Studies on communication between neuroaxons via oligodendrocytes.

• Project Area: Glial assembly: a new regulatory machinery of brain function and disorders
• Project/Area Number: 25117005
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: National Institute for Physiological Sciences
• Principal Investigator: Ikenaka Kazuhiro 生理学研究所, 分子細胞生理研究領域, 教授 (00144527)
• Co-Investigator(Kenkyū-buntansha): 山崎 良彦 山形大学, 医学部, 准教授 (10361247) ; 田中 謙二 慶應義塾大学, 医学部(信濃町), 准教授 (30329700) ; 清水 健史 名古屋市立大学, 医学部, 講師 (60398237) ; 小林 憲太 生理学研究所, 行動・代謝分子解析センター, 准教授 (70315662) ; 畑中 伸彦 生理学研究所, システム脳科学研究領域, 助教 (80296053) ; 吉村 武 生理学研究所, 分子細胞生理研究領域, 助教 (60402567)
• Project Period (FY): 2013-06-28 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥136,760,000 (Direct Cost: ¥105,200,000、Indirect Cost: ¥31,560,000); Fiscal Year 2017: ¥27,300,000 (Direct Cost: ¥21,000,000、Indirect Cost: ¥6,300,000); Fiscal Year 2016: ¥27,430,000 (Direct Cost: ¥21,100,000、Indirect Cost: ¥6,330,000); Fiscal Year 2015: ¥26,000,000 (Direct Cost: ¥20,000,000、Indirect Cost: ¥6,000,000); Fiscal Year 2014: ¥30,160,000 (Direct Cost: ¥23,200,000、Indirect Cost: ¥6,960,000); Fiscal Year 2013: ¥25,870,000 (Direct Cost: ¥19,900,000、Indirect Cost: ¥5,970,000)
• Keywords: グリア / 精神疾患 / 神経興奮制御 / 活動電位の伝達速度 / 活動電位の伝導速度 / ｸﾞﾘｱ

Outline of Final Research Achievements

Oligodendrocytes (OLs) have recently been shown to modulate conduction velocity in an axonal activity-dependent manner even after myelination is completed. The axonal activity also promotes the proliferation and differentiation of OL precursor cells, and these are required for motor skill learning. Taken together, these findings suggest that neuronal activity and subsequent myelin remodeling are required for executing higher brain function. We thus examined whether and/or how OLs play roles in higher brain functions, using following experimental systems. (1) A method for simultaneously labeling both axons from different brain regions and the myelinating OL, (2) Mouse lines with channelrhodopsin-2 expression in OL, (3) NF155 conditional knockout mice, whose paranodes are disrupted after their initial formation.

Research Products

• [Int'l Joint Research] University of Texas(米国)
• [Int'l Joint Research] Universite Libre de Bruxelles(ベルギー)
• [Journal Article] Modulatory effects of perineuronal oligodendrocytes on neuronal activity in the rat hippocampus (2018)
  • Author(s): Yamazaki Y, Hozumi Y, Kaneko K, Fujii S
  • Journal Title: Neurochemical Research Volume: 43 Issue: 1 Pages: 18-31
  • DOI: 10.1007/s11064-017-2278-9
  • Peer Reviewed
• [Journal Article] Strong sonic hedgehog signaling in the mouse ventral spinal cord is not required for oligodendrocyte precursor cell (OPC) generation but is necessary for correct timing of its generation (2017)
  • Author(s): Hashimoto H, Jiang W, Yoshimura T, Moon KH, Bok J, Ikenaka K
  • Journal Title: Neurochem Int Volume: 印刷中 Pages: 178-183
  • DOI: 10.1016/j.neuint.2017.11.003
  • Peer Reviewed
• [Journal Article] Sulfatase 2 Modulates Fate Change from Motor Neurons to Oligodendrocyte Precursor Cells through Coordinated Regulation of Shh Signaling with Sulfatase 1 (2017)
  • Author(s): Jiang Wen、Ishino Yugo、Hashimoto Hirokazu、Keino-Masu Kazuko、Masu Masayuki、Uchimura Kenji、Kadomatsu Kenji、Yoshimura Takeshi、Ikenaka Kazuhiro
  • Journal Title: Developmental Neuroscience Volume: 39 Issue: 5 Pages: 361-374
  • DOI: 10.1159/000464284
  • Peer Reviewed
• [Journal Article] The balance between Cathepsin C and Cystatin F controls remyelination in the brain of Plp1-overexpressing mouse, a chronic demyelinating disease model. (2017)
  • Author(s): Shimizu T, Wisessmith W, Li J, Abe M, Sakimura K, Chetsawang B, Sahara Y, Tohyama K, Tanaka KF, Ikenaka K
  • Journal Title: Glia Volume: in press Issue: 6 Pages: 917-930
  • DOI: 10.1002/glia.23134
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] GlcNAc6ST-1 regulates sulfation of N-glycans and myelination in the peripheral nervous system. (2017)
  • Author(s): Yoshimura T, Hayashi A, Handa-Narumi M, Yagi H, Ohno N, Koike T, Yamaguchi Y, Uchimura K, Kadomatsu K, Sedzik J, Kitamura K, Kato K, Trapp BD, Baba H, Ikenaka K.
