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低酸素シグナルが拓く生活習慣病の新しい病態制御

Planned

Project AreaOxygen biology: a new criterion for integrated understanding of life
Project/Area Number 26111003
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokyo

Principal Investigator

南学 正臣  東京大学, 医学部附属病院, 教授 (90311620)

Co-Investigator(Kenkyū-buntansha) 合田 亘人  早稲田大学, 理工学術院, 教授 (00245549)
武田 憲彦  東京大学, 医学部附属病院, 助教 (40422307)
Project Period (FY) 2014-07-10 – 2019-03-31
Project Status Granted (Fiscal Year 2018)
Budget Amount *help
¥120,250,000 (Direct Cost: ¥92,500,000、Indirect Cost: ¥27,750,000)
Fiscal Year 2018: ¥22,750,000 (Direct Cost: ¥17,500,000、Indirect Cost: ¥5,250,000)
Fiscal Year 2017: ¥24,570,000 (Direct Cost: ¥18,900,000、Indirect Cost: ¥5,670,000)
Fiscal Year 2016: ¥22,750,000 (Direct Cost: ¥17,500,000、Indirect Cost: ¥5,250,000)
Fiscal Year 2015: ¥24,570,000 (Direct Cost: ¥18,900,000、Indirect Cost: ¥5,670,000)
Fiscal Year 2014: ¥25,610,000 (Direct Cost: ¥19,700,000、Indirect Cost: ¥5,910,000)
Keywords低酸素 / エネルギー / 炎症 / 線維化 / 低酸素応答 / 低酸素センサー / HIF / 内科 / ストレス / 生活習慣病 / 低酸素シグナル
Outline of Annual Research Achievements

臓器リモデリングによる低酸素応答機構の解析として、主な病態を形成している腎臓・心臓・肝臓の実質細胞の障害、炎症細胞の活性化、臓器の線維化に注目して、解析を進めている。
低酸素状態を in vivo で定量的に評価するため、本研究領域 飛田成史と共同研究で新規低酸素感知プローブの開発を進め、生体内で細胞レベルの酸素分圧を評価することに成功し、論文報告を行った。また、新規低酸素感知プローブで低酸素の関与を示した線維化モデルにおいて、低酸素に伴いエピジェネティックな変化が起きており、これをターゲットとした介入が治療に有効であることを示し、論文報告を行った。
また、非がん細胞においてHIF-1alpha-PDK1シグナルが最も鋭敏な低酸素センサーとして機能し、解糖系への代謝シフトを誘導すること(Active Glycolysis)が、線維化過程での線維芽細胞活性化において中心的役割を果たしていることを同定し、論文報告を行った。更に、腫瘍細胞において正常酸素分圧下においても解糖系代謝が優位となるWarburg効果の分子機序について、本研究領域 中山恒と共同研究を行い、低酸素状態がピルビン酸脱水素酵素(PDH)複合体の一つPDH-E1beta発現を低下させること、PDH-E1beta発現低下が正常酸素分圧下においてもPDH活性を低下させることを確認し、腫瘍細胞におけるWarburg効果を説明する新たな機序として論文発表を行った。
更に、アセトアミノフェン肝炎モデルを用いて、T細胞系自然免疫細胞を介した急性炎症における低酸素ストレス応答の解明に取り組んだ。T細胞の低酸素応答転写因子HIF-1欠損により肝炎が遷延すること、この肝炎の増悪が好中球の過剰な浸潤によることを見いだし、この作用機序としてHIF-1欠損に起因したT細胞の障害肝への異常な集積が関わっていることを明らかに、論文発表した。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

本研究領域内での共同研究が順調に発展し、低酸素感知方法については予定以上の進展が得られ、当初予定していた低酸素に伴うエピジェネティックな制御機構の解明も順調に進展している。また、本研究領域で見出したActive Glycolysis機構が線維芽細胞活性化に重要であることを同定し、更にがん細胞におけるWarburg効果の新たな機序を突き止め論文化することができた。心臓リモデリングにおける低酸素・炎症シグナルの機序解明についても予備的知見を集積している。薬剤性急性肝炎の病態形成にかかわるT細胞の低酸素ストレス応答の役割についても、その分子機構の一端を明らかにし報告した。この解析結果は、慢性炎症だけでなく、急性炎症においても、T細胞のHIF-1が病態保護的に働いていることを示した重要な知見である。また、マクロファージや好中球の細胞遊走におけるHIF-1の促進的な作用とは異なり、T細胞のHIF-1が炎症部位への過剰な集積を抑制する因子として作用を持つことを示した点でも興味深い。一方、マウス、培養細胞やショウジョウバエを用いて、糖尿病や肥満などの生活習慣病の病態進展におけるHIF-1の生物機能解析にも継続的に取り組むことで、肝臓や脂肪組織のHIF-1による新しい代謝調節メカニズムの解明が進んできている。

Strategy for Future Research Activity

最終年度となる今年度は、これまでに取り組んで来た研究をさらに加速させることで、生活習慣病における低酸素応答とHIF-1の病態作用の解明に取り組む。
腎臓の障害における低酸素応答の役割を、細胞種特異的な HIF の活性化動物や HIF 活性化化合物を用いて、メタボロームなどを組み合わせて解析を進める。
心臓リモデリングにおける低酸素シグナル、Active Glycolysisを介する炎症細胞集積の分子機構とその病態における役割を明らかにする予定である。既に病態モデルでの解析を開始しており、臓器リモデリングを調節する鍵となる分子を探索する。
また、肝臓特異的HIF-1欠損マウスを用いて見いだしてきた抗糖尿病因子のニューレグリン1やGPNMBの生物作用を解明する。また、個体発生や生体内糖代謝調節におけるHIF-1による機能を分子レベルで明らかにしていく。これらの解析を通じて、低酸素応答ストレスと生活習慣病の関わりを、代謝制御の側面からさらに理解を深めていく。

Report

(4 results)
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report

Research Products

(151 results)

All 2018 2017 2016 2015 2014 Other

All Int'l Joint Research Journal Article Presentation Funded Workshop

  • [Int'l Joint Research] Uppsala University(Sweden)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Genome-wide analysis revealed that Dznep reduces tubulointerstitial fibrosis via down-regulation of pro-fibrotic genes.2018

    • Author(s)
      Mimura I, Hirakawa Y, Kanki Y, Nakaki R, Suzuki Y, Tanaka T, Aburatani H, Nangaku M.
    • Journal Title

      Sci Rep

      Volume: 28 Pages: 3779-3779

    • DOI
      10.1038/s41598-018-22180-5
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intravital phosphorescence lifetime imaging of the renal cortex accurately measures renal hypoxia2018

    • Author(s)
      Hirakawa Y, Mizukami K, Yoshihara T, Takahashi I, Khulan P, Honda T, Mimura I, Tanaka T, Tobita S, Nangaku M.
    • Journal Title

      Kidney Int

      Volume: 印刷中

    • DOI
      10.1016/j.kint.2018.01.015
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glycemic variability in continuous glucose monitoring is inversely associated with baroreflex sensitivity in type 2 diabetes: a preliminary report2018

    • Author(s)
      Matsutani Daisuke、Sakamoto Masaya、Iuchi Hiroyuki、Minato Souichirou、Suzuki Hirofumi、Kayama Yosuke、Takeda Norihiko、Horiuchi Ryuzo、Utsunomiya Kazunori
    • Journal Title

      Cardiovasc Diabetol

      Volume: 17 Pages: 36-36

    • DOI
      10.1186/s12933-018-0683-2
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pyruvate dehydrogenase PDH-E1beta is downregulated under prolonged hypoxic condition, and controls the progression of tumor growth by altering the metabolic status in cancer cells2018

