低酸素シグナルが拓く生活習慣病の新しい病態制御

• Project Area: Oxygen biology: a new criterion for integrated understanding of life
• Project/Area Number: 26111003
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokyo
• Principal Investigator: 南学 正臣 東京大学, 医学部附属病院, 教授 (90311620)
• Co-Investigator(Kenkyū-buntansha): 合田 亘人 早稲田大学, 理工学術院, 教授 (00245549) ; 武田 憲彦 東京大学, 医学部附属病院, 助教 (40422307)
• Project Period (FY): 2014-07-10 – 2019-03-31
• Project Status: Granted (Fiscal Year 2018)
• Budget Amount: ¥120,250,000 (Direct Cost: ¥92,500,000、Indirect Cost: ¥27,750,000); Fiscal Year 2018: ¥22,750,000 (Direct Cost: ¥17,500,000、Indirect Cost: ¥5,250,000); Fiscal Year 2017: ¥24,570,000 (Direct Cost: ¥18,900,000、Indirect Cost: ¥5,670,000); Fiscal Year 2016: ¥22,750,000 (Direct Cost: ¥17,500,000、Indirect Cost: ¥5,250,000); Fiscal Year 2015: ¥24,570,000 (Direct Cost: ¥18,900,000、Indirect Cost: ¥5,670,000); Fiscal Year 2014: ¥25,610,000 (Direct Cost: ¥19,700,000、Indirect Cost: ¥5,910,000)
• Keywords: 低酸素 / エネルギー / 炎症 / 線維化 / 低酸素応答 / 低酸素センサー / HIF / 内科 / ストレス / 生活習慣病 / 低酸素シグナル

Outline of Annual Research Achievements

臓器リモデリングによる低酸素応答機構の解析として、主な病態を形成している腎臓・心臓・肝臓の実質細胞の障害、炎症細胞の活性化、臓器の線維化に注目して、解析を進めている。
低酸素状態を in vivo で定量的に評価するため、本研究領域　飛田成史と共同研究で新規低酸素感知プローブの開発を進め、生体内で細胞レベルの酸素分圧を評価することに成功し、論文報告を行った。また、新規低酸素感知プローブで低酸素の関与を示した線維化モデルにおいて、低酸素に伴いエピジェネティックな変化が起きており、これをターゲットとした介入が治療に有効であることを示し、論文報告を行った。
また、非がん細胞においてHIF-1alpha-PDK1シグナルが最も鋭敏な低酸素センサーとして機能し、解糖系への代謝シフトを誘導すること（Active Glycolysis）が、線維化過程での線維芽細胞活性化において中心的役割を果たしていることを同定し、論文報告を行った。更に、腫瘍細胞において正常酸素分圧下においても解糖系代謝が優位となるWarburg効果の分子機序について、本研究領域　中山恒と共同研究を行い、低酸素状態がピルビン酸脱水素酵素(PDH)複合体の一つPDH-E1beta発現を低下させること、PDH-E1beta発現低下が正常酸素分圧下においてもPDH活性を低下させることを確認し、腫瘍細胞におけるWarburg効果を説明する新たな機序として論文発表を行った。
更に、アセトアミノフェン肝炎モデルを用いて、T細胞系自然免疫細胞を介した急性炎症における低酸素ストレス応答の解明に取り組んだ。T細胞の低酸素応答転写因子HIF-1欠損により肝炎が遷延すること、この肝炎の増悪が好中球の過剰な浸潤によることを見いだし、この作用機序としてHIF-1欠損に起因したT細胞の障害肝への異常な集積が関わっていることを明らかに、論文発表した。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

本研究領域内での共同研究が順調に発展し、低酸素感知方法については予定以上の進展が得られ、当初予定していた低酸素に伴うエピジェネティックな制御機構の解明も順調に進展している。また、本研究領域で見出したActive Glycolysis機構が線維芽細胞活性化に重要であることを同定し、更にがん細胞におけるWarburg効果の新たな機序を突き止め論文化することができた。心臓リモデリングにおける低酸素・炎症シグナルの機序解明についても予備的知見を集積している。薬剤性急性肝炎の病態形成にかかわるT細胞の低酸素ストレス応答の役割についても、その分子機構の一端を明らかにし報告した。この解析結果は、慢性炎症だけでなく、急性炎症においても、T細胞のHIF-1が病態保護的に働いていることを示した重要な知見である。また、マクロファージや好中球の細胞遊走におけるHIF-1の促進的な作用とは異なり、T細胞のHIF-1が炎症部位への過剰な集積を抑制する因子として作用を持つことを示した点でも興味深い。一方、マウス、培養細胞やショウジョウバエを用いて、糖尿病や肥満などの生活習慣病の病態進展におけるHIF-1の生物機能解析にも継続的に取り組むことで、肝臓や脂肪組織のHIF-1による新しい代謝調節メカニズムの解明が進んできている。

Strategy for Future Research Activity

最終年度となる今年度は、これまでに取り組んで来た研究をさらに加速させることで、生活習慣病における低酸素応答とHIF-1の病態作用の解明に取り組む。
腎臓の障害における低酸素応答の役割を、細胞種特異的な HIF の活性化動物や HIF 活性化化合物を用いて、メタボロームなどを組み合わせて解析を進める。
心臓リモデリングにおける低酸素シグナル、Active Glycolysisを介する炎症細胞集積の分子機構とその病態における役割を明らかにする予定である。既に病態モデルでの解析を開始しており、臓器リモデリングを調節する鍵となる分子を探索する。
また、肝臓特異的HIF-1欠損マウスを用いて見いだしてきた抗糖尿病因子のニューレグリン1やGPNMBの生物作用を解明する。また、個体発生や生体内糖代謝調節におけるHIF-1による機能を分子レベルで明らかにしていく。これらの解析を通じて、低酸素応答ストレスと生活習慣病の関わりを、代謝制御の側面からさらに理解を深めていく。

Research Products