  • Journal Title: Sci Rep. Volume: 7 Issue: 1 Pages: 42257-42257
  • DOI: 10.1038/srep42257
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] YAP functions as a mechanotransducer in oligodendrocyte morphogenesis and maturation. (2017)
  • Author(s): Shimizu T, Osanai Y, Tanaka KF, Abe M, Natsume R, Sakimura K, Ikenaka K.
  • Journal Title: Glia Volume: 65 Issue: 2 Pages: 360-374
  • DOI: 10.1002/glia.23096
  • Peer Reviewed
• [Journal Article] Astrocyte-mediated infantile-onset leukoencephalopathy mouse model (2017)
  • Author(s): Sugio S, Tohyama K, Oku S, Fujiyoshi K, Yoshimura T, Hikishima K, Yano R, Fukuda T, Nakamura M, Okano H, Watanabe M1, Fukata M, Ikenaka K, F Tanaka K
  • Journal Title: Glia Volume: 65 Issue: 1 Pages: 150-168
  • DOI: 10.1002/glia.23084
  • Peer Reviewed / Open Access
• [Journal Article] Rabies virus-mediated oligodendrocyte labeling reveals a single oligodendrocyte myelinates axons from distinct brain regions (2017)
  • Author(s): Osanai Y, Shimizu T, Mori T, Yoshimura Y, Hatanaka N, Nambu A, Kimori Y, Koyama S, Kobayashi K, Ikenaka K.
  • Journal Title: Glia Volume: 65 Issue: 1 Pages: 93-105
  • DOI: 10.1002/glia.23076
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Maturation of Cerebellar Purkinje Cell Population Activity during Postnatal Refinement of Climbing Fiber Network (2017)
  • Author(s): Good JM, Mahoney M, Miyazaki T, Tanaka KF, Sakimura K, Watanabe M, Kitamura K, Kano M.
  • Journal Title: Cell Rep. Volume: 21 Issue: 8 Pages: 2066
  • DOI: 10.1016/j.celrep.2017.10.101
  • URL: https://pure.teikyo.jp/en/publications/ab9f004b-e71d-4879-a8d4-6f2b187db3f5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Abrogated Freud-1/Cc2d1a Repression of 5-HT1A Autoreceptors Induces Fluoxetine-Resistant Anxiety/Depression-Like Behavior. (2017)
  • Author(s): Vahid-Ansari F, Daigle M, Manzini MC, Tanaka KF, Hen R, Geddes SD, Beique JC, James J, Merali Z, Albert PR.
  • Journal Title: J Neurosci. Volume: 37 Issue: 49 Pages: 11967-11978
  • DOI: 10.1523/jneurosci.1668-17.2017
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Time-controllable Nkcc1 knockdown replicates reversible hearing loss in postnatal mice. (2017)
  • Author(s): Watabe T, Xu M, Watanabe M, Nabekura J, Higuchi T, Hori K, Sato MP, Nin F, Hibino H, Ogawa K, Masuda M, Tanaka KF
  • Journal Title: Science Reports Volume: 7 Issue: 1 Pages: 13605-14007
  • DOI: 10.1038/s41598-017-13997-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Quantitative temporal changes in DTI values coupled with histological properties in cuprizone-induced demyelination and remyelination (2017)
  • Author(s): Ryutaro Yano, Junichi Hata, Yoshifumi Abe, Fumiko Seki, Keitaro Yoshida, Yuji Komaki, Hideyuki Okano, Kenji F. Tanaka
  • Journal Title: Neurochemistry International Volume: 17 Pages: 186-197
  • DOI: 10.1016/j.neuint.2017.10.004
  • Peer Reviewed
• [Journal Article] Hearing Loss Controlled by Optogenetic Stimulation of Nonexcitable Nonglial Cells in the Cochlea of the Inner Ear (2017)
  • Author(s): Sato MP, et al.
  • Journal Title: Frontiers in Molecular Neuroscience Volume: 10 Pages: 300-300
  • DOI: 10.3389/fnmol.2017.00300
  • Peer Reviewed / Open Access
• [Journal Article] Distinct Roles of Ventromedial versus Ventrolateral Striatal Medium Spiny Neurons in Reward-Oriented Behavior. (2017)
  • Author(s): Tsutsui-Kimura I, Natsubori A, Mori M, Kobayashi K, Drew MR, de Kerchove d'Exaerde A, Mimura M, Tanaka KF.
  • Journal Title: Curr Biol Volume: 27 Issue: 19 Pages: 3042-3048
  • DOI: 10.1016/j.cub.2017.08.061
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Mitochondrial DNA Double-Strand Breaks in Oligodendrocytes Cause Demyelination, Axonal Injury, and CNS Inflammation. (2017)
  • Author(s): Madsen PM, Pinto M, Patel S, McCarthy S, Gao H, Taherian M, Karmally S, Pereira CV, Dvoriantchikova G, Ivanov D, Tanaka KF, Moraes CT, Brambilla R.
  • Journal Title: J Neurosci. Volume: 37 Issue: 42 Pages: 10185-10199
  • DOI: 10.1523/jneurosci.1378-17.2017
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Serotonin hormonally regulates lacrimal gland secretory function via the serotonin type 3a receptor. (2017)
  • Author(s): Imada T, Nakamura S, Hisamura R, Izuta Y, Jin K, Ito M, Kitamura N, Tanaka KF, Mimura M, Shibuya I, Tsubota K.
