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Molecular mechanisms for empathetic systems

Planned Research

Project AreaEmpathic system
Project/Area Number 25118007
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Complex systems
Research InstitutionAzabu University

Principal Investigator

Kikusui Takefumi  麻布大学, 獣医学部, 教授 (90302596)

Co-Investigator(Kenkyū-buntansha) 茂木 一孝  麻布大学, 獣医学部, 准教授 (50347308)
永澤 美保  麻布大学, 獣医学部, その他 (70533082)
Co-Investigator(Renkei-kenkyūsha) NAGASAWA Miho  麻布大学, 獣医学部, 講師 (70533082)
Project Period (FY) 2013-06-28 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥104,780,000 (Direct Cost: ¥80,600,000、Indirect Cost: ¥24,180,000)
Fiscal Year 2017: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2016: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2015: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2014: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2013: ¥29,380,000 (Direct Cost: ¥22,600,000、Indirect Cost: ¥6,780,000)
Keywordsマウス / 情動伝染 / 帯状回 / 中脳水道周囲灰白質 / オキシトシン / 心拍変動解析 / 涙 / イヌ / 共感性 / 犬 / 共感 / PAG / 社会シグナル / 絆 / すくみ行動 / 発達
Outline of Final Research Achievements

In mice, visual and olfactory cues are responsible for fear-contagion. In observer mice, ACC to PAG circuits in the brain is involved in fear-contagion. TRPV1 is also a regulatory molecule in this circuit. The mice weaned earlier showed decreased capacity of emotional contagion, and physical contact from mom increased ACC oxytocin release in pups. If this oxytocin was blocked, their social cognition and affiliation was impaired.
In dog-human dyad, eye-gaze contact increase oxytocin release in both, and if the dog watch the owner, their emotion became similar to that of the owners. When dogs reunite with their owners, they secret tears via oxytocin.

Report

(6 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (94 results)

All 2018 2017 2016 2015 2014 2013 Other

All Int'l Joint Research (4 results) Journal Article (42 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 42 results,  Open Access: 20 results,  Acknowledgement Compliant: 8 results) Presentation (45 results) (of which Int'l Joint Research: 3 results,  Invited: 6 results) Remarks (3 results)

  • [Int'l Joint Research] Unversity of Chicago/New York University(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] McGill University(Canada)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Berlin Free University(ドイツ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] University of Vienna(Austria)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Identification of an Intra- and Inter-specific Tear Protein Signal in Rodents2018

    • Author(s)
      Tsunoda Mai、Miyamichi Kazunari、Eguchi Ryo、Sakuma Yasuo、Yoshihara Yoshihiro、Kikusui Takefumi、Kuwahara Masayoshi、Touhara Kazushige
    • Journal Title

      Current Biology

      Volume: 28 Issue: 8 Pages: 1213-1223

    • DOI

      10.1016/j.cub.2018.02.060

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of the Oxytocin Receptor Gene Polymorphism on Successful Training for Drug Detection Dogs.2018

    • Author(s)
      Konno A, Yabuta S, Inoue-Murayama M, Tonoike A, Nagasawa M, Mogi K, Kikusui T
    • Journal Title

      Journal of Heredity

      Volume: - Issue: 5 Pages: 0-0

    • DOI

      10.1093/jhered/esy012

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sex differences in olfactory-induced neural activation of the amygdala.2018

    • Author(s)
      Kikusui T, Kajita M, Otsuka N, Hattori T, Kumazawa K, Watarai A, Nagasawa M, Inutsuka A, Yamanaka A, Matsuo N, Covington HE 3rd, Mogi K.
    • Journal Title

      Behav Brain Res.

      Volume: 27 Pages: 96-104

    • DOI

      10.1016/j.bbr.2017.11.034

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Exocrine Gland-Secreting Peptide 1 Is a Key Chemosensory Signal Responsible for the Bruce Effect in Mice.2017

    • Author(s)
      Hattori T, Osakada T, Masaoka T, Ooyama R, Horio N, Mogi K, Nagasawa M, Haga-Yamanaka S, Touhara K, Kikusui T.
    • Journal Title

      Curr Biol.

