;The roles of hypoxia signaling in the pathogenesis of lifestyle related diseases

• Project Area: Oxygen biology: a new criterion for integrated understanding of life
• Project/Area Number: 26111003
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokyo
• Principal Investigator: Nangaku Masaomi 東京大学, 医学部附属病院, 教授 (90311620)
• Co-Investigator(Kenkyū-buntansha): 合田 亘人 早稲田大学, 理工学術院, 教授 (00245549) ; 武田 憲彦 東京大学, 医学部附属病院, 助教 (40422307)
• Project Period (FY): 2014-07-10 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥120,250,000 (Direct Cost: ¥92,500,000、Indirect Cost: ¥27,750,000); Fiscal Year 2018: ¥22,750,000 (Direct Cost: ¥17,500,000、Indirect Cost: ¥5,250,000); Fiscal Year 2017: ¥24,570,000 (Direct Cost: ¥18,900,000、Indirect Cost: ¥5,670,000); Fiscal Year 2016: ¥22,750,000 (Direct Cost: ¥17,500,000、Indirect Cost: ¥5,250,000); Fiscal Year 2015: ¥24,570,000 (Direct Cost: ¥18,900,000、Indirect Cost: ¥5,670,000); Fiscal Year 2014: ¥25,610,000 (Direct Cost: ¥19,700,000、Indirect Cost: ¥5,910,000)
• Keywords: 生活習慣病 / 低酸素 / 慢性腎臓病 / 肝臓病 / 心臓病 / 炎症 / 線維化 / エネルギー / 低酸素応答 / 低酸素センサー / HIF / 内科 / ストレス / 低酸素シグナル

Outline of Final Research Achievements

Kidney, liver or heart consumes a large amount of molecular oxygen to maintain its activity, thus oxygen availability in each organ could influence its function. The molecular link, however, between hypoxic environment and the disease progression has not been fully elucidated.
In this study, we examined the roles of hypoxia inducible factor (HIF)-1alpha; signaling during the pathogenesis of lifestyle related diseases including chronic kidney disease, drug-induced liver injury and heart failure. Based on the in vivo animal models, we identified part of the critical pathways which augment the disease progression. In addition, we established a phosphorescence-based technology where we could measure tissue oxygen concentration quantitatively. These results will help us to gain a novel insight into the pathogenesis of lifestyle related disorders.

Academic Significance and Societal Importance of the Research Achievements

本研究により慢性腎臓病、薬剤性肝障害、心不全の病態進展における低酸素シグナルの役割を明らかにすると共に将来的な治療標的候補を同定した。今後、新たな生活習慣病治療介入への応用が期待される。併せて本研究では腎臓における組織酸素濃度の定量的計測を可能にする新規燐光プローブを用いた解析法を開発した。この手法は腎臓体内の各臓器への応用が可能であり、今後の酸素生物学の進展における重要な技術的基盤になると考えられる。

Research Products

• [Int'l Joint Research] Alessia Fornoni/University of Miami(米国)
• [Int'l Joint Research] Kai-Uwe Eckardt, Juergen Floege/University of Berlin/University of Aachen(ドイツ)
• [Int'l Joint Research] Roger Evans/Monash University(オーストラリア)
• [Int'l Joint Research] Bart Staels/Université de Lille(フランス)
• [Int'l Joint Research] Thitinun Anusornvongchai/Lerdsin General Hospital(タイ)
• [Int'l Joint Research] Uppsala University(Sweden)
• [Journal Article] Non-canonical cholinergic anti-inflammatory pathway-mediated activation of peritoneal macrophages induces Hes1 and blocks ischemia/reperfusion injury in the kidney (2019)
  • Author(s): Inoue T,Abe C, Kohro T, Tanaka S, Huang L, Yao J, Zheng S, Ye H, Inagi R, Stornetta RL, Rosin DL, Nangaku M, Wada Y, Okusa MD
  • Journal Title: Kidney International Volume: 95(3) Pages: 563-576
  • DOI: 10.1016/j.kint.2018.09.020
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A Placebo-Controlled, Randomized Trial of Enarodustat in Patients with Chronic Kidney Disease Followed by Long-Term Trial (2019)
  • Author(s): Akizawa Tadao、Nangaku Masaomi、Yamaguchi Takuhiro、Arai Masanobu、Koretomo Ryosuke、Matsui Atsushi、Hirakata Hideki
  • Journal Title: American Journal of Nephrology Volume: 49 Pages: 165-174
  • DOI: 10.1159/000496929
  • Peer Reviewed / Open Access
• [Journal Article] ATF6α downregulation of PPARα promotes lipotoxicity-induced tubulointerstitial fibrosis (2019)
  • Author(s): Jao Tzu-Ming、Nangaku Masaomi、Wu Chia-Hsien、Sugahara Mai、Saito Hisako、Maekawa Hiroshi、Ishimoto Yu、Aoe Mari、Inoue Tsuyoshi、Tanaka Tetsuhiro、Staels Bart、Mori Kazutoshi、Inagi Reiko
  • Journal Title: Kidney International Volume: 95 Pages: 577-589
  • DOI: 10.1016/j.kint.2018.09.023
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M. (2019)
  • Author(s): Abe H, Takeda N, Isagawa T, Semba H, Nishimura S, Morioka MS, Nakagama Y, Sato T, Soma K, Koyama K, Wake M, Katoh M, Asagiri M, Neugent ML, Kim JW, Stockmann C, Yonezawa T, Inuzuka R, Hirota Y, Maemura K, Yamashita T, Otsu K, Manabe I, Nagai R, Komuro I.
  • Journal Title: Nature Communications Volume: in press
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Establishment of Novel Cells Stably Secreting Various Human IL-18 Recombinant Proteins (2019)
  • Author(s): Asuka Kumagai, Kenji Shimizu, Riho Kurata, Xiaofeng Cui, Takayuki Isagawa, Msamitsu Harada, Jun Nagai, Yasuhiro Yoshida, Kei-ichi Ozaki, Norihiko Takeda, Hiroaki Semba and Tomo Yonezawa
  • Journal Title: Curr Pharm Biotechnol. Volume: 20 Pages: 47-55
  • DOI: 10.2174/1389201020666190206203640
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Seasonal Variations in the Achievement of Guideline Targets for HbA1c, Blood Pressure, and Cholesterol Among Patients With Type 2 Diabetes: A Nationwide Population-Based Study (ABC Study JDDM49) (2019)
  • Author(s): Sakamoto Masaya、Matsutani Daisuke、Minato Soichiro、Tsujimoto Yuki、Kayama Yosuke、Takeda Norihiko、Ichikawa Seiichi、Horiuchi Ryuzo、Utsunomiya Kazunori、Nishikawa Masako
  • Journal Title: Diabetes Care Volume: 42 Pages: 816-823
  • DOI: 10.2337/dc18-1953
  • Peer Reviewed
• [Journal Article] Cell cycle perturbation induces collagen production in fibroblasts. (2019)
  • Author(s): Wake M, Takeda N, Isagawa T, Sato T, Nakagama Y, Morioka MS, Hirota Y, Asagiri M, Maemura K, Manabe I, Tanabe K, Komuro I.
  • Journal Title: Int Heart J. Volume: in press
  • NAID: 130007684138
  • Peer Reviewed
• [Journal Article] Murine Model of Pulmonary Artery Overflow Vasculopathy Revealed Macrophage Accumulation in the Lung (2019)
  • Author(s): Minatsuki Shun、Takeda Norihiko、Soma Katsura、Katoh Manami、Maki Hisataka、Hatano Masaru、Takimoto Eiki、Manabe Ichiro、Komuro Issei
  • Journal Title: Int. Heart J. Volume: 60 Issue: 2 Pages: 451-456
  • DOI: 10.1536/ihj.18-281
  • NAID: 130007617444
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed / Open Access
• [Journal Article] Transcriptional profiles in the chicken ductus arteriosus during hatching (2019)
  • Author(s): Akaike T, Shinjo S, Ohmori E, Kajimura I, Goda N, Minamisawa S
  • Journal Title: PLoS One Volume: 14
  • DOI: 10.1371/journal.pone.0214139
  • Peer Reviewed / Open Access
• [Journal Article] Sodium-glucose cotransporter 2 inhibition normalizes glucose metabolism and suppresses oxidative stress in the kidneys of diabetic mice (2018)
  • Author(s): Tanaka Shinji、Sugiura Yuki、Saito Hisako、Sugahara Mai、Higashijima Yoshiki、Yamaguchi Junna、Inagi Reiko、Suematsu Makoto、Nangaku Masaomi、Tanaka Tetsuhiro
  • Journal Title: Kidney International Volume: 94 Pages: 912-925
  • DOI: 10.1016/j.kint.2018.04.025
  • Peer Reviewed
• [Journal Article] Palmitate deranges erythropoietin production via transcription factor ATF4 activation of unfolded protein response (2018)
  • Author(s): Anusornvongchai Thitinun、Nangaku Masaomi、Jao Tzu-Ming、Wu Chia-Hsien、Ishimoto Yu、Maekawa Hiroshi、Tanaka Tetsuhiro、Shimizu Akira、Yamamoto Masayuki、Suzuki Norio、Sassa Ryoji、Inagi Reiko
  • Journal Title: Kidney International Volume: 94 Pages: 536-550
  • DOI: 10.1016/j.kint.2018.03.011
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Persistent expression of neutrophil gelatinase-associated lipocalin and M2 macrophage markers and chronic fibrosis after acute kidney injury. (2018)
  • Author(s): Saito Hisako、Tanaka Tetsuhiro、Tanaka Shinji、Higashijima Yoshiki、Yamaguchi Junna、Sugahara Mai、Ito Marie、Uchida Lisa、Hasegawa Sho、Wakashima Takeshi、Fukui Kenji、Nangaku Masaomi
  • Journal Title: Physiological Reports Volume: 6
  • DOI: 10.14814/phy2.13707
  • Peer Reviewed / Open Access
• [Journal Article] Intravital phosphorescence lifetime imaging of the renal cortex accurately measures renal hypoxia (2018)
  • Author(s): Hirakawa Y, Mizukami K, Yoshihara T, Takahashi I, Khulan P, Honda T, Mimura I, Tanaka T, Tobita S, Nangaku M.