  • Journal Title: Sci Rep Volume: 7 Issue: 1 Pages: 6965-6965
  • DOI: 10.1038/s41598-017-06022-4
  • Peer Reviewed / Open Access
• [Journal Article] High-speed and scalable whole-brain imaging in rodents and primates (2017)
  • Author(s): Seiriki K, Kasai A, Hashimoto T, Schulze W, Niu M, Yamaguchi S, Nakazawa T, Inoue K, Uezono S, Takada M, Naka Y, Igarashi H, Tanuma M, Waschek JA, Ago Y, Tanaka KF, Hayata-Takano A, Nagayasu K, Shintani N, Hashimoto R, Kunii Y, Hino M, Matsumoto J, Yabe H, Nagai T, Fujita K, Matsuda T, Takuma K, Baba A, Hashimoto H
  • Journal Title: Neuron Volume: 94 Issue: 6 Pages: 1085-1100
  • DOI: 10.1016/j.neuron.2017.05.017
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association of impaired neuronal migration with cognitive deficits in extremely preterm infants. (2017)
  • Author(s): Kubo, K.I., Deguchi, K., Nagai, T,, Ito, Y., Yoshida, K., Endo, T., Benner, S., Shan, W., Kitazawa, A., Aramaki, M., Ishii, K., Shin, M., Matsunaga, Y., Hayashi, K., Kakeyama, M., Tohyama, C., Tanaka, K.F., Tanaka, K., Takashima, S., Nakayama, M.
  • Journal Title: JCI Insight. Volume: 2 Issue: 10 Pages: 88609-88609
  • DOI: 10.1172/jci.insight.88609
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] OCD candidate gene SLC1A1/EAAT3 impacts basal ganglia-mediated activity and stereotypic behavior. (2017)
  • Author(s): Zike ID, Chohan MO, Kopelman JM, Krasnow EN, Flicker D, Nautiyal KM, Bubser M, Kellendonk C, Jones CK, Stanwood G, Tanaka KF, Moore H, Ahmari SE, Veenstra-VanderWeele J.
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 114 Issue: 22 Pages: 5719-5724
  • DOI: 10.1073/pnas.1701736114
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation. (2017)
  • Author(s): Tsutsui-Kimura I, Takiue H, Yoshida K, Xu M, Yano R, Ohta H, Nishida H, Bouchekioua Y, Okano H, Uchigashima M, Watanabe M, Takata N, Drew MR, Sano H, Mimura M, Tanaka KF.
  • Journal Title: Nat Commun. Volume: 8 Issue: 1 Pages: 14304-14304
  • DOI: 10.1038/ncomms14304
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Ventrolateral striatal medium spiny neurons positively regulate food-incentive, goal-directed behavior independently of D1 and D2 selectivity. (2017)
  • Author(s): Akiyo Natsubori, Iku Tsustui-Kimura, Hiroshi Nishida, Youcef Bouchekioua, Hiroshi Sekiya, Motokazu Uchigashima, Masahiko Watanabe, Alban de Kerchove d'Exaerde, Masaru Mimura, Norio Takata, and Kenji Tanaka
  • Journal Title: Journal of Neuroscience Volume: 37 Issue: 10 Pages: 2723-2733
  • DOI: 10.1523/jneurosci.3377-16.2017
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 強迫症研究のこれからtranslational researchの可能性について (2017)
  • Author(s): 酒井 雄希, 田中 謙二
  • Journal Title: 精神科治療学 Volume: 32(3) Pages: 399-404
• [Journal Article] Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway (2017)
  • Author(s): Morizawa Yosuke M.、Hirayama Yuri、Ohno Nobuhiko、Shibata Shinsuke、Shigetomi Eiji、Sui Yang、Nabekura Junichi、Sato Koichi、Okajima Fumikazu、Takebayashi Hirohide、Okano Hideyuki、Koizumi Schuichi
  • Journal Title: Nature Communications Volume: 8 Issue: 1 Pages: 28-28
  • DOI: 10.1038/s41467-017-00037-1
  • Peer Reviewed / Open Access
• [Journal Article] Physiological effects of a habituation procedure for functional MRI in awake mice using a cryogenic radiofrequency probe (2016)
  • Author(s): Keitaro Yoshida, Yu Mimura, Ryosuke Ishihara, Hiroshi Nishida, Yuji Komaki, Tomohito Minakuchi, Tomokazu Tsurugizawa, Masaru Mimura, Hideyuki Okano, Kenji F. Tanaka, Norio Takata
  • Journal Title: J Neurosci Methods. Volume: 274 Pages: 38-48
  • DOI: 10.1016/j.jneumeth.2016.09.013
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Microglial phospholipase D4 deficiency influences myelination during brain development (2016)
  • Author(s): Chiba T, Otani Y, Yamaguchi Y, Ishibashi T, Hayashi A, Tanaka KF, Yamazaki M, Sakimura K, Baba H.