      Volume: 27 Issue: 20 Pages: 3197-3201

    • DOI

      10.1016/j.cub.2017.09.013

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intranasal Oxytocin Treatment Increases Eye-Gaze Behavior toward the Owner in Ancient Japanese Dog Breeds.2017

    • Author(s)
      M. Nagasawa, M. Ogawa, K. Mogi, T. Kikusui
    • Journal Title

      Frontiers in Psychology

      Volume: 8 Pages: 1624-1624

    • DOI

      10.3389/fpsyg.2017.01624

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nrp2 is sufficient to instruct circuit formation of mitral-cells to mediate odour-induced attractive social responses2017

    • Author(s)
      K. Inokuchi, F. Imamura, H. Takeuchi, R. Kim, H. Okuno, H. Nishizumi, H. Bito, T. Kikusui, H. Sakano
    • Journal Title

      Nature Communications

      Volume: 8 Issue: 1 Pages: 15977-15977

    • DOI

      10.1038/ncomms15977

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Immobility responses are induced by photoactivation of single glomerular species responsive to fox odour TMT2017

    • Author(s)
      H. Saito, H. Nishizumi, S. Suzuki, H. Matsumoto, N. Ieki, T. Abe, H. Kiyonari, M. Morita, H. Yokota, N. Hirayama, T. Yamazaki, T. Kikusui, K. Mori, H. Sakano
    • Journal Title

      Nature Communications

      Volume: 8 Issue: 1 Pages: 16011-16011

    • DOI

      10.1038/ncomms16011

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Male mice ultrasonic vocalizations enhance female sexual approach and hypothalamic kisspeptin neuron activity.2017

    • Author(s)
      A. Asaba, T. Osakada, K. Touhara, M. Kato, T. K. Mogi, T. Kikusui
    • Journal Title

      Hormones and Behavior

      Volume: 94 Pages: 53-60

    • DOI

      10.1016/j.yhbeh.2017.06.006

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Faecal transplantation for the treatment of Clostridium difficile infection in a marmoset2017

    • Author(s)
      Yamazaki Yumiko、Kawarai Shinpei、Morita Hidetoshi、Kikusui Takefumi、Iriki Atsushi
    • Journal Title

      BMC Veterinary Research

      Volume: 13 Issue: 1 Pages: 150-150

    • DOI

      10.1186/s12917-017-1070-z

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Draft Genome Sequence of Bifidobacterium lemurum DSM 28807 T Isolated from the Gastrointestinal Tracts of Ring-Tailed Lemurs ( Lemur catta )2017

    • Author(s)
      Toh Hidehiro、Matsubara Takehiro、Tomida Shuta、Mimura Iyo、Arakawa Kensuke、Kikusui Takefumi、Morita Hidetoshi
    • Journal Title

      Genome Announcements

      Volume: 5 Issue: 8

    • DOI

      10.1128/genomea.01656-16

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Emotional changes induced by social stress in juvenile period2017

    • Author(s)
      T. Kikusui, K. Mogi
    • Journal Title

      Folia Pharmacologica Japonica

      Volume: 149 Issue: 2 Pages: 66-71

    • DOI

      10.1254/fpj.149.66

    • NAID

      130005306342

    • ISSN
      0015-5691, 1347-8397
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutual mother-infant recognition in mice: the role of pup ultrasonic vocalizations2017

    • Author(s)
      Mogi K, Takakuda A, Tsukamoto C, Oyama R, Okabe S, Koshida N, Nagasawa M, Kikusui T.
    • Journal Title

      Behav Brain Res.

      Volume: 325 Pages: 138-146

    • DOI

      10.1016/j.bbr.2016.08.044

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A Self-Generated Environmental Factor as a Potential Contributor to Atypical Early Social Communication in Autism2017

    • Author(s)
      Kikusui T, Hiroi N
    • Journal Title

      Neuropsychopharmacology.

      Volume: 42 Issue: 1 Pages: 378-378

    • DOI

      10.1038/npp.2016.225

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pup exposure facilitates retrieving behavior via the oxytocin neural system in female mice2017

    • Author(s)
      Okabe, S., Tsuneoka, Y., Takahashi, A., Ooyama, R., Watarai, A., Maeda, S., Honda, Y., Nagasawa, M., Mogi, K., Nishimori, K., Kuroda, M., Koide, T., Kikusui, T.
    • Journal Title

      Psychoneuroendocrinology

      Volume: 79 Pages: 20-30

    • DOI

      10.1016/j.psyneuen.2017.01.036

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Owners' direct gazes increase dogs' attention-getting behaviors2016

    • Author(s)
      Midori Ohkita, Miho Nagasawa, Mogi Kazutaka, and Takefumi Kikusui
    • Journal Title

      Behavioral Processes.

