.1371/journal.pone.0186974

    • NAID

      120006539368

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phosphorylation of CBX2 controls its nucleosome-binding specificity2017

    • Author(s)
      Takayuki Kawaguchi, Shinichi Machida, Hitoshi Kurumizaka, Hideaki Tagami, Jun-ichi Nakayama
    • Journal Title

      The Journal of Biochemistry

      Volume: 162 Issue: 5 Pages: 343-355

    • DOI

      10.1093/jb/mvx040

    • NAID

      40021394855

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histone H3 Methylated at Arginine 17 Is Essential for Reprogramming the Paternal Genome in Zygotes.2017

    • Author(s)
      Hatanaka Y, Tsusaka T, Shimizu N, Morita K, Suzuki T, Machida S, Satoh M, Honda A, Hirose M, Kamimura S, Ogonuki N, Nakamura T, Inoue K, Hosoi Y, Dohmae N, Nakano T, Kurumizaka H, Matsumoto K, Shinkai Y, Ogura A.
    • Journal Title

      Cell Rep

      Volume: 20(12) Issue: 12 Pages: 2756-2765

    • DOI

      10.1016/j.celrep.2017.08.088

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] SYCP3 regulates strand invasion activities of RAD51 and DMC12017

    • Author(s)
      Kobayashi Wataru、Hosoya Noriko、Machida Shinichi、Miyagawa Kiyoshi、Kurumizaka Hitoshi
    • Journal Title

      Genes to Cells

      Volume: 22 Issue: 9 Pages: 799-809

    • DOI

      10.1111/gtc.12513

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of M18BP1/KNL2 with CENP-A Nucleosome Is Essential for Centromere Formation in Non-mammalian Vertebrates2017

    • Author(s)
      Tetsuya Hori, Wei-Hao Shang, Masatoshi Hara, Mariko Ariyoshi, Yasuhiro Arimura, Risa Fujita, Hitoshi Kurumizaka, Tatsuo Fukagawa
    • Journal Title

      Developmental Cell

      Volume: 42 Issue: 2 Pages: 181-189

    • DOI

      10.1016/j.devcel.2017.06.019

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Synthetic Posttranslational Modifications: Chemical Catalyst-Driven Regioselective Histone Acylation of Native Chromatin2017

    • Author(s)
      Amamoto Yoshifumi、Aoi Yuki、Nagashima Nozomu、Suto Hiroki、Yoshidome Daisuke、Arimura Yasuhiro、Osakabe Akihisa、Kato Daiki、Kurumizaka Hitoshi、Kawashima Shigehiro A.、Yamatsugu Kenzo、Kanai Motomu
    • Journal Title

      Journal of the American Chemical Society

      Volume: 139 Issue: 22 Pages: 7568-7576

    • DOI

      10.1021/jacs.7b02138

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RFWD3-Mediated Ubiquitination Promotes Timely Removal of Both RPA and RAD51 from DNA Damage Sites to Facilitate Homologous Recombination2017

    • Author(s)
      Inano Shojiro、Sato Koichi、Katsuki Yoko、Kobayashi Wataru、Tanaka Hiroki、Nakajima Kazuhiro、Nakada Shinichiro、Miyoshi Hiroyuki、Knies Kerstin、Takaori-Kondo Akifumi、Schindler Detlev、Ishiai Masamichi、Kurumizaka Hitoshi、Takata Minoru
    • Journal Title

      Molecular Cell

      Volume: 66 Issue: 5 Pages: 622-634

    • DOI

      10.1016/j.molcel.2017.04.022

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Structure and Dynamics of a 197?bp Nucleosome in Complex with Linker Histone H12017

    • Author(s)
      Bednar J., Garcia-Saez I., Boopathi R., Cutter A.R., Papai G., Reymer A., Syed S.H., Lone I.N., Tonchev O., Crucifix C., Menoni H., Papin C., Skoufias D.A., Kurumizaka H., Lavery R., Hamiche A., Hayes J.J., Schultz P., Angelov D., Petosa C., Dimitrov S.
    • Journal Title

      Molecular Cell

      Volume: 66 Issue: 3 Pages: 384-397.e8

    • DOI

      10.1016/j.molcel.2017.04.012

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Crystal Structure and Characterization of Novel Human Histone H3 Variants, H3.6, H3.7, and H3.82017

    • Author(s)
      Taguchi H, Xie Y, Horikoshi N, Maehara K, Harada A, Nogami J, Sato K, Arimura Y, Osakabe A, Kujirai T, Iwasaki T, Semba Y, Tachibana T, Kimura H, Ohkawa Y, Kurumizaka H.
    • Journal Title

      Biochemistry

      Volume: 56 Issue: 16 Pages: 2184-2196

    • DOI

      10.1021/acs.biochem.6b01098

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Crystal structure of the overlapping dinucleosome composed of hexasome and octasome2017

    • Author(s)
      Daiki Kato, Akihisa Osakabe, Yasuhiro Arimura, Yuka Mizukami, Naoki Horikoshi, Kazumi Saikusa, Satoko Akashi, Yoshifumi Nishimura, Sam-Yong Park, Jumpei Nogami, Kazumitsu Maehara, Yasuyuki Ohkawa, Atsushi Matsumoto, Hidetoshi Kono, Rintaro Inoue, Masaaki Sugiyama, Hitoshi Kurumizaka
    • Journal Title

      Science

      Volume: 356 Issue: 6334 Pages: 205-208

    • DOI

      10.1126/science.aak9867

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Histone variant H2A.L.2 guides transition protein-dependent protamine assembly in male germ cells2017

    • Author(s)
      Barral S, Morozumi Y, Tanaka H, Montellier E, Govin J, de Dieuleveult M, Charbonnier G, Coute Y, Puthier D, Buchou T, Boussouar F, Urahama T, Fenaille F, Curtet S, Hery P, Fernandez-Nunez N, Shiota H, Gerard M, Rousseaux S, Kurumizaka H, Khochbin S.
    • Journal Title

      Molecular Cell

      Volume: 66 Issue: 1 Pages: 89-101

    • DOI

      10.1016/j.molcel.2017.02.025

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Structural diversity of the nucleosome2017

    • Author(s)
      Koyama M., Kurumizaka H.
    • Journal Title

      The Journal of Biochemistry

      Volume: 163 Issue: 2 Pages: 85-95

    • DOI

      10.1093/jb/mvx081

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Activation of the FA pathway mediated by phosphorylation and ubiquitination2017

    • Author(s)
      Ishiai M., Sato K, Tomida J, Kitao H., Kurumizaka H., Takata M.
    • Journal Title

      Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

      Volume: 803-805 Pages: 89-95

    • DOI

      10.1016/j.mrfmmm.2017.05.003

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Xeroderma pigmentosum group C protein interacts with histones: regulation by acetylated states of histone H3.2017

    • Author(s)
      Kakumu E
    • Journal Title

      Genes Cells.

      Volume: 3 Issue: 3 Pages: 310-327

    • DOI

      10.1111/gtc.12479

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Polymorphism of apyrimidinic DNA structures in the nucleosome.2017

    • Author(s)
      Osakabe, A., Arimura, Y., Matsumoto, S., Horikoshi, N., Sugasawa, K., Kurumizaka, H.
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 41783-41783

    • DOI

      10.1038/srep41783

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of the amino acid residues responsible for stable nucleosome formation by histone H3.Y.2017

    • Author(s)
      Kujirai T, Horikoshi N, Xie Y, Taguchi H, Kurumizaka H.
    • Journal Title

      Nucleus.

      Volume: - Issue: 3 Pages: 1-10

    • DOI

      10.1080/19491034.2016.1277303

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Testis-Specific Histone Variant H3t Gene Is Essential for Entry into Spermatogenesis2017

    • Author(s)
      Ueda J., Harada A., Urahama T., Machida S., Maehara K., Hada M., Makino Y., Nogami J., Horikoshi N., Osakabe A., Taguchi H., Tanaka H., Tachiwana H., Yao T., Yamada M., Iwamoto T., Isotani A., Ikawa M., Tachibana T., Okada Y., Kimura H., Ohkawa Y., Kurumizaka H., Yamagata K.
    • Journal Title

      Cell Reports

      Volume: 18(3) Issue: 3 Pages: 593-600

    • DOI

      10.1016/j.celrep.2016.12.065

    • NAID

      120006957416

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] In vitro reconstitution and biochemical analyses of theSchizosaccharomyces pombe nucleosome.2017

    • Author(s)
      Masako Koyama, Wataru Nagakura, Hiroki Tanaka, Tomoya Kujirai, Yuji Chikashige, Tokuko Haraguchi, Yasushi Hiraoka, Hitoshi Kurumizaka.
    • Journal Title

      Biochemical and biophysical research communications.