  • Journal Title: Kidney International Volume: 印刷中 Pages: 1483-1489
  • DOI: 10.1016/j.kint.2018.01.015
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Genome-wide analysis revealed that DZNep reduces tubulointerstitial fibrosis via down-regulation of pro-fibrotic genes. (2018)
  • Author(s): Mimura I, Hirakawa Y, Kanki Y, Nakaki R, Suzuki Y, Tanaka T, Aburatani H, Nangaku M.
  • Journal Title: Sci Rep Volume: 28 Issue: 1 Pages: 3779-3779
  • DOI: 10.1038/s41598-018-22180-5
  • Peer Reviewed / Open Access
• [Journal Article] Hypoxia-inducible factor stabilizers for treating anemia of chronic kidney disease (2018)
  • Author(s): Hasegawa Sho、Tanaka Tetsuhiro、Nangaku Masaomi
  • Journal Title: Current Opinion in Nephrology and Hypertension Volume: 27 Pages: 331-338
  • DOI: 10.1097/mnh.0000000000000431
  • Peer Reviewed
• [Journal Article] Targeting Hypoxia-Inducible Factor-1α/Pyruvate Dehydrogenase Kinase 1 Axis by Dichloroacetate Suppresses Bleomycin-induced Pulmonary Fibrosis (2018)
  • Author(s): Goodwin J, Choi H, Hsieh MH, Nuegent ML, Ahn JM, Hayenga HN, Singh PK, Shackelford DB, Lee IK, Shulaev V, Dhar S, Takeda N, Kim JW.
  • Journal Title: American Journal of Respiratory Cell and Molecular Biology Volume: 58 Pages: 216-231
  • DOI: 10.1165/rcmb.2016-0186oc
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] HIF2α in the uterine stroma permits embryo invasion and Iuminal epithelium detachment. (2018)
  • Author(s): Matsumoto L, Hirota Y, Saito-Fujita T, Takeda N, Tanaka T, Hiraoka T, Akaeda S, Fujita H, Shimizu-Hirota R, Igaue S, Matsuo M, Haraguchi H, Saito-Kanatani M, Fujii T, Osuga Y.
  • Journal Title: J Clin Invest Volume: 128 Pages: 3186-3197
  • DOI: 10.1172/jci98931
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Visit-to-visit HbA1c variability is inversely related to baroreflex sensitivity independently of HbA1c value in type 2 diabetes (2018)
  • Author(s): Matsutani Daisuke、Sakamoto Masaya、Minato Soichiro、Kayama Yosuke、Takeda Norihiko、Horiuchi Ryuzo、Utsunomiya Kazunori
  • Journal Title: Cardiovascular Diabetology Volume: 17 Pages: 100-100
  • DOI: 10.1186/s12933-018-0743-7
  • Peer Reviewed / Open Access
• [Journal Article] Necrostatin-7 suppresses RANK-NFATc1 signaling and attenuates macrophage to osteoclast differentiation (2018)
  • Author(s): Fuji H、Ohmae S、Noma N、Takeiri M、Yasutomi H、Izumi K、Ito M、Toyomoto M、Iwaki S、Takemoto K、Seo S、Taura K、Hida S、Aoyama M、Ishihama Y、Hagiwara M、Takeda N、Hatano E、Iwaisako K、Uemoto S、Asagiri M
  • Journal Title: iochemical and Biophysical Research Communications Volume: 503 Pages: 544-549
  • DOI: 10.1016/j.bbrc.2018.05.153
  • Peer Reviewed
• [Journal Article] Effect of canagliflozin on left ventricular diastolic function in patients with type 2 diabetes (2018)
  • Author(s): Matsutani Daisuke、Sakamoto Masaya、Kayama Yosuke、Takeda Norihiko、Horiuchi Ryuzo、Utsunomiya Kazunori
  • Journal Title: Cardiovascular Diabetology Volume: 17 Pages: 73-73
  • DOI: 10.1186/s12933-018-0717-9
  • Peer Reviewed / Open Access
• [Journal Article] Accelerated Cardiomyocyte Proliferation in the Heart of a Neonate With LEOPARD Syndrome-Associated Fatal Cardiomyopathy (2018)
  • Author(s): Nakagama Y, Inuzuka R, Ichimura K, Hinata M, Takehara H, Takeda N, Kakiuchi S, Shiraga K, Asakai H, Shindo T, Hirata Y, Saitoh M, Oka A
  • Journal Title: Circuation: Heart Failure Volume: 11
  • DOI: 10.1161/circheartfailure.117.004660
  • Peer Reviewed
• [Journal Article] Pyruvate Dehydrogenase PDH-E1β Controls Tumor Progression by Altering the Metabolic Status of Cancer Cells (2018)
  • Author(s): Yonashiro R, Eguchi K, Wake M, Takeda N, Nakayama K.
  • Journal Title: Cancer Res Volume: 78 Pages: 1592-1603
  • DOI: 10.1158/0008-5472.can-17-1751
  • Peer Reviewed / Open Access
• [Journal Article] Combined Surgical and Medical Therapy for <i>Candida</i> Prosthetic Endocarditis in a Patient with Repaired Tetralogy of Fallot (2018)
  • Author(s): Kubota Kana、Soma Katsura、Uehara Masae、Inaba Toshiro、Saito Akihito、Takeda Norihiko、Hatano Masaru、Morita Hiroyuki、Inuzuka Ryo、Hirata Yasutaka、Yao Atsushi、Komuro Issei
  • Journal Title: Int. Heart J. Volume: 59 Issue: 4 Pages: 877-880
  • DOI: 10.1536/ihj.17-314
  • NAID: 130007427442
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed / Open Access
• [Journal Article] Pyruvate dehydrogenase activation precedes the down-regulation of fatty acid oxidation in monocrotaline-induced myocardial toxicity in mice (2018)
  • Author(s): Nakai Gaku、Shimura Daisuke、Uesugi Ken、Kajimura Ichige、Jiao Qibin、Kusakari Yoichiro、Soga Tomoyoshi、Goda Nobuhito、Minamisawa Susumu
  • Journal Title: Heart and Vessels Volume: 34 Pages: 545-555
  • DOI: 10.1007/s00380-018-1293-3
  • Peer Reviewed
• [Journal Article] HIF-1-dependent lipin1 induction prevents excessive lipid accumulation in choline-deficient diet-induced fatty liver (2018)
  • Author(s): Arai Takatomo、Tanaka Masako、Goda Nobuhito
  • Journal Title: Scientific Reports Volume: 8 Pages: 14230-14230
  • DOI: 10.1038/s41598-018-32586-w
  • Peer Reviewed / Open Access
• [Journal Article] Differential expression of Lutheran/BCAM regulates biliary tissue remodeling in ductular reaction during liver regeneration. (2018)
  • Author(s): Miura Yasushi、Matsui Satoshi、Miyata Naoko、Harada Kenichi、Kikkawa Yamato、Ohmuraya Masaki、Araki Kimi、Tsurusaki Shinya、Okochi Hitoshi、Goda Nobuhito、Miyajima Atsushi、Tanaka Minoru
  • Journal Title: Elife. Volume: 7 Pages: 36572-36572
  • DOI: 10.7554/elife.36572
  • Peer Reviewed / Open Access
• [Journal Article] Effects of Aging on Serum Levels of Lipid Molecular Species as Determined by Lipidomics Analysisin Japanese Men and Women. (2018)
  • Author(s): Kawanishi Noriaki、Kato Yuki、Yokozeki Kyosuke、Sawada Shuji、Sakurai Ryota、Fujiwara Yoshinori、Shinkai Shoji、Goda Nobuhito、Suzuki Katsuhiko
  • Journal Title: Lipids in Health and Disease Volume: 17 Pages: 135-135
  • DOI: 10.1186/s12944-018-0785-6
  • Peer Reviewed / Open Access
• [Journal Article] Loss of hypoxia inducible factor-1α aggravates γδ T-cell-mediated inflammation during acetaminophen-induced liver injury (2018)
  • Author(s): Suzuki T, Minagawa S, Yamazaki T, Arai T, Kanai M, Shinjo S, Goda N
  • Journal Title: Hepatology Communications Volume: in press Pages: 571-581
  • DOI: 10.1002/hep4.1175
  • Peer Reviewed / Open Access
• [Journal Article] Glycemic variability in continuous glucose monitoring is inversely associated with baroreflex sensitivity in type 2 diabetes: a preliminary report (2018)
  • Author(s): Matsutani Daisuke、Sakamoto Masaya、Iuchi Hiroyuki、Minato Souichirou、Suzuki Hirofumi、Kayama Yosuke、Takeda Norihiko、Horiuchi Ryuzo、Utsunomiya Kazunori
  • Journal Title: Cardiovasc Diabetol Volume: 17 Pages: 36-36
  • DOI: 10.1186/s12933-018-0683-2
  • Peer Reviewed / Open Access
• [Journal Article] Mitochondrial Abnormality Facilitates Cyst Formation in Autosomal Dominant Polycystic Kidney Disease (2018)
  • Author(s): Ishimoto Y, Inagi R, Yoshihara D, Kugita M, Nagao S, Shimizu A, Takeda N, Wake M, Honda K, Zhou J, Nangaku M
  • Journal Title: Mol Cell Biol. Volume: e-Pub
  • DOI: 10.1128/mcb.00337-17
  • NAID: 40021751803
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Mechanisms of metabolic memory and renal hypoxia as a therapeutic target in diabetic kidney disease (2017)
  • Author(s): Hirakawa Y, Tanaka T, Nangaku M.
  • Journal Title: Journal of Diabetes Investigation Volume: - Pages: 261-271
  • DOI: 10.1111/jdi.12624
  • Peer Reviewed / Open Access
• [Journal Article] Renal Hypoxia in CKD; Pathophysiology and Detecting Methods (2017)
  • Author(s): Hirakawa Y, Tanaka T, Nangaku M.
  • Journal Title: Front Physiol Volume: ８ Pages: 99-99
  • DOI: 10.3389/fphys.2017.00099
  • Peer Reviewed / Open Access
• [Journal Article] Novel lnc RNA regulated by HIF-1 inhibits apoptotic cell death in the renal tubular epithelial cells under hypoxia (2017)
  • Author(s): Mimura I, Hirakawa Y, Kanki Y, Kushida N, Nakaki R, Suzuki Y, Tanaka T, Aburatani H, Nangaku M.