      Volume: 125 Pages: 96-100

    • DOI

      10.1016/j.beproc.2016.02.013

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Heart rate variability predicts the emotional state in dogs2016

    • Author(s)
      M. Katayama, T. Kubo, K. Mogi, K. Ikeda, M. Nagasawa, T. Kikusui
    • Journal Title

      Behavioural Processes

      Volume: 128 Pages: 108-112

    • DOI

      10.1016/j.beproc.2016.04.015

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early weaning impairs a social contagion of pain-related stretching behavior in mice.2016

    • Author(s)
      Takefumi Kikusui, Yukino Ishio, Miho Nagasawa, Jeffrey Mogil, Kazutaka Mogi.
    • Journal Title

      Dev Psychobiol

      Volume: 58 Issue: 8 Pages: 1101-1107

    • DOI

      10.1002/dev.21443

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Early weaning influences short-term synaptic plasticity in the medial prefrontal-anterior basolateral amygdala pathway2016

    • Author(s)
      Takita M, Kikusui T
    • Journal Title

      Neuroscience Research

      Volume: 103 Pages: 48-53

    • DOI

      10.1016/j.neures.2015.08.003

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Structure and function of neonatal social communication in a genetic mouse model of autism.2016

    • Author(s)
      T. Takahashi, S. Okabe, P. Ó Broin, A. Nishi, K. Ye, M. V. Beckert, T. Izumi, A. Machida, G. Kang, Seiji Abe, J. L. Pena, A. Golden, T. Kikusui, N. Hiroi.
    • Journal Title

      Molecular Psychiatry

      Volume: in press Issue: 9 Pages: 1-7

    • DOI

      10.1038/mp.2015.190

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Self-Exposure to the Male Pheromone ESP1 Enhances Male Aggressiveness in Mice2016

    • Author(s)
      Tatsuya Hattori, Takuya Osakada, Ayaka Matsumoto, Naoki Matsuo, Sachiko Haga-Yamanaka, Takaya Nishida, Yuji Mori, Kazutaka Mogi, Kazushige Touhara, Takefumi Kikusui
    • Journal Title

      Current Biology

      Volume: 26 Issue: 9 Pages: 1229-1234

    • DOI

      10.1016/j.cub.2016.03.029

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Social evolution. Oxytocin-gaze positive loop and the coevolution of human-dog bonds.2015

    • Author(s)
      Nagasawa M, Mitsui S, En S, Ohtani N, Ohta M, Sakuma Y, Onaka T, Mogi K, Kikusui T.
    • Journal Title

      Science

      Volume: 348 Issue: 6232 Pages: 333-336

    • DOI

      10.1126/science.1261022

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Determining Ultrasonic Vocalization Preferences in Mice using a Two-choice Playback Test.2015

    • Author(s)
      Asaba A, Kato M, Koshida N, Kikusui T. Determining Ultrasonic Vocalization Preferences in Mice using a Two-choice Playback Test
    • Journal Title

      J Vis Exp.

      Volume: Sep3 Issue: 103 Pages: 103-103

    • DOI

      10.3791/53074

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Copy number variations in the amylase gene (AMY2B) in Japanese native dog breeds2015

    • Author(s)
      Tonoike, A., Hori, Y., Inoue-Murayama, M., Konno, A., Fujita, K., Miyado, M., Fukami, M., Nagasawa, M., Mogi, K., & Kikusui, T.
    • Journal Title

      Animal Genetics

      Volume: 46 Issue: 5 Pages: 580-583

    • DOI

      10.1111/age.12344

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Comparison of owner-reported behavioral characteristics among genetically clustered breeds of dog (Canis familiaris).2015

    • Author(s)
      Tonoike, A., Nagasawa, M., Mogi, K., Serpell, J. A., Ohtsuki, H., Kikusui, T.
    • Journal Title

      Sci. Rep.

