|Budget Amount *help
¥120,250,000 (Direct Cost: ¥92,500,000、Indirect Cost: ¥27,750,000)
Fiscal Year 2018: ¥22,750,000 (Direct Cost: ¥17,500,000、Indirect Cost: ¥5,250,000)
Fiscal Year 2017: ¥24,570,000 (Direct Cost: ¥18,900,000、Indirect Cost: ¥5,670,000)
Fiscal Year 2016: ¥22,750,000 (Direct Cost: ¥17,500,000、Indirect Cost: ¥5,250,000)
Fiscal Year 2015: ¥24,570,000 (Direct Cost: ¥18,900,000、Indirect Cost: ¥5,670,000)
Fiscal Year 2014: ¥25,610,000 (Direct Cost: ¥19,700,000、Indirect Cost: ¥5,910,000)
|Outline of Final Research Achievements
Kidney, liver or heart consumes a large amount of molecular oxygen to maintain its activity, thus oxygen availability in each organ could influence its function. The molecular link, however, between hypoxic environment and the disease progression has not been fully elucidated.
In this study, we examined the roles of hypoxia inducible factor (HIF)-1alpha; signaling during the pathogenesis of lifestyle related diseases including chronic kidney disease, drug-induced liver injury and heart failure. Based on the in vivo animal models, we identified part of the critical pathways which augment the disease progression. In addition, we established a phosphorescence-based technology where we could measure tissue oxygen concentration quantitatively. These results will help us to gain a novel insight into the pathogenesis of lifestyle related disorders.