      Volume: 482 Issue: 4 Pages: 896-901

    • DOI

      10.1016/j.bbrc.2016.11.130

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Influence of polynucleosome preparation methods on sedimentation velocity analysis of chromatin.2017

    • Author(s)
      Kujirai T, Machida S, Osakabe A, Kurumizaka H.
    • Journal Title

      J. Biochem.

      Volume: 161 Issue: 4 Pages: 381-388

    • DOI

      10.1093/jb/mvw081

    • NAID

      40021219908

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Constitutive centromere-associated network controls centromere drift in vertebrate cells2017

    • Author(s)
      Hori, T. Kagawa, N. Toyoda, A. Fujiyama, A. Misu, S. Monma, N. Makino, F. Ikeo, K. Fukagawa, T.
    • Journal Title

      The Journal of cell biology

      Volume: 1 Issue: 1 Pages: 101-113

    • DOI

      10.1083/jcb.201605001

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A genetically encoded probe for live-cell imaging of H4K20 monomethylation2016

    • Author(s)
      Sato Y., Kujirai T., Arai R., Asakawa H., Ohtsuki C., Horikoshi N., Yamagata K., Ueda J., Nagase T., Haraguchi T., Hiraoka Y., Kimura A., Kurumizaka H., Kimura, H.
    • Journal Title

      J. Mol. Biol.

      Volume: 428 Issue: 20 Pages: 3885-3902

    • DOI

      10.1016/j.jmb.2016.08.010

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structure of the human DNA repair protein RAD52 containing surface mutations.2016

    • Author(s)
      Saotome, M., Saito, K., Onodera, K., Kurumizaka, H., and Kagawa, W.
    • Journal Title

      Acta Cryst. F

      Volume: 72 Issue: 8 Pages: 598-603

    • DOI

      10.1107/s2053230x1601027x

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The Flexible Ends of CENP-A Nucleosome Are Required for Mitotic Fidelity2016

    • Author(s)
      Roulland Y, Ouararhni K, Naidenov M, Ramos L, Shuaib M, Syed SH, Lone IN, Boopathi R, Fontaine E, Papai G, Tachiwana H, Gautier T, Skoufias D, Padmanabhan K, Bednar J, Kurumizaka H, Schultz P, Angelov D, Hamiche A, Dimitrov S.
    • Journal Title

      Mol Cell.

      Volume: 63 Issue: 4 Pages: 674-685

    • DOI

      10.1016/j.molcel.2016.06.023

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Structure and function of human histone H3.Y nucleosome.2016

    • Author(s)
      Kujirai, T., Horikoshi, N., Sato, K., Maehara, K., Machida, S., Osakabe, A., Kimura, H., Ohkawa, Y. and Kurumizaka, H.
    • Journal Title

      Nucleic Acids Research

      Volume: 1 Issue: 13 Pages: 1-15

    • DOI

      10.1093/nar/gkw202

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structural and biochemical analyses of monoubiquitinated human histones H2B and H42016

    • Author(s)
      Machida S, Sekine S, Nishiyama Y, Horikoshi N, Kurumizaka H.
    • Journal Title

      Open Biol.

      Volume: 6 Issue: 6 Pages: 160090-160090

    • DOI

      10.1098/rsob.160090

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Crystal structures of heterotypic nucleosomes containing histones H2A.Z and H2A2016

    • Author(s)
      Horikoshi N, Arimura Y, Taguchi H, Kurumizaka H.
    • Journal Title

      Open Biol.

      Volume: 6 Issue: 6 Pages: 160127-160127

    • DOI

      10.1098/rsob.160127

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Chromatin architecture may dictate the target site for DMC1, but not for RAD51, during homologous pairing2016

    • Author(s)
      Kobayashi W., Takaku M., Machida S., Tachiwana H., Maehara K., Ohkawa Y. and Kurumizaka H
    • Journal Title

      Scientific reports

      Volume: 6 Issue: 1 Pages: 24428-24428

    • DOI

      10.1038/srep24228

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Crystal structure of the nucleosome containing ultraviolet light-induced cyclobutane pyrimidine dimer.2016

    • Author(s)
      Horikoshi N, Tachiwana H, Kagawa W, Osakabe A, Matsumoto S, Iwai S, Sugasawa K, Kurumizaka H.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 471 Issue: 1 Pages: 117-122

    • DOI

      10.1016/j.bbrc.2016.01.170

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] GATA3-dependent cellular reprogramming requires activation-domain dependent recruitment of a chromatin remodeler.2016

    • Author(s)
      Takaku M, Grimm SA, Shimbo T, Perera L, Menafra R, Stunnenberg HG, Archer TK, Machida S, Kurumizaka H, Wade P.
    • Journal Title

      Genome Biol.

      Volume: 17 Issue: 1 Pages: 36-36

    • DOI

      10.1186/s13059-016-0897-0

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Histone H3.5 forms an unstable nucleosome and accumulates around transcription start sites in human testis.2016

    • Author(s)
      Urahama T, Harada A, Maehara K, Horikoshi N, Sato K, Sato Y, Shiraishi K, Sugino N, Osakabe A, Tachiwana H, Kagawa W, Kimura H, Ohkawa Y, Kurumizaka H.
    • Journal Title

      Epigenetics Chromatin

      Volume: 9 Issue: 1 Pages: 1-16

    • DOI

      10.1186/s13072-016-0051-y

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relaxed Chromatin Formation and Weak Suppression of Homologous Pairing by the Testis-Specific Linker Histone H1T.2016

    • Author(s)
      Machida S, Hayashida R, Takaku M, Fukuto A, Sun J, Kinomura A, Tashiro S, Kurumizaka H.
    • Journal Title

      Biochemistry.

      Volume: 55 Issue: 4 Pages: 637-646

    • DOI

      10.1021/acs.biochem.5b01126

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Crystal structure of the nucleosome containing histone H3 with crotonylated lysine 122.2016

    • Author(s)
      Suzuki Y, Horikoshi N, Kato D, Kurumizaka H.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 469 Issue: 3 Pages: 483-489

    • DOI

      10.1016/j.bbrc.2015.12.041

    • Related Report
      2015 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] Bivalent interaction of the PZP domain of BRPF1 with the nucleosome impacts chromatin dynamics and acetylation.2016

    • Author(s)
      Klein BJ, Muthurajan UM, Lalonde ME, Gibson MD, Andrews FH, Hepler M, Machida S, Yan K, Kurumizaka H, Poirier MG, Cote J, Luger K, Kutateladze TG.
    • Journal Title

      Nucleic Acids Res.

      Volume: 44 Issue: 1 Pages: 472-484

    • DOI

      10.1093/nar/gkv1321

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Structural basis of pyrimidine-pyrimidone (6-4) photoproduct recognition by UV-DDB in the nucleosome.2015

    • Author(s)
      Osakabe, A., Tachiwana, H., Kagawa, W., Horikoshi, N., Matsumoto, S., Hasegawa, M., Matsumoto, N., Toga, T., Yamamoto, J., Hanaoka, F., Thoma, N.H., Sugasawa, K., Iwai, S., Kurumizaka, H.
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 16330-16330

    • DOI

      10.1038/srep16330

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Influence of DNA methylation on positioning and DNA flexibility of nucleosomes with pericentric satellite DNA.2015

    • Author(s)
      Osakabe A, Adachi F, Arimura Y, Maehara K, Ohkawa Y, Kurumizaka H.
    • Journal Title

      Open Biol.

      Volume: 5 Issue: 10 Pages: 150128-150128

    • DOI

      10.1098/rsob.150128

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Structure of RizA, an L-amino-acid ligase from Bacillus subtilis.2015

    • Author(s)
      Kagawa W, Arai T, Ishikura S, Kino K, Kurumizaka H.
    • Journal Title

      Acta Crystallogr F Struct Biol Commun.