  • Journal Title: Physiol Rep Volume: 5
  • DOI: 10.14814/phy2.13203
  • Peer Reviewed / Open Access
• [Journal Article] Epigenetic Changes in the Acute Kidney Injury-to-Chronic Kidney Disease Transition (2017)
  • Author(s): Nangaku M, Hirakawa Y, Mimura I, Inagi R, Tanaka T.
  • Journal Title: Nephron Volume: 137 Pages: 256-259
  • DOI: 10.1159/000476078
  • Peer Reviewed / Open Access
• [Journal Article] Echinomycin inhibits adipogenesis in 3T3-L1 cells in a HIF-independent manner (2017)
  • Author(s): Yamaguchi J, Tanaka T, Saito H, Nomura S, Aburatani H, Waki H, Kadowaki T, Nangaku M.
  • Journal Title: Sci Rep Volume: 26 Pages: 6516-6516
  • DOI: 10.1038/s41598-017-06761-4
  • Peer Reviewed / Open Access
• [Journal Article] Prolyl hydroxylase domain inhibitors as a novel therapeutic approach against anemia in chronic kidney disease (2017)
  • Author(s): Sugahara M, Tanaka T, Nangaku M.
  • Journal Title: Kidney International Volume: 92 Pages: 306-312
  • DOI: 10.1016/j.kint.2017.02.035
  • Peer Reviewed
• [Journal Article] Vascular adhesion protein-1 enhances neutrophil infiltration by generation of hydrogen peroxide in renal ischemia/reperfusion injury (2017)
  • Author(s): Tanaka S, Tanaka T, Kawakami T, Takano H, Sugahara M, Saito H, Higashijima Y, Yamaguchi J, Inagi R, Nangaku M
  • Journal Title: Kidney International Volume: 印刷中 Pages: 154-164
  • DOI: 10.1016/j.kint.2017.01.014
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Time-dependent effects of ipragliflozin on behaviour and energy homeostasis in normal and type 2 diabetic rats: continuous glucose telemetry analysis (2017)
  • Author(s): Iuchi H, Sakamoto M, Matsutani D, Suzuki H, Kayama Y, Takeda N, Minamisawa S, Utsunomiya K.
  • Journal Title: Sci Rep Volume: 22 Pages: 11906-11906
  • DOI: 10.1038/s41598-017-12106-y
  • Peer Reviewed / Open Access
• [Journal Article] Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis (2017)
  • Author(s): Krzywinska E, Kantari-Mimoun C, Kerdiles Y, Sobecki M, Isagawa T, Gotthardt D, Castells M, Haubold J, Millien C, Viel T, Tavitian B, Takeda N, Fandrey J, Vivier E, Sexl V, Stockmann C.
  • Journal Title: Nature Communications Volume: 8 Pages: 1597-1597
  • DOI: 10.1038/s41467-017-01599-w
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association between day-by-day and ambulatory blood pressure variability in type 2 diabetes patients (2017)
  • Author(s): Iuchi H, Sakamoto M, Matsutani D, Suzuki H, Kayama Y, Takeda N, Utsunomiya K
  • Journal Title: Blood Press Monit Volume: 22 Pages: 351-354
  • DOI: 10.1097/mbp.0000000000000285
  • Peer Reviewed
• [Journal Article] The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition (2017)
  • Author(s): Goodwin J, Neugent ML, Lee SY, Choe JH, Choi H, Jenkins DMR, Ruthenborg RJ, Robinson MW, Jeong JY, Wake M, Abe H, Takeda N, Endo H, Inoue M, Xuan Z, Yoo H, Chen M, Ahn JM, Minna JD, Helke KL, Singh PK, Shackelford DB, Kim JW.
  • Journal Title: Nat Commun Volume: 8 Pages: 15503-15503
  • DOI: 10.1038/ncomms15503
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The Roles of Hypoxia Signaling in the Pathogenesis of Cardiovascular Diseases (2017)
  • Author(s): Abe Hajime、Semba Hiroaki、Takeda Norihiko
  • Journal Title: J Atheroscler Thromb Volume: 24 Issue: 9 Pages: 884-894
  • DOI: 10.5551/jat.rv17009 10.5551/jat.RV17009
  • NAID: 130006038428
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Disruption of the mitochondria-associated ER membrane (MAM) plays a central role in palmitic acid?induced insulin resistance (2017)
  • Author(s): Shinjo Satoko、Jiang Shuying、Nameta Masaaki、Suzuki Tomohiro、Kanai Mai、Nomura Yuta、Goda Nobuhito
  • Journal Title: Exp Cell Res Volume: 359 Pages: 86-93
  • DOI: 10.1016/j.yexcr.2017.08.006
  • Peer Reviewed
• [Journal Article] Previous dropout from diabetic care as a predictor of patients' willingness to use mobile applications for self-management: A cross-sectional study. (2017)
  • Author(s): Yamaguchi S, Waki K, Tomizawa N, Waki H, Nannya Y, Nangaku M, Kadowaki T, Ohe K.
  • Journal Title: Journal of Diabetes Investigation Volume: 印刷中
  • DOI: 10.1111/jdi.12613
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Effects of Daprodustat, a Novel Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor on Anemia Management in Japanese Hemodialysis Subjects. (2017)
  • Author(s): Akizawa T, Tsubakihara Y, Nangaku M, Endo Y, Nakajima H, Kohno T, Imai Y, Kawase N, Hara K, Lepore J, Cobitz A.
  • Journal Title: Am J Nephrol Volume: 45 Pages: 127-135
  • DOI: 10.1159/000454818
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Mizoribine therapy combined with steroids and mizoribine blood concentration monitoring for idiopathic membranous nephropathy with steroid-resistant nephrotic syndrome. (2017)
  • Author(s): Saito T, Iwano M, Matsumoto K, Mitarai T, Yokoyama H, Yorioka N, Nishi S, Yoshimura A, Sato H, Ogahara S, Sasatomi Y, Kataoka Y, Ueda S, Koyama A, Maruyama S, Nangaku M, Imai E, Matsuo S, Tomino Y; Refractory Nephrotic Syndrome Study Group.
  • Journal Title: Clin Exp Nephrol Volume: 印刷中
  • NAID: 120006373812
  • Peer Reviewed
• [Journal Article] Urinary N-acetyl-β-glucosaminidase and eGFR may identify patients to be treated with immuno-suppression at diagnosis in idiopathic membranous nephropathy. (2017)
  • Author(s): Bazzi C, Usui T, Rizza V, Casellato D, Gallieni M, Nangaku M.
  • Journal Title: Nephrology Volume: 印刷中
  • DOI: 10.1111/nep.12952
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Selective plasma exchange can reduce auto-antibodies in patients with bullous pemphigoid without affecting factor XIII and fibrinogen. (2017)
  • Author(s): Nasu K, Hanafusa N, Nangaku M.
  • Journal Title: J Clin Apher Volume: 印刷中
  • DOI: 10.1002/jca.21513
  • Peer Reviewed
• [Journal Article] Impact of end-stage renal disease on hospital outcomes among patients admitted to intensive care units: A retrospective matched-pair cohort study. (2017)
  • Author(s): Iwagami M, Yasunaga H, Matsui H, Horiguchi H, Fushimi K, Noiri E, Nangaku M, Doi K.
  • Journal Title: Nephrology Volume: 印刷中
  • DOI: 10.1111/nep.12830
  • Peer Reviewed
• [Journal Article] Development of quality indicators for care of chronic kidney disease in the primary care setting using electronic health data: a RAND-modified Delphi method. (2017)
  • Author(s): Fukuma S, Shimizu S, Niihata K, Sada KE, Yanagita M, Hatta T, Nangaku M, Katafuchi R, Fujita Y, Koizumi J, Koizumi S, Kimura K, Fukuhara S, Shibagaki Y.
  • Journal Title: Clin Exp Nephrol Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Ulcerative colitis with hepatitis B virus infection treated successfully by granulocyte monocyte apheresis. (2017)
  • Author(s): Saito H, Hanafusa N, Kishikawa J, Noiri E, Sunami E, Ishihara S, Watanabe T, Nangaku M.
  • Journal Title: J Clin Apher Volume: 印刷中
  • DOI: 10.1002/jca.21450
  • Peer Reviewed
• [Journal Article] HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity (2017)
  • Author(s): Semba, H., Takeda, N., Isagawa, T., Sugiura, Y., Honda, K., Wake, M., Miyazawa, H., Yamaguchi, Y., Miura, M., Jenkins, DM., Choi, H., Kim, JW., Asagiri, M., Cowburn, AS., Abe, H., Soma, K., Koyama, K., Katoh, M., Sayama, K., Goda, N., Johnson, RS., Manabe, I., Nagai, R., Komuro, I.
  • Journal Title: Nat Commun. 2016 May 18;7:11635. Volume: 7 Pages: 11635-11635
  • DOI: 10.1038/ncomms11635
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Type I neuregulin1α is a novel local mediator to suppress hepatic gluconeogenesis in mice (2017)
  • Author(s): Arai T, Ono Y, Arimura Y, Sayama K, Suzuki T, Shinjo S, Kanai M, Abe S, Semba K, Goda N.
  • Journal Title: Scientific Reports Volume: 7 Pages: 42959-42959
  • DOI: 10.1038/srep42959
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Distinct Metabolic Phenotypes within Non-small Cell 1 Lung Cancer Define Selective Vulnerability to Glycolytic Inhibition of Lung Squamous Cell Carcinoma. (2017)
  • Author(s): Goodwin J, Neugent ML, Lee SY, Choe JH, Choi H, Jenkins DMR, Ruthenborg RJ, Robinson MW, Jeong JY, Wake M, Abe H, Takeda N, Endo H, Inoue M, Xuan Z, Yoo H, Chen M, Ahn JM, Minna JD, Helke KL, Singh PK, Shackelford DB, Kim JW.
  • Journal Title: Nat Commun Volume: 印刷中
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Bevacizumab-related microvascular angina and its management with nicorandil. (2017)
  • Author(s): Katoh M, Takeda N, Arimoto T, Abe H, Oda K, Osuga Y, Fujii T, Komuro I.
  • Journal Title: Int Heart J Volume: 印刷中
  • NAID: 130006179206
  • Peer Reviewed
• [Journal Article] Cardiac Sarcoidosis Diagnosed by Incidental Lymph Node Biopsy (2017)
  • Author(s): Matsuda J, Fujiu K, Roh S, Tajima M, Maki H, Kojima T, Ushiku T, Nawata K, Takeda N, Watanabe M, Akazawa H, Komuro I.