  • Journal Title: Proceedings of the Japan Academy, Series B Volume: 92 Issue: 7 Pages: 237-254
  • DOI: 10.2183/pjab.92.237
  • NAID: 130005253188
  • ISSN: 0386-2208, 1349-2896
  • Peer Reviewed / Open Access
• [Journal Article] Subcellular calcium dynamics during juvenile development in mouse hippocampal astrocytes. (2016)
  • Author(s): R. Nakayama, T. Sasaki*, KF. Tanaka, Y. Ikegaya*
  • Journal Title: European Journal of Neuroscience Volume: 43 Issue: 7 Pages: 923-32
  • DOI: 10.1111/ejn.13188
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Photoactivated adenylyl cyclase (PAC) reveals novel mechanisms underlying cAMP-dependent axonal morphogenesis (2016)
  • Author(s): Zhou Z, Tanaka KF, Matsunaga S, Iseki M, Watanabe M, Matsuki N, Ikegaya Y, Koyama R
  • Journal Title: Sci Rep Volume: 5 Issue: 1 Pages: 19679-19679
  • DOI: 10.1038/srep19679
  • Peer Reviewed / Open Access
• [Journal Article] Keratan Sulfate Regulates the Switch from Motor Neuron to Oligodendrocyte Generation During Development of the Mouse Spinal Cord. (2016)
  • Author(s): Hashimoto H, Ishino Y, Jiang W, Yoshimura T, Takeda-Uchimura Y, Uchimura K, Kadomatsu K, Ikenaka K.
  • Journal Title: Neurochem Res. Volume: 41 Issue: 1-2 Pages: 450-462
  • DOI: 10.1007/s11064-016-1861-9
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] オリゴデンドロサイトと神経伝導調節－脳白質の機能的可塑性― (2016)
  • Author(s): 山崎良彦
  • Journal Title: 分子精神医学 Volume: 16 Pages: 25-31
• [Journal Article] 大脳皮質オリゴデンドロサイトの起源 (2015)
  • Author(s): 成瀬雅衣、池中一裕、等誠司
  • Journal Title: 生体の科学 Volume: 66(6) Pages: 541-545
• [Journal Article] The Dorsovental Boundary of the Germinal Zone is a Specialized Niche for the Generation of Cortical Oligodendorocytes during a Restricted Temporal Window. (2015)
  • Author(s): Naruse M, Ishino Y, Kumar A, Ono K, Takebayashi H, Yamaguchi M, Ishizaki Y, Ikenaka K, Hitoshi S.
  • Journal Title: Cereb Cortex Volume: online June 23 Pages: 1-11
  • Peer Reviewed
• [Journal Article] Oligodendrocyte generation during mouse development. (2015)
  • Author(s): Takebayashi H, Ikenaka K
  • Journal Title: Glia Volume: 63(8) Issue: 8 Pages: 1350-1356
  • DOI: 10.1002/glia.22863
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Activity-dependent modulation of the axonal conduction of action potentials along rat hippocampal mossy fibers. (2015)
  • Author(s): Chida K, Kaneko K, Fujii S, Yamazaki Y
  • Journal Title: European Journal of Neuroscience Volume: 41 Issue: 1 Pages: 45-54
  • DOI: 10.1111/ejn.12762
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] <b>Extracellular ATP modulates synaptic plasticity induced by activation of metabotropic glutamate receptors in the </b><b>hippocampus </b> (2015)
  • Author(s): Yamazaki Y, Fujii S
  • Journal Title: Biomedical Research Volume: 36 Issue: 1 Pages: 1-9
  • DOI: 10.2220/biomedres.36.1
  • NAID: 130004903878
  • ISSN: 0388-6107, 1880-313X
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Activation of inositol 1,4,5-trisphosphate receptors during preconditioning low-frequency stimulation suppresses subsequent induction of long-term potentiation in hippocampal CA1 neurons. (2015)
  • Author(s): Yamazaki Y, Fujii S, Goto JI, Fujiwara H, Mikoshiba K
  • Journal Title: Neuroscience Volume: 311 Pages: 195-206
  • DOI: 10.1016/j.neuroscience.2015.10.030
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Astroglial Glutamate Transporter Deficiency Increases Synaptic Excitability and Leads to Pathological Repetitive Behaviors in Mice. (2015)
  • Author(s): Aida T, Yoshida J, Nomura M, Tanimura A, Iino Y, Soma M, Bai N, Ito Y, Cui W, Aizawa H, Yanagisawa M, Nagai T, Takata N, Tanaka KF, Takayanagi R, Kano M, Gotz M, Hirase H, Tanaka K.
  • Journal Title: Neuropsychopharmacology Volume: in press Issue: 7 Pages: 1660-1660
  • DOI: 10.1038/npp.2015.26
  • Peer Reviewed / Open Access
• [Journal Article] Optogenetic Activation of CA1 Pyramidal Neurons at the Dorsal and Ventral Hippocampus Evokes Distinct Brain-Wide Responses Revealed by Mouse fMRI. (2015)
  • Author(s): N, Yoshida K, Komaki Y, Xu M, Sakai Y, Hikishima K, Mimura M, Okano H, Tanaka KF.