      Volume: 71 Issue: 9 Pages: 1125-1130

    • DOI

      10.1107/s2053230x15012698

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Human FAN1 promotes strand incision in 5'-flapped DNA complexed with RPA.2015

    • Author(s)
      Takahashi D, Sato K, Hirayama E, Takata M, Kurumizaka H.
    • Journal Title

      J Biochem

      Volume: 158 Issue: 3 Pages: 263-70

    • DOI

      10.1093/jb/mvv043

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Stable complex formation of CENP-B with the CENP-A nucleosome.2015

    • Author(s)
      Fujita R, Otake K, Arimura Y, Horikoshi N, Miya Y, Shiga T, Osakabe A, Tachiwana H, Ohzeki JI, Larionov V, Masumoto H, Kurumizaka H.
    • Journal Title

      Nucleic Acids Res.

      Volume: in press Issue: 10 Pages: 4949-4922

    • DOI

      10.1093/nar/gkv405

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Dynamic changes in CCAN organization through CENP-C during cell-cycle progression.2015

    • Author(s)
      Nagpal H, Hori T, Furukawa A, Sugase K, Osakabe A, Kurumizaka H, Fukagawa T
    • Journal Title

      Molecular biology of the cell

      Volume: 26 Issue: 21 Pages: 3768-3776

    • DOI

      10.1091/mbc.e15-07-0531

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nucleosome organization and chromatin dynamics in telomeres2015

    • Author(s)
      Yuichi Ichikawa, Yoshifumi Nishimura, Hitoshi Kurumizaka, and Mitsuhiro Shimizu
    • Journal Title

      Biomolecular Concepts

      Volume: 6 Issue: 1 Pages: 67-75

    • DOI

      10.1515/bmc-2014-0035

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Charge-neutralization effect of the tail regions on the histone H2A/H2B dimer structure.2015

    • Author(s)
      Saikusa, K., Shimoyama, S., Asano, Y., Nagadoi, A., Sato, M., Kurumizaka, H., Nishimura, Y., and Akashi, S.
    • Journal Title

      Protein Science

      Volume: - Issue: 8 Pages: 20-27

    • DOI

      10.1002/pro.2673

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Two arginine residues suppress the flexibility of nucleosomal DNA in the canonical nucleosome core.2015

    • Author(s)
      Kono H, Shirayama K, Arimura Y, Tachiwana H, Kurumizaka H.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 3 Pages: e0120635-e0120635

    • DOI

      10.1371/journal.pone.0120635

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Human tNASP promotes in vitro nucleosome assembly with histone H3.3.2015

    • Author(s)
      Kato, D., Osakabe, A., Tachiwana, H., Tanaka, H., and Kurumizaka, H.
    • Journal Title

      Biochemistry

      Volume: 54 Issue: 5 Pages: 1171-1179

    • DOI

      10.1021/bi501307g

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Mass spectrometric approach for characterizing the disordered tail regions of the histone H2A/H2B dimer.2015

    • Author(s)
      Saikusa, K., Nagadoi, A., Hara, K., Fuchigami, S., Kurumizaka, H., Nishimura, Y., and Akashi, S.
    • Journal Title

      Anal. Chem.

      Volume: 87 Issue: 4 Pages: 2220-2227

    • DOI

      10.1021/ac503689w

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Green fluorescent protein fused to the C terminus of RAD51 specifically interferes with secondary DNA binding by the RAD51-ssDNA complex2014

    • Author(s)
      Kobayashi, W., Sekine, S., Machida, S., and Kurumizaka, H.
    • Journal Title

      Genes & Genetic Systems

      Volume: 89 Issue: 4 Pages: 169-179

    • DOI

      10.1266/ggs.89.169

    • NAID

      130004750050

    • ISSN
      1341-7568, 1880-5779
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Defective FANCI Binding by a Fanconi Anemia-Related FANCD2 Mutant.2014

    • Author(s)
      Sato K, Ishiai M, Takata M, Kurumizaka H.
    • Journal Title

      PLoS One

      Volume: 9 Issue: 12 Pages: e114752-e114752

    • DOI

      10.1371/journal.pone.0114752

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Crystal structure and stable property of the cancer-associated heterotypic nucleosome containing CENP-A and H3.3.2014

    • Author(s)
      Arimura Y, Shirayama K, Horikoshi N, Fujita R, Taguchi H, Kagawa W, Fukagawa T, Almouzni G, Kurumizaka H.
    • Journal Title

      Sci Rep.

      Volume: 4 Issue: 1 Pages: 7115-7115

    • DOI

      10.1038/srep07115

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A method for evaluating nucleosome stability with a protein-binding fluorescent dye.2014

    • Author(s)
      Taguchi H, Horikoshi N, Arimura Y, Kurumizaka H.
    • Journal Title

      Methods.

      Volume: 70 Issue: 2-3 Pages: 119-126

    • DOI

      10.1016/j.ymeth.2014.08.019

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] N-terminal phosphorylation of HP1α increases its nucleosome-binding specificity.2014

    • Author(s)
      Nishibuchi G, Machida S, Osakabe A, Murakoshi H, Hiragami-Hamada K, Nakagawa R, Fischle W, Nishimura Y, Kurumizaka H, Tagami H, Nakayama JI.
    • Journal Title

      Nucleic Acids Res.

      Volume: 42 Issue: 20 Pages: 12498-12511

    • DOI

      10.1093/nar/gku995

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] DNA binding properties of the actin-related protein Arp8 and its role in DNA repair.2014

    • Author(s)
      Osakabe, A., Takahashi, Y., Murakami, H., Otawa, K., Tachiwana, H., Oma, Y., Hitoshi Nishijima, H., Shibahara, K., Kurumizaka, H., Harata, M.
    • Journal Title

      PLoS One

      Volume: 9 Issue: 10 Pages: e108354-e108354

    • DOI

      10.1371/journal.pone.0108354

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expression and purification of human FANCI and FANCD2 using Escherichia coli cells.2014

    • Author(s)
      Daisuke Takahashi, Koichi Sato, Mayo Shimomuki, Minoru Takata, Hitoshi Kurumizaka
    • Journal Title

      Protein Expression and Purification

      Volume: 103 Pages: 8-15

    • DOI

      10.1016/j.pep.2014.08.012

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Evaluation of chemical fluorescent dyes as a protein conjugation partner for live cell imaging.2014

    • Author(s)
      Hayashi-Takanaka Y, Stasevich TJ, Kurumizaka H, Nozaki N, Kimura H
    • Journal Title

      PLoS One

      Volume: 9 Issue: 9 Pages: e106271-e106271

    • DOI

      10.1371/journal.pone.0106271

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Nap1 stimulates homologous recombination by RAD51 and RAD54 in higher-ordered chromatin containing histone H1.2014

    • Author(s)
      Machida, S., Takaku, M., Ikura, M., Sun, J., Suzuki, H., Kobayashi, W., Kinomura, A., Osakabe, A., Tachiwana, H., Horikoshi, Y., Fukuto, A., Matsuda, R., Ura, K., Tashiro, S., Ikura, T., and Kurumizaka, H.
    • Journal Title

      Scientific Rep.

      Volume: 4 Issue: 1 Pages: 4863-4863

    • DOI

      10.1038/srep04863

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Distinct features of the histone core structure in nucleosomes containing the histone H2A.B variant.2014

    • Author(s)
      Sugiyama M, Arimura Y, Shirayama K, Fujita R, Oba Y, Sato N, Inoue R, Oda T, Sato M, Heenan RK, Kurumizaka H.
    • Journal Title

      Biophys J.

      Volume: 106 Issue: 10 Pages: 2206-2213

    • DOI

      10.1016/j.bpj.2014.04.007

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] FANCD2 Binds CtIP and Regulates DNA-End Resection during DNA Interstrand Crosslink Repair.2014

    • Author(s)
      Unno J
    • Journal Title

      Cell Rep.

      Volume: 7 Issue: 4 Pages: 1039-1047

    • DOI

      10.1016/j.celrep.2014.04.005

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Crystal structure of human nucleosome containing the testis-specific histone variant TSH2B.2014

    • Author(s)
      Urahama, T., Horikoshi, N., Osakabe, A., Tachiwana, H., and Kurumizaka, H.
    • Journal Title

      Acta Cryst.