      Volume: 5 Issue: 1 Pages: 17710-17710

    • DOI

      10.1038/srep17710

    • NAID

      120006667789

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Impairment of interstrain social recognition during territorial aggressive behavior in oxytocin receptor-null mice.2015

    • Author(s)
      Tatsuya Hattori, Kouta Kanno, Miho Nagasawa, Katsuhiko Nishimori, Kazutaka Mogi, and Takefumi Kikusui.
    • Journal Title

      Neuroscience Research

      Volume: 90 Pages: 90-94

    • DOI

      10.1016/j.neures.2014.05.003

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Genetic dissection of pheromone processing reveals main olfactory system-mediated social behaviors in mice2015

    • Author(s)
      Matsuo T, Hattori T, Asaba A, Inoue N, Kanomata N, Kikusui T, Kobayakawa R, Kobayakawa K.
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 112(3) Issue: 3 Pages: 88-92

    • DOI

      10.1073/pnas.1416723112

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] N-Acetyl-D-Mannosamine Treatment Alleviates Age-Related Decline in Place-Learning Ability in Dogs2014

    • Author(s)
      Nagasawa M1, Shimozawa A, Mogi K, Kikusui T.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 76 Issue: 5 Pages: 757-761

    • DOI

      10.1292/jvms.13-0351

    • NAID

      130003391262

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxytocin promotes social bonding in dogs.2014

    • Author(s)
      Romero T1, Nagasawa M2, Mogi K3, Hasegawa T4, Kikusui T3.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 111 Issue: 25 Pages: 9085-9090

    • DOI

      10.1073/pnas.1322868111

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of neonatal oxytocin manipulation on development of social behaviors in mice.2014

    • Author(s)
      Mogi, M., Ooyama, R., Nagasawa, M., Kikusui, T.
    • Journal Title

      Physiol. Behav.

      Volume: 133 Pages: 68-75

    • DOI

      10.1016/j.physbeh.2014.05.010

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Urinary oxytocin positively correlates with performance in facial visual search in unmarried males, without specific reaction to infant face.2014

    • Author(s)
      Saito A, Hamada H, Kikusui T, Mogi K, Nagasawa M, Mitsui S, Higuchi T, Hasegawa T, Hiraki K.
    • Journal Title

      Front Neurosci.

      Volume: 8 Pages: 217-217

    • DOI

      10.3389/fnins.2014.00217

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sexual attractiveness of male chemicals and vocalizations in mice2014

    • Author(s)
      Asaba A, Hattori T, Mogi K, Kikusui T
    • Journal Title

      Frontiers in neuroscience

      Volume: 8:231 Pages: 231-231

    • DOI

      10.3389/fnins.2014.00231

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] IL1RAPL1 knockout mice show learning deficiency, memory decline, hyperactivity and reduced anxiety-like behaviours.2014

    • Author(s)
      Misato Yasumura, Tomoyuki Yoshida, Maya Yamazaki, Manabu Abe, Rie Natsume, Kouta Kanno, Takeshi Uemura, Keizo Takao, Kenji Sakimura, Takefumi Kikusui, Tsuyoshi Miyakawa, Masayoshi Mishina
    • Journal Title

      Scientific Reports

      Volume: 4: 6613 Issue: 1 Pages: 6613-6613

    • DOI

      10.1038/srep06613

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sex differences in spatiotemporal expression of AR, ERα, and ERβ mRNA in the perinatal mouse brain.2014

    • Author(s)
      Kazutaka Mogi, Haruka Takanashi, Miho Nagasawa, and Takefumi Kikusui
    • Journal Title

      Neuroscience Letters

      Volume: 584 Pages: 88-92

    • DOI

      10.1016/j.neulet.2014.10.028

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] he behavioral and endocrinological development of stress response in dogs.2014

    • Author(s)
      Nagasawa M, Shibata Y, Yonezawa A, Morita T, Kanai M, Mogi K, Kikusui T.
    • Journal Title

      Developmental Psychobiology

      Volume: 56 Issue: 4 Pages: 726-733

    • DOI

      10.1002/dev.21141

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Developmental social environment imprints female preference for male song in mice2014

    • Author(s)
      Akari Asaba, Shota Okabe, Miho Nagasawa, Masahiro Kato, Nobuyoshi Koshida, Takuya Osakada, Kazutaka Mogi, Takefumi Kikusui.
    • Journal Title

      PloS ONE

      Volume: 9(2): e87186 Issue: 2 Pages: 1-7

    • DOI

      10.1371/journal.pone.0087186

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Infant calming responses during maternal carrying in humans and mice2013

    • Author(s)
      Gianluca Esposito, Sachine Yoshida (equal contribution)
    • Journal Title

      Current Biology

      Volume: 23 Issue: 9 Pages: 1-7

    • DOI

      10.1016/j.cub.2013.03.041

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Organizational effects of estrogen on male-type vulnerability to early weaning.2013

