|Budget Amount *help
¥48,750,000 (Direct Cost: ¥37,500,000、Indirect Cost: ¥11,250,000)
Fiscal Year 2018: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2017: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2016: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2015: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2014: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
|Outline of Final Research Achievements
In general, cell death is classified into two major categories, apoptosis and necrosis, according to its morphological features. Apoptosis is associated with characteristic and regulated morphological changes, but necrosis results in cellular swelling and rupture of cell membrane, which could be induced by accidental physical injury. Therefore, only apoptosis was believed to be regulated, and necrosis had been considered as uncontrolled and accidental cell death. However, recent studies have revealed novel mechanisms for controlling necrosis.
We previously developed indolylmaleimide (IM) derivatives as novel inhibitors for oxidative-stress-induced necrosis. In this study, we have revealed unique cell death inhibition profile of IM derivatives and developed a water-soluble IM derivative IM-17, which showed cardioprotective effects in ischemia-reperfusion injury.