      Volume: F70 Issue: 4 Pages: 444-449

    • DOI

      10.1107/s2053230x14004695

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Histone H4 Lys 20 monomethylation of the CENP-A nucleosome is essential for kinetochore assembly.2014

    • Author(s)
      Hori, T., Shang, W.H., Toyoda, A., Misu, S., Monma, N., Ikeo, K., Molina, O., Vargiu, G., Fujiyama, A., Kimura, H., Earnshaw, W.C., Fukagawa, T.
    • Journal Title

      Dev Cell

      Volume: 29 Issue: 6 Pages: 740-749

    • DOI

      10.1016/j.devcel.2014.05.001

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The CENP-O complex requirement varies among different cell types.2014

    • Author(s)
      Kagawa, N., Hori, T., Hoki, Y., Hosoya, O., Tsutsui, K., Saga, Y., Sado, T., and *Fukagawa, T.
    • Journal Title

      Chrom. Research

      Volume: in press Issue: 3 Pages: 293-303

    • DOI

      10.1007/s10577-014-9404-1

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mislocalization of the centromeric histone variant CenH3/CENP-A in human cells depends on the chaperone DAXX.2014

    • Author(s)
      Lacoste, N., Woolfe, A., Tachiwana, H., Villar Garea, A., Barth, T., Cantaloube, S., Kurumizaka, H., Imhof, A., and Almouzni, G.
    • Journal Title

      Molecular Cell

      Volume: 53 Issue: 4 Pages: 631-644

    • DOI

      10.1016/j.molcel.2014.01.018

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The centromeric nucleosome-like CENP-T-W-S-X complex induces positive supercoils into DNA.2013

    • Author(s)
      Kozo Takeuchi, Tatsuya Nishino, Kouta Mayanagi, Naoki Horikoshi, Akihisa Osakabe, Hiroaki Tachiwana, Tetsuya Hori, Hitoshi Kurumizaka and Tatsuo Fukagawa.
    • Journal Title

      Nucleic Acids Research

      Volume: 42 Issue: 3 Pages: 1644-1655

    • DOI

      10.1093/nar/gkt1124

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structural basis of a nucleosome containing histone H2A. B/H2A. Bbd that transiently associates with reorganized chromatin.2013

    • Author(s)
      Arimura Y., Kimura H., Oda T., Sato K., Osakabe A., Tachiwana H., Sato Y., Kinugasa Y., Ikura T., Sugiyama M., Sato M., Kurumizaka H.
    • Journal Title

      Sci Rep.

      Volume: 3 Issue: 1 Pages: 3510-3510

    • DOI

      10.1038/srep03510

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structural polymorphism in the L1 loop regions of human H2A. Z. 1 and H2A. Z. 2.2013

    • Author(s)
      Naoki Horikoshi, Koichi Sato, Keisuke Shimada, Yasuhiro Arimura, Akihisa Osakabe, Hiroaki Tachiwana, Yoko Hayashi-Takanaka, Wakana Iwasaki, Wataru Kagawa, Masahiko Harata, Hiroshi Kimura and Hitoshi Kurumizaka.
    • Journal Title

      Acta Crystallographica Section D

      Volume: 69 Issue: 12 Pages: 2431-2439

    • DOI

      10.1107/s090744491302252x

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conclusive evidence of the reconstituted hexasome proven by native mass spectrometry2013

    • Author(s)
      Azegami, N., Saikusa, K., Todokoro, Y., Nagadoi, A., Kurumizaka, H., Nishimura, Y., and Akashi, S.
    • Journal Title

      Biochemistry

      Volume: 52 Issue: 31 Pages: 5155-5157

    • DOI

      10.1021/bi4005655

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contribution of histone N-terminal tails to the structure and stability of nucleosomes.2013

    • Author(s)
      Wakana Iwasaki, Yuta Miya, Naoki Horikoshi, Akihisa Osakabe, Hiroyuki Taguchi, Hiroaki Tachiwana, Takehiko Shibata, Wataru Kagawa and Hitoshi Kurumizaka.
    • Journal Title

      FEBS Open Bio

      Volume: 3 Issue: 1 Pages: 363-369

    • DOI

      10.1016/j.fob.2013.08.007

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetically encoded system to track histone modification in vivo.2013

    • Author(s)
      Yuko Sato, Masanori Mukai, Jun Ueda, Michiko Muraki, Timothy J. Stasevich, Naoki Horikoshi, Tomoya Kujirai, Hiroaki Kita, Taisuke Kimura, Seiji Hira, Yasushi Okada, Yoko Hayashi-Takanaka, Chikashi Obuse, Hitoshi Kurumizaka, Atsuo Kawahara, Kazuo Yamagata, Naohito Nozaki and Hiroshi Kimura
    • Journal Title

      Scientific Reports

      Volume: 3 Issue: 1 Pages: 2436-2436

    • DOI

      10.1038/srep02436

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Nucleosome Remodeling and Structure2018

    • Author(s)
      Hitoshi Kurumizaka
    • Organizer
      INDO-JAPAN Conference (2018): Epigenetics, Human Microbiomes and Disease
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 形からみる遺伝子のはたらき2018

    • Author(s)
      胡桃坂 仁志
    • Organizer
      文部科学省科科学研究費補助金新学術領域「動的クロマチン構造と機能」一般公開シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] クロマチンの高次構造とダイナミクスの相関構造解析2018

    • Author(s)
      胡桃坂 仁志
    • Organizer
      第31回日本放射光学会年会・放射光科学合同シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] クロマチンコーディングの構造基盤2018

    • Author(s)
      胡桃坂 仁志
    • Organizer
      染色体研究の最前線2018
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Structural basis of epigenetic chromatin regulation2017

    • Author(s)
      Hitoshi Kurumizaka
    • Organizer
      The 5th International Symposium of the Mathematics on Chromatin Dynamics
    • Place of Presentation
      広島
    • Year and Date
      2017-03-07
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] クライオ電験とX線結晶構造解析によるクロマチン高次構造とダイナミクス2017

    • Author(s)
      胡桃坂 仁志
    • Organizer
      よこはまNMR研究会 第56回ワークショップ
    • Place of Presentation
      横浜
    • Year and Date
      2017-03-03
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Structural studies for functional chromatin2017

    • Author(s)
      Hitoshi Kurumizaka
    • Organizer
      Japan-Swiss Symposium Chromatin Structure and Dynamics
    • Place of Presentation
      スイス
    • Year and Date
      2017-01-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 染色体の構造基盤2017

    • Author(s)
      胡桃坂 仁志
    • Organizer
      ワークショップ染色体研究の最前線
    • Place of Presentation
      大阪
    • Year and Date
      2017-01-16
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Chromatin contribution in DNA repair2017

    • Author(s)
      Hitoshi Kurumizaka
    • Organizer
      The 6th US-Japan DNA Repair Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Structural versatility and dynamics of chromatin units2017

    • Author(s)
      Hitoshi Kurumizaka
    • Organizer
      EMBO CONFERENCE “The Nucleosome: From Atoms to Genomes”
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Structural studies of reconstituted chromatin units2017

    • Author(s)
      Hitoshi Kurumizaka
    • Organizer
      HMGU-Japan Epigenetics and Chromatin Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Structural Biology of Epigenetic Chromatin Regulation2017

    • Author(s)
      Hitoshi Kurumizaka
    • Organizer
      15th Chinese Biophysics Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] エピジェネティクスの制御基盤としてのクロマチン構造多様性2017

    • Author(s)
      胡桃坂 仁志
    • Organizer
      DSSBシンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Structural studies for dynamic chromatin architecture2017

    • Author(s)
      胡桃坂 仁志
    • Organizer
      Dynamic Structural Biology"(DSB)第一回研究報告会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ヌクレオソームの構造と動的多様性によるゲノムDNA機構制御2017

    • Author(s)
      胡桃坂 仁志
    • Organizer
      第17回日本蛋白質科学会年会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 細胞核でのクロマチン機能制御の構造基盤2017

    • Author(s)
      胡桃坂 仁志
    • Organizer
      日本大学文理学部生命科学科セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ゲノムDNA機能制御のクロマチン構造基盤2017

    • Author(s)
      胡桃坂 仁志
    • Organizer
      大阪大学蛋白質研究所セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ヌクレオソームのリモデリング機構2017

    • Author(s)
      胡桃坂 仁志
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] クロマチン構造とゲノム機能制御機構2017

    • Author(s)
      胡桃坂 仁志
    • Organizer
      平成29年度遺伝研研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 再構成クロマチンによるエピジェネティクス機構の解析2017