  • Journal Title: Int. Heart J. Volume: 58 Issue: 1 Pages: 140-143
  • DOI: 10.1536/ihj.16-218
  • NAID: 130005330527
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Actin-binding protein coronin 1A controls osteoclastic bone resorption by regulating lysosomal secretion of cathepsin K (2017)
  • Author(s): Ohmae S, Noma N, Toyomoto M, Shinohara M, Takeiri M, Fuji, Takemoto K, Iwaisako K, Fujita T, Takeda N, Kawatani M, Aoyama M, Hagiwara M, Ishihama Y, Asagiri M.
  • Journal Title: Sci. Rep. Volume: 7 Pages: 1-12
  • DOI: 10.1038/srep41710
  • NAID: 120006313626
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Planimetry of the orifice area in aortic valve stenosis using phase-contrast cardiac magnetic resonance imaging. (2017)
  • Author(s): Abe H., Iguchi N, Utanohara Y, Takada K, Hen Y, Machida H, Takeda N, Sumiyoshi T.
  • Journal Title: Int Heart J Volume: 印刷中
  • NAID: 130006321387
  • Peer Reviewed
• [Journal Article] Hypoxia-Inducible Factor-1α Activates the Transforming Growth Factor-β/SMAD3 Pathway in Kidney Tubular Epithelial Cells. (2016)
  • Author(s): Kushida N, Nomura S, Mimura I, Fujita T, Yamamoto S, Nangaku M, Aburatani H.
  • Journal Title: Am J Nephrol Volume: 44 Pages: 276-285
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Umbilical Cord Blood Transplantation-associated Nephrotic Syndrome Successfully Treated by Low-density Lipoprotein Apheresis. (2016)
  • Author(s): Sugawara Y, Honda K, Katagiri D, Nakamura M, Kawakami T, Nasu R, Hayashi A, Shintani Y, Tojo A, Noiri E, Kurokawa M, Fukayama M, Nangaku M.
  • Journal Title: Intern Med Volume: 55 Pages: 2831-2836
  • NAID: 130005605877
  • Peer Reviewed / Open Access
• [Journal Article] Impact of clinical context on acute kidney injury biomarker performances: differences between neutrophil gelatinase-associated lipocalin and L-type fatty acid-binding protein. (2016)
  • Author(s): Asada T, Isshiki R, Hayase N, Sumida M, Inokuchi R, Noiri E, Nangaku M, Yahagi N, Doi K.
  • Journal Title: Sci Rep Volume: 6 Pages: 33077-33077
  • DOI: 10.1038/srep33077
  • Peer Reviewed / Open Access
• [Journal Article] Analysis of the V2 Vasopressin Receptor (V2R) Mutations Causing Partial Nephrogenic Diabetes Insipidus Highlights a Sustainable Signaling by a Non-peptide V2R Agonist. (2016)
  • Author(s): Makita N, Sato T, Yajima-Shoji Y, Sato J, Manaka K, Eda-Hashimoto M, Ootaki M, Matsumoto N, Nangaku M, Iiri T.
  • Journal Title: J Biol Chem Volume: 291 Pages: 22460-22471
  • Peer Reviewed
• [Journal Article] DialBetics: Smartphone-Based Self-Management for Type 2 Diabetes Patients on Insulin Injections. (2016)
  • Author(s): Waki K, Fujiu K, Hayashi A, Kimura S, Kobayashi H, Nangaku M, Kadowaki T, Ohe K.
  • Journal Title: J Diabetes Sci Technol Volume: 10 Pages: 804-805
  • DOI: 10.1177/1932296815619638
  • Peer Reviewed / Open Access
• [Journal Article] Lactoferrin Suppresses Neutrophil Extracellular Traps Release in Inflammation (2016)
  • Author(s): Okubo K, Kamiya M, Urano Y, Nishi H, Herter JM, Mayadas T, Hirohama D, Suzuki K, Kawakami H, Tanaka M, Kurosawa M, Kagaya S, Hishikawa K, Nangaku M, Fujita T, Hayashi M, Hirahashi J.
  • Journal Title: EBioMedicine Volume: 10 Pages: 204-215
  • DOI: 10.1016/j.ebiom.2016.07.012
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Complete remission of thrombotic microangiopathy after treatment with eculizumab in a patient with non-Shiga toxin-associated bacterial enteritis: A case report. (2016)
  • Author(s): Omura T, Watanabe E, Otsuka Y, Yoshida Y, Kato H, Nangaku M, Miyata T, Oda S.
  • Journal Title: Medicine (Baltimore) Volume: 95
  • DOI: 10.1097/md.0000000000004104
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] No association between dysplasminogenemia with p.Ala620Thr mutation and atypical hemolytic uremic syndrome. (2016)
  • Author(s): Miyata T, Uchida Y, Yoshida Y, Kato H, Matsumoto M, Kokame K, Fujimura Y, Nangaku M.
  • Journal Title: Int J Hematol Volume: 104 Pages: 223-227
  • Peer Reviewed
• [Journal Article] Potential Survival Benefit of Polymyxin B Hemoperfusion in Septic Shock Patients on Continuous Renal Replacement Therapy: A Propensity-Matched Analysis. (2016)
  • Author(s): Iwagami M, Yasunaga H, Noiri E, Horiguchi H, Fushimi K, Matsubara T, Yahagi N, Nangaku M, Doi K.
  • Journal Title: Blood Purif Volume: 42 Pages: 9-17
  • Peer Reviewed
• [Journal Article] Erythropoietin concentration in acute kidney injury is associated with insulin-like growth factor-binding protein-1. (2016)
  • Author(s): Yamashita T, Noiri E, Hamasaki Y, Matsubara T, Ishii T, Yahagi N, Nangaku M, Doi K.
  • Journal Title: Nephrology Volume: 21 Pages: 693-9
  • DOI: 10.1111/nep.12656
  • Peer Reviewed
• [Journal Article] Association of Urinary Neutrophil Gelatinase-Associated Lipocalin With Long-Term Renal Outcomes in ICU Survivors: A Retrospective Observational Cohort Study. (2016)
  • Author(s): Isshiki R, Asada T, Sato D, Sumida M, Hamasaki Y, Inokuchi R, Matsubara T, Ishii T, Yahagi N, Nangaku M, Noiri E, Doi K.
  • Journal Title: Shock Volume: 46 Pages: 44-51
  • DOI: 10.1097/shk.0000000000000580
  • Peer Reviewed
• [Journal Article] Interstitial renal fibrosis due to multiple cisplatin treatments is ameliorated by semicarbazide-sensitive amine oxidase inhibition. (2016)
  • Author(s): Katagiri D, Hamasaki Y, Doi K, Negishi K, Sugaya T, Nangaku M, Noiri E.
  • Journal Title: Kidney Int Volume: 89 Pages: 374-85
  • Peer Reviewed / Open Access
• [Journal Article] The reduced expression of proximal tubular transporters in acquired Fanconi syndrome with κ light chain deposition. (2016)
  • Author(s): Tojo A, Asaba K, Kinugasa S, Ikeda Y, Shintani Y, Fukayama M, Nangaku M.
  • Journal Title: Med Mol Morphol Volume: 49 Pages: 48-52
  • Peer Reviewed
• [Journal Article] Correction of Metabolic Alkalosis and Elevated Calcium Levels by Sodium Chloride in a Hemodialysis Patient With Inadequate Chloride Intake. (2016)
  • Author(s): Hirakawa Y, Hanafusa N, Nangaku M
  • Journal Title: Ther Apher Dial Volume: 20 Pages: 86-7
  • DOI: 10.1111/1744-9987.12335
  • Peer Reviewed
• [Journal Article] Impact of continuous renal replacement therapy intensity on septic acute kidney injury. (2016)
  • Author(s): Mayumi K, Yamashita T, Hamasaki Y, Noiri E, Nangaku M, Yahagi N, Doi K.
  • Journal Title: Shock Volume: 45 Pages: 133-138
  • DOI: 10.1097/shk.0000000000000496
  • Peer Reviewed
• [Journal Article] Rationale and study design of a randomized controlled trial to assess the effects of maintaining hemoglobin levels using darbepoetin alfa on prevention of development of end-stage kidney disease in non-diabetic CKD patients (PREDICT Trial). (2016)
  • Author(s): Imai E, Maruyama S, Nangaku M, Hirakata H, Hayashi T, Narita I, Kono H, Nakatani E, Morita S, Tsubakihara Y, Akizawa T.
  • Journal Title: Clin Exp Nephrol Volume: 20 Pages: 71-76
  • DOI: 10.1007/s10157-015-1133-z
  • Peer Reviewed
• [Journal Article] High serum ALP level is associated with increased risk of denosumab-related hypocalcemia in patients with bone metastases from solid tumors (2016)
  • Author(s): Kinoshita Y, Arai M, Ito N, Takashi Y, Makita N, Nangaku M, Shinoda Y, Fukumoto S.
  • Journal Title: Endocr J Volume: 63 Issue: 5 Pages: 479-484
  • DOI: 10.1507/endocrj.ej16-0003 10.1507/endocrj.EJ16-0003
  • NAID: 130005154205
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed / Open Access
• [Journal Article] p38α activates purine metabolism to initiate hematopoietic stem/progenitor cell cycling. (2016)
  • Author(s): Karigane D, Kobayashi H, Morikawa T, Ootomo Y, Sakai M, Nagamatsu G, Kubota Y, Goda N, Matsumoto M, Nishimura EK, Soga T, Otsu K, Suematsu M, Okamoto S, Suda T, Takubo K.
  • Journal Title: Cell Stem Cell. Volume: 19 Pages: 192-204
  • DOI: 10.1016/j.stem.2016.05.013
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] The H3K9 methyltransferase Setdb1 regulates TLR4-mediated inflammatory responses in macrophages. (2016)
  • Author(s): R. Hachiya, T. Shiihashi, I. Shirakawa, Y. Iwasaki, Y. Matsumura, Y. Oishi, Y. Nakayama, Y. Miyamoto, I. Manabe, K. Ochi, M. Tanaka, N. Goda, J. Sakai, T. Suganami, Y. Ogawa.