  • Journal Title: PLoS One Volume: 10 Issue: 3 Pages: e0121417-e0121417
  • DOI: 10.1371/journal.pone.0121417
  • Peer Reviewed / Open Access
• [Journal Article] Distinct Circuits Underlie the Effects of 5-HT1B Receptors on Aggression and Impulsivity. (2015)
  • Author(s): Nautiyal KM, Tanaka KF, Barr MM, Tritschler L, Le Dantec Y, David DJ, Gardier AM, Blanco C, Hen R, Ahmari SE
  • Journal Title: Neuron Volume: 86 Issue: 3 Pages: 813-826
  • DOI: 10.1016/j.neuron.2015.03.041
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Identification of the extent of cortical spreading depression propagation by Npas4 mRNA expression (2015)
  • Author(s): Keitaro Yoshida, Ming Xu, Akiyo Natsubori, Masaru Mimura, Norio Takata, Kenji F Tanaka
  • Journal Title: Neuroscinece Research Volume: - Pages: 1-8
  • DOI: 10.1016/j.neures.2015.04.003
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Cloning-free CRISPR/Cas system facilitates functional cassette knockin in mice (2015)
  • Author(s): Aida T, Chiyo K, Usami T, Ishikubo H, Imahashi R, Wada Y, Tanaka K, Sakuma T, Yamamoto T, Tanaka K
  • Journal Title: Genome Biol Volume: 16 Issue: 1 Pages: 87-87
  • DOI: 10.1186/s13059-015-0653-x
  • Peer Reviewed / Open Access
• [Journal Article] Unveiling astrocytic control of cerebral blood flow with optogenetics (2015)
  • Author(s): Masamoto K, Unekawa M, Watanabe T, Toriumi H, Takuwa H, Kawaguchi H, Kanno I, Matsui K, Tanaka K F, Tomita Y, Suzuki N
  • Journal Title: Scientific reports Volume: 5 Issue: 1 Pages: 11455-11455
  • DOI: 10.1038/srep11455
  • Peer Reviewed / Open Access
• [Journal Article] Adult Hippocampal Neurogenesis Modulates Fear Learning through Associative and Nonassociative Mechanisms. (2015)
  • Author(s): Seo DO, Carillo MA, Chih-Hsiung Lim S, Tanaka KF, Drew MR
  • Journal Title: J Neurosci. Volume: 35 Issue: 32 Pages: 11330-11345
  • DOI: 10.1523/jneurosci.0483-15.2015
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Short- and long-term functional plasticity of white matter induced by oligodendrocyte depolarization in the hippocampus. (2014)
  • Author(s): Yamazaki Y, Fujiwara H, Kaneko K, Hozumi Y, Xu M, Ikenaka K, Fujii S, Tanaka KF.
  • Journal Title: Glia Volume: 62 Issue: 8 Pages: 1299-1312
  • DOI: 10.1002/glia.22681
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Increased adenosine levels in mice expressing mutant glial fibrillary acidic protein in astrocytes result in failure of induction of LTP reversal (depotentiation) in hippocampal CA1 neurons. (2014)
  • Author(s): Fujii S, Tanaka KF, Ikenaka K, Yamazaki Y.
  • Journal Title: Brain Res Volume: 1578 Pages: 1-13
  • DOI: 10.1016/j.brainres.2014.07.005
  • Peer Reviewed / Open Access
• [Journal Article] In vivo visualization of subtle, transient and local activity of astrocytes using an ultrasensitive Ca2+ indicator. (2014)
  • Author(s): Kanemaru K, Sekiya H, Xu M, Satoh K, Kitajima N, Yoshida K, Okubo Y, Sasaki T, Moritoh S, Hasuwa H, Mimura M, Horikawa K, Matsui K, Nagai T, Iino M, Tanaka KF
  • Journal Title: Cell Rep Volume: 8(1),311 Issue: 1 Pages: 311-318
  • DOI: 10.1016/j.celrep.2014.05.056
  • Peer Reviewed / Open Access
• [Journal Article] Synaptic plasticity in hippocampal CA1 neurons and learning behavior in transient ischemia-loaded gerbils (2013)
  • Author(s): Li J, Sasaki H, Fujiwara H, Kato H, Kaneko K, Yamazaki Y, Fujii S.
  • Journal Title: Biomedical Research Volume: 34 Issue: 2 Pages: 75-85
  • DOI: 10.2220/biomedres.34.75
  • NAID: 130004470839
  • ISSN: 0388-6107, 1880-313X
  • Peer Reviewed
• [Presentation] Mechanism that arrests myelin regeneration in chronic demyelinated lesions (2018)
  • Author(s): 池中一裕
  • Organizer: 第8回 新潟大学脳研研究所共同研究拠点国際シンポジウム
  • Invited
• [Presentation] 意欲行動の開始を支配する島皮質-線条体回路 (2017)
  • Author(s): 田中謙二
  • Organizer: 次世代脳 新学術領域合同シンポジウム