    • Author(s)
      胡桃坂 仁志
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Epigenetics and Kinetochore assembly in Vertebrate Cells2017

    • Author(s)
      堀 哲也
    • Organizer
      EMBO Workshop "Dynamic kinetochore"
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] セントロメア機能に必須なエピジェネティック機構2017

    • Author(s)
      堀 哲也
    • Organizer
      第40回日本分子生物学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 岡崎フラグメント50周年シンポジウム2016

    • Author(s)
      胡桃坂 仁志
    • Organizer
      岡崎フラグメント50周年シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2016-12-21
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] エピジェネティクスのクロマチン構造基盤2016

    • Author(s)
      胡桃坂 仁志
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Three dimensional structures and dynamics of chromatin2016

    • Author(s)
      胡桃坂 仁志
    • Organizer
      第54回生物物理学会
    • Place of Presentation
      つくば
    • Year and Date
      2016-11-25
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Structural studies for epigenetic regulation of genomic DNA2016

    • Author(s)
      Hitoshi Kurumizaka
    • Organizer
      10th International 3R (Replication, Recombination and Repair) Symposium
    • Place of Presentation
      松江
    • Year and Date
      2016-11-13
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] クロマチン・細胞核の動的構造変換とエピジェネティック制御2016

    • Author(s)
      胡桃坂 仁志
    • Organizer
      平成28年度遺伝研研究会
    • Place of Presentation
      三島
    • Year and Date
      2016-10-27
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] がん細胞で見られるヒストン変異のクロマチン構造・動態変動への影響2016

    • Author(s)
      胡桃坂 仁志
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Structural Versatility of Nucleosomes and Chromatin Dynamics2016

    • Author(s)
      Hitoshi Kurumizaka
    • Organizer
      Colorado Chromatin Meeting 2016
    • Place of Presentation
      アメリカ
    • Year and Date
      2016-08-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Structural basis of chromatin dynamics2016

    • Author(s)
      Hitoshi Kurumizaka
    • Organizer
      Telluride workshop on chromatin structure and dynamics
    • Place of Presentation
      アメリカ
    • Year and Date
      2016-08-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ALTERED STRUCTURES AND PHYSICAL CHARACTERISTICS OF NUCLEOSOMES CONTAINING CANCER-ASSOCIATED HISTONE MUTATIONS2016

    • Author(s)
      Hitoshi Kurumizaka
    • Organizer
      DNA metabolism, genome stability and diseases
    • Place of Presentation
      中国
    • Year and Date
      2016-06-13
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] HISTONE CONTRIBUTIONS TO CHROMATIN DYNAMICS2016

    • Author(s)
      Hitoshi Kurumizaka
    • Organizer
      Chromatin, Epigenetics and Transcription
    • Place of Presentation
      中国
    • Year and Date
      2016-05-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 天然変性ハブとしてのクロマチン構造2016

    • Author(s)
      胡桃坂 仁志
    • Organizer
      横浜NMR研究会
    • Place of Presentation
      理化学研究所、横浜
    • Year and Date
      2016-01-08
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] クロマチン構造とダイナミクスの分子機構2015

    • Author(s)
      胡桃坂 仁志
    • Organizer
      国際高等研究所 クロマチン・デコーディング
    • Place of Presentation
      国際高等研究所、京都
    • Year and Date
      2015-12-19
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Structural basis of chromatin dynamics2015

    • Author(s)
      Hitoshi Kurumizaka
    • Organizer
      4th International Symposium of the Mathematics on Chromatin Live Dynamics
    • Place of Presentation
      JMSアステールプラザ,広島
    • Year and Date
      2015-12-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] クロマチン構造によるDNA機能のエピジェネティック制御2015

    • Author(s)
      胡桃坂 仁志
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド、神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ヒストンバリアントによるクロマチン動構造制御2015

    • Author(s)
      胡桃坂 仁志
    • Organizer
      遺伝研研究会 クロマチン・細胞核構造の形成とダイナミクスによるゲノム機能制御
    • Place of Presentation
      国立遺伝学研究所、三島
    • Year and Date
      2015-10-29
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Structural properties of the nucleosomes containing cancer-associated mutations2015

    • Author(s)
      胡桃坂 仁志
    • Organizer
      大阪大学蛋白研セミナーNuclear organization and actin-dependent mechanisms in genome stability
    • Place of Presentation
      大阪大学蛋白質研究所、吹田
    • Year and Date
      2015-05-18
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 原子レベルで見る生命の設計図2015

    • Author(s)
      胡桃坂仁志
    • Organizer
      一般公開シンポジウム第2弾「生き物と細胞の設計図~DNA・クロマチン・核」
    • Place of Presentation
      千里ライフサイエンスセンター
    • Year and Date
      2015-01-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Structural and functional studies of various nucleosomes as fundamental building blocks for Chromatin2014

    • Author(s)
      Kurumizaka, H.
    • Organizer
      The 4D Nucleosome 2014
    • Place of Presentation
      安芸グランドホテル
    • Year and Date
      2014-12-17 – 2014-12-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Structural basis of the nucleosomes in the transcription start site2014

    • Author(s)
      Naoki Horikoshi, Koichi Sato, Yasuhiro Arimura, Hiroyuki Taguchi, Masahiko Harata, Hiroshi Kimura, Hitoshi Kurumizaka
    • Organizer
      The 4D Nucleome 2014
    • Place of Presentation
      広島
    • Year and Date
      2014-12-17 – 2014-12-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヌクレオソームの安定性におけるH3 K122のクロトニル化の影響2014

    • Author(s)
      鈴木佑弥. 堀越直樹. 胡桃坂仁志
    • Organizer
      32回染色体ワークショップ、13回核ダイナミックス
    • Place of Presentation
      広島県廿日市市
    • Year and Date
      2014-12-15 – 2014-12-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヒストンシャペロンtNASPはヒストンH3.3特異的にヌクレオソームの形成を触媒する2014

    • Author(s)
      加藤大貴,越阪部晃永,立和名博昭,胡桃坂仁志
    • Organizer
      32回染色体ワークショップ、13回核ダイナミックス
    • Place of Presentation
      広島県廿日市市
    • Year and Date
      2014-12-15 – 2014-12-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] 新規マウスヒストンH3バリアントを含むヌクレオソームの構造安定性と機能解析2014

    • Author(s)
      田口裕之, 堀越直樹, 謝炎, 鯨井智也, 有村泰宏, 越阪部晃永, 前原一満, 木村宏, 大川恭行, 胡桃坂仁志
    • Organizer
      第32回染色体ワークショップ・第13回核ダイナミクス研究会
    • Place of Presentation
      広島県廿日市市
    • Year and Date
      2014-12-15 – 2014-12-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] CENP-A ヌクレオソームのフレキシブルな DNA 末端はセントロメアタンパク質 CENP-B の結合を安定化する2014

    • Author(s)
      藤田 理紗, 大竹 興一郎, 有村 泰宏, 堀越 直樹, 宮 優太, 志賀 達哉, 越阪部 晃永, 立和名 博昭, 大関 淳一郎, 舛本 寛, 胡桃坂 仁志
    • Organizer
      第32回染色体ワークショップ
    • Place of Presentation
      広島県廿日市市
    • Year and Date
      2014-12-15 – 2014-12-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] 転写開始点近傍に形成される多様なヌクレオソームのX線結晶構造解析2014

    • Author(s)
      堀越直樹, 佐藤浩一, 有村泰宏, 田口裕之, 原田昌彦, 木村宏, 胡桃坂仁志
    • Organizer
      第32回染色体ワークショップ 第13回核ダイナミクス研究会
    • Place of Presentation
      広島
    • Year and Date
      2014-12-15 – 2014-12-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヒストンH3.YのC末端領域は安定なヌクレオソーム形成に重要である2014

    • Author(s)
      鯨井智也、堀越直樹、佐藤浩一、前原一満、越阪部晃永、町田晋一、田口裕之、立和名博昭、大川恭行、木村宏、胡桃坂仁志
    • Organizer
      第32回染色体ワークショップ 第13回核ダイナミクス研究会
    • Place of Presentation
      広島 廿日市市
    • Year and Date
      2014-12-15 – 2014-12-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] クロマチンのエピジェネティック制御と創薬2014

    • Author(s)
      胡桃坂仁志
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] マウス精巣特異的な発現を示すヒストンバリアントH3mmTを含むヌクレオソームの構造解析および生化学的解析2014