  • Journal Title: Scientific Reports Volume: 6 Pages: 28845-28845
  • DOI: 10.1038/srep28845
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] HIF-1α in myeloid cells promotes adipose tissue remodeling toward insulin resistance. (2016)
  • Author(s): Takikawa A, Mahmood A , Nawaz A, Kado T, Okabe K, Yamamoto S, Arif A, Senda S, Tsuneyama K, Ikutani M, Watanabe Y, Igarashi Y, Nagai Y, Takatsu K, Koizumi K, Imura J, Goda N, Sasahara M, Matsumoto M, Saeki K, Nakagawa T, Fujisaka S, Usui I, Tobe K.
  • Journal Title: Diabetes Volume: 65 Pages: 3649-3659
  • NAID: 40021380120
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles. (2016)
  • Author(s): Yamano, E., Sugimoto, M., Hirayama, A., Kume, S., Yamato, M., Jin, G., Tajima, S., Goda, N., Iwai, K., Fukuda, S., Yamaguti, K., Kuratsune, H., Soga, T., Watanabe, Y., and Kataoka, Y.
  • Journal Title: Sci Rep Volume: 6 Pages: 34990-34990
  • DOI: 10.1038/srep34990
  • NAID: 120006349325
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Cardiogenic syncope possibly related to bevacizumab-containing combination chemotherapy for advanced non-small cell lung cancer. (2016)
  • Author(s): Chino H, Amano Y, Yamauchi Y, Matsuda J, Takeda N, Tanaka G, Takai D, Nagase T.
  • Journal Title: J Thorac Dis Volume: 8 Pages: 2646-2650
  • Peer Reviewed / Open Access
• [Journal Article] Atypical hemolytic uremic syndrome (aHUS): essential aspects of an accurate diagnosis. (2016)
  • Author(s): Laurence J, Haller H, Mannucci PM, Nangaku M, Praga M, Rodriguez de Cordoba S.
  • Journal Title: Clin Adv Hematol Oncol Volume: 14 Suppl 11 Pages: 2-15
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] New insights into molecular mechanisms of epigenetic regulation in kidney disease (2016)
  • Author(s): Mimura I, Tanaka T, Nangaku M.
  • Journal Title: Clin Exp Pharmacol Physiol. Volume: 43 Pages: 1159-1167
  • DOI: 10.1111/1440-1681.12663
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Progression after AKI: Understanding Maladaptive Repair Processes to Predict and Identify Therapeutic Treatments. (2016)
  • Author(s): Basile DP, Bonventre JV, Mehta R, Nangaku M, Unwin R, Rosner MH, Kellum JA, Ronco C; ADQI XIII Work Group.
  • Journal Title: J Am Soc Nephrol Volume: 27 Pages: 687-697
  • DOI: 10.1681/asn.2015030309
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Targeting Endogenous Repair Pathways after AKI. (2016)
  • Author(s): Humphreys BD, Cantaluppi V, Portilla D, Singbartl K, Yang L, Rosner MH, Kellum JA, Ronco C; Acute Dialysis Quality Initiative (ADQI) XIII Work Group.
  • Journal Title: J Am Soc Nephrol Volume: 27 Pages: 990-998
  • DOI: 10.1681/asn.2015030286
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Inflammation in AKI: Current Understanding, Key Questions, and Knowledge Gaps. (2016)
  • Author(s): Rabb H, Griffin MD, McKay DB, Swaminathan S, Pickkers P, Rosner MH, Kellum JA, Ronco C; Acute Dialysis Quality Initiative Consensus XIII Work Group.
  • Journal Title: J Am Soc Nephrol Volume: 27 Pages: 371-379
  • DOI: 10.1681/asn.2015030261
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Therapeutic Targets of Human AKI: Harmonizing Human and Animal AKI. (2016)
  • Author(s): Okusa MD, Rosner MH, Kellum JA, Ronco C; Acute Dialysis Quality Initiative XIII Workgroup.
  • Journal Title: J Am Soc Nephrol Volume: 27 Pages: 44-48
  • DOI: 10.1681/asn.2015030233
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Renal Hemodynamics in AKI: In Search of New Treatment Targets. (2016)
  • Author(s): Matejovic M, Ince C, Chawla LS, Blantz R, Molitoris BA, Rosner MH, Okusa MD, Kellum JA, Ronco C; ADQI XIII Work Group.
  • Journal Title: J Am Soc Nephrol Volume: 27 Pages: 49-58
  • DOI: 10.1681/asn.2015030234
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Circadian clock and the onset of cardiovascular events. (2016)
  • Author(s): Takeda N, Maemura K.
  • Journal Title: Hypertens Res Volume: in press Pages: 383-90
  • DOI: 10.1038/hr.2016.9
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Heterozygous deletion of Sarcolipin maintains normal cardiac function (2016)
  • Author(s): Shimura D, Kusakari Y, Sasano T, Nakashima Y, Nakai G, Jiao Q, Jin M, Yokota T, Ishikawa Y, Nakano A, Goda N, Minamisawa S.
  • Journal Title: American Journal of Physiology - Heart and Circulatory Physiology Volume: 310(1) Pages: 92-103
  • DOI: 10.1152/ajpheart.00411.2015
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Low cardiac output leads hepatic fibrosis in right heart failure model rats (2016)
  • Author(s): Fujimoto Y, Urashima T, Shimura D, Ito R, Kawachi S, Kajimura I, Akaike T, Kusakari Y, Fujiwara M, Ogawa K, Goda N, Ida H, Minamisawa S
  • Journal Title: Plos one Volume: 11(2)
  • DOI: 10.1371/journal.pone.0148666
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] HIF-1α-PDK1 axis induced active glycolysis plays an essential role in macrophage migratory capacity. (2016)
  • Author(s): Semba H, Takeda N, Isagawa T, Sugiura Y, Honda K, Wake M, Miyazawa H, Yamaguchi Y, Miura M, Jenkins D, Choi H, Kim JW, Asagiri M, Cowburn AS, Abe H, Soma K, Koyama K, Katoh M, Sayama K, Goda N, Johnson RS, Manabe I, Nagai R, Komuro I.
  • Journal Title: Nat commun. Volume: in press
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Redox-sensitive transient receptor potential channels in oxygen sensing and adaptation (2016)
  • Author(s): Mori Y, Takahashi N, Polat OK, Kuroakwa T, Takeda N, Inoue M
  • Journal Title: Pflugers Arch-Eur J Physiol Volume: 468 Pages: 85-97
  • DOI: 10.1007/s00424-015-1716-2
  • NAID: 120005980858
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Innate Response to Human Cancer Cells with or without IL-2 Receptor Common g-Chain Function in the NOD Background Mice Lacking Adaptive Immunity. (2015)
  • Author(s): Nishime C, Kawai K, Yamamoto T, Katano I, Monnai M, Goda N, Mizushima T, Suemizu H, Nakamura M, Murata M, Suematsu M, Wakui M.
  • Journal Title: J Immunol. Volume: 195 Pages: 1883-1890
  • DOI: 10.4049/jimmunol.1402103
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes (2015)
  • Author(s): Tojo Y, Sekine H, Hirano I, Pan X, Souma T, Tsujita T, Kawaguchi S, Takeda N, Takeda K, Fong GH, Dan T, Ichinose M, Miyata T, Yamamoto M, Suzuki N.
  • Journal Title: Mol Cell Biol Volume: 35 Pages: 2658-2672
  • DOI: 10.1128/mcb.00161-15
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Quantitating Intracellular Oxygen Tension in Vivo by Phosphorescence Lifetime Measurement (2015)
  • Author(s): Hirakawa Y, Yoshihara T, Kamiya M, Mimura I, Fujikura D, Masuda T, Kikuchi R, Takahashi I, Urano Y, Tobita S, Nangaku M.
  • Journal Title: Sci. Rep. Volume: 5 Pages: 17838-17838
  • DOI: 10.1038/srep17838
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Inflammation and hypoxia linked to renal injury by CCAAT/enhancer-binding protein δ. (2015)
  • Author(s): Yamaguchi J, Tanaka T, Eto N, Nangaku M.
  • Journal Title: Kidney Int. Volume: 印刷中 Pages: 262-275
  • DOI: 10.1038/ki.2015.21
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The role of clock genes and circadian rhythm in the development of cardiovascular diseases. (2015)
  • Author(s): Takeda N, Maemura K.
  • Journal Title: Cell Mol Life Sci. Volume: 72 Pages: 3225-3234
  • DOI: 10.1007/s00018-015-1923-1
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Potential Biomarkers of Fatigue Identified by Plasma Metabolome Analysis in rats (2015)
  • Author(s): Kume, S., Yamato, M., Tamura, Y., Jin, G., Nakano, M., Miyashige, Y., Eguchi, A., Ogata, Y., Goda, N., Iwai, K., Yamano, E., Watanabe, Y., Soga, T., and Kataoka, Y.
  • Journal Title: PLoS One. Volume: 10(3)
  • DOI: 10.1371/journal.pone.0120106
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Endothelin-converting enzyme is a plausible target gene for hypoxia-inducible factor. (2015)
  • Author(s): Khamaisi M, Toukan H, Axelrod JH, Rosenberger C, Skarzinski G, Shina A, Meidan R, Koesters R, Rosen S, Walkinshaw G, Mimura I, Nangaku M, Heyman SN.
  • Journal Title: Kidney Int Volume: 87 Pages: 761-70
  • DOI: 10.1038/ki.2014.362
  • Peer Reviewed
• [Journal Article] Activation of hypoxia-inducible factors prevents diabetic nephropathy. (2015)
  • Author(s): 8)Nordquist L, Friederich-Persson M, Fasching A, Liss P, Shoji K, Nangaku M, Hansell P, Palm F.
  • Journal Title: J Am Soc Nephrol Volume: 26 Pages: 328-338
  • DOI: 10.1681/asn.2013090990
  • Peer Reviewed
• [Journal Article] Anti-inflammatory role of DPP-4 inhibitors in a non-diabetic model of glomerular injury. (2015)
  • Author(s): Higashijima Y, Tanaka T, Yamaguchi J, Tanaka S, Nangaku M
  • Journal Title: Am J Physiol Renal Physiol. Volume: ahead of print
  • DOI: 10.1152/ajprenal.00590.2014
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Non-invasive diagnosis of coronary artery disease by 123I-BMIPP/201TlCl dual myocardial SPECT in patients with heart failure. (2014)
  • Author(s): Abe H, Iguchi N, Utanohara Y, Inoue K, Takamisawa I, Seki A, Tanizaki K, Takeda N, Tohbaru T, Asano R, Nagayama M, Takayama M, Umemura J, Sumiyoshi T, Tomoike H.