  • Invited
• [Presentation] Fiberphotometry (2017)
  • Author(s): 田中謙二
  • Organizer: 第28回 マイクロダイアリシス研究会
  • Invited
• [Presentation] DGK‐εノックアウトマウスを用いた行動解析 (2017)
  • Author(s): 多田裕治, 松本翔平, 水野綱紀, 武内健太朗, 田﨑太一, 藤原浩樹, 後藤薫, 藤井聡
  • Organizer: 山形大学医学部実験動物セミナー・第28回研究成果発表会
• [Presentation] シナプス可塑性の刺激パターンの依存性 (2017)
  • Author(s): 藤井聡, 山崎良彦, 後藤純一, 藤原浩樹
  • Organizer: 第34回山形電気生理研究会
• [Presentation] 結節硬化症原因遺伝子欠損マウスにおけるシナプス可塑性異常の改善に向けたアプローチ (2017)
  • Author(s): 後藤純一, 山形要人, 島田忠之, 藤原浩樹, 山崎良彦, 藤井聡
  • Organizer: 第34回山形電気生理研究会
• [Presentation] 海馬シナプス可塑性の刺激パターン依存性 (2017)
  • Author(s): 藤井聡, 山崎良彦, 後藤純一, 藤原浩樹
  • Organizer: 第49回東北生理談話会
• [Presentation] 光操作・光計測 (2017)
  • Author(s): 田中謙二
  • Organizer: 第４９回藤田学園医学会・研究最前線セミナー
  • Invited
• [Presentation] 島皮質-線条体回路と意欲行動 (2017)
  • Author(s): 田中謙二
  • Organizer: 第5回心身医学のニューロサイエンス研究会
  • Invited
• [Presentation] Oligodendrocyte is a dynamic modulator of conduction velocity (2017)
  • Author(s): 田中謙二、山崎良彦
  • Organizer: 第60回 日本神経化学会
• [Presentation] 光観察と光操作を組み合わせた意欲行動研究 (2017)
  • Author(s): 田中謙二
  • Organizer: 第2回 ルミノジェネティクス研究会
  • Invited
• [Presentation] Exploring the factors causing remyelination arrest through studying cystatin F gene expression regulatory mechanism (2017)
  • Author(s): Jiayi Li
  • Organizer: 13th Biennial ISN Satellite Metting Myelin Biology 2017 Glial Neuronal Interactions
  • Int'l Joint Research
• [Presentation] Origodendrocytes myelinate axons by sensing neuronal subtypes and/or sensory inputs with individual variance in selectivity (2017)
  • Author(s): Kazuhiro Ikenaka
  • Organizer: 13th Biennial ISN Satellite Metting Myelin Biology 2017 Glial Neuronal Interactions
  • Int'l Joint Research / Invited
• [Presentation] Exploring the factors causing remyelination arrest through studying cystatin F gene expression regulatory mechanism (2017)
  • Author(s): Jiayi Li
  • Organizer: ISN-ESN Meeting
  • Int'l Joint Research
• [Presentation] Exploring the factors causing remyelination arrest through studying cystatin F gene expression regulatory mechanism (2017)
  • Author(s): Jiayi Li
  • Organizer: 第40回日本神経科学大会
• [Presentation] Analysis of neuronal resposes against disruption of paranodal junction (2017)
  • Author(s): 池中一裕
  • Organizer: 第40回日本神経科学大会
• [Presentation] Functional analysis of Rho/Rho-kinase signaling pathway in corticostriatal neuron survival using a new gene delivery system (2017)
  • Author(s): 小林憲太
  • Organizer: 第40回日本神経科学大会
• [Presentation] Modulatory effects of the changes in membrane potential of oligodendrocytes on axonal conduction and synaptic responses in the hippocampus (2017)
  • Author(s): 山崎良彦
  • Organizer: 第94回日本生理学会大会
  • Place of Presentation: アクトシティ浜松(静岡県浜松市)
• [Presentation] 単分子研究から行動研究へ (2016)
  • Author(s): 田中謙二
  • Organizer: 第2回 バイオ単分子研究会
  • Place of Presentation: いわき湯本温泉 新つた（福島県いわき市）
  • Year and Date: 2016-03-30
  • Invited
• [Presentation] アパシーの神経基盤 (2016)
  • Author(s): 田中謙二
  • Organizer: 第121回 日本解剖学会総会
  • Place of Presentation: ビッグパレットふくしま（福島県郡山市）
  • Year and Date: 2016-03-29
  • Invited
• [Presentation] グリアアセンブリ活動の観察と操作 (2016)
  • Author(s): 田中謙二
  • Organizer: 第89回日本薬理学会
  • Place of Presentation: パシフィコ横浜 会議センター（神奈川県横浜市）
  • Year and Date: 2016-03-11
  • Invited
• [Presentation] グリアアセンブリによる脳機能発現の制御と病態 (2016)
  • Author(s): 池中一裕
  • Organizer: 次世代脳プロジェクト冬のシンポジウム2016
  • Place of Presentation: 一橋講堂(東京都千代田区)
• [Presentation] モルモット海馬CA1領域における脱長期増強誘導に対するストア作動性カルシウム流入及び細胞内カルシウム放出の寄与 (2016)
  • Author(s): 後藤純一, 金子健也, 藤原浩樹, 山崎良彦, 藤井聡
  • Organizer: 第33回山形電気生理研究会
  • Place of Presentation: 山形大学医学部(山形県山形市)
• [Presentation] Role of mechanical factors in oligodendrocyte morphogenesis and maturation (2016)
  • Author(s): 清水健史
  • Organizer: 第21回グリア研究会
  • Place of Presentation: 千里ライフサイエンスセンター(大阪府豊中市)