• [Int'l Joint Research] Uppsala University(Sweden)
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• [Journal Article] Urinary N-acetyl-β-glucosaminidase and eGFR may identify patients to be treated with immuno-suppression at diagnosis in idiopathic membranous nephropathy. (2017)
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• [Journal Article] Impact of end-stage renal disease on hospital outcomes among patients admitted to intensive care units: A retrospective matched-pair cohort study. (2017)
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• [Journal Article] Development of quality indicators for care of chronic kidney disease in the primary care setting using electronic health data: a RAND-modified Delphi method. (2017)
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• [Journal Article] Ulcerative colitis with hepatitis B virus infection treated successfully by granulocyte monocyte apheresis. (2017)
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• [Journal Article] HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity (2017)
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• [Journal Article] Type I neuregulin1α is a novel local mediator to suppress hepatic gluconeogenesis in mice (2017)
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• [Journal Article] Distinct Metabolic Phenotypes within Non-small Cell 1 Lung Cancer Define Selective Vulnerability to Glycolytic Inhibition of Lung Squamous Cell Carcinoma. (2017)
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  • Journal Title: Nat Commun Volume: 印刷中
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• [Journal Article] Bevacizumab-related microvascular angina and its management with nicorandil. (2017)
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• [Journal Article] Cardiac Sarcoidosis Diagnosed by Incidental Lymph Node Biopsy (2017)
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• [Journal Article] Hypoxia-Inducible Factor-1α Activates the Transforming Growth Factor-β/SMAD3 Pathway in Kidney Tubular Epithelial Cells. (2016)
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• [Journal Article] DialBetics: Smartphone-Based Self-Management for Type 2 Diabetes Patients on Insulin Injections. (2016)
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• [Journal Article] Lactoferrin Suppresses Neutrophil Extracellular Traps Release in Inflammation (2016)
  • Author(s): Okubo K, Kamiya M, Urano Y, Nishi H, Herter JM, Mayadas T, Hirohama D, Suzuki K, Kawakami H, Tanaka M, Kurosawa M, Kagaya S, Hishikawa K, Nangaku M, Fujita T, Hayashi M, Hirahashi J.
  • Journal Title: EBioMedicine Volume: 10 Pages: 204-215
  • DOI: 10.1016/j.ebiom.2016.07.012
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Complete remission of thrombotic microangiopathy after treatment with eculizumab in a patient with non-Shiga toxin-associated bacterial enteritis: A case report. (2016)
  • Author(s): Omura T, Watanabe E, Otsuka Y, Yoshida Y, Kato H, Nangaku M, Miyata T, Oda S.