    • Author(s)
      Kikusui T, Shimokawa Y, Kanbara N, Nagasawa M, Mogi K.
    • Journal Title

      Hormones and Behavior

      Volume: 64 Issue: 1 Pages: 37-43

    • DOI

      10.1016/j.yhbeh.2013.04.007

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pup odor and ultrasonic vocalizations synergistically stimulate maternal attention in mice.2013

    • Author(s)
      Shota Okabe, Miho Nagasawa, Takashi Kihara, Masahiro Kato, Toshihiro Harada, Nobuyoshi Koshida, Kazutaka Mogi, Takefumi Kikusui.
    • Journal Title

      Behavioral Neuroscience

      Volume: 127 Issue: 3 Pages: 432-438

    • DOI

      10.1037/a0032395

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transport response is a filial specific behavioral response to maternal carrying in C57BL/6 mice2013

    • Author(s)
      Sachine Yoshida, Gianluca Espostio, Ryuko Ohnishi, Yosuke Tsuneoka, Shota Okabe, Takefumi Kikusui. Tadafumi Kato. Kumi
    • Journal Title

      Frontiers in Zoology

      Volume: 0 Issue: 1 Pages: 50-50

    • DOI

      10.1186/1742-9994-10-50

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of Male Aggressive and Sexual Behavior in Mice.2013

    • Author(s)
      Kikusui T
    • Journal Title

      Pheromone Signaling

      Volume: 1068 Pages: 307-318

    • DOI

      10.1007/978-1-62703-619-1_23

    • ISBN
      9781627036184, 9781627036191
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dogs show left facial lateralization upon reunion with their owners2013

    • Author(s)
      Nagasawa M, Kawai E, Mogi K, Kikusui T
    • Journal Title

      Behav Processes

      Volume: 98 Pages: 112-116

    • DOI

      10.1016/j.beproc.2013.05.012

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Production of Sry knockout mouse using TALEN via oocyte injection.2013

    • Author(s)
      Kato T, Miyata K, Sonobe M, Yamashita S, Tamano M, Miura K, Kanai Y, Miyamoto S, Sakuma T, Yamamoto T, Inui M, Kikusui T, Asahara H, Takada S.
    • Journal Title

      Scientific reports

      Volume: 3 Issue: 1 Pages: 3136-3136

    • DOI

      10.1038/srep03136

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] オキシトシンによる母子間の絆形成2018

    • Author(s)
      菊水健史
    • Organizer
      小児内分泌研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Reciprocal communication and endocrine response in human-dog interaction2017

    • Author(s)
      菊水健史
    • Organizer
      国際シンポジウム 異種間情報伝達から学ぶコミュニケーションの基礎
    • Related Report
      2017 Annual Research Report
  • [Presentation] Individual differences in male mice ultrasonic vocalizations to females are correlated with sexual motivation and neuronal activity in the ventral tegmental area2015

    • Author(s)
      Kouta Kanno, Takefumi Kikusui
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Chicago
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Male mice ultrasonic vocalizations enhance female reproductive function2015

    • Author(s)
      Akari Asaba, Mogi Kazutaka, and Takefumi Kikusui
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Chicago
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Non-breeder’s alloparenting behaviors are enhanced by coprophagy in eusocial rodents, the naked mole-rats2015

    • Author(s)
      Akiyuki Watarai, Miho Nagasawa, Mogi Kazutaka, and Takefumi Kikusui
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Chicago
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 内分泌を社会から考える2015

    • Author(s)
      菊水健史
    • Organizer
      神経内分泌学会
    • Place of Presentation
      東北大学
    • Year and Date
      2015-09-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Majority synching bias toward humans in dogs2015

    • Author(s)
      Miho Nagasawa, Kazutaka Mogi, Takefumi Kikusui
    • Organizer
      日本動物心理学会
    • Place of Presentation
      日本女子大
    • Year and Date
      2015-09-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] Heart rate variability predicts emotional valence in dogs2015

    • Author(s)
      Maki Katayama, Takatomi Kubo, Kazutaka Mogi, Kazushi Ikeda, Miho Nagasawa, Takefumi Kikusui.
    • Organizer
      日本動物心理学会
    • Place of Presentation
      日本女子大
    • Year and Date
      2015-09-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] Owner's gaze at its dog increases the dog's attachment behaviors2015

    • Author(s)
      Midori Ohkita, Miho Nagasawa, Mogi Kazutaka, and Takefumi Kikusui
    • Organizer
      日本動物心理学会
    • Place of Presentation
      日本女子大
    • Year and Date
      2015-09-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] Oxytocin forms inter-individual relationship2015