• [Presentation] Exploring the factors causing remyelination arrest through studying Cystatin F gene expression regulatory mechanism (2016)
  • Author(s): 李 佳益
  • Organizer: 第63回中部日本生理学会
  • Place of Presentation: 岡崎コンファレンスセンター(愛知県岡崎市)
• [Presentation] 小脳登上線維-プルキンエ細胞間シナプスの精緻化へ のグリア細胞の関与 (2016)
  • Author(s): 菊地原沙織
  • Organizer: 第63回中部日本生理学会
  • Place of Presentation: 岡崎コンファレンスセンター(愛知県岡崎市)
• [Presentation] オリゴデンドロサイトのアデノシンA1受容体活性化による活動電位の軸索伝導の修飾 (2016)
  • Author(s): 山崎良彦，金子健也，藤原浩樹，後藤純一，藤井 聡
  • Organizer: 第48回東北生理談話会
  • Place of Presentation: 岩手医科大学循環器センター(岩手県盛岡市)
• [Presentation] 恐怖条件づけ記憶の想起に対する慢性アルコール投与の影響 (2016)
  • Author(s): 藤原浩樹，添川清貴，金子健也，山崎良彦，後藤純一，大津芳，藤井聡
  • Organizer: 第48回東北生理談話会
  • Place of Presentation: 岩手医科大学循環器センター(岩手県盛岡市)
• [Presentation] Analysis of neuronal responses against disruption of paranodal junction (2016)
  • Author(s): 國澤和生
  • Organizer: 第６回生理学研究所・名古屋大学医学系研究科合同シンポジウム
  • Place of Presentation: 名古屋大学医学部附属病院中央診療棟3階行動(愛知県名古屋市)
• [Presentation] 遺伝子改変を駆使したGliopsychiatry研究 (2016)
  • Author(s): 田中謙二
  • Organizer: 第38回日本生物学的精神医学会・第59回日本神経化学会大会合同年会
  • Place of Presentation: 福岡国際会議場(福岡県福岡市)
• [Presentation] 脳白質異常と神経疾患 (2016)
  • Author(s): 池中一裕
  • Organizer: 第38回日本生物学的精神医学会・第59回日本神経化学会大会合同年会
  • Place of Presentation: 福岡国際会議場(福岡県福岡市)
  • Invited
• [Presentation] Visualization of oligodendrocyte-axon interaction with a combinational injection of attenuated rabies virus and adeno-associated virus (2016)
  • Author(s): 長内康幸
  • Organizer: 第38回日本生物学的精神医学会・第59回日本神経化学会大会合同年会
  • Place of Presentation: 福岡国際会議場(福岡県福岡市)
• [Presentation] Analysis of neuronal responses against disruption of paranodal junction (2016)
  • Author(s): 國澤和生
  • Organizer: 第38回日本生物学的精神医学会・第59回日本神経化学会大会合同年会
  • Place of Presentation: 福岡国際会議場(福岡県福岡市)
• [Presentation] The role of mechanosensors in oligodendrocyte morphogenesis and maturation (2016)
  • Author(s): 清水健史
  • Organizer: 第38回日本生物学的精神医学会・第59回日本神経化学会大会合同年会
  • Place of Presentation: 福岡国際会議場(福岡県福岡市)
• [Presentation] Sulfated N-glycans modulate myelination in the peripheral nervous system (2016)
  • Author(s): 吉村 武
  • Organizer: 第38回日本生物学的精神医学会・第59回日本神経化学会大会合同年会
  • Place of Presentation: 福岡国際会議場(福岡県福岡市)
• [Presentation] Microglia-induced activation of non-canonical Wnt signaling aggravates neurodegeneration in demyelinating disorders (2016)
  • Author(s): 清水健史
  • Organizer: 14th Meeting of the Asian-Pacific Society for NEUROCHEMISTRY
  • Place of Presentation: マレーシア/クアラルンプール
  • Int'l Joint Research
• [Presentation] Analysis of neuronal responses against disruption of paranodal junction (2016)
  • Author(s): 國澤和生
  • Organizer: 14th Meeting of the Asian-Pacific Society for NEUROCHEMISTRY
  • Place of Presentation: マレーシア/クアラルンプール
  • Int'l Joint Research
• [Presentation] アデノシンA1受容体活性化による活動電位の軸索伝導の修飾 (2016)
  • Author(s): 山崎良彦
  • Organizer: 第2回日本ミエリン研究会
  • Place of Presentation: 横浜ランドマークセンター(神奈川県横浜市)
• [Presentation] Functional analysis of Rho GTPase signaling in corticostriatal neurons using a dual viral vector system (2016)
  • Author(s): Kenta Kobayashi, Hiromi Sano, Shigeki Kato, Keisuke Kuroda, Shinichi Nakamuta, Tadashi Isa, Atsushi Nambu, Kozo Kaibuchi, Kazuto Kobayashi
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
• [Presentation] GlcNAc6ST-1 regulates sulfation of N-glycans and myelination in the peripheral nervous system (2016)
  • Author(s): 吉村 武
  • Organizer: 第3回グリアアセンブリ夏のワークショップ
  • Place of Presentation: 山形国際ホテル(山形県山形市)
• [Presentation] グリア研究の変遷と若手グリア研究者へのメッセージ (2016)
  • Author(s): 池中一裕
  • Organizer: 第3回グリアアセンブリ若手の会
  • Place of Presentation: 蔵王アストリアホテル(山形県山形市)
• [Presentation] Oligodendrocyte-neuron interaction in physiological and pathological statea (2016)
  • Author(s): 池中一裕
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 神戸コンベンションセンター・神戸ポートピアホテル(兵庫県神戸市)
  • Invited