    • Author(s)
      Yonashiro R, Eguchi K, Wake M, Takeda N, Nakayama K.
    • Journal Title

      Cancer Res

      Volume: 78 Pages: 1592-1603

    • DOI
      10.1158/0008-5472.can-17-1751
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeting HIF-1α/PDK1 Axis by Dichloroacetate (DCA) Suppresses Bleomycin-induced Pulmonary Fibrosis2018

    • Author(s)
      Goodwin J, Choi H, Hsieh MH, Nuegent ML, Ahn JM, Hayenga HN, Singh PK, Shackelford DB, Lee IK, Shulaev V, Dhar S, Takeda N, Kim JW.
    • Journal Title

      Am J Respir Cell Mol Biol

      Volume: 58 Pages: 216-231

    • DOI
      10.1165/rcmb.2016-0186oc
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial Abnormality Facilitates Cyst Formation in Autosomal Dominant Polycystic Kidney Disease2018

    • Author(s)
      Ishimoto Y, Inagi R, Yoshihara D, Kugita M, Nagao S, Shimizu A, Takeda N, Wake M, Honda K, Zhou J, Nangaku M
    • Journal Title

      Mol Cell Biol.

      Volume: e-Pub

    • DOI
      10.1128/mcb.00337-17
    • NAID
      40021751803
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Loss of hypoxia inducible factor-1alpha; aggravates gamma,deltaT cell-mediated inflammation during acetaminophen-induced liver injury2018

    • Author(s)
      Suzuki T, Minagawa S, Yamazaki T, Arai T, Kanai M, Shinjo S, Goda N
    • Journal Title

      Hepatol Commun

      Volume: in press

    • DOI
      10.1002/hep4.1175
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mechanisms of metabolic memory and renal hypoxia as a therapeutic target in diabetic kidney disease2017

    • Author(s)
      Hirakawa Y, Tanaka T, Nangaku M.
    • Journal Title

      Journal of Diabetes Investigation

      Volume: - Pages: 261-271

    • DOI
      10.1111/jdi.12624
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Renal Hypoxia in CKD; Pathophysiology and Detecting Methods2017

    • Author(s)
      Hirakawa Y, Tanaka T, Nangaku M.
    • Journal Title

      Front Physiol

      Volume: 8 Pages: 99-99

    • DOI
      10.3389/fphys.2017.00099
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Novel lnc RNA regulated by HIF-1 inhibits apoptotic cell death in the renal tubular epithelial cells under hypoxia2017

    • Author(s)
      Mimura I, Hirakawa Y, Kanki Y, Kushida N, Nakaki R, Suzuki Y, Tanaka T, Aburatani H, Nangaku M.
    • Journal Title

      Physiol Rep

      Volume: 5

    • DOI
      10.14814/phy2.13203
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epigenetic Changes in the Acute Kidney Injury-to-Chronic Kidney Disease Transition2017

    • Author(s)
      Nangaku M, Hirakawa Y, Mimura I, Inagi R, Tanaka T.
    • Journal Title

      Nephron

      Volume: 137 Pages: 256-259

    • DOI
      10.1159/000476078
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Echinomycin inhibits adipogenesis in 3T3-L1 cells in a HIF-independent manner2017

    • Author(s)
      Yamaguchi J, Tanaka T, Saito H, Nomura S, Aburatani H, Waki H, Kadowaki T, Nangaku M.
    • Journal Title

      Sci Rep

      Volume: 26 Pages: 6516-6516

    • DOI
      10.1038/s41598-017-06761-4
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prolyl hydroxylase domain inhibitors as a novel therapeutic approach against anemia in chronic kidney disease2017

    • Author(s)
      Sugahara M, Tanaka T, Nangaku M.
    • Journal Title

      Kidney International

      Volume: 92 Pages: 306-312

    • DOI
      10.1016/j.kint.2017.02.035
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vascular adhesion protein-1 enhances neutrophil infiltration by generation of hydrogen peroxide in renal ischemia/reperfusion injury2017

    • Author(s)
      Tanaka S, Tanaka T, Kawakami T, Takano H, Sugahara M, Saito H, Higashijima Y, Yamaguchi J, Inagi R, Nangaku M
    • Journal Title

      Kidney International

      Volume: 印刷中 Pages: 154-164

    • DOI
      10.1016/j.kint.2017.01.014
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Time-dependent effects of ipragliflozin on behaviour and energy homeostasis in normal and type 2 diabetic rats: continuous glucose telemetry analysis2017

    • Author(s)
      Iuchi H, Sakamoto M, Matsutani D, Suzuki H, Kayama Y, Takeda N, Minamisawa S, Utsunomiya K.
    • Journal Title

      Sci Rep

      Volume: 22 Pages: 11906-11906

    • DOI
      10.1038/s41598-017-12106-y
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis2017

    • Author(s)
      Krzywinska E, Kantari-Mimoun C, Kerdiles Y, Sobecki M, Isagawa T, Gotthardt D, Castells M, Haubold J, Millien C, Viel T, Tavitian B, Takeda N, Fandrey J, Vivier E, Sexl V, Stockmann C.
    • Journal Title

      Nature Communications

      Volume: 8 Pages: 1597-1597

    • DOI
      10.1038/s41467-017-01599-w
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association between day-by-day and ambulatory blood pressure variability in type 2 diabetes patients2017

    • Author(s)
      Iuchi H, Sakamoto M, Matsutani D, Suzuki H, Kayama Y, Takeda N, Utsunomiya K
    • Journal Title

      Blood Press Monit

      Volume: 22 Pages: 351-354

    • DOI
      10.1097/mbp.0000000000000285
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition2017

    • Author(s)
      Goodwin J, Neugent ML, Lee SY, Choe JH, Choi H, Jenkins DMR, Ruthenborg RJ, Robinson MW, Jeong JY, Wake M, Abe H, Takeda N, Endo H, Inoue M, Xuan Z, Yoo H, Chen M, Ahn JM, Minna JD, Helke KL, Singh PK, Shackelford DB, Kim JW.
    • Journal Title

      Nat Commun

      Volume: 8 Pages: 15503-15503

    • DOI
      10.1038/ncomms15503
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Roles of Hypoxia Signaling in the Pathogenesis of Cardiovascular Diseases2017

    • Author(s)
      Abe Hajime、Semba Hiroaki、Takeda Norihiko
    • Journal Title

      J Atheroscler Thromb

      Volume: 24 Issue: 9 Pages: 884-894

    • DOI
      10.5551/jat.RV17009
    • NAID
      130006038428
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Disruption of the mitochondria-associated ER membrane (MAM) plays a central role in palmitic acid?induced insulin resistance2017

    • Author(s)
      Shinjo Satoko、Jiang Shuying、Nameta Masaaki、Suzuki Tomohiro、Kanai Mai、Nomura Yuta、Goda Nobuhito
    • Journal Title

      Exp Cell Res

      Volume: 359 Pages: 86-93

    • DOI
      10.1016/j.yexcr.2017.08.006
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Previous dropout from diabetic care as a predictor of patients' willingness to use mobile applications for self-management: A cross-sectional study.2017

    • Author(s)
      Yamaguchi S, Waki K, Tomizawa N, Waki H, Nannya Y, Nangaku M, Kadowaki T, Ohe K.
    • Journal Title

      Journal of Diabetes Investigation

      Volume: 印刷中

    • DOI
      10.1111/jdi.12613
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effects of Daprodustat, a Novel Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor on Anemia Management in Japanese Hemodialysis Subjects.2017

