| Budget Amount *help |
¥134,420,000 (Direct Cost: ¥103,400,000、Indirect Cost: ¥31,020,000)
Fiscal Year 2017: ¥21,710,000 (Direct Cost: ¥16,700,000、Indirect Cost: ¥5,010,000)
Fiscal Year 2016: ¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
Fiscal Year 2015: ¥22,750,000 (Direct Cost: ¥17,500,000、Indirect Cost: ¥5,250,000)
Fiscal Year 2014: ¥22,100,000 (Direct Cost: ¥17,000,000、Indirect Cost: ¥5,100,000)
Fiscal Year 2013: ¥47,320,000 (Direct Cost: ¥36,400,000、Indirect Cost: ¥10,920,000)
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| Outline of Final Research Achievements |
Learning and experience-dependent brain functions can be acquired at the postnatal critical period, when neural circuits receive remodeling and pruning of synapses. Imaging and electrophysiology were applied to study glial contributions to circuit remodeling in the critical period. In the cerebral cortex, the cortical volume is segmented into multiple zones defined by the distance from microglial cell bodies and these zones specify dendritic segments with higher or lower spine dynamics. On the other hand, a study of microglia-specific knockout mice of Csf1r revealed an important role of microglia in climbing fiber pruning in the cerebellum. Regulation of climbing fiber pruning was not dependent on phagocytotic activity, but was suggested to be mediated via inhibitory synapses.
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