  • Journal Title: Medicine (Baltimore) Volume: 95
  • DOI: 10.1097/md.0000000000004104
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] No association between dysplasminogenemia with p.Ala620Thr mutation and atypical hemolytic uremic syndrome. (2016)
  • Author(s): Miyata T, Uchida Y, Yoshida Y, Kato H, Matsumoto M, Kokame K, Fujimura Y, Nangaku M.
  • Journal Title: Int J Hematol Volume: 104 Pages: 223-227
  • Peer Reviewed
• [Journal Article] Potential Survival Benefit of Polymyxin B Hemoperfusion in Septic Shock Patients on Continuous Renal Replacement Therapy: A Propensity-Matched Analysis. (2016)
  • Author(s): Iwagami M, Yasunaga H, Noiri E, Horiguchi H, Fushimi K, Matsubara T, Yahagi N, Nangaku M, Doi K.
  • Journal Title: Blood Purif Volume: 42 Pages: 9-17
  • Peer Reviewed
• [Journal Article] Erythropoietin concentration in acute kidney injury is associated with insulin-like growth factor-binding protein-1. (2016)
  • Author(s): Yamashita T, Noiri E, Hamasaki Y, Matsubara T, Ishii T, Yahagi N, Nangaku M, Doi K.
  • Journal Title: Nephrology Volume: 21 Pages: 693-9
  • DOI: 10.1111/nep.12656
  • Peer Reviewed
• [Journal Article] Association of Urinary Neutrophil Gelatinase-Associated Lipocalin With Long-Term Renal Outcomes in ICU Survivors: A Retrospective Observational Cohort Study. (2016)
  • Author(s): Isshiki R, Asada T, Sato D, Sumida M, Hamasaki Y, Inokuchi R, Matsubara T, Ishii T, Yahagi N, Nangaku M, Noiri E, Doi K.
  • Journal Title: Shock Volume: 46 Pages: 44-51
  • DOI: 10.1097/shk.0000000000000580
  • Peer Reviewed
• [Journal Article] Interstitial renal fibrosis due to multiple cisplatin treatments is ameliorated by semicarbazide-sensitive amine oxidase inhibition. (2016)
  • Author(s): Katagiri D, Hamasaki Y, Doi K, Negishi K, Sugaya T, Nangaku M, Noiri E.
  • Journal Title: Kidney Int Volume: 89 Pages: 374-85
  • Peer Reviewed / Open Access
• [Journal Article] The reduced expression of proximal tubular transporters in acquired Fanconi syndrome with κ light chain deposition. (2016)
  • Author(s): Tojo A, Asaba K, Kinugasa S, Ikeda Y, Shintani Y, Fukayama M, Nangaku M.
  • Journal Title: Med Mol Morphol Volume: 49 Pages: 48-52
  • Peer Reviewed
• [Journal Article] Correction of Metabolic Alkalosis and Elevated Calcium Levels by Sodium Chloride in a Hemodialysis Patient With Inadequate Chloride Intake. (2016)
  • Author(s): Hirakawa Y, Hanafusa N, Nangaku M
  • Journal Title: Ther Apher Dial Volume: 20 Pages: 86-7
  • DOI: 10.1111/1744-9987.12335
  • Peer Reviewed
• [Journal Article] Impact of continuous renal replacement therapy intensity on septic acute kidney injury. (2016)
  • Author(s): Mayumi K, Yamashita T, Hamasaki Y, Noiri E, Nangaku M, Yahagi N, Doi K.
  • Journal Title: Shock Volume: 45 Pages: 133-138
  • DOI: 10.1097/shk.0000000000000496
  • Peer Reviewed
• [Journal Article] Rationale and study design of a randomized controlled trial to assess the effects of maintaining hemoglobin levels using darbepoetin alfa on prevention of development of end-stage kidney disease in non-diabetic CKD patients (PREDICT Trial). (2016)
  • Author(s): Imai E, Maruyama S, Nangaku M, Hirakata H, Hayashi T, Narita I, Kono H, Nakatani E, Morita S, Tsubakihara Y, Akizawa T.