    • Author(s)
      Akizawa T, Tsubakihara Y, Nangaku M, Endo Y, Nakajima H, Kohno T, Imai Y, Kawase N, Hara K, Lepore J, Cobitz A.
    • Journal Title

      Am J Nephrol

      Volume: 45 Pages: 127-135

    • DOI
      10.1159/000454818
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Mizoribine therapy combined with steroids and mizoribine blood concentration monitoring for idiopathic membranous nephropathy with steroid-resistant nephrotic syndrome.2017

    • Author(s)
      Saito T, Iwano M, Matsumoto K, Mitarai T, Yokoyama H, Yorioka N, Nishi S, Yoshimura A, Sato H, Ogahara S, Sasatomi Y, Kataoka Y, Ueda S, Koyama A, Maruyama S, Nangaku M, Imai E, Matsuo S, Tomino Y; Refractory Nephrotic Syndrome Study Group.
    • Journal Title

      Clin Exp Nephrol

      Volume: 印刷中

    • NAID
      120006373812
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Urinary N-acetyl-β-glucosaminidase and eGFR may identify patients to be treated with immuno-suppression at diagnosis in idiopathic membranous nephropathy.2017

    • Author(s)
      Bazzi C, Usui T, Rizza V, Casellato D, Gallieni M, Nangaku M.
    • Journal Title

      Nephrology

      Volume: 印刷中

    • DOI
      10.1111/nep.12952
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Selective plasma exchange can reduce auto-antibodies in patients with bullous pemphigoid without affecting factor XIII and fibrinogen.2017

    • Author(s)
      Nasu K, Hanafusa N, Nangaku M.
    • Journal Title

      J Clin Apher

      Volume: 印刷中

    • DOI
      10.1002/jca.21513
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of end-stage renal disease on hospital outcomes among patients admitted to intensive care units: A retrospective matched-pair cohort study.2017

    • Author(s)
      Iwagami M, Yasunaga H, Matsui H, Horiguchi H, Fushimi K, Noiri E, Nangaku M, Doi K.
    • Journal Title

      Nephrology

      Volume: 印刷中

    • DOI
      10.1111/nep.12830
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of quality indicators for care of chronic kidney disease in the primary care setting using electronic health data: a RAND-modified Delphi method.2017

    • Author(s)
      Fukuma S, Shimizu S, Niihata K, Sada KE, Yanagita M, Hatta T, Nangaku M, Katafuchi R, Fujita Y, Koizumi J, Koizumi S, Kimura K, Fukuhara S, Shibagaki Y.
    • Journal Title

      Clin Exp Nephrol

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ulcerative colitis with hepatitis B virus infection treated successfully by granulocyte monocyte apheresis.2017

    • Author(s)
      Saito H, Hanafusa N, Kishikawa J, Noiri E, Sunami E, Ishihara S, Watanabe T, Nangaku M.
    • Journal Title

      J Clin Apher

      Volume: 印刷中

    • DOI
      10.1002/jca.21450
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity2017

    • Author(s)
      Semba, H., Takeda, N., Isagawa, T., Sugiura, Y., Honda, K., Wake, M., Miyazawa, H., Yamaguchi, Y., Miura, M., Jenkins, DM., Choi, H., Kim, JW., Asagiri, M., Cowburn, AS., Abe, H., Soma, K., Koyama, K., Katoh, M., Sayama, K., Goda, N., Johnson, RS., Manabe, I., Nagai, R., Komuro, I.
    • Journal Title

      Nat Commun. 2016 May 18;7:11635.

      Volume: 7 Pages: 11635-11635

    • DOI
      10.1038/ncomms11635
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Type I neuregulin1α is a novel local mediator to suppress hepatic gluconeogenesis in mice2017

    • Author(s)
      Arai T, Ono Y, Arimura Y, Sayama K, Suzuki T, Shinjo S, Kanai M, Abe S, Semba K, Goda N.
    • Journal Title

      Scientific Reports

      Volume: 7 Pages: 42959-42959

    • DOI
      10.1038/srep42959
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Distinct Metabolic Phenotypes within Non-small Cell 1 Lung Cancer Define Selective Vulnerability to Glycolytic Inhibition of Lung Squamous Cell Carcinoma.2017

    • Author(s)
      Goodwin J, Neugent ML, Lee SY, Choe JH, Choi H, Jenkins DMR, Ruthenborg RJ, Robinson MW, Jeong JY, Wake M, Abe H, Takeda N, Endo H, Inoue M, Xuan Z, Yoo H, Chen M, Ahn JM, Minna JD, Helke KL, Singh PK, Shackelford DB, Kim JW.
    • Journal Title

      Nat Commun

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Bevacizumab-related microvascular angina and its management with nicorandil.2017

    • Author(s)
      Katoh M, Takeda N, Arimoto T, Abe H, Oda K, Osuga Y, Fujii T, Komuro I.
    • Journal Title

      Int Heart J

      Volume: 印刷中

    • NAID
      130006179206
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cardiac Sarcoidosis Diagnosed by Incidental Lymph Node Biopsy2017

    • Author(s)
      Matsuda J, Fujiu K, Roh S, Tajima M, Maki H, Kojima T, Ushiku T, Nawata K, Takeda N, Watanabe M, Akazawa H, Komuro I.
    • Journal Title

      Int. Heart J.

      Volume: 58 Issue: 1 Pages: 140-143

    • DOI
      10.1536/ihj.16-218
    • NAID
      130005330527
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Actin-binding protein coronin 1A controls osteoclastic bone resorption by regulating lysosomal secretion of cathepsin K2017

    • Author(s)
      Ohmae S, Noma N, Toyomoto M, Shinohara M, Takeiri M, Fuji, Takemoto K, Iwaisako K, Fujita T, Takeda N, Kawatani M, Aoyama M, Hagiwara M, Ishihama Y, Asagiri M.
    • Journal Title

      Sci. Rep.

      Volume: 7 Pages: 1-12

    • DOI
      10.1038/srep41710
    • NAID
      120006313626
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Planimetry of the orifice area in aortic valve stenosis using phase-contrast cardiac magnetic resonance imaging.2017

    • Author(s)
      Abe H., Iguchi N, Utanohara Y, Takada K, Hen Y, Machida H, Takeda N, Sumiyoshi T.
    • Journal Title

      Int Heart J

      Volume: 印刷中

    • NAID
      130006321387
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypoxia-Inducible Factor-1α Activates the Transforming Growth Factor-β/SMAD3 Pathway in Kidney Tubular Epithelial Cells.2016

    • Author(s)
      Kushida N, Nomura S, Mimura I, Fujita T, Yamamoto S, Nangaku M, Aburatani H.
    • Journal Title

      Am J Nephrol

      Volume: 44 Pages: 276-285

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Umbilical Cord Blood Transplantation-associated Nephrotic Syndrome Successfully Treated by Low-density Lipoprotein Apheresis.2016

    • Author(s)
      Sugawara Y, Honda K, Katagiri D, Nakamura M, Kawakami T, Nasu R, Hayashi A, Shintani Y, Tojo A, Noiri E, Kurokawa M, Fukayama M, Nangaku M.
    • Journal Title

      Intern Med

      Volume: 55 Pages: 2831-2836

    • NAID
      130005605877
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of clinical context on acute kidney injury biomarker performances: differences between neutrophil gelatinase-associated lipocalin and L-type fatty acid-binding protein.2016

    • Author(s)
      Asada T, Isshiki R, Hayase N, Sumida M, Inokuchi R, Noiri E, Nangaku M, Yahagi N, Doi K.
    • Journal Title