  • Journal Title: Int J Cardiol. Volume: 176 Pages: 969-974
  • DOI: 10.1016/j.ijcard.2014.08.129
  • Peer Reviewed
• [Journal Article] Necrostatin-1 protects against reactive oxygen species (ROS)-induced hepatotoxicity in acetaminophen-induced acute liver failure (2014)
  • Author(s): Takemoto K, Hatano E, Iwaisako K, Takeiri M, Noma N, Ohmae S, Toriguchi K, Tanabe K, Tanaka H, Seo S, Taura K, Machida K, Takeda N, Saji S, Uemoto S, Asagiri M.
  • Journal Title: FEBS Open Bio. Volume: 4 Pages: 777-787
  • DOI: 10.1016/j.fob.2014.08.007
  • NAID: 120005496668
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Transcription Profiles of the Ductus Arteriosus in Brown-Norway Rats With Irregular Elastic Fiber Formation (2014)
  • Author(s): Hsieh YT, Liu NM, Ohmori E, Yokota T, Kajimura I, Akaike T, Ohshima T, Goda N, Minamisawa S.
  • Journal Title: Circ J Volume: 78 Issue: 5 Pages: 1224-1233
  • DOI: 10.1253/circj.cj-13-1029 10.1253/circj.CJ-13-1029
  • NAID: 130003391069
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Regulation of wound healing and fibrosis by hypoxia and hypoxia-inducible factor-1. (2014)
  • Author(s): Ruthenborg RJ, Ban JJ, Wazir A, Takeda N, Kim JW.
  • Journal Title: Mol Cells Volume: 37 Pages: 637-643
  • DOI: 10.14348/molcells.2014.0150
  • Peer Reviewed / Open Access
• [Journal Article] Hypoxia and fatty liver. (2014)
  • Author(s): Suzuki T, Shinjo S, Arai T, Kanai M, Goda N.
  • Journal Title: World J Gastroenterol. Volume: 20 Pages: 15087-15097
  • DOI: 10.3748/wjg.v20.i41.15087
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Hypoxia and fibrosis in chronic kidney disease: crossing at pericytes. (2014)
  • Author(s): Kawakami T, Mimura I, Shoji K, Tanaka T, Nangaku M.
  • Journal Title: Kidney Int Suppl Volume: 4 Pages: 107-112
  • Peer Reviewed / Open Access
• [Presentation] The Role of Hypoxia and HIF in Tubule Injury (2019)
  • Author(s): Masaomi Nangaku
  • Organizer: Keystone Symposium
  • Int'l Joint Research / Invited
• [Presentation] 組織リモデリングにおける低酸素シグナル (2019)
  • Author(s): 武田憲彦
  • Organizer: 第92回日本薬理学会年会
  • Invited
• [Presentation] Roles of Ly6Chi macrophages hypoxia signaling in cardiac fibrosis (2019)
  • Author(s): Norihiko Takeda
  • Organizer: Keystone Symposium
  • Int'l Joint Research
• [Presentation] Diabetic Nephropathy: What is new? (2018)
  • Author(s): Masaomi Nangaku
  • Organizer: Academic Conference of 70th Establishment Anniversary of VMMU
  • Int'l Joint Research / Invited
• [Presentation] AKI to CKD Transition (2018)
  • Author(s): Masaomi Nangaku
  • Organizer: Annual Meeting of the American Society of Nephrology
  • Int'l Joint Research / Invited
• [Presentation] The Burden of CKD; Challenges and Successes (2018)
  • Author(s): Masaomi Nangaku
  • Organizer: Annual Meeting of the American Society of Nephrology
  • Int'l Joint Research / Invited
• [Presentation] Mitochondrial DNA Leakage Causes Inflammation via the cGAS-STING Axis in Cisplatin-Mediated Tubular Damage (2018)
  • Author(s): Maekawa H, Jao T-M, Inoue R, Nishi H, Inoue T, Nangaku M, Inagi R.
  • Organizer: Annual Meeting of the American Society of Nephrology
  • Int'l Joint Research
• [Presentation] Efficacy and Safety of Daprodustat on Anemia Management in Japanese Hemodialysis Patients Not Using Erythropoiesis-Stimulating Agents (2018)
  • Author(s): Fujii T, Tsubakihara Y, Akizawa T, Nangaku M, Onoue T, Yonekawa T, Endo Y, Cobitz AR.
  • Organizer: Annual Meeting of the American Society of Nephrology
  • Int'l Joint Research
• [Presentation] Randomized, Placebo-Controlled Phase 2 Trials of Vadadustat, an Oral Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor (HIF-PHI), to Treat Anemia of CKD (2018)
  • Author(s): Nangaku M, Khawaja Z, Luo W, Garafola S, deGoma E, Komatsu Y.
  • Organizer: Annual Meeting of the American Society of Nephrology
  • Int'l Joint Research
• [Presentation] Multiple, Systemic Effects of PHD Inhibitors Signify an Anti-Fibrotic and Anti-Inflammatory Impact on Cardiovascular Complications in the Remnant Kidney (2018)
  • Author(s): Uchida L, Tanaka T, Saito H, Sugahara M, Fukui K, Wakashima T, Nangaku M.
  • Organizer: Annual Meeting of the American Society of Nephrology
  • Int'l Joint Research
• [Presentation] Mitochondrial Morphological Abnormality in Cyst Epithelial Cells of Autosomal Dominant Polycystic Kidney Disease Patients (2018)
  • Author(s): Ishimoto Y, Shimizu A, Kugita M, Nagao S, Honda K, Inagi R, Nangauk M, Nishio S, Kawano H, Horie S, Kasahara T, Osafune K, Hoshino J, Ubara Y.
  • Organizer: Annual Meeting of the American Society of Nephrology
  • Int'l Joint Research
• [Presentation] PHD Inhibition Reduces Reactive Oxidative Stress in In Vitro Ischemia Model (2018)
  • Author(s): Ito M, Tanaka T, Wakashima T, Nangaku M, Fukui K.
  • Organizer: Annual Meeting of the American Society of Nephrology
  • Int'l Joint Research
• [Presentation] Hes1, a Newly Identified Downstream Mediator of alpha7nAChR on Macrophages in the Cholinergic Anti-Inflammatory Pathway, Plays a Protective Role in AKI (2018)
  • Author(s): Inoue T, Abe C, Tanaka S, Rosin DL, Nangaku M, Wada Y, Okusa MD.
  • Organizer: Annual Meeting of the American Society of Nephrology
  • Int'l Joint Research
• [Presentation] ATF6alpha and PPARalpha Cross-Talk Provides New Insights into Lipotoxicity-Induced Tubulointerstitial Fibrosis (2018)
  • Author(s): Jao T-M, Inoue T, Sugahara M, Maekawa H, Ishimoto Y, Tanaka T, Nangaku M, Inagi R.
  • Organizer: Annual Meeting of the American Society of Nephrology
  • Int'l Joint Research
• [Presentation] The molecular mechanisms of AKI to CKD transition and its clinical implication (2018)
  • Author(s): Masaomi Nangaku
  • Organizer: Asia Pacific AKI CRRT conference
  • Int'l Joint Research / Invited
• [Presentation] The AKI to CKD Continuum: a Clinical Perspective (2018)
  • Author(s): Masaomi Nangaku
  • Organizer: Annual Meeting of the Hong Kong Society of Nephrology
  • Int'l Joint Research / Invited
• [Presentation] Anemia treatment in CKD: Update (2018)
  • Author(s): Masaomi Nangaku
  • Organizer: Annual Meeting of the Malaysian Society of Nephrology
  • Int'l Joint Research / Invited
• [Presentation] 慢性腎臓病における心・血管障害 (2018)
  • Author(s): 南学正臣
  • Organizer: 日本下肢救済・足病学会学術集会
  • Invited
• [Presentation] 慢性腎不全治療薬の開発 その課題と今後への期待 (2018)
  • Author(s): 南学正臣
  • Organizer: 日本腎臓学会
  • Invited
• [Presentation] New insights into AKI to CKD continuum and the role of maladaptive repair (2018)
  • Author(s): Masaomi Nangaku
  • Organizer: Anuual Meeting of the Korean Society of Nephrology
  • Int'l Joint Research / Invited
• [Presentation] The roles of glucose and lactate metabolism in the regulation of mitochondrial respiration (2018)
  • Author(s): 武田憲彦
  • Organizer: 第6回低酸素研究会・酸素生物学領域国際シンポジウム
  • Invited
• [Presentation] The roles of glucose and lactate metabolism in the regulation of mitochondrial respiration (2018)
  • Author(s): Norihiko Takeda
  • Organizer: Hypoxia Research Meeting
  • Int'l Joint Research / Invited
• [Presentation] Pathological role of HIF-1 in the liver (2018)
  • Author(s): 合田亘人
  • Organizer: 第6回低酸素研究会・酸素生物学領域国際シンポジウム
  • Invited
• [Presentation] Pathological role of HIF-1 in the liver (2018)
  • Author(s): Nobuhito Goda
  • Organizer: Hypoxia Research Meeting
  • Int'l Joint Research / Invited
• [Presentation] 自然免疫様T細胞のHIF-1による急性炎症制御機構の解明 (2018)
  • Author(s): 合田亘人
  • Organizer: 第91回日本生化学会
• [Presentation] 新しい糖新生調節因子の探索とその機能解析 (2018)
  • Author(s): 合田亘人
  • Organizer: 第5回肝臓と糖尿病・代謝研究会
  • Invited
• [Presentation] From diabetic nephropathy to diabetic kidney disease (2018)
  • Author(s): Nangaku M.
  • Organizer: The 16th Asian Pacific Congress of Nephrology
  • Int'l Joint Research / Invited
• [Presentation] Epigenetic change in progression of AKI to CKD (2018)
  • Author(s): Nangaku M.