  • Journal Title: Clin Exp Nephrol Volume: 20 Pages: 71-76
  • DOI: 10.1007/s10157-015-1133-z
  • Peer Reviewed
• [Journal Article] High serum ALP level is associated with increased risk of denosumab-related hypocalcemia in patients with bone metastases from solid tumors (2016)
  • Author(s): Kinoshita Y, Arai M, Ito N, Takashi Y, Makita N, Nangaku M, Shinoda Y, Fukumoto S.
  • Journal Title: Endocr J Volume: 63 Issue: 5 Pages: 479-484
  • DOI: 10.1507/endocrj.EJ16-0003
  • NAID: 130005154205
  • Peer Reviewed / Open Access
• [Journal Article] p38α activates purine metabolism to initiate hematopoietic stem/progenitor cell cycling. (2016)
  • Author(s): Karigane D, Kobayashi H, Morikawa T, Ootomo Y, Sakai M, Nagamatsu G, Kubota Y, Goda N, Matsumoto M, Nishimura EK, Soga T, Otsu K, Suematsu M, Okamoto S, Suda T, Takubo K.
  • Journal Title: Cell Stem Cell. Volume: 19 Pages: 192-204
  • DOI: 10.1016/j.stem.2016.05.013
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] The H3K9 methyltransferase Setdb1 regulates TLR4-mediated inflammatory responses in macrophages. (2016)
  • Author(s): R. Hachiya, T. Shiihashi, I. Shirakawa, Y. Iwasaki, Y. Matsumura, Y. Oishi, Y. Nakayama, Y. Miyamoto, I. Manabe, K. Ochi, M. Tanaka, N. Goda, J. Sakai, T. Suganami, Y. Ogawa.
  • Journal Title: Scientific Reports Volume: 6 Pages: 28845-28845
  • DOI: 10.1038/srep28845
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] HIF-1α in myeloid cells promotes adipose tissue remodeling toward insulin resistance. (2016)
  • Author(s): Takikawa A, Mahmood A , Nawaz A, Kado T, Okabe K, Yamamoto S, Arif A, Senda S, Tsuneyama K, Ikutani M, Watanabe Y, Igarashi Y, Nagai Y, Takatsu K, Koizumi K, Imura J, Goda N, Sasahara M, Matsumoto M, Saeki K, Nakagawa T, Fujisaka S, Usui I, Tobe K.
  • Journal Title: Diabetes Volume: 65 Pages: 3649-3659
  • NAID: 40021380120
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles. (2016)
  • Author(s): Yamano, E., Sugimoto, M., Hirayama, A., Kume, S., Yamato, M., Jin, G., Tajima, S., Goda, N., Iwai, K., Fukuda, S., Yamaguti, K., Kuratsune, H., Soga, T., Watanabe, Y., and Kataoka, Y.
  • Journal Title: Sci Rep Volume: 6 Pages: 34990-34990
  • DOI: 10.1038/srep34990
  • NAID: 120006349325
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Cardiogenic syncope possibly related to bevacizumab-containing combination chemotherapy for advanced non-small cell lung cancer. (2016)
  • Author(s): Chino H, Amano Y, Yamauchi Y, Matsuda J, Takeda N, Tanaka G, Takai D, Nagase T.
  • Journal Title: J Thorac Dis Volume: 8 Pages: 2646-2650
  • Peer Reviewed / Open Access
• [Journal Article] Atypical hemolytic uremic syndrome (aHUS): essential aspects of an accurate diagnosis. (2016)
  • Author(s): Laurence J, Haller H, Mannucci PM, Nangaku M, Praga M, Rodriguez de Cordoba S.
  • Journal Title: Clin Adv Hematol Oncol Volume: 14 Suppl 11 Pages: 2-15
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] New insights into molecular mechanisms of epigenetic regulation in kidney disease (2016)
  • Author(s): Mimura I, Tanaka T, Nangaku M.