    • Author(s)
      浦浜 嵩、堀越 直樹、田口 裕之、鈴木 佑弥、越阪部 晃永、木村 宏、大川 恭行、胡桃坂 仁志
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] CENP-Aヌクレオソーム特異的DNA構造のセントロメアタンパク質CENP-B結合への影響2014

    • Author(s)
      藤田 理紗、宮 優太、志賀 達哉、有村 泰宏、越阪部 晃永、立和名 博昭、胡桃坂 仁志
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] クロトニル化ヒストンH3を含むヌクレオソームの安定性解析2014

    • Author(s)
      鈴木 佑弥、堀越 直樹、胡桃坂 仁志
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヒストンコア領域におけるメチル化がヌクレオソーム構造に及ぼす影響2014

    • Author(s)
      村越 大夢、町田 晋一、堀越 直樹、有村 泰宏、胡桃坂 仁志
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] モノユビキチン化ヒストンを含むヌクレオソームの解析2014

    • Author(s)
      西山 友貴、町田 晋一、有村 泰宏、堀越 直樹、小林 航、胡桃坂 仁志
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 霊長類特異的ヒストンバリアントH3.Yを含むヌクレオソームの機能解析2014

    • Author(s)
      鯨井 智也、堀越 直樹、佐藤 浩一、前原 一満、越阪部 晃永、町田 晋一、田口 裕之、立和名 博昭、大川 恭行、木村 宏、胡桃坂 仁志
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヒストンシャペロンNASPアイソフォーム、testicular NASP (tNASP)の生化学的解析2014

    • Author(s)
      加藤 大貴、越阪部 晃永、胡桃坂 仁志
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] マウス特異的ヒストンバリアントH3mm7を含むヌクレオソームの構造生物学的解析及び生化学的解析2014

    • Author(s)
      田口 裕之、堀越 直樹、謝 炎、鯨井 智也、有村 泰宏、越阪部 晃永、前原 一満、木村 宏、大川 恭行、胡桃坂 仁志
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Overlapping di-nucleosomeの再構成および生化学・構造生物学的解析2014

    • Author(s)
      足立 風水也、越阪部 晃永、有村 泰宏、加藤 大貴、七種 和美、明石 知子、西村 善文、杉山 正明、胡桃坂 仁志
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヌクレオソームにおける紫外線損傷塩基の収納およびその認識機構の解析2014

    • Author(s)
      越阪部 晃永、立和名 博昭、堀越 直樹、香川 亘、山元 淳平、安田 武嗣、花岡 文雄、菅澤 薫、岩井 成憲、胡桃坂 仁志
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] DNA損傷修復におけるアクチンファミリーArp8の機能解析2014

    • Author(s)
      村上 寛和、高橋 裕一朗、越阪部 晃永、胡桃坂 仁志、原田 昌彦
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Biochemical studies for homologous recombination reaction in chromatin2014

    • Author(s)
      Kurumizaka, H.
    • Organizer
      The 9th 3R Symposium
    • Place of Presentation
      御殿場高原ホテル時之栖
    • Year and Date
      2014-11-17 – 2014-11-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] Structures of the nucleosomes containing UV-damaged DNA bases and the damaged base recognition mechanism by DNA repair proteins2014

    • Author(s)
      Akihisa Osakabe, Hiroaki Tachiwana, Naoki Horikoshi, Wataru Kagawa, Junpei Yamamoto, Takeshi Yasuda, Fumio Hanaoka, Kaoru Sugasawa, Shigenori Iwai, Hitoshi Kurumizaka
    • Organizer
      US-Japan DNA Repair Meeting
    • Place of Presentation
      徳島
    • Year and Date
      2014-10-28 – 2014-10-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヒストンバリアントによるヌクレオソーム構造とダイナミクス制御2014

    • Author(s)
      胡桃坂仁志
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Structural diversity of H2A.Z nucleosomes at the transcription start site2014

    • Author(s)
      堀越 直樹, 佐藤 浩一, 島田 桂丞, 有村 泰宏, 越阪部 晃永, 田口 裕之, 立和名 博昭, 林-高中 陽子, 岩崎 わかな, 香川 亘, 原田 昌彦, 木村 宏, 胡桃坂 仁志
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] がん化の進行に関わる、ヒストンバリアントCENP-A、H3.3を1分子ずつ含むヌクレオソームの構造生物学解析2014

    • Author(s)
      有村 泰宏, 白山 一義, 堀越 直樹, 藤田 理紗, 田口 裕之, 香川 亘, 胡桃坂 仁志
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 西淵 剛平, 町田 晋一, 越阪部 晃永, 村越 大夢, 浜田 京子, 中川 れい子, Fischle Wolfgang, 胡桃坂 仁志, 田上 英明, 中山 潤一2014

    • Author(s)
      HP1のリン酸化はH3K9me3 nucleosomeに対する結合特異性を制御している
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-15 – 2014-10-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] クロマチン動構造とヒストンバリアント2014

    • Author(s)
      胡桃坂仁志
    • Organizer
      第52回日本生物物理学会年会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] クロマチン構造とダイナミクスの多様性による遺伝子のエピジェネティクス制御機構2014

    • Author(s)
      胡桃坂仁志
    • Organizer
      第26回高遠・分子細胞生物学シンポジウム
    • Place of Presentation
      高遠さくらホテル 長野
    • Year and Date
      2014-08-28 – 2014-08-29
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] がんに関わるヌクレオソームの生化学的・構造生物学的解析2014

    • Author(s)
      有村泰宏, 白山一義, 野田真美子, 藤田理紗, 堀越直樹, 胡桃坂仁志
    • Organizer
      第26回高遠分子細胞生物学シンポジウム
    • Place of Presentation
      長野県伊那市高遠町
    • Year and Date
      2014-08-28 – 2014-08-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] BIOCHEMICAL ANALYSES OF RICE DNA RECOMBINASES RAD51 AND DMC12014

    • Author(s)
      Kurumizaka, H.
    • Organizer
      Plant Genome Stability and Change 2014
    • Place of Presentation
      アシロマカンファレンスセンター アメリカ
    • Year and Date
      2014-07-17 – 2014-07-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 再構成ヌクレオソームを用いた動的クロマチン構造の解明2014

    • Author(s)
      胡桃坂仁志
    • Organizer
      「動的クロマチン構造と機能」第2回班会議
    • Place of Presentation
      サホロリゾート 北海道
    • Year and Date
      2014-07-02 – 2014-07-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヌクレオソーム構造におけるメチル化DNA の寄与2014

    • Author(s)
      越阪部晃永、有村泰宏、足立風水也、堀越直樹、大川恭行、胡桃坂仁志
    • Organizer
      クロマチン動構造 若手交流ワークショップ
    • Place of Presentation
      北海道
    • Year and Date
      2014-07-02 – 2014-07-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] クロマチンの動態構造とDNA機能発現機構2014

    • Author(s)
      胡桃坂仁志
    • Organizer
      第14回日本蛋白質科学会年会
    • Place of Presentation
      ワークピア横浜 横浜産貿ホールマリネリア
    • Year and Date
      2014-06-25 – 2014-06-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Biochemical and structural analyses of the nucleosome containing methylated DNA2014

    • Author(s)
      Akihisa Osakabe, Fumiya Adachi, Yasuhiro Arimura, Naoki Horikoshi, Yasuyuki Ohkawa, Hitoshi Kurumizaka
    • Organizer
      EMBO Workshop Histone variants
    • Place of Presentation
      ドイツ、ストラスブール
    • Year and Date
      2014-06-02 – 2014-06-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] Preparation and analysis of the heterotypic nucleosome with CENP-A and H3.32014

    • Author(s)
      Yasuhiro Arimura, Kazuyoshi Shirayama, Naoki Horikoshi, Risa Fujita, Hiroyuki Taguchi, Wataru Kagawa and Hitoshi Kurumizaka
    • Organizer
      EMBO Workshop on Histone Variants
    • Place of Presentation
      Strasbourg, France
    • Year and Date
      2014-06-02 – 2014-06-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] Structures and physical properties of nucleosome isoforms with histone variants2014

    • Author(s)
      Kurumizaka, H.
    • Organizer
      EMBO meeting on Histone Variants
    • Place of Presentation
      igbmc(フランス国立科学研究センター)
    • Year and Date
      2014-06-02 – 2014-06-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] Structural basis and biological significance of nucleosomes containing human H2A.Z2014