  • Organizer: The 16th Asian Pacific Congress of Nephrology
  • Int'l Joint Research / Invited
• [Presentation] 低酸素シグナルを介する心臓リモデリング (2018)
  • Author(s): 武田憲彦
  • Organizer: 第47回日本心脈管作動物質学会
  • Invited
• [Presentation] The roles of lactate metabolism in cardiac function (2018)
  • Author(s): 武田憲彦
  • Organizer: 第82回日本循環器学会学術集会
  • Invited
• [Presentation] Genomewide analysis of HIF-1α target genes in macrophage adaptation for the microenvironment (2018)
  • Author(s): Isagawa T, Takeda N, Semba H, Morioka M, Maemura K.
  • Organizer: 第1回日本循環器学会基礎研究フォーラム
• [Presentation] マクロファージ微小環境適応における転写制御機構 (2018)
  • Author(s): 砂河孝行, 武田憲彦, 仙波宏章，安部 元, 相馬 桂, 和氣正樹, 加藤愛巳, 森岡勝樹, 魏碩俣, 前村浩二
  • Organizer: 第47回日本心脈管作動物質学会
• [Presentation] 低酸素誘導性肺血管リモデリングにおける炎症細胞の役割 (2017)
  • Author(s): 武田憲彦
  • Organizer: 第9回日本生理学会大会
  • Place of Presentation: アクトシティ浜松、静岡
  • Year and Date: 2017-03-30
  • Invited
• [Presentation] The Role of Eosinophils in Pulmonary Arterial Remodelling (2017)
  • Author(s): 武田憲彦
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: ホテル日航金沢、金沢
  • Year and Date: 2017-03-17
  • Invited
• [Presentation] HIF-1alpha-PDK1 axis induced active glycolysis plays an essential role in macrophage migratory capacity. (2017)
  • Author(s): Takeda N.
  • Organizer: Keystone Symposium “Adaptaions to Hypoxia in Physiology and Disease”
  • Place of Presentation: Whistler Conference Centre, Whistler, British Columbia, Canada
  • Year and Date: 2017-03-09
  • Int'l Joint Research / Invited
• [Presentation] Oxygen biology in the kidney (2017)
  • Author(s): Nangaku M.
  • Organizer: The 2nd NTU-UTokyo Joint Conference
  • Int'l Joint Research / Invited
• [Presentation] Epigenetics and AKI-CKD transition (2017)
  • Author(s): Nangaku M.
  • Organizer: 22nd International Conference on Advances in Critical Care: AKI & CRRT 2017
  • Int'l Joint Research / Invited
• [Presentation] The role of HIF stabilizer in renal fibrosis (2017)
  • Author(s): Nangaku M.
  • Organizer: The 37th Annual Meeting of the Korean Society of Nephrology
  • Int'l Joint Research / Invited
• [Presentation] Metabolic memory and hypoxic memory: epigenetics in diabetic nephropathy (2017)
  • Author(s): Nangaku M.
  • Organizer: The 53rd Annual Meeting of the Australia-New Zealand Society of Nephrology
  • Int'l Joint Research / Invited
• [Presentation] Gene Expression Profiles of Glomeruli from BTBR ob/ob Mice Treated with Prolyl Hydroxylase Inhibitor Suggest Involvement of Extracellular Matrix Modulators in Pathogenesis of Diabetic Kidney Disease (2017)
  • Author(s): Sugahara M, Tanaka T, Tanaka S, Fukui K, Shimizu A, Ishimoto Y, Inagi R, Nangaku M
  • Organizer: The 61st Annual Meeting of the American Society of Nephrology
  • Int'l Joint Research
• [Presentation] Inhibition of Glycolysis Attenuates Ischemia-Reperfusion Injury via Metabolic and Redox Changes in Proximal Tubular Cells (2017)
  • Author(s): Shinohara A, Kawakami T, Nangaku M.
  • Organizer: The 61st Annual Meeting of the American Society of Nephrology
  • Int'l Joint Research
• [Presentation] Inhibition of Prolyl Hydroxylase Domain (PHD) Reduces Glomerular Macrophage Infiltration and Improves Albuminuria in Mice with a High Fat Diet (2017)
  • Author(s): Saito H, Tanaka T, Sugahara M, Fukui K, Wakashima T, Nangaku M.
  • Organizer: The 61st Annual Meeting of the American Society of Nephrology
  • Int'l Joint Research
• [Presentation] Treatment of anemia in CKD and doping (2017)
  • Author(s): Nangaku M.
  • Organizer: Cunio Richardson Lecture at University of Miami
  • Int'l Joint Research / Invited
• [Presentation] Anemia in CKD (2017)
  • Author(s): Nangaku M.
  • Organizer: Vietnam Society of Nephrology
  • Int'l Joint Research / Invited
• [Presentation] Update of anemia management in CKD patients (2017)
  • Author(s): Nangaku M.
  • Organizer: The 2nd International Congress of Chinese Nephrologists
  • Int'l Joint Research / Invited
• [Presentation] Flt-1 in M1 macrophages promotes immature vascular formation (2017)
  • Author(s): Soma K, Takeda N, Isagawa T, Abe H, Semba H, Koyama K, Wake M, Kato M, Nakagama Y, Manabe I, Nagai R, Komuro I
  • Organizer: European society of cardiology, ESC congress 2017
  • Int'l Joint Research
• [Presentation] High-Throughput shRNA Screening of the Molecular Mechanisms in Cardiac Fibroblast Activation (2017)
  • Author(s): Koyama K, Takeda N, Abe H, Semba H, Soma K, Wake M, Katoh M, Nakagama Y, Isagawa T, Komuro I
  • Organizer: European society of cardiology, ESC congress 2017
  • Int'l Joint Research
• [Presentation] The roles of hypoxia or inflammatory signals in cardiovascular remodeling (2017)
  • Author(s): Takeda N.
  • Organizer: Special Research Seminar at 神戸女子薬科大学
  • Invited
• [Presentation] The roles of lactate metabolism in cardiac function (2017)
  • Author(s): Takeda N.
  • Organizer: Consortium of Biological Sciences 2017
  • Invited
• [Presentation] マクロファージ活性化における細胞内グルコース代謝の役割 (2016)
  • Author(s): 武田憲彦
  • Organizer: 第20回日本適応医学会学術集会
  • Place of Presentation: 東京コンベンションホール、東京
  • Year and Date: 2016-12-16
  • Invited
• [Presentation] Perivascular accumulation of M1 macrophages elicits the development of immature vascular formation. (2016)
  • Author(s): 武田憲彦
  • Organizer: 第24回日本血管生物医学会学術集会
  • Place of Presentation: 長崎ブリックホール、長崎
  • Year and Date: 2016-12-10
  • Invited
• [Presentation] Oxygen biology in the kidney. (2016)
  • Author(s): Nangaku M.
  • Organizer: 2nd NTU-UTokyo Joint Conference
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2016-12-01
  • Int'l Joint Research / Invited
• [Presentation] Novel therapeutic targets in PKD, DKD, and CKD: mitochondria, ER, and oxygen metabolism. (2016)
  • Author(s): Nangaku M.
  • Organizer: Yale University Nephrology Seminar
  • Place of Presentation: New Haven, USA
  • Year and Date: 2016-11-21
  • Invited
• [Presentation] Hypoxia-inducible factors in diabetic nephropathy. (2016)
  • Author(s): Nangaku M.
  • Organizer: 50th American Society of Nephrology
  • Place of Presentation: Chicago, USA
  • Year and Date: 2016-11-19
  • Int'l Joint Research / Invited
• [Presentation] 低酸素応答システムが拓く代謝性疾患の新しい病態理解 (2016)
  • Author(s): 合田亘人
  • Organizer: 第20回酸素ダイナミクス研究会
  • Place of Presentation: 東京
  • Year and Date: 2016-11-19
  • Invited
• [Presentation] HIF-1alpha-PDK1経路を介した代謝リプログラミングはマクロファージ遊走能を促進する (2016)
  • Author(s): 武田憲彦
  • Organizer: 第37回日本肥満学会
  • Place of Presentation: 東京ファッションタウン、東京
  • Year and Date: 2016-10-08
  • Invited
• [Presentation] Metabolic diseases and HIF-1 (2016)
  • Author(s): Goda N.
  • Organizer: 第89回生化学会大会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2016-09-26
  • Invited
• [Presentation] Switching of two HIF-alpha; isforms regulates inflammatory processes and cardiac remodeling (2016)
  • Author(s): 武田憲彦
  • Organizer: 第52回高血圧関連疾患モデル学会
  • Place of Presentation: 秋葉原UDX、東京
  • Year and Date: 2016-09-22
  • Invited
• [Presentation] Epigenetics of renal disease. (2016)
  • Author(s): Nangaku M.
  • Organizer: 15th Asian Pacific Congress of Nephrology
  • Place of Presentation: Perth, Australia
  • Year and Date: 2016-09-20
  • Int'l Joint Research / Invited
• [Presentation] Epigenetics of Renal Disease (2016)
  • Author(s): Nangaku M.
  • Organizer: 15th Asian Pacific Congress of Nephrology
  • Place of Presentation: Perth, Australia
  • Year and Date: 2016-09-20
  • Int'l Joint Research / Invited
• [Presentation] Anemia management update. (2016)
  • Author(s): Nangaku M.
  • Organizer: 15th Asian Pacific Congress of Nephrology
  • Place of Presentation: Perth, Australia
  • Year and Date: 2016-09-17
  • Int'l Joint Research / Invited
• [Presentation] 心血管リモデリングにおける炎症細胞・低酸素シグナルの役割 (2016)
  • Author(s): 武田憲彦
  • Organizer: 第48回日本動脈硬化学会総会学術集会
  • Place of Presentation: 京王プラザホテル、東京
  • Year and Date: 2016-07-14
  • Invited
• [Presentation] HIF-1alpha-PDK1 axis induced active glycolysis plays an essential role in macrophage migratory capacity. (2016)
  • Author(s): Takeda N.
  • Organizer: 2016 HDRC International Symposium
  • Place of Presentation: Incheon, Korea
  • Year and Date: 2016-06-17
  • Int'l Joint Research / Invited
• [Presentation] Development of novel drugs targeting renal hypoxia and anaemia. (2016)
  • Author(s): Nangaku M.
  • Organizer: 53rd European Renal Association/European Dialysis and Transplantation Association
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2016-05-24
  • Int'l Joint Research / Invited
• [Presentation] Hypoxia and persistent inflammation in CKD. (2016)
  • Author(s): Nangaku M.