    • Author(s)
      Takefumi Kikusui
    • Organizer
      日本神経科学学会
    • Place of Presentation
      神戸国際会館
    • Year and Date
      2015-07-27
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Early weaning impaired fear extinction and decreased BDNF expression in the prefrontal cortex in adult C57BL/6 mice2015

    • Author(s)
      Kazutaka Mogi, Takefumi Kikusui
    • Organizer
      日本神経科学学会
    • Place of Presentation
      神戸国際会館
    • Year and Date
      2015-07-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 収斂進化がもたらしたヒトーイヌ間の絆形成とオキシトシンの役割2014

    • Author(s)
      永澤美保
    • Organizer
      包括脳「共感性領域」「自己制御精神領域」合同若手育成シンポジウム
    • Place of Presentation
      東京医科歯科大学
    • Year and Date
      2014-12-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 「人と犬の共生 心のつながり2014

    • Author(s)
      菊水健史
    • Organizer
      日本神経消化器病学会
    • Place of Presentation
      学術総合センター・一橋講堂
    • Year and Date
      2014-11-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 痛み情動伝染に対する母子間関係性の影響2014

    • Author(s)
      菊水健史
    • Organizer
      平成26年度生理研研究会 『情動研究会』
    • Place of Presentation
      生理学研究所
    • Year and Date
      2014-10-07 – 2014-10-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] Neural basis for Empathetic systesm2014

    • Author(s)
      菊水健史
    • Organizer
      The 37th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-11 – 2014-09-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] 早期離乳がC57BL/6マウスの行動及び前頭前野BDNF遺伝子に与える影響2014

    • Author(s)
      石田結子, 茂木一孝, 菊水健史
    • Organizer
      第157回日本獣医学会学術集会
    • Place of Presentation
      北海道大学
    • Year and Date
      2014-09-08 – 2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] イヌにおけるストレス内分泌の発達特性と行動との関連2014

    • Author(s)
      柴田曜、茂木一孝, 菊水健史
    • Organizer
      第157回日本獣医学会学術集会
    • Place of Presentation
      北海道大学
    • Year and Date
      2014-09-08 – 2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] ハダカデバネズミの非繁殖個体における養育行動発現メカニズム2014

    • Author(s)
      度会晃行、茂木一孝, 菊水健史
    • Organizer
      第157回日本獣医学会学術集会
    • Place of Presentation
      北海道大学
    • Year and Date
      2014-09-08 – 2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] マウス性行動の性差構築過程におけるステロイドホルモンの制御の解析2014

    • Author(s)
      園部未来、茂木一孝, 菊水健史
    • Organizer
      第157回日本獣医学会学術集会
    • Place of Presentation
      北海道大学
    • Year and Date
      2014-09-08 – 2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] "母性行動に系統差がみられるHatano高回避系(HAA)および低高回避系(LAA)ラットのpup ultrasonic vocalizations (USVs) "2014

    • Author(s)
      長谷川雄太、茂木一孝, 菊水健史
    • Organizer
      第157回日本獣医学会学術集会
    • Place of Presentation
      北海道大学
    • Year and Date
      2014-09-08 – 2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] マウス求愛歌発声の各パラメーターの関係性と性的動機づけ2014

    • Author(s)
      菅野康太、菊水健史
    • Organizer
      第21回日本行動神経内分泌研究会
    • Place of Presentation
      埼玉県秩父市
    • Year and Date
      2014-09-03 – 2014-09-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] マウス求愛歌による繁殖機能促進メカニズムの解明2014

    • Author(s)
      浅場明莉、菊水健史
    • Organizer
      第21回日本行動神経内分泌研究会
    • Place of Presentation
      埼玉県秩父市
    • Year and Date
      2014-09-03 – 2014-09-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Testosterone regulations on male sexual behavior and emission of ultrasounds in mice.2014

    • Author(s)
      菊水健史
    • Organizer
      ICN2014
    • Place of Presentation
      Sydney
    • Year and Date
      2014-08-17 – 2014-08-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Neonatal oxytocin treatments recover social deficits in oxytocin knock-out mice.2014

    • Author(s)
      茂木一孝, 菊水健史
    • Organizer
      ICN2014
    • Place of Presentation
      Sydney
    • Year and Date
      2014-08-17 – 2014-08-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Basic relations among song and behavioral parameters2014