  • Journal Title: Clin Exp Pharmacol Physiol. Volume: 43 Pages: 1159-1167
  • DOI: 10.1111/1440-1681.12663
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Progression after AKI: Understanding Maladaptive Repair Processes to Predict and Identify Therapeutic Treatments. (2016)
  • Author(s): Basile DP, Bonventre JV, Mehta R, Nangaku M, Unwin R, Rosner MH, Kellum JA, Ronco C; ADQI XIII Work Group.
  • Journal Title: J Am Soc Nephrol Volume: 27 Pages: 687-697
  • DOI: 10.1681/asn.2015030309
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Targeting Endogenous Repair Pathways after AKI. (2016)
  • Author(s): Humphreys BD, Cantaluppi V, Portilla D, Singbartl K, Yang L, Rosner MH, Kellum JA, Ronco C; Acute Dialysis Quality Initiative (ADQI) XIII Work Group.
  • Journal Title: J Am Soc Nephrol Volume: 27 Pages: 990-998
  • DOI: 10.1681/asn.2015030286
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Inflammation in AKI: Current Understanding, Key Questions, and Knowledge Gaps. (2016)
  • Author(s): Rabb H, Griffin MD, McKay DB, Swaminathan S, Pickkers P, Rosner MH, Kellum JA, Ronco C; Acute Dialysis Quality Initiative Consensus XIII Work Group.
  • Journal Title: J Am Soc Nephrol Volume: 27 Pages: 371-379
  • DOI: 10.1681/asn.2015030261
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Therapeutic Targets of Human AKI: Harmonizing Human and Animal AKI. (2016)
  • Author(s): Okusa MD, Rosner MH, Kellum JA, Ronco C; Acute Dialysis Quality Initiative XIII Workgroup.
  • Journal Title: J Am Soc Nephrol Volume: 27 Pages: 44-48
  • DOI: 10.1681/asn.2015030233
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Renal Hemodynamics in AKI: In Search of New Treatment Targets. (2016)
  • Author(s): Matejovic M, Ince C, Chawla LS, Blantz R, Molitoris BA, Rosner MH, Okusa MD, Kellum JA, Ronco C; ADQI XIII Work Group.
  • Journal Title: J Am Soc Nephrol Volume: 27 Pages: 49-58
  • DOI: 10.1681/asn.2015030234
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Circadian clock and the onset of cardiovascular events. (2016)
  • Author(s): Takeda N, Maemura K.
  • Journal Title: Hypertens Res Volume: in press Pages: 383-90
  • DOI: 10.1038/hr.2016.9
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Heterozygous deletion of Sarcolipin maintains normal cardiac function (2016)
  • Author(s): Shimura D, Kusakari Y, Sasano T, Nakashima Y, Nakai G, Jiao Q, Jin M, Yokota T, Ishikawa Y, Nakano A, Goda N, Minamisawa S.
  • Journal Title: American Journal of Physiology - Heart and Circulatory Physiology Volume: 310(1) Pages: 92-103
  • DOI: 10.1152/ajpheart.00411.2015
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Low cardiac output leads hepatic fibrosis in right heart failure model rats (2016)
  • Author(s): Fujimoto Y, Urashima T, Shimura D, Ito R, Kawachi S, Kajimura I, Akaike T, Kusakari Y, Fujiwara M, Ogawa K, Goda N, Ida H, Minamisawa S
  • Journal Title: Plos one Volume: 11(2)
  • DOI: 10.1371/journal.pone.0148666
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] HIF-1α-PDK1 axis induced active glycolysis plays an essential role in macrophage migratory capacity. (2016)
  • Author(s): Semba H, Takeda N, Isagawa T, Sugiura Y, Honda K, Wake M, Miyazawa H, Yamaguchi Y, Miura M, Jenkins D, Choi H, Kim JW, Asagiri M, Cowburn AS, Abe H, Soma K, Koyama K, Katoh M, Sayama K, Goda N, Johnson RS, Manabe I, Nagai R, Komuro I.