      Sci Rep

      Volume: 6 Pages: 33077-33077

    • DOI
      10.1038/srep33077
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Analysis of the V2 Vasopressin Receptor (V2R) Mutations Causing Partial Nephrogenic Diabetes Insipidus Highlights a Sustainable Signaling by a Non-peptide V2R Agonist.2016

    • Author(s)
      Makita N, Sato T, Yajima-Shoji Y, Sato J, Manaka K, Eda-Hashimoto M, Ootaki M, Matsumoto N, Nangaku M, Iiri T.
    • Journal Title

      J Biol Chem

      Volume: 291 Pages: 22460-22471

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DialBetics: Smartphone-Based Self-Management for Type 2 Diabetes Patients on Insulin Injections.2016

    • Author(s)
      Waki K, Fujiu K, Hayashi A, Kimura S, Kobayashi H, Nangaku M, Kadowaki T, Ohe K.
    • Journal Title

      J Diabetes Sci Technol

      Volume: 10 Pages: 804-805

    • DOI
      10.1177/1932296815619638
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lactoferrin Suppresses Neutrophil Extracellular Traps Release in Inflammation2016

    • Author(s)
      Okubo K, Kamiya M, Urano Y, Nishi H, Herter JM, Mayadas T, Hirohama D, Suzuki K, Kawakami H, Tanaka M, Kurosawa M, Kagaya S, Hishikawa K, Nangaku M, Fujita T, Hayashi M, Hirahashi J.
    • Journal Title

      EBioMedicine

      Volume: 10 Pages: 204-215

    • DOI
      10.1016/j.ebiom.2016.07.012
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Complete remission of thrombotic microangiopathy after treatment with eculizumab in a patient with non-Shiga toxin-associated bacterial enteritis: A case report.2016

    • Author(s)
      Omura T, Watanabe E, Otsuka Y, Yoshida Y, Kato H, Nangaku M, Miyata T, Oda S.
    • Journal Title

      Medicine (Baltimore)

      Volume: 95

    • DOI
      10.1097/md.0000000000004104
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] No association between dysplasminogenemia with p.Ala620Thr mutation and atypical hemolytic uremic syndrome.2016

    • Author(s)
      Miyata T, Uchida Y, Yoshida Y, Kato H, Matsumoto M, Kokame K, Fujimura Y, Nangaku M.
    • Journal Title

      Int J Hematol

      Volume: 104 Pages: 223-227

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potential Survival Benefit of Polymyxin B Hemoperfusion in Septic Shock Patients on Continuous Renal Replacement Therapy: A Propensity-Matched Analysis.2016

    • Author(s)
      Iwagami M, Yasunaga H, Noiri E, Horiguchi H, Fushimi K, Matsubara T, Yahagi N, Nangaku M, Doi K.
    • Journal Title

      Blood Purif

      Volume: 42 Pages: 9-17

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Erythropoietin concentration in acute kidney injury is associated with insulin-like growth factor-binding protein-1.2016

    • Author(s)
      Yamashita T, Noiri E, Hamasaki Y, Matsubara T, Ishii T, Yahagi N, Nangaku M, Doi K.
    • Journal Title

      Nephrology

      Volume: 21 Pages: 693-9

    • DOI
      10.1111/nep.12656
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of Urinary Neutrophil Gelatinase-Associated Lipocalin With Long-Term Renal Outcomes in ICU Survivors: A Retrospective Observational Cohort Study.2016

    • Author(s)
      Isshiki R, Asada T, Sato D, Sumida M, Hamasaki Y, Inokuchi R, Matsubara T, Ishii T, Yahagi N, Nangaku M, Noiri E, Doi K.
    • Journal Title

      Shock

      Volume: 46 Pages: 44-51

    • DOI
      10.1097/shk.0000000000000580
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interstitial renal fibrosis due to multiple cisplatin treatments is ameliorated by semicarbazide-sensitive amine oxidase inhibition.2016

    • Author(s)
      Katagiri D, Hamasaki Y, Doi K, Negishi K, Sugaya T, Nangaku M, Noiri E.
    • Journal Title

      Kidney Int

      Volume: 89 Pages: 374-85

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The reduced expression of proximal tubular transporters in acquired Fanconi syndrome with κ light chain deposition.2016

    • Author(s)
      Tojo A, Asaba K, Kinugasa S, Ikeda Y, Shintani Y, Fukayama M, Nangaku M.
    • Journal Title

      Med Mol Morphol

      Volume: 49 Pages: 48-52

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correction of Metabolic Alkalosis and Elevated Calcium Levels by Sodium Chloride in a Hemodialysis Patient With Inadequate Chloride Intake.2016

    • Author(s)
      Hirakawa Y, Hanafusa N, Nangaku M
    • Journal Title

      Ther Apher Dial

      Volume: 20 Pages: 86-7

    • DOI
      10.1111/1744-9987.12335
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of continuous renal replacement therapy intensity on septic acute kidney injury.2016

    • Author(s)
      Mayumi K, Yamashita T, Hamasaki Y, Noiri E, Nangaku M, Yahagi N, Doi K.
    • Journal Title

      Shock

      Volume: 45 Pages: 133-138

    • DOI
      10.1097/shk.0000000000000496
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rationale and study design of a randomized controlled trial to assess the effects of maintaining hemoglobin levels using darbepoetin alfa on prevention of development of end-stage kidney disease in non-diabetic CKD patients (PREDICT Trial).2016

    • Author(s)
      Imai E, Maruyama S, Nangaku M, Hirakata H, Hayashi T, Narita I, Kono H, Nakatani E, Morita S, Tsubakihara Y, Akizawa T.
    • Journal Title

      Clin Exp Nephrol

      Volume: 20 Pages: 71-76

    • DOI
      10.1007/s10157-015-1133-z
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High serum ALP level is associated with increased risk of denosumab-related hypocalcemia in patients with bone metastases from solid tumors2016

    • Author(s)
      Kinoshita Y, Arai M, Ito N, Takashi Y, Makita N, Nangaku M, Shinoda Y, Fukumoto S.
    • Journal Title

      Endocr J

      Volume: 63 Issue: 5 Pages: 479-484

    • DOI
      10.1507/endocrj.EJ16-0003
    • NAID
      130005154205
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] p38α activates purine metabolism to initiate hematopoietic stem/progenitor cell cycling.2016

    • Author(s)
      Karigane D, Kobayashi H, Morikawa T, Ootomo Y, Sakai M, Nagamatsu G, Kubota Y, Goda N, Matsumoto M, Nishimura EK, Soga T, Otsu K, Suematsu M, Okamoto S, Suda T, Takubo K.
    • Journal Title

      Cell Stem Cell.