    • Author(s)
      菅野康太、菊水健史
    • Organizer
      Workshop on Ultrasonic Communication in Rodents
    • Place of Presentation
      東京大学
    • Year and Date
      2014-08-04 – 2014-08-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] "Developmental imprinting of female preference for male song and its’ neuroendocrine effect in mice and it's neuroendocrine effects in mice"2014

    • Author(s)
      浅場明莉、菊水健史
    • Organizer
      Workshop on Ultrasonic Communication in Rodents
    • Place of Presentation
      東京大学
    • Year and Date
      2014-08-04 – 2014-08-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Higher behavioral functions in animals; their mind and evolution2014

    • Author(s)
      菊水健史
    • Organizer
      日本動物心理学会第74回大会
    • Place of Presentation
      犬山国際観光センター“フロイデ”
    • Year and Date
      2014-07-19 – 2014-07-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] "The development of endocrine stress response in early socialization period is associated with that in adulthood in dogs."2014

    • Author(s)
      永澤美保
    • Organizer
      日本動物心理学会第74回大会
    • Place of Presentation
      犬山国際観光センター“フロイデ”
    • Year and Date
      2014-07-19 – 2014-07-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] 社会的ストレスと脳機能の変化:社会経験や発達期環境がどのように脳内で社会認知機構を変容させるか2013

    • Author(s)
      菊水健史
    • Organizer
      第32回心身統合BAMISセミナー
    • Place of Presentation
      筑波大学
    • Year and Date
      2013-12-19
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Cellular localization concerned with pheromonal memory in the accessory olfactory bulb in mice.2013

    • Author(s)
      K. Mogi, S. Tsuchiya, K. Murata, M. Nagasawa, N. Matsuo, T. Kikusui
    • Organizer
      Neuroscience 2013
    • Place of Presentation
      San Diego
    • Year and Date
      2013-11-09 – 2013-11-13
    • Related Report
      2013 Annual Research Report
  • [Presentation] Developmental imprinting of female preference for male song and its' multimodal information processing in mice.2013

    • Author(s)
      A. Asaba, S. Okabe, M. Nagasawa, M. Kato, N. Koshida, T. Osakada, T. Matsuo, K. Kobatakawa, R. Kobayakawa, K. Mogi, T. Kikusui
    • Organizer
      Neuroscience 2013
    • Place of Presentation
      San Diego
    • Year and Date
      2013-11-09 – 2013-11-13
    • Related Report
      2013 Annual Research Report
  • [Presentation] Neuromolecular mechanisms for sex differences in response to maternal deprivation by early weaning.2013

    • Author(s)
      T. Kikusui, M. Takaki, H. Takanashi, Y. Shimokawa, N. Kanbara, M. Nagasawa, K. Mogi
    • Organizer
      Neuroscience 2013
    • Place of Presentation
      San Diego
    • Year and Date
      2013-11-09 – 2013-11-13
    • Related Report
      2013 Annual Research Report
  • [Presentation] Pup ultrasonic vocalizations (USVs) has a individual signature and can trigger retrieving behavior dependently on social experience and gonadal hormones.2013

    • Author(s)
      S. Okabe, C. Tsukamoto, M. Nagasawa, M. Kato, N. Koshida, K. Mogi, T. Kikusui
    • Organizer
      Neuroscience 2013
    • Place of Presentation
      San Diego
    • Year and Date
      2013-11-09 – 2013-11-13
    • Related Report
      2013 Annual Research Report
  • [Presentation] N―アセチル―D―マンノサミンによる老齢マウスとイヌの認知機能改善2013

    • Author(s)
      下沢 明希、北川 彩、永澤 美保、茂木 一孝、菊水 健史
    • Organizer
      第156回日本獣医学会学術集会
    • Place of Presentation
      岐阜大学
    • Year and Date
      2013-09-20 – 2013-09-22
    • Related Report
      2013 Annual Research Report
  • [Presentation] 新生仔期オキシトシン投与によるオキシトシン欠損マウスの社会行動異常の回復2013

    • Author(s)
      大山 瑠泉、永澤 美保、西森 克彦、茂木 一孝、菊水 健史
    • Organizer
      第156回日本獣医学会学術集会
    • Place of Presentation
      岐阜大学
    • Year and Date
      2013-09-20 – 2013-09-22
    • Related Report
      2013 Annual Research Report
  • [Presentation] 早期離乳によるグルココルチコイド上昇の中枢作用点解明2013