  • Journal Title: Nat commun. Volume: in press
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Redox-sensitive transient receptor potential channels in oxygen sensing and adaptation (2016)
  • Author(s): Mori Y, Takahashi N, Polat OK, Kuroakwa T, Takeda N, Inoue M
  • Journal Title: Pflugers Arch-Eur J Physiol Volume: 468 Pages: 85-97
  • DOI: 10.1007/s00424-015-1716-2
  • NAID: 120005980858
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Innate Response to Human Cancer Cells with or without IL-2 Receptor Common g-Chain Function in the NOD Background Mice Lacking Adaptive Immunity. (2015)
  • Author(s): Nishime C, Kawai K, Yamamoto T, Katano I, Monnai M, Goda N, Mizushima T, Suemizu H, Nakamura M, Murata M, Suematsu M, Wakui M.
  • Journal Title: J Immunol. Volume: 195 Pages: 1883-1890
  • DOI: 10.4049/jimmunol.1402103
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes (2015)
  • Author(s): Tojo Y, Sekine H, Hirano I, Pan X, Souma T, Tsujita T, Kawaguchi S, Takeda N, Takeda K, Fong GH, Dan T, Ichinose M, Miyata T, Yamamoto M, Suzuki N.
  • Journal Title: Mol Cell Biol Volume: 35 Pages: 2658-2672
  • DOI: 10.1128/mcb.00161-15
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Quantitating Intracellular Oxygen Tension in Vivo by Phosphorescence Lifetime Measurement (2015)
  • Author(s): Hirakawa Y, Yoshihara T, Kamiya M, Mimura I, Fujikura D, Masuda T, Kikuchi R, Takahashi I, Urano Y, Tobita S, Nangaku M.
  • Journal Title: Sci. Rep. Volume: 5 Pages: 17838-17838
  • DOI: 10.1038/srep17838
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Inflammation and hypoxia linked to renal injury by CCAAT/enhancer-binding protein δ. (2015)
  • Author(s): Yamaguchi J, Tanaka T, Eto N, Nangaku M.
  • Journal Title: Kidney Int. Volume: 印刷中 Pages: 262-275
  • DOI: 10.1038/ki.2015.21
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The role of clock genes and circadian rhythm in the development of cardiovascular diseases. (2015)
  • Author(s): Takeda N, Maemura K.
  • Journal Title: Cell Mol Life Sci. Volume: 72 Pages: 3225-3234
  • DOI: 10.1007/s00018-015-1923-1
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Potential Biomarkers of Fatigue Identified by Plasma Metabolome Analysis in rats (2015)
  • Author(s): Kume, S., Yamato, M., Tamura, Y., Jin, G., Nakano, M., Miyashige, Y., Eguchi, A., Ogata, Y., Goda, N., Iwai, K., Yamano, E., Watanabe, Y., Soga, T., and Kataoka, Y.
  • Journal Title: PLoS One. Volume: 10(3)
  • DOI: 10.1371/journal.pone.0120106
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Endothelin-converting enzyme is a plausible target gene for hypoxia-inducible factor. (2015)
  • Author(s): Khamaisi M, Toukan H, Axelrod JH, Rosenberger C, Skarzinski G, Shina A, Meidan R, Koesters R, Rosen S, Walkinshaw G, Mimura I, Nangaku M, Heyman SN.
  • Journal Title: Kidney Int Volume: 87 Pages: 761-70
  • DOI: 10.1038/ki.2014.362
  • Peer Reviewed
• [Journal Article] Activation of hypoxia-inducible factors prevents diabetic nephropathy. (2015)
  • Author(s): 8)Nordquist L, Friederich-Persson M, Fasching A, Liss P, Shoji K, Nangaku M, Hansell P, Palm F.
  • Journal Title: J Am Soc Nephrol Volume: 26 Pages: 328-338
  • DOI: 10.1681/asn.2013090990
  • Peer Reviewed
• [Journal Article] Anti-inflammatory role of DPP-4 inhibitors in a non-diabetic model of glomerular injury. (2015)
  • Author(s): Higashijima Y, Tanaka T, Yamaguchi J, Tanaka S, Nangaku M
  • Journal Title: Am J Physiol Renal Physiol. Volume: ahead of print
  • DOI: 10.1152/ajprenal.00590.2014
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Non-invasive diagnosis of coronary artery disease by 123I-BMIPP/201TlCl dual myocardial SPECT in patients with heart failure. (2014)
  • Author(s): Abe H, Iguchi N, Utanohara Y, Inoue K, Takamisawa I, Seki A, Tanizaki K, Takeda N, Tohbaru T, Asano R, Nagayama M, Takayama M, Umemura J, Sumiyoshi T, Tomoike H.