      Volume: 19 Pages: 192-204

    • DOI
      10.1016/j.stem.2016.05.013
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The H3K9 methyltransferase Setdb1 regulates TLR4-mediated inflammatory responses in macrophages.2016

    • Author(s)
      R. Hachiya, T. Shiihashi, I. Shirakawa, Y. Iwasaki, Y. Matsumura, Y. Oishi, Y. Nakayama, Y. Miyamoto, I. Manabe, K. Ochi, M. Tanaka, N. Goda, J. Sakai, T. Suganami, Y. Ogawa.
    • Journal Title

      Scientific Reports

      Volume: 6 Pages: 28845-28845

    • DOI
      10.1038/srep28845
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] HIF-1α in myeloid cells promotes adipose tissue remodeling toward insulin resistance.2016

    • Author(s)
      Takikawa A, Mahmood A , Nawaz A, Kado T, Okabe K, Yamamoto S, Arif A, Senda S, Tsuneyama K, Ikutani M, Watanabe Y, Igarashi Y, Nagai Y, Takatsu K, Koizumi K, Imura J, Goda N, Sasahara M, Matsumoto M, Saeki K, Nakagawa T, Fujisaka S, Usui I, Tobe K.
    • Journal Title

      Diabetes

      Volume: 65 Pages: 3649-3659

    • NAID
      40021380120
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles.2016

    • Author(s)
      Yamano, E., Sugimoto, M., Hirayama, A., Kume, S., Yamato, M., Jin, G., Tajima, S., Goda, N., Iwai, K., Fukuda, S., Yamaguti, K., Kuratsune, H., Soga, T., Watanabe, Y., and Kataoka, Y.
    • Journal Title

      Sci Rep

      Volume: 6 Pages: 34990-34990

    • DOI
      10.1038/srep34990
    • NAID
      120006349325
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Cardiogenic syncope possibly related to bevacizumab-containing combination chemotherapy for advanced non-small cell lung cancer.2016

    • Author(s)
      Chino H, Amano Y, Yamauchi Y, Matsuda J, Takeda N, Tanaka G, Takai D, Nagase T.
    • Journal Title

      J Thorac Dis

      Volume: 8 Pages: 2646-2650

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Atypical hemolytic uremic syndrome (aHUS): essential aspects of an accurate diagnosis.2016

    • Author(s)
      Laurence J, Haller H, Mannucci PM, Nangaku M, Praga M, Rodriguez de Cordoba S.
    • Journal Title

      Clin Adv Hematol Oncol

      Volume: 14 Suppl 11 Pages: 2-15

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] New insights into molecular mechanisms of epigenetic regulation in kidney disease2016

    • Author(s)
      Mimura I, Tanaka T, Nangaku M.
    • Journal Title

      Clin Exp Pharmacol Physiol.

      Volume: 43 Pages: 1159-1167

    • DOI
      10.1111/1440-1681.12663
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Progression after AKI: Understanding Maladaptive Repair Processes to Predict and Identify Therapeutic Treatments.2016

    • Author(s)
      Basile DP, Bonventre JV, Mehta R, Nangaku M, Unwin R, Rosner MH, Kellum JA, Ronco C; ADQI XIII Work Group.
    • Journal Title

      J Am Soc Nephrol

      Volume: 27 Pages: 687-697

    • DOI
      10.1681/asn.2015030309
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Targeting Endogenous Repair Pathways after AKI.2016

    • Author(s)
      Humphreys BD, Cantaluppi V, Portilla D, Singbartl K, Yang L, Rosner MH, Kellum JA, Ronco C; Acute Dialysis Quality Initiative (ADQI) XIII Work Group.
    • Journal Title

      J Am Soc Nephrol

      Volume: 27 Pages: 990-998

    • DOI
      10.1681/asn.2015030286
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Inflammation in AKI: Current Understanding, Key Questions, and Knowledge Gaps.2016

    • Author(s)
      Rabb H, Griffin MD, McKay DB, Swaminathan S, Pickkers P, Rosner MH, Kellum JA, Ronco C; Acute Dialysis Quality Initiative Consensus XIII Work Group.
    • Journal Title

      J Am Soc Nephrol

      Volume: 27 Pages: 371-379

    • DOI
      10.1681/asn.2015030261
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Therapeutic Targets of Human AKI: Harmonizing Human and Animal AKI.2016

    • Author(s)
      Okusa MD, Rosner MH, Kellum JA, Ronco C; Acute Dialysis Quality Initiative XIII Workgroup.
    • Journal Title

      J Am Soc Nephrol

      Volume: 27 Pages: 44-48

    • DOI
      10.1681/asn.2015030233
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Renal Hemodynamics in AKI: In Search of New Treatment Targets.2016

    • Author(s)
      Matejovic M, Ince C, Chawla LS, Blantz R, Molitoris BA, Rosner MH, Okusa MD, Kellum JA, Ronco C; ADQI XIII Work Group.
    • Journal Title

      J Am Soc Nephrol

      Volume: 27 Pages: 49-58

    • DOI
      10.1681/asn.2015030234
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Circadian clock and the onset of cardiovascular events.2016

    • Author(s)
      Takeda N, Maemura K.
    • Journal Title

      Hypertens Res

      Volume: in press Pages: 383-90

    • DOI
      10.1038/hr.2016.9
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Heterozygous deletion of Sarcolipin maintains normal cardiac function2016

    • Author(s)
      Shimura D, Kusakari Y, Sasano T, Nakashima Y, Nakai G, Jiao Q, Jin M, Yokota T, Ishikawa Y, Nakano A, Goda N, Minamisawa S.
    • Journal Title

      American Journal of Physiology - Heart and Circulatory Physiology

      Volume: 310(1) Pages: 92-103

    • DOI
      10.1152/ajpheart.00411.2015
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Low cardiac output leads hepatic fibrosis in right heart failure model rats2016

    • Author(s)
      Fujimoto Y, Urashima T, Shimura D, Ito R, Kawachi S, Kajimura I, Akaike T, Kusakari Y, Fujiwara M, Ogawa K, Goda N, Ida H, Minamisawa S
    • Journal Title

      Plos one

      Volume: 11(2)

    • DOI
      10.1371/journal.pone.0148666
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] HIF-1α-PDK1 axis induced active glycolysis plays an essential role in macrophage migratory capacity.2016

    • Author(s)
      Semba H, Takeda N, Isagawa T, Sugiura Y, Honda K, Wake M, Miyazawa H, Yamaguchi Y, Miura M, Jenkins D, Choi H, Kim JW, Asagiri M, Cowburn AS, Abe H, Soma K, Koyama K, Katoh M, Sayama K, Goda N, Johnson RS, Manabe I, Nagai R, Komuro I.
    • Journal Title

      Nat commun.

      Volume: in press

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Redox-sensitive transient receptor potential channels in oxygen sensing and adaptation2016

    • Author(s)
      Mori Y, Takahashi N, Polat OK, Kuroakwa T, Takeda N, Inoue M
    • Journal Title

      Pflugers Arch-Eur J Physiol

      Volume: 468 Pages: 85-97

    • DOI
      10.1007/s00424-015-1716-2
    • NAID
      120005980858
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Innate Response to Human Cancer Cells with or without IL-2 Receptor Common g-Chain Function in the NOD Background Mice Lacking Adaptive Immunity.2015

    • Author(s)
      Nishime C, Kawai K, Yamamoto T, Katano I, Monnai M, Goda N, Mizushima T, Suemizu H, Nakamura M, Murata M, Suematsu M, Wakui M.
    • Journal Title

      J Immunol.

      Volume: 195 Pages: 1883-1890

    • DOI
      10.4049/jimmunol.1402103
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes2015

    • Author(s)
      Tojo Y, Sekine H, Hirano I, Pan X, Souma T, Tsujita T, Kawaguchi S, Takeda N, Takeda K, Fong GH, Dan T, Ichinose M, Miyata T, Yamamoto M, Suzuki N.
    • Journal Title

      Mol Cell Biol

      Volume: 35 Pages: 2658-2672

    • DOI
      10.1128/mcb.00161-15
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Quantitating Intracellular Oxygen Tension in Vivo by Phosphorescence Lifetime Measurement2015

    • Author(s)
      Hirakawa Y, Yoshihara T, Kamiya M, Mimura I, Fujikura D, Masuda T, Kikuchi R, Takahashi I, Urano Y, Tobita S, Nangaku M.
    • Journal Title

      Sci. Rep.