• [Presentation] Involvement of adenosine A1 receptors on oligodendrocytes in regulation of axonal conduction of action potentials (2015)
  • Author(s): 山崎良彦
  • Organizer: 第20回グリア研究会
  • Place of Presentation: 名古屋市立大学医学部（愛知県名古屋市）
  • Year and Date: 2015-12-05
• [Presentation] オリゴデンドロサイトによる神経伝導調節と脳白質の機能的可塑性 (2015)
  • Author(s): 山崎良彦
  • Organizer: 第32回山形電気生理研究会
  • Place of Presentation: 山形大学医学部（山形県、山形市）
  • Year and Date: 2015-11-27
  • Invited
• [Presentation] 代謝型グルタミン酸受容体活性化で誘導する海馬CA1ニューロンのシナプス可塑性への細胞外ATPの関与 －ATPを介するグリアとニューロン機能のcross talking－ (2015)
  • Author(s): 藤井聡，金子健也，藤原浩樹，後藤純一，山崎良彦
  • Organizer: 第47回東北生理談話会
  • Place of Presentation: 弘前大学医学部コミュニケーションセンター（青森県、弘前市）
  • Year and Date: 2015-10-31
• [Presentation] Tetracycline-controllable gene expression system in glial cell biology. (2015)
  • Author(s): 田中謙二
  • Organizer: Glia Heterogeneity SPP 1757
  • Place of Presentation: (Homburg, German)
  • Year and Date: 2015-10-08
  • Int'l Joint Research / Invited
• [Presentation] Analysis of axon selective myelination depending on neuronal subtypes and neuronal activity. (2015)
  • Author(s): 長内康幸、清水健史、森琢磨、吉村由美子、畑中伸彦、南部篤、小林憲太、池中一裕
  • Organizer: 第58回神経化学会
  • Place of Presentation: 大宮ソニックシティ（埼玉県さいたま市）
  • Year and Date: 2015-09-11
• [Presentation] Promotion of glial cell research by virtue of transgenic approach. (2015)
  • Author(s): 田中謙二
  • Organizer: 第58回日本神経化学会大会
  • Place of Presentation: 大宮ソニックシティ（埼玉県さいたま市）
  • Year and Date: 2015-09-11
  • Invited
• [Presentation] How does an oligodendrocyte select axons to myelinate? (2015)
  • Author(s): Kazuhiro Ikenaka
  • Organizer: XII European Meeting on Glial Cells in Health and Disease Symposium
  • Place of Presentation: (Bilbao, Spain)
  • Year and Date: 2015-07-15
  • Int'l Joint Research / Invited
• [Presentation] KENGE-tet system: promising strategy to achieve sufficient probe expression in glial cells. (2015)
  • Author(s): Tanaka KF
  • Organizer: XII European Meeting on Glial Cells in Health and Disease Symposium
  • Place of Presentation: (Bilbao, Spain)
  • Year and Date: 2015-07-15
  • Int'l Joint Research / Invited
• [Presentation] 髄鞘-軸索間相互作用破綻に応答して発現変化するニューロン遺伝子の解析および脳機能に与える影響 (2015)
  • Author(s): 國澤和生、清水健史、畑中伸彦、小林憲太、長内康幸、Manzoor A. bhat、久島周、尾崎紀夫、池中一裕
  • Organizer: 第79回日本生化学会中部支部例会・シンポジウム
  • Place of Presentation: 信州大学（長野県松本市）
  • Year and Date: 2015-05-23
• [Presentation] Functional plasticity of white matter in the hippocampus (2015)
  • Author(s): 山崎良彦
  • Organizer: 第92回日本生理学会大会
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2015-03-23
• [Presentation] Tetracycline-Controllable Gene Expression and Knockdown (2015)
  • Author(s): 田中謙二
  • Organizer: BRI International Symposium 2015
  • Place of Presentation: 新潟大学医学部（新潟県新潟市）
  • Year and Date: 2015-03-05 – 2015-03-06
  • Invited
• [Presentation] Optogenetics (2015)
  • Author(s): 田中謙二
  • Organizer: 第9回日仏先端科学シンポジウム
  • Place of Presentation: 京都ブライトンホテル（京都府京都市）
  • Year and Date: 2015-01-23 – 2015-01-25
  • Invited
• [Presentation] 精神医学研究にオプトジェネティクスが期待されること (2014)
  • Author(s): 田中謙二
  • Organizer: 第35回日本レーザー医学会総会
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2014-11-30
  • Invited
• [Presentation] オプトジェネティクス (2014)
  • Author(s): 田中謙二
  • Organizer: 第110回日本精神神経学会学術総会 ワークショップ
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-06-27
• [Presentation] Plastic changes of axonal conduction induced by oligodendrocytes depolarization in hippocampus (2013)
  • Author(s): Yamazaki Y, Tanaka KF, Fujii S.
  • Organizer: International Symposium Optogenetics 2013
  • Place of Presentation: 慶應大学三田キャンパス北館ホール（東京都港区）
  • Invited
• [Presentation] アストロサイト機能不全マウスにおけるシナプス伝達の変化 (2013)
  • Author(s): 山崎良彦，田中 謙二，金子健也，藤原浩樹，後藤純一，藤井 聡
  • Organizer: 第45回東北生理談話会
  • Place of Presentation: 東北大学片平キャンパス（仙台市）
• [Remarks] グリアアセンブリによる脳機能発現の制御と病態
  • URL: http://square.umin.ac.jp/glialassembl/