  • Organizer: XVIII International Congress on Nutrition and Metabolism in Renal Disease
  • Place of Presentation: Okinawa, Japan
  • Year and Date: 2016-04-22
  • Int'l Joint Research / Invited
• [Presentation] HIF-1α - Pdk1 axis induced metabolic reprogramming critically regulates macrophage function in inflammatory conditions (2016)
  • Author(s): Semba H, Takeda N, Isagawa T, Wake M, Abe H, Soma K, Koyama K, Katoh M, Manabe I, Nagai R, Takeshi Yamashita, Komuro I
  • Organizer: 第80回日本循環器学会総会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-18
• [Presentation] HIF-1α - PDK1 axis induced active glycolysis plays an essential role in macrophage migratory capacity (2016)
  • Author(s): Takeda N, Semba H, Isagawa T, Abe H, Sugiura Y, Honda K, Wake M, Kim JW, Soma K, Koyama K, Katoh M, Johnson RS, Manabe I, Nagai R, Komuro I
  • Organizer: Keystone symposium; Immunometabolism in immune function and inflammatory disease
  • Place of Presentation: Alberta, Canada
  • Year and Date: 2016-02-24
  • Int'l Joint Research
• [Presentation] Roles of Ly6Chi monocytes hypoxia signaling in cardiac remodeling (2016)
  • Author(s): Abe H, Takeda N, Semba H, Soma K, Koyama K, Wake M, Katoh M, Manabe I, Nagai R, Komuro I
  • Organizer: Keystone symposium; Immunometabolism in immune function and inflammatory disease
  • Place of Presentation: Alberta, Canada
  • Year and Date: 2016-02-22
  • Int'l Joint Research
• [Presentation] M1マクロファージの集積遷延は腫瘍内血管の未熟化を引き起こす (2015)
  • Author(s): 相馬桂 武田憲彦 砂河孝行 安部元 仙波宏章 小山雄広 和氣正樹 加藤愛巳 真鍋一郎 永井良三 小室一成
  • Organizer: 第23回日本血管生物医学会学術集会
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2015-12-12
• [Presentation] Roles of macrophages hypoxia signaling in pressure overload-induced cardiac remodeling (2015)
  • Author(s): Abe H, Takeda N, Semba H, Soma K, Koyama K, Wake M, Katoh M, Manabe I, Nagai R, Komuro I
  • Organizer: 第32回国際心臓研究学会日本部会
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2015-12-10
• [Presentation] りん光寿命測定を用いた腎臓尿細管細胞内分圧の測定 (2015)
  • Author(s): 平川陽亮、吉原利忠、神谷真子、三村維真理、田中真司、田中哲洋、浦野泰照、飛田成史、南学正臣
  • Organizer: 第３８回日本分子生物学会年会・第８８回日本生化学会大会合同大会
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2015-12-04
• [Presentation] HIF-1α;-PDK1を介する解糖系代謝シフトがマクロファージ遊走能を促進する (2015)
  • Author(s): 武田憲彦
  • Organizer: 第３８回日本分子生物学会年会・第８８回日本生化学会大会合同大会
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2015-12-04
  • Invited
• [Presentation] 低酸素とTGF-βは、下流にある IGFBP3 を介して、尿細管上皮細胞に apoptosis を誘導する． (2015)
  • Author(s): 串田夏樹、野村征太郎、藤田隆教、三村維真理、南学正臣、油谷浩幸
  • Organizer: 第３８回日本分子生物学会年会・第８８回日本生化学会大会合同大会
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2015-12-01
• [Presentation] 炎症プロセスにおけるマクロファージ細胞内代謝調節機構の役割 (2015)
  • Author(s): 武田憲彦
  • Organizer: 脳心血管抗加齢研究会2015
  • Place of Presentation: 大阪梅田スカイビル（大阪府大阪市）
  • Year and Date: 2015-11-25
  • Invited
• [Presentation] Quantitating Intracellular Oxygen Tension in Kidney by Phosphorescence Lifetime Measurement. (2015)
  • Author(s): Yosuke Hirakawa, Imari Mimura, Toshitada Yoshihara, Mako Kamiya, Yasuteru Urano, Seiji Tobita, Masaomi Nangaku.
  • Organizer: The 49th Annual Meeting of the American Society of Nephrology
  • Place of Presentation: San Diego, USA
  • Year and Date: 2015-11-07
  • Int'l Joint Research
• [Presentation] Oxidative Stres and Kidney Injury. (2015)
  • Author(s): Nangaku M.
  • Organizer: The 49th Annual Meeting of the American Society of Nephrology
  • Place of Presentation: San Diego, USA
  • Year and Date: 2015-11-06
  • Int'l Joint Research / Invited
• [Presentation] Palmitate Exacerbates Renal Anemia: Suppression of Renal Erythropoietin Production via Endoplasmic Reticulum Stress. (2015)
  • Author(s): Reiko Inagi, Thitinun Anusornvongchai, Yu Ishimoto, Akira Okada, Norio Suzuki, Masayuki Yamamoto, Masaomi Nangaku.
  • Organizer: The 49th Annual Meeting of the American Society of Nephrology
  • Place of Presentation: San Diego, USA
  • Year and Date: 2015-11-06
  • Int'l Joint Research
• [Presentation] Estimation of intracellular oxygen concentration in diabetic kidney by phosphorescence lifetime measurement. (2015)
  • Author(s): Hirakawa Y, Mimura I, Yoshihara T, Kamiya M, Tanaka S, Tanaka T, Inagi R, Urano Y, Tobita S, Nangaku M.
  • Organizer: Keystone Symposia: Diabetes: New insights into molecular mechanisms and therapeutic strategies.
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2015-10-26
  • Int'l Joint Research
• [Presentation] Palmitate suppresses EPO production via ER stress in renal EPO producing cells. (2015)
  • Author(s): Anusomvongchai T, Tanaka S, Hirakawa Y, Suzuki n, Yamamoto M, Nangaku M, Inagi R.
  • Organizer: Keystone Symposia: Diabetes: New insights into molecular mechanisms and therapeutic strategies.
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2015-10-26
  • Int'l Joint Research
• [Presentation] 腎不全に至る共通経路と高血圧の役割 (2015)
  • Author(s): 南学正臣
  • Organizer: 第３８回日本高血圧学会総会
  • Place of Presentation: 愛媛県県民文化会館（愛媛県松山市）
  • Year and Date: 2015-10-11
  • Invited
• [Presentation] HIF-1αを介する解糖系代謝シフトはマクロファージ遊走能を促進する (2015)
  • Author(s): 武田憲彦
  • Organizer: 第19回酸素ダイナミクス研究会
  • Place of Presentation: 東京女子医科大学 健保会館（東京都新宿区）
  • Year and Date: 2015-09-12
• [Presentation] Perivascular accumulation of M1 macrophages elicits the development of immature vascular formation. (2015)
  • Author(s): Soma K, Takeda N, Isagawa T, Abe H, Semba H, Koyama K, Wake M, Manabe I, Nagai R, Komuro I
  • Organizer: ESC Congress2015
  • Place of Presentation: London, UK
  • Year and Date: 2015-09-01
  • Int'l Joint Research
• [Presentation] Hypoxia induced metabolic reprograming in macrophages. (2015)
  • Author(s): Takeda N.
  • Organizer: An International Symposium on Oxygen Biology
  • Place of Presentation: 早稲田大学 先端生命医科学センター/TWIns（東京都新宿区）
  • Year and Date: 2015-07-24
  • Int'l Joint Research
• [Presentation] 低酸素シグナルを介する心血管病態治療の可能性 (2015)
  • Author(s): 武田憲彦
  • Organizer: 第47回日本動脈硬化学会総会学術集会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2015-07-09
  • Invited
• [Presentation] AKI-to-CKD: epidemiology and pathogenesis. (2015)
  • Author(s): Nangaku M.
  • Organizer: Shanghai International AKI-CRRT Forum
  • Place of Presentation: Shanghai, China
  • Year and Date: 2015-07-04
  • Int'l Joint Research / Invited
• [Presentation] 腎性貧血とHIF (2015)
  • Author(s): 南学正臣
  • Organizer: 第60回日本透析医学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2015-06-27
  • Invited
• [Presentation] Hypoxia as a new therapeutic target in CKD. (2015)
  • Author(s): 南学正臣
  • Organizer: 第５８回日本腎臓学会学術総会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-06-06
  • Invited
• [Presentation] Development of novel drugs targeting CKD: hypoxia, oxidative stress, and epigenetics. (2015)
  • Author(s): Nangaku M.
  • Organizer: 52nd European Renal Association/European Dialysis and Transplantation Association
  • Place of Presentation: London, UK
  • Year and Date: 2015-05-30
  • Int'l Joint Research / Invited
• [Presentation] Roles of Macrophages Hypoxia Signaling in Pressure Overload Induced Cardiac Remodeling (2015)
  • Author(s): Abe H, Takeda N, Semba H, Soma K, Koyama K, Wake M, Manabe I, Nagai R, Komuro I.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24
• [Presentation] Hypoxia and Renal Disease (2015)
  • Author(s): Nangaku M
  • Organizer: 第８回国際腎臓学会
  • Place of Presentation: Cape Town, South Africa
  • Year and Date: 2015-03-15
  • Invited
• [Presentation] マクロファージの代謝リプログラミングにおける細胞内低酸素センサー (2014)
  • Author(s): 仙波宏章, 武田憲彦, 砂河孝行, 杉浦悠毅, 安部元, 相馬桂, 小山雄広, 和氣正樹, 真鍋一郎, 小室一成, 永井良三
  • Organizer: 第37回日本分子生物学会年会ワークショップ
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-11-26
• [Presentation] 慢性腎臓病の進展とエピゲノム~低酸素刺激によるクロマチン立体構造変化 (2014)
  • Author(s): 三村維真理
  • Organizer: 第37回日本分子生物学会年会ワークショップ
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-11-26
• [Presentation] Hypoxic HIF, Fibrosis, and CKD. (2014)
  • Author(s): Nangaku M
  • Organizer: 第４７回アメリカ腎臓学会
  • Place of Presentation: Philadelphia, U.S.A.
  • Year and Date: 2014-11-15
  • Invited
• [Funded Workshop] Hypoxia Research Meeting 2018 (2018)
• [Funded Workshop] 国際低酸素シンポジウム（CARPEDIEMと共催） (2015)
  • Place of Presentation: 東京
  • Year and Date: 2015-07-29