      Volume: 5 Pages: 17838-17838

    • DOI
      10.1038/srep17838
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Inflammation and hypoxia linked to renal injury by CCAAT/enhancer-binding protein δ.2015

    • Author(s)
      Yamaguchi J, Tanaka T, Eto N, Nangaku M.
    • Journal Title

      Kidney Int.

      Volume: 印刷中 Pages: 262-275

    • DOI
      10.1038/ki.2015.21
    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The role of clock genes and circadian rhythm in the development of cardiovascular diseases.2015

    • Author(s)
      Takeda N, Maemura K.
    • Journal Title

      Cell Mol Life Sci.

      Volume: 72 Pages: 3225-3234

    • DOI
      10.1007/s00018-015-1923-1
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Potential Biomarkers of Fatigue Identified by Plasma Metabolome Analysis in rats2015

    • Author(s)
      Kume, S., Yamato, M., Tamura, Y., Jin, G., Nakano, M., Miyashige, Y., Eguchi, A., Ogata, Y., Goda, N., Iwai, K., Yamano, E., Watanabe, Y., Soga, T., and Kataoka, Y.
    • Journal Title

      PLoS One.

      Volume: 10(3)

    • DOI
      10.1371/journal.pone.0120106
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Endothelin-converting enzyme is a plausible target gene for hypoxia-inducible factor.2015

    • Author(s)
      Khamaisi M, Toukan H, Axelrod JH, Rosenberger C, Skarzinski G, Shina A, Meidan R, Koesters R, Rosen S, Walkinshaw G, Mimura I, Nangaku M, Heyman SN.
    • Journal Title

      Kidney Int

      Volume: 87 Pages: 761-70

    • DOI
      10.1038/ki.2014.362
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of hypoxia-inducible factors prevents diabetic nephropathy.2015

    • Author(s)
      8)Nordquist L, Friederich-Persson M, Fasching A, Liss P, Shoji K, Nangaku M, Hansell P, Palm F.
    • Journal Title

      J Am Soc Nephrol

      Volume: 26 Pages: 328-338

    • DOI
      10.1681/asn.2013090990
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-inflammatory role of DPP-4 inhibitors in a non-diabetic model of glomerular injury.2015

    • Author(s)
      Higashijima Y, Tanaka T, Yamaguchi J, Tanaka S, Nangaku M
    • Journal Title

      Am J Physiol Renal Physiol.

      Volume: ahead of print

    • DOI
      10.1152/ajprenal.00590.2014
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Non-invasive diagnosis of coronary artery disease by 123I-BMIPP/201TlCl dual myocardial SPECT in patients with heart failure.2014

    • Author(s)
      Abe H, Iguchi N, Utanohara Y, Inoue K, Takamisawa I, Seki A, Tanizaki K, Takeda N, Tohbaru T, Asano R, Nagayama M, Takayama M, Umemura J, Sumiyoshi T, Tomoike H.
    • Journal Title

      Int J Cardiol.

      Volume: 176 Pages: 969-974

    • DOI
      10.1016/j.ijcard.2014.08.129
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Necrostatin-1 protects against reactive oxygen species (ROS)-induced hepatotoxicity in acetaminophen-induced acute liver failure2014

    • Author(s)
      Takemoto K, Hatano E, Iwaisako K, Takeiri M, Noma N, Ohmae S, Toriguchi K, Tanabe K, Tanaka H, Seo S, Taura K, Machida K, Takeda N, Saji S, Uemoto S, Asagiri M.
    • Journal Title

      FEBS Open Bio.

      Volume: 4 Pages: 777-787

    • DOI
      10.1016/j.fob.2014.08.007
    • NAID
      120005496668
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Transcription Profiles of the Ductus Arteriosus in Brown-Norway Rats With Irregular Elastic Fiber Formation2014

    • Author(s)
      Hsieh YT, Liu NM, Ohmori E, Yokota T, Kajimura I, Akaike T, Ohshima T, Goda N, Minamisawa S.
    • Journal Title

      Circ J

      Volume: 78 Issue: 5 Pages: 1224-1233

    • DOI
      10.1253/circj.CJ-13-1029
    • NAID
      130003391069
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Regulation of wound healing and fibrosis by hypoxia and hypoxia-inducible factor-1.2014

    • Author(s)
      Ruthenborg RJ, Ban JJ, Wazir A, Takeda N, Kim JW.
    • Journal Title

      Mol Cells

      Volume: 37 Pages: 637-643

    • DOI
      10.14348/molcells.2014.0150
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hypoxia and fatty liver.2014

    • Author(s)
      Suzuki T, Shinjo S, Arai T, Kanai M, Goda N.
    • Journal Title

      World J Gastroenterol.

      Volume: 20 Pages: 15087-15097

    • DOI
      10.3748/wjg.v20.i41.15087
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Hypoxia and fibrosis in chronic kidney disease: crossing at pericytes.2014

    • Author(s)
      Kawakami T, Mimura I, Shoji K, Tanaka T, Nangaku M.
    • Journal Title

      Kidney Int Suppl

      Volume: 4 Pages: 107-112

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] From diabetic nephropathy to diabetic kidney disease2018

    • Author(s)
      Nangaku M.
    • Organizer
      The 16th Asian Pacific Congress of Nephrology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Epigenetic change in progression of AKI to CKD2018

    • Author(s)
      Nangaku M.
    • Organizer
      The 16th Asian Pacific Congress of Nephrology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 低酸素シグナルを介する心臓リモデリング2018

    • Author(s)
      武田憲彦
    • Organizer
      第47回日本心脈管作動物質学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] The roles of lactate metabolism in cardiac function2018

    • Author(s)
      武田憲彦
    • Organizer
      第82回日本循環器学会学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Genomewide analysis of HIF-1α target genes in macrophage adaptation for the microenvironment2018

    • Author(s)
      Isagawa T, Takeda N, Semba H, Morioka M, Maemura K.
    • Organizer
      第1回日本循環器学会基礎研究フォーラム
    • Related Report
      2017 Annual Research Report
  • [Presentation] マクロファージ微小環境適応における転写制御機構2018

    • Author(s)
      砂河孝行, 武田憲彦, 仙波宏章,安部 元, 相馬 桂, 和氣正樹, 加藤愛巳, 森岡勝樹, 魏碩俣, 前村浩二
    • Organizer
      第47回日本心脈管作動物質学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 低酸素誘導性肺血管リモデリングにおける炎症細胞の役割2017

    • Author(s)
      武田憲彦
    • Organizer
      第9回日本生理学会大会
    • Place of Presentation
      アクトシティ浜松、静岡
    • Year and Date
      2017-03-30
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] The Role of Eosinophils in Pulmonary Arterial Remodelling2017

    • Author(s)
      武田憲彦
    • Organizer
      第81回日本循環器学会学術集会
    • Place of Presentation
      ホテル日航金沢、金沢
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] HIF-1alpha-PDK1 axis induced active glycolysis plays an essential role in macrophage migratory capacity.2017

    • Author(s)
      Takeda N.
    • Organizer
      Keystone Symposium “Adaptaions to Hypoxia in Physiology and Disease”
    • Place of Presentation
      Whistler Conference Centre, Whistler, British Columbia, Canada
    • Year and Date
      2017-03-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Oxygen biology in the kidney2017

    • Author(s)
      Nangaku M.
    • Organizer
      The 2nd NTU-UTokyo Joint Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Epigenetics and AKI-CKD transition2017

    • Author(s)
      Nangaku M.
    • Organizer
      22nd International Conference on Advances in Critical Care: AKI & CRRT 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The role of HIF stabilizer in renal fibrosis2017