    • Author(s)
      Naoki Horikoshi, Koichi Sato, Yasuhiro Arimura, Akihisa Osakabe, Hiroaki Tachiwana, Yoko Hayashi-Takanaka, Wakana Iwasaki, Masahiko Harata, Hiroshi Kimura, Hitoshi Kurumizaka
    • Organizer
      EMBO Workshop Histone variants
    • Place of Presentation
      Strasbourg, France
    • Year and Date
      2014-06-02 – 2014-06-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] エピジェネティクスにおけるヒストンバリアントの役割2014

    • Author(s)
      胡桃坂仁志
    • Organizer
      第8回日本エピジェネティクス研究会年会
    • Place of Presentation
      東大・伊藤国際学術研究センター
    • Year and Date
      2014-05-25 – 2014-05-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] メチル化DNAを含むヌクレオソームの生化学的・構造生物学的機能解析2014

    • Author(s)
      越阪部晃永, 足立風水也, 有村泰宏, 堀越直樹, 大川恭行, 胡桃坂仁志
    • Organizer
      第8回日本エピジェネティクス研究会年会
    • Place of Presentation
      東京
    • Year and Date
      2014-05-25 – 2014-05-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Functional analysis of the nucleosome containing the primate specific histone variant, H3.Y2014

    • Author(s)
      鯨井智也、堀越直樹、佐藤浩一、前原一満、越阪部晃永、田口裕之、立和名博昭、大川恭行、木村宏、胡桃坂仁志
    • Organizer
      第8回エピジェネティクス研究会年会
    • Place of Presentation
      東京
    • Year and Date
      2014-05-25 – 2014-05-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Structural and functional analysese of nucleosomes containing human H2A.Z2014

    • Author(s)
      Naoki Horikoshi, Koichi Sato, Keisuke Shimada, Yasuhiro Arimura, Akihisa Osakabe, Hiroyuki Taguchi, Hiroaki Tachiwana, Yoko Hayashi-Takanaka, Wakana Iwasaki, Wataru Kagawa, Masahiko Harata, Hiroshi Kimura, Hitoshi Kurumizaka
    • Organizer
      IIAS Research Conference 2014 Chromatin Decoding
    • Place of Presentation
      京都
    • Year and Date
      2014-05-12 – 2014-05-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Structure and dynamics of the nucleosome isoforms2014

    • Author(s)
      Kurumizaka, H.
    • Organizer
      高等研カンファレンス2014「クロマチン・デコーディング」
    • Place of Presentation
      公益財団法人国際高等研究所
    • Year and Date
      2014-05-12 – 2014-05-15
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Structural and biochemical analyses of the heterotypic nucleosome containing CENP-A and H3.32014

    • Author(s)
      Yasuhiro Arimura, Kazuyoshi Shirayama, Naoki Horikoshi, Risa Fujita, Hiroyuki Taguchi, Wataru Kagawa and Hitoshi Kurumizaka
    • Organizer
      IIAF Reserch Conference 2014“Chromatin Decoding”
    • Place of Presentation
      京都府木津川市木津川台
    • Year and Date
      2014-05-12 – 2014-05-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] セントロメアタンパク質CENP-Aによって誘起されるクロマチン構造の多様性2014

    • Author(s)
      胡桃坂 仁志
    • Organizer
      国際高等研究所 研究プロジェクト「クロマチン・デコーディング」2013年度第1回研究会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Structural basis for chromatin dynamics2014

    • Author(s)
      Kurumizaka, H.
    • Organizer
      第2回 クロマチン動態数理研究拠点 国際シンポジウム
    • Place of Presentation
      広島
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] The size of centromere is controlled by coordination of centromere proteins2013

    • Author(s)
      Hori, T.
    • Organizer
      ASCB Annual Meeting
    • Place of Presentation
      New Orleans (USA)
    • Related Report
      2013 Annual Research Report
  • [Presentation] クロマチン機能発現の基盤としてのヌクレオソーム構造多様性2013

    • Author(s)
      胡桃坂仁志
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ICL修復に重要なFAN1ヌクレアーゼの生化学的機能解析2013

    • Author(s)
      佐藤 浩一, 高橋 大介, 平山 恵美子, 高田 穣, 胡桃坂 仁志
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] Histone H3-ubiquitination by UHRF1 in maintenance of DNA methylation2013

    • Author(s)
      高橋大介, 佐藤浩一, 下向真代, 西山敦哉, 中西真, 有田恭平, 胡桃坂仁志
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] CENP-Aヌクレオソームにおける動的なDNA構造とその制御機構2013

    • Author(s)
      有村 泰宏, 越阪部 晃永, 白山 一義, 宮 優太, 竹田 瑶弥, 立和名 博昭, 河野 秀俊, 胡桃坂 仁志
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] メチル化DNAを含むヌクレオソームの再構成および生化学的物理学的解析2013

    • Author(s)
      越阪部晃永, 足立風水也, 加藤大貴, 町田晋一, 堀越直樹, 林田亮太, 胡桃坂仁志
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] Biochemical analysis of the ICL repair proteins, FANCI-FANCD2 complex2013

    • Author(s)
      Koichi Sato, Daisuke Takahashi, Mayo Shimomuki, Emiko Hirayama, Masamichi Ishiai, Minoru Takata, Hitoshi Kurumizaka
    • Organizer
      29th RBC-NIRS International Symposium
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 新規ヒトヒストンバリアント H3F3AP6 を含むヌクレオソームの機能解析2013

    • Author(s)
      田口 裕之、堀越 直樹、佐藤 浩一、有村 泰宏、越阪部 晃永、前原 一満、木村 宏、大川 恭行、胡桃坂 仁志
    • Organizer
      第31回 染色体ワークショップ・第12回 核ダイナミクス研究会
    • Place of Presentation
      箱根
    • Related Report
      2013 Annual Research Report
  • [Presentation] ヒトヒストンバリアントH2A.B を含むヌクレオソームの機能解析2013

    • Author(s)
      有村泰宏,木村宏,小田隆,佐藤浩一,佐藤優子,衣笠泰葉,藤田理紗,白山一義,堀越直樹,越阪部晃永,立和名博昭,杉山正明,佐藤衛,胡桃坂仁志
    • Organizer
      第31回 染色体ワークショップ・第12回 核ダイナミクス研究会
    • Place of Presentation
      箱根
    • Related Report
      2013 Annual Research Report
  • [Presentation] 分裂酵母ヒストンバリアント Pht1 および Cnp1 を含むヌクレオソームの 生化学的解析2013

    • Author(s)
      鈴木佑弥、堀越直樹、鯨井智也、越阪部晃永、近重裕次、平岡泰、 石井浩二郎、胡桃坂仁志
    • Organizer
      第31回染色体ワークショップ・第12回核ダイナミクス研究会
    • Place of Presentation
      箱根
    • Related Report
      2013 Annual Research Report
  • [Presentation] メチル化DNAを含むヌクレオソームの再構成および生化学的解析2013

    • Author(s)
      越阪部晃永, 足立風水也, 竹田瑶弥, 有村泰宏, 堀越直樹, 胡桃坂仁志
    • Organizer
      第31回染色体ワークショップ・第12回核ダイナミクス研究会
    • Place of Presentation
      箱根
    • Related Report
      2013 Annual Research Report
  • [Presentation] セントロメアタンパク質CENP-BのCENP-B boxへの結合におけるCENP-Aヌクレオソームの影響2013

    • Author(s)
      藤田理紗, 宮優太, 白山一義, 竹田瑶弥 , 有村泰宏, 越阪部晃永, 立和名博昭, 胡桃坂仁志
    • Organizer
      第31回染色体ワークショップ・第12回核ダイナミクス研究会
    • Place of Presentation
      箱根
    • Related Report
      2013 Annual Research Report
  • [Presentation] ヒストン修飾特異的scFv の生化学的・構造生物学的解析2013

    • Author(s)
      鯨井智也、堀越直樹、佐藤優子、香川亘、田口裕之、越阪部晃永、立和名博昭、木村宏、胡桃坂仁志
    • Organizer
      第31回染色体ワークショップ・第12回核ダイナミクス研究会
    • Place of Presentation
      箱根
    • Related Report
      2013 Annual Research Report
  • [Presentation] FAN1 ヌクレアーゼが担うDNA 鎖間架橋除去機構の解明2013