    • Author(s)
      蒲原 菜津実、飯島 希、井田 久美子、永澤 美保、茂木 一孝、菊水 健史
    • Organizer
      第156回日本獣医学会学術集会
    • Place of Presentation
      岐阜大学
    • Year and Date
      2013-09-20 – 2013-09-22
    • Related Report
      2013 Annual Research Report
  • [Presentation] イヌのヒトとのコミュニケーション能力の品種差,関連遺伝子の探索2013

    • Author(s)
      外池亜紀子,寺内豪,永澤美保,茂木一孝,菊水健史
    • Organizer
      日本動物心理学会第73回大会
    • Place of Presentation
      筑波大学
    • Year and Date
      2013-09-14 – 2013-09-15
    • Related Report
      2013 Annual Research Report
  • [Presentation] オキシトシン投与によるヒトへの視線増強の日本犬種と洋犬種の比較2013

    • Author(s)
      小川美里,菊水健史,茂木一孝,永澤美保,圓史緒理
    • Organizer
      日本動物心理学会第73回大会
    • Place of Presentation
      筑波大学
    • Year and Date
      2013-09-14 – 2013-09-15
    • Related Report
      2013 Annual Research Report
  • [Presentation] マウスにおける情動伝染と早期離乳の影響2013

    • Author(s)
      石尾雪乃,永澤美保,茂木一孝,菊水健史
    • Organizer
      日本動物心理学会第73回大会
    • Place of Presentation
      筑波大学
    • Year and Date
      2013-09-14 – 2013-09-15
    • Related Report
      2013 Annual Research Report
  • [Presentation] 体位や情動の変化がイヌの心拍変動に及ぼす影響2013

    • Author(s)
      片山真希,永澤美保,茂木一孝,菊水健史
    • Organizer
      日本動物心理学会第73回大会
    • Place of Presentation
      筑波大学
    • Year and Date
      2013-09-14 – 2013-09-15
    • Related Report
      2013 Annual Research Report
  • [Presentation] 「愛する心をはぐくむオキシトシンホルモン」 動物行動学の視点から2013

    • Author(s)
      菊水健史
    • Organizer
      第2回 プライマルヘルスケア学会
    • Place of Presentation
      神奈川県鎌倉市鎌倉芸術館
    • Year and Date
      2013-08-29
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 早期離乳と児への影響2013

    • Author(s)
      菊水健史
    • Organizer
      日本周産期・新生児医学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2013-07-13 – 2013-07-15
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] イヌにおけるストレス内分泌の発達特性と行動の関連2013

    • Author(s)
      柴田曜、永澤美保、茂木一孝、菊水健史
    • Organizer
      日本行動神経内分泌研究会(JSBN)
    • Place of Presentation
      鹿児島市レインボー桜島
    • Year and Date
      2013-07-05 – 2013-07-07
    • Related Report
      2013 Annual Research Report
  • [Presentation] 強制音声曝露による雄マウス超音波発生の変化強制音声曝露による雄マウス courtship vocalization の構造変化2013

    • Author(s)
      菅野康太、浅場明莉、横山和樹、永澤美保、茂木一孝、菊水健史
    • Organizer
      日本行動神経内分泌研究会(JSBN)
    • Place of Presentation
      鹿児島市レインボー桜島
    • Year and Date
      2013-07-05 – 2013-07-07
    • Related Report
      2013 Annual Research Report
  • [Presentation] 早期離乳がC57BL/6 系マウスの恐怖記憶制御と母性行動に与える影響2013

    • Author(s)
      石田結子、神谷麻愛、永澤美保、茂木一孝、菊水健史
    • Organizer
      日本行動神経内分泌研究会(JSBN)
    • Place of Presentation
      鹿児島市レインボー桜島
    • Year and Date
      2013-07-05 – 2013-07-07
    • Related Report
      2013 Annual Research Report
  • [Remarks] 麻布大学伴侶動物学研究室

    • URL

      https://sites.google.com/a/carazabu.com/car/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 伴侶動物学研究室Publications

    • URL

      https://sites.google.com/a/carazabu.com/car/publications

    • Related Report
      2016 Annual Research Report
  • [Remarks] 研究室WEBサイト

    • URL

      https://sites.google.com/a/carazabu.com/car/

    • Related Report
      2013 Annual Research Report

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Published: 2013-07-10   Modified: 2022-05-13  

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