    • Author(s)
      Nangaku M.
    • Organizer
      The 37th Annual Meeting of the Korean Society of Nephrology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Metabolic memory and hypoxic memory: epigenetics in diabetic nephropathy2017

    • Author(s)
      Nangaku M.
    • Organizer
      The 53rd Annual Meeting of the Australia-New Zealand Society of Nephrology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Gene Expression Profiles of Glomeruli from BTBR ob/ob Mice Treated with Prolyl Hydroxylase Inhibitor Suggest Involvement of Extracellular Matrix Modulators in Pathogenesis of Diabetic Kidney Disease2017

    • Author(s)
      Sugahara M, Tanaka T, Tanaka S, Fukui K, Shimizu A, Ishimoto Y, Inagi R, Nangaku M
    • Organizer
      The 61st Annual Meeting of the American Society of Nephrology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Inhibition of Glycolysis Attenuates Ischemia-Reperfusion Injury via Metabolic and Redox Changes in Proximal Tubular Cells2017

    • Author(s)
      Shinohara A, Kawakami T, Nangaku M.
    • Organizer
      The 61st Annual Meeting of the American Society of Nephrology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Inhibition of Prolyl Hydroxylase Domain (PHD) Reduces Glomerular Macrophage Infiltration and Improves Albuminuria in Mice with a High Fat Diet2017

    • Author(s)
      Saito H, Tanaka T, Sugahara M, Fukui K, Wakashima T, Nangaku M.
    • Organizer
      The 61st Annual Meeting of the American Society of Nephrology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Treatment of anemia in CKD and doping2017

    • Author(s)
      Nangaku M.
    • Organizer
      Cunio Richardson Lecture at University of Miami
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Anemia in CKD2017

    • Author(s)
      Nangaku M.
    • Organizer
      Vietnam Society of Nephrology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Update of anemia management in CKD patients2017

    • Author(s)
      Nangaku M.
    • Organizer
      The 2nd International Congress of Chinese Nephrologists
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Flt-1 in M1 macrophages promotes immature vascular formation2017

    • Author(s)
      Soma K, Takeda N, Isagawa T, Abe H, Semba H, Koyama K, Wake M, Kato M, Nakagama Y, Manabe I, Nagai R, Komuro I
    • Organizer
      European society of cardiology, ESC congress 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] High-Throughput shRNA Screening of the Molecular Mechanisms in Cardiac Fibroblast Activation2017

    • Author(s)
      Koyama K, Takeda N, Abe H, Semba H, Soma K, Wake M, Katoh M, Nakagama Y, Isagawa T, Komuro I
    • Organizer
      European society of cardiology, ESC congress 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The roles of hypoxia or inflammatory signals in cardiovascular remodeling2017

    • Author(s)
      Takeda N.
    • Organizer
      Special Research Seminar at 神戸女子薬科大学
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] The roles of lactate metabolism in cardiac function2017

    • Author(s)
      Takeda N.
    • Organizer
      Consortium of Biological Sciences 2017
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] マクロファージ活性化における細胞内グルコース代謝の役割2016

    • Author(s)
      武田憲彦
    • Organizer
      第20回日本適応医学会学術集会
    • Place of Presentation
      東京コンベンションホール、東京
    • Year and Date
      2016-12-16
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Perivascular accumulation of M1 macrophages elicits the development of immature vascular formation.2016

    • Author(s)
      武田憲彦
    • Organizer
      第24回日本血管生物医学会学術集会
    • Place of Presentation
      長崎ブリックホール、長崎
    • Year and Date
      2016-12-10
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Oxygen biology in the kidney.2016

    • Author(s)
      Nangaku M.
    • Organizer
      2nd NTU-UTokyo Joint Conference
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2016-12-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Novel therapeutic targets in PKD, DKD, and CKD: mitochondria, ER, and oxygen metabolism.2016

    • Author(s)
      Nangaku M.
    • Organizer
      Yale University Nephrology Seminar
    • Place of Presentation
      New Haven, USA
    • Year and Date
      2016-11-21
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Hypoxia-inducible factors in diabetic nephropathy.2016

    • Author(s)
      Nangaku M.
    • Organizer
      50th American Society of Nephrology
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2016-11-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 低酸素応答システムが拓く代謝性疾患の新しい病態理解2016

    • Author(s)
      合田亘人
    • Organizer
      第20回酸素ダイナミクス研究会
    • Place of Presentation
      東京
    • Year and Date
      2016-11-19
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] HIF-1alpha-PDK1経路を介した代謝リプログラミングはマクロファージ遊走能を促進する2016

    • Author(s)
      武田憲彦
    • Organizer
      第37回日本肥満学会
    • Place of Presentation
      東京ファッションタウン、東京
    • Year and Date
      2016-10-08
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Metabolic diseases and HIF-12016

    • Author(s)
      Goda N.
    • Organizer
      第89回生化学会大会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2016-09-26
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Switching of two HIF-alpha; isforms regulates inflammatory processes and cardiac remodeling2016

    • Author(s)
      武田憲彦
    • Organizer
      第52回高血圧関連疾患モデル学会
    • Place of Presentation
      秋葉原UDX、東京
    • Year and Date
      2016-09-22
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Anemia management update.2016

    • Author(s)
      Nangaku M.
    • Organizer
      15th Asian Pacific Congress of Nephrology
    • Place of Presentation
      Perth, Australia
    • Year and Date
      2016-09-17
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 心血管リモデリングにおける炎症細胞・低酸素シグナルの役割2016

    • Author(s)
      武田憲彦
    • Organizer
      第48回日本動脈硬化学会総会学術集会
    • Place of Presentation
      京王プラザホテル、東京
    • Year and Date
      2016-07-14
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] HIF-1alpha-PDK1 axis induced active glycolysis plays an essential role in macrophage migratory capacity.2016

    • Author(s)
      Takeda N.
    • Organizer
      2016 HDRC International Symposium
    • Place of Presentation
      Incheon, Korea
    • Year and Date
      2016-06-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of novel drugs targeting renal hypoxia and anaemia.2016

    • Author(s)
      Nangaku M.
    • Organizer
      53rd European Renal Association/European Dialysis and Transplantation Association
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2016-05-24
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Hypoxia and persistent inflammation in CKD.2016

    • Author(s)
      Nangaku M.
    • Organizer
      XVIII International Congress on Nutrition and Metabolism in Renal Disease
    • Place of Presentation
      Okinawa, Japan
    • Year and Date
      2016-04-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] HIF-1α - Pdk1 axis induced metabolic reprogramming critically regulates macrophage function in inflammatory conditions2016

    • Author(s)
      Semba H, Takeda N, Isagawa T, Wake M, Abe H, Soma K, Koyama K, Katoh M, Manabe I, Nagai R, Takeshi Yamashita, Komuro I
    • Organizer
      第80回日本循環器学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] HIF-1α - PDK1 axis induced active glycolysis plays an essential role in macrophage migratory capacity2016

    • Author(s)
      Takeda N, Semba H, Isagawa T, Abe H, Sugiura Y, Honda K, Wake M, Kim JW, Soma K, Koyama K, Katoh M, Johnson RS, Manabe I, Nagai R, Komuro I
    • Organizer
      Keystone symposium; Immunometabolism in immune function and inflammatory disease
    • Place of Presentation
      Alberta, Canada
    • Year and Date
      2016-02-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Roles of Ly6Chi monocytes hypoxia signaling in cardiac remodeling2016