    • Author(s)
      高橋大介, 佐藤浩一, 平山恵美子, 石合正道, 高田穣, 胡桃坂仁志
    • Organizer
      第22回DNA複製・組換え・修復ワークショップ
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
  • [Presentation] 紫外線損傷DNAを含むヌクレオソームの構造生物学・生化学的解析2013

    • Author(s)
      越阪部晃永, 立和名博昭, 堀越直樹, 香川亘, 安田 武嗣, 花岡文雄, 菅澤薫, 岩井成憲, 胡桃坂仁志
    • Organizer
      第22回 DNA複製・組換え・修復ワークショップ
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
  • [Presentation] クロマチン高次構造形成におけるヌクレオソーム構造多様性2013

    • Author(s)
      胡桃坂仁志
    • Organizer
      第51回生物物理学会年会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ヒストンバリアントによるエピジェネティクスの構造基盤2013

    • Author(s)
      胡桃坂仁志
    • Organizer
      第86回生化学会大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] DNA鎖間架橋の修復に働くFANCI-FANCD2複合体及びFAN1ヌクレアーゼの機能解析2013

    • Author(s)
      佐藤 浩一, 高橋 大介, 石合 正道, 高田 穣, 胡桃坂 仁志
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] CENP-Aヌクレオソーム特異的なDNA構造の構造生物学的・生化学的解析2013

    • Author(s)
      白山 一義, 有村 泰宏, 宮 優太, 堀越 直樹, 越阪部 晃永, 立和名 博昭, 河野 秀俊, 胡桃坂 仁志
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] ヒト精巣特異的に高発現するヒストンバリアントH3.5を含むヌクレオソームの構造解析および機能解析2013

    • Author(s)
      浦浜 嵩, 越阪部 晃永, 堀越 直樹, 佐藤 浩一, 立和名 博昭, 香川 亘, 大川 恭行, 木村 宏, 胡桃坂 仁志
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Stability of nucleosomes containing histone variants2013

    • Author(s)
      田口 裕之、堀越 直樹、有村 泰宏、越阪部 晃永、胡桃坂 仁志
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] ヒトヒストンバリアントH2A.Bの機能解析2013

    • Author(s)
      有村泰宏,小田隆,佐藤浩一,藤田理紗,松本亮平,田口裕之,堀越直樹,越阪部晃永,立和名博昭,杉山正明,佐藤衛,木村宏,胡桃坂仁志
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] リンカーヒストンH1-ヌクレオソーム複合体(クロマトソーム)の生化学および構造生物学的解析2013

    • Author(s)
      加藤 大貴, 越阪部 晃永, 林田 亮太, 町田 晋一, 堀越 直樹, 有村 泰宏, 立和名 博昭, 胡桃坂 仁志
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 紫外線損傷DNAを含むヌクレオソームの生化学的解析2013

    • Author(s)
      越阪部晃永, 堀越直樹, 立和名博昭, 香川亘, 安田 武嗣, 花岡文雄, 菅澤薫, 岩井成憲, 胡桃坂仁志
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] リンカーヒストンH1バリアントの生化学的解析2013

    • Author(s)
      林田 亮太, 加藤 大貴, 高久 誉大, 越阪部 晃永, 町田 晋一, 胡桃坂 仁志
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] ヒトH2A/H2A.Z.1を含むハイブリッドヌクレオソームの機能解析2013

    • Author(s)
      堀越直樹、佐藤浩一、立和名博昭、香川亘、有村泰宏、越阪部晃永、鯨井智也、田口裕之、島田桂丞、木村宏、胡桃坂仁志
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] ヒストン修飾特異的scFv抗体の機能解析2013

    • Author(s)
      鯨井 智也, 堀越 直樹, 立和名 博昭, 越阪部 晃永, 佐藤 優子, 木村 宏, 胡桃坂 仁志
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] ICL修復に重要なFAN1ヌクレアーゼの生化学的機能解析

    • Author(s)
      佐藤 浩一, 石合 正道, 戸田 和江, 古越 聡, 越阪部 晃永, 立和名 博昭, 香川 亘, 堂前 直, 小布施 力史, 木村 宏, 高田 穣, 胡桃坂 仁志
    • Organizer
      新学術領域「クロマチン動構造」若手の会 第1回 シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] エピジェネティクス機構の理解を目指したクロマチン構造生物学

    • Author(s)
      胡桃坂仁志
    • Organizer
      平成25年度遺伝研研究会 「クロマチンによる遺伝情報のエピジェネティック制御機構」
    • Place of Presentation
      静岡
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 再構成ヌクレオソームを用いた動的クロマチン構造の解明

    • Author(s)
      胡桃坂仁志
    • Organizer
      「動的クロマチン構造と機能」第1回班会議
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] ヒト精巣特異的クロマチンの構造と性質の解析

    • Author(s)
      胡桃坂仁志
    • Organizer
      エピジェネティクスの深淵
    • Place of Presentation
      金沢
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] 生体の科学, vol. 68 No. 3(担当:パイオニア転写因子によるクロマチン構造変換)2017

    • Author(s)
      小山昌子, 胡桃坂仁志
    • Total Pages
      99
    • Publisher
      金原一郎記念医学医療振興財団
    • Related Report
      2017 Annual Research Report
  • [Book] ナノバイオ・メディシン2017

    • Author(s)
      宇理須 恒雄、佐久間 哲史、高田 望、竹中 繁織、小澤 岳昌、吉村 英哲、胡桃坂 仁志、越阪部 晃永、原田 昌彦、束田 裕一、宮成 悠介、塩見 美喜子、大西 遼
    • Total Pages
      232
    • Publisher
      近代科学社
    • ISBN
      4764950286
    • Related Report
      2017 Annual Research Report
  • [Book] Annual Review 呼吸器 20162016

    • Author(s)
      堀越直樹、有村泰宏、胡桃坂仁志
    • Total Pages
      238
    • Publisher
      中外医学社
    • Related Report
      2015 Annual Research Report
  • [Book] Surgery frontier2015

    • Author(s)
      有村泰宏、胡桃坂仁志
    • Total Pages
      96
    • Publisher
      メディカルレビュー社
    • Related Report
      2015 Annual Research Report
  • [Book] 構造生命科学で何がわかるのか,何ができるのか(田中啓二,若槻壮市)2014

    • Author(s)
      越阪部晃永,堀越直樹,胡桃坂仁志
    • Total Pages
      15
    • Publisher
      羊土社
    • Related Report
      2014 Annual Research Report
  • [Book] 実験医学Vol32 No.13.2014[通巻541号]2014

    • Author(s)
      胡桃坂仁志
    • Total Pages
      6
    • Publisher
      ヒストンバリアント―ベールの向こうの多様な機能
    • Related Report
      2014 Annual Research Report
  • [Book] 染色体と細胞核のダイナミクス(担当:ヌクレオソーム)2013

    • Author(s)
      胡桃坂仁志, 木村宏
    • Total Pages
      30
    • Publisher
      化学同人
    • Related Report
      2013 Annual Research Report
  • [Book] エピジェネティクスキーワード事典(担当:ヌクレオソーム)2013

    • Author(s)
      胡桃坂仁志,越阪部晃永,有村泰宏
    • Total Pages
      4
    • Publisher
      羊土社
    • Related Report
      2013 Annual Research Report
  • [Book] 基礎コース 細胞生物学(担当:情報記憶媒体としてのDNA)2013

    • Author(s)
      胡桃坂仁志,市川雄一
    • Total Pages
      11
    • Publisher
      東京化学同人
    • Related Report
      2013 Annual Research Report
  • [Remarks] 新学術領域研究(研究領域提案型) 「動的クロマチン構造と機能」ホームページ

    • URL

      http://nucleosome.kyushu-u.ac.jp

    • Related Report
      2014 Annual Research Report
  • [Remarks] 胡桃坂研究室ホームページ

    • URL

      http://www.eb.waseda.ac.jp/kurumizaka/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 新学術領域研究(研究領域提案型)「動的クロマチン構造と機能」ホームページ

    • URL

      http://nucleosome.kyushu-u.ac.jp

    • Related Report
      2013 Annual Research Report
  • [Remarks] 胡桃坂研究室ホームページ

    • URL

      http://www.eb.waseda.ac.jp/kurumizaka/

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2013-07-10   Modified: 2022-02-28  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi