| Budget Amount *help |
¥80,080,000 (Direct Cost: ¥61,600,000、Indirect Cost: ¥18,480,000)
Fiscal Year 2017: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
Fiscal Year 2016: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2015: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2014: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2013: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
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| Outline of Final Research Achievements |
In microglial specific IRF8-deficient mice, it was recognized that the social recognition ability was selectively decreased. We also found that in IRF8 deficient mice microglial cell bodies moves within the brain although microglia in normal mice moves only processes. In addition, it was found that similar protrusion dysplasia and morphological change were reproduced in timing specific and microglia specific IRF8-deficient mice, and it was revealed that IRF8 is a transcription factor involved in maintaining microglial morphology. The microglia morphology and function abnormality affects the brain circuit formation and confuses the expression of higher-order functions, and it is considered that the normal activity of microglia also contributes to the maintenance of brain circuit formation and higher-order functions.
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