    • Author(s)
      Abe H, Takeda N, Semba H, Soma K, Koyama K, Wake M, Katoh M, Manabe I, Nagai R, Komuro I
    • Organizer
      Keystone symposium; Immunometabolism in immune function and inflammatory disease
    • Place of Presentation
      Alberta, Canada
    • Year and Date
      2016-02-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] M1マクロファージの集積遷延は腫瘍内血管の未熟化を引き起こす2015

    • Author(s)
      相馬桂 武田憲彦 砂河孝行 安部元 仙波宏章 小山雄広 和氣正樹 加藤愛巳 真鍋一郎 永井良三 小室一成
    • Organizer
      第23回日本血管生物医学会学術集会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-12-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] Roles of macrophages hypoxia signaling in pressure overload-induced cardiac remodeling2015

    • Author(s)
      Abe H, Takeda N, Semba H, Soma K, Koyama K, Wake M, Katoh M, Manabe I, Nagai R, Komuro I
    • Organizer
      第32回国際心臓研究学会日本部会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-12-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] りん光寿命測定を用いた腎臓尿細管細胞内分圧の測定2015

    • Author(s)
      平川陽亮、吉原利忠、神谷真子、三村維真理、田中真司、田中哲洋、浦野泰照、飛田成史、南学正臣
    • Organizer
      第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-12-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] HIF-1α;-PDK1を介する解糖系代謝シフトがマクロファージ遊走能を促進する2015

    • Author(s)
      武田憲彦
    • Organizer
      第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-12-04
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 低酸素とTGF-βは、下流にある IGFBP3 を介して、尿細管上皮細胞に apoptosis を誘導する.2015

    • Author(s)
      串田夏樹、野村征太郎、藤田隆教、三村維真理、南学正臣、油谷浩幸
    • Organizer
      第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 炎症プロセスにおけるマクロファージ細胞内代謝調節機構の役割2015

    • Author(s)
      武田憲彦
    • Organizer
      脳心血管抗加齢研究会2015
    • Place of Presentation
      大阪梅田スカイビル(大阪府大阪市)
    • Year and Date
      2015-11-25
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Quantitating Intracellular Oxygen Tension in Kidney by Phosphorescence Lifetime Measurement.2015

    • Author(s)
      Yosuke Hirakawa, Imari Mimura, Toshitada Yoshihara, Mako Kamiya, Yasuteru Urano, Seiji Tobita, Masaomi Nangaku.
    • Organizer
      The 49th Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Oxidative Stres and Kidney Injury.2015

    • Author(s)
      Nangaku M.
    • Organizer
      The 49th Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2015-11-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Palmitate Exacerbates Renal Anemia: Suppression of Renal Erythropoietin Production via Endoplasmic Reticulum Stress.2015

    • Author(s)
      Reiko Inagi, Thitinun Anusornvongchai, Yu Ishimoto, Akira Okada, Norio Suzuki, Masayuki Yamamoto, Masaomi Nangaku.
    • Organizer
      The 49th Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2015-11-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Estimation of intracellular oxygen concentration in diabetic kidney by phosphorescence lifetime measurement.2015

    • Author(s)
      Hirakawa Y, Mimura I, Yoshihara T, Kamiya M, Tanaka S, Tanaka T, Inagi R, Urano Y, Tobita S, Nangaku M.
    • Organizer
      Keystone Symposia: Diabetes: New insights into molecular mechanisms and therapeutic strategies.
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2015-10-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Palmitate suppresses EPO production via ER stress in renal EPO producing cells.2015

    • Author(s)
      Anusomvongchai T, Tanaka S, Hirakawa Y, Suzuki n, Yamamoto M, Nangaku M, Inagi R.
    • Organizer
      Keystone Symposia: Diabetes: New insights into molecular mechanisms and therapeutic strategies.
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2015-10-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 腎不全に至る共通経路と高血圧の役割2015

    • Author(s)
      南学正臣
    • Organizer
      第38回日本高血圧学会総会
    • Place of Presentation
      愛媛県県民文化会館(愛媛県松山市)
    • Year and Date
      2015-10-11
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] HIF-1αを介する解糖系代謝シフトはマクロファージ遊走能を促進する2015

    • Author(s)
      武田憲彦
    • Organizer
      第19回酸素ダイナミクス研究会
    • Place of Presentation
      東京女子医科大学 健保会館(東京都新宿区)
    • Year and Date
      2015-09-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] Perivascular accumulation of M1 macrophages elicits the development of immature vascular formation.2015

    • Author(s)
      Soma K, Takeda N, Isagawa T, Abe H, Semba H, Koyama K, Wake M, Manabe I, Nagai R, Komuro I
    • Organizer
      ESC Congress2015
    • Place of Presentation
      London, UK
    • Year and Date
      2015-09-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Hypoxia induced metabolic reprograming in macrophages.2015

    • Author(s)
      Takeda N.
    • Organizer
      An International Symposium on Oxygen Biology
    • Place of Presentation
      早稲田大学 先端生命医科学センター/TWIns(東京都新宿区)
    • Year and Date
      2015-07-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 低酸素シグナルを介する心血管病態治療の可能性2015

    • Author(s)
      武田憲彦
    • Organizer
      第47回日本動脈硬化学会総会学術集会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2015-07-09
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] AKI-to-CKD: epidemiology and pathogenesis.2015

    • Author(s)
      Nangaku M.
    • Organizer
      Shanghai International AKI-CRRT Forum
    • Place of Presentation
      Shanghai, China
    • Year and Date
      2015-07-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 腎性貧血とHIF2015

    • Author(s)
      南学正臣
    • Organizer
      第60回日本透析医学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2015-06-27
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Hypoxia as a new therapeutic target in CKD.2015

    • Author(s)
      南学正臣
    • Organizer
      第58回日本腎臓学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-06-06
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Development of novel drugs targeting CKD: hypoxia, oxidative stress, and epigenetics.2015

    • Author(s)
      Nangaku M.
    • Organizer
      52nd European Renal Association/European Dialysis and Transplantation Association
    • Place of Presentation
      London, UK
    • Year and Date
      2015-05-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Roles of Macrophages Hypoxia Signaling in Pressure Overload Induced Cardiac Remodeling2015

    • Author(s)
      Abe H, Takeda N, Semba H, Soma K, Koyama K, Wake M, Manabe I, Nagai R, Komuro I.
    • Organizer
      第79回日本循環器学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] Hypoxia and Renal Disease2015

    • Author(s)
      Nangaku M
    • Organizer
      第8回国際腎臓学会
    • Place of Presentation
      Cape Town, South Africa
    • Year and Date
      2015-03-15
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] マクロファージの代謝リプログラミングにおける細胞内低酸素センサー2014

    • Author(s)
      仙波宏章, 武田憲彦, 砂河孝行, 杉浦悠毅, 安部元, 相馬桂, 小山雄広, 和氣正樹, 真鍋一郎, 小室一成, 永井良三
    • Organizer
      第37回日本分子生物学会年会ワークショップ
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 慢性腎臓病の進展とエピゲノム~低酸素刺激によるクロマチン立体構造変化2014

    • Author(s)
      三村維真理
    • Organizer
      第37回日本分子生物学会年会ワークショップ
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Hypoxic HIF, Fibrosis, and CKD.2014

    • Author(s)
      Nangaku M
    • Organizer
      第47回アメリカ腎臓学会
    • Place of Presentation
      Philadelphia, U.S.A.
    • Year and Date
      2014-11-15
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Funded Workshop] 国際低酸素シンポジウム(CARPEDIEMと共催)2015

    • Place of Presentation
      東京
    • Year and Date
      2015-07-29
    • Related Report
      2015 Annual Research Report

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Published: 2014-11-20   Modified: 2018-12-17  

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