  • Journal Title: Int J Cardiol. Volume: 176 Pages: 969-974
  • DOI: 10.1016/j.ijcard.2014.08.129
  • Peer Reviewed
• [Journal Article] Necrostatin-1 protects against reactive oxygen species (ROS)-induced hepatotoxicity in acetaminophen-induced acute liver failure (2014)
  • Author(s): Takemoto K, Hatano E, Iwaisako K, Takeiri M, Noma N, Ohmae S, Toriguchi K, Tanabe K, Tanaka H, Seo S, Taura K, Machida K, Takeda N, Saji S, Uemoto S, Asagiri M.
  • Journal Title: FEBS Open Bio. Volume: 4 Pages: 777-787
  • DOI: 10.1016/j.fob.2014.08.007
  • NAID: 120005496668
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Transcription Profiles of the Ductus Arteriosus in Brown-Norway Rats With Irregular Elastic Fiber Formation (2014)
  • Author(s): Hsieh YT, Liu NM, Ohmori E, Yokota T, Kajimura I, Akaike T, Ohshima T, Goda N, Minamisawa S.
  • Journal Title: Circ J Volume: 78 Issue: 5 Pages: 1224-1233
  • DOI: 10.1253/circj.CJ-13-1029
  • NAID: 130003391069
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Regulation of wound healing and fibrosis by hypoxia and hypoxia-inducible factor-1. (2014)
  • Author(s): Ruthenborg RJ, Ban JJ, Wazir A, Takeda N, Kim JW.
  • Journal Title: Mol Cells Volume: 37 Pages: 637-643
  • DOI: 10.14348/molcells.2014.0150
  • Peer Reviewed / Open Access
• [Journal Article] Hypoxia and fatty liver. (2014)
  • Author(s): Suzuki T, Shinjo S, Arai T, Kanai M, Goda N.
  • Journal Title: World J Gastroenterol. Volume: 20 Pages: 15087-15097
  • DOI: 10.3748/wjg.v20.i41.15087
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Hypoxia and fibrosis in chronic kidney disease: crossing at pericytes. (2014)
  • Author(s): Kawakami T, Mimura I, Shoji K, Tanaka T, Nangaku M.
  • Journal Title: Kidney Int Suppl Volume: 4 Pages: 107-112
  • Peer Reviewed / Open Access
• [Presentation] From diabetic nephropathy to diabetic kidney disease (2018)
  • Author(s): Nangaku M.
  • Organizer: The 16th Asian Pacific Congress of Nephrology
  • Int'l Joint Research / Invited
• [Presentation] Epigenetic change in progression of AKI to CKD (2018)
  • Author(s): Nangaku M.
  • Organizer: The 16th Asian Pacific Congress of Nephrology
  • Int'l Joint Research / Invited
• [Presentation] 低酸素シグナルを介する心臓リモデリング (2018)
  • Author(s): 武田憲彦
  • Organizer: 第47回日本心脈管作動物質学会
  • Invited
• [Presentation] The roles of lactate metabolism in cardiac function (2018)
  • Author(s): 武田憲彦
  • Organizer: 第82回日本循環器学会学術集会
  • Invited
• [Presentation] Genomewide analysis of HIF-1α target genes in macrophage adaptation for the microenvironment (2018)
  • Author(s): Isagawa T, Takeda N, Semba H, Morioka M, Maemura K.
  • Organizer: 第1回日本循環器学会基礎研究フォーラム
• [Presentation] マクロファージ微小環境適応における転写制御機構 (2018)
  • Author(s): 砂河孝行, 武田憲彦, 仙波宏章，安部 元, 相馬 桂, 和氣正樹, 加藤愛巳, 森岡勝樹, 魏碩俣, 前村浩二
  • Organizer: 第47回日本心脈管作動物質学会
• [Presentation] 低酸素誘導性肺血管リモデリングにおける炎症細胞の役割 (2017)
  • Author(s): 武田憲彦
  • Organizer: 第9回日本生理学会大会
  • Place of Presentation: アクトシティ浜松、静岡
  • Year and Date: 2017-03-30
  • Invited
• [Presentation] The Role of Eosinophils in Pulmonary Arterial Remodelling (2017)
  • Author(s): 武田憲彦
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: ホテル日航金沢、金沢
  • Year and Date: 2017-03-17
  • Invited
• [Presentation] HIF-1alpha-PDK1 axis induced active glycolysis plays an essential role in macrophage migratory capacity. (2017)
  • Author(s): Takeda N.
  • Organizer: Keystone Symposium “Adaptaions to Hypoxia in Physiology and Disease”
  • Place of Presentation: Whistler Conference Centre, Whistler, British Columbia, Canada
  • Year and Date: 2017-03-09
  • Int'l Joint Research / Invited
• [Presentation] Oxygen biology in the kidney (2017)
  • Author(s): Nangaku M.
  • Organizer: The 2nd NTU-UTokyo Joint Conference
  • Int'l Joint Research / Invited
• [Presentation] Epigenetics and AKI-CKD transition (2017)
  • Author(s): Nangaku M.
  • Organizer: 22nd International Conference on Advances in Critical Care: AKI & CRRT 2017
  • Int'l Joint Research / Invited
• [Presentation] The role of HIF stabilizer in renal fibrosis (2017)
  • Author(s): Nangaku M.
  • Organizer: The 37th Annual Meeting of the Korean Society of Nephrology
  • Int'l Joint Research / Invited
• [Presentation] Metabolic memory and hypoxic memory: epigenetics in diabetic nephropathy (2017)
  • Author(s): Nangaku M.
  • Organizer: The 53rd Annual Meeting of the Australia-New Zealand Society of Nephrology
  • Int'l Joint Research / Invited
• [Presentation] Gene Expression Profiles of Glomeruli from BTBR ob/ob Mice Treated with Prolyl Hydroxylase Inhibitor Suggest Involvement of Extracellular Matrix Modulators in Pathogenesis of Diabetic Kidney Disease (2017)
  • Author(s): Sugahara M, Tanaka T, Tanaka S, Fukui K, Shimizu A, Ishimoto Y, Inagi R, Nangaku M
  • Organizer: The 61st Annual Meeting of the American Society of Nephrology
  • Int'l Joint Research
• [Presentation] Inhibition of Glycolysis Attenuates Ischemia-Reperfusion Injury via Metabolic and Redox Changes in Proximal Tubular Cells (2017)
  • Author(s): Shinohara A, Kawakami T, Nangaku M.
  • Organizer: The 61st Annual Meeting of the American Society of Nephrology
  • Int'l Joint Research
• [Presentation] Inhibition of Prolyl Hydroxylase Domain (PHD) Reduces Glomerular Macrophage Infiltration and Improves Albuminuria in Mice with a High Fat Diet (2017)
  • Author(s): Saito H, Tanaka T, Sugahara M, Fukui K, Wakashima T, Nangaku M.
  • Organizer: The 61st Annual Meeting of the American Society of Nephrology
  • Int'l Joint Research
• [Presentation] Treatment of anemia in CKD and doping (2017)
  • Author(s): Nangaku M.
  • Organizer: Cunio Richardson Lecture at University of Miami
  • Int'l Joint Research / Invited
• [Presentation] Anemia in CKD (2017)
  • Author(s): Nangaku M.
  • Organizer: Vietnam Society of Nephrology
  • Int'l Joint Research / Invited
• [Presentation] Update of anemia management in CKD patients (2017)
  • Author(s): Nangaku M.
  • Organizer: The 2nd International Congress of Chinese Nephrologists
  • Int'l Joint Research / Invited
• [Presentation] Flt-1 in M1 macrophages promotes immature vascular formation (2017)
  • Author(s): Soma K, Takeda N, Isagawa T, Abe H, Semba H, Koyama K, Wake M, Kato M, Nakagama Y, Manabe I, Nagai R, Komuro I
  • Organizer: European society of cardiology, ESC congress 2017
  • Int'l Joint Research
• [Presentation] High-Throughput shRNA Screening of the Molecular Mechanisms in Cardiac Fibroblast Activation (2017)
  • Author(s): Koyama K, Takeda N, Abe H, Semba H, Soma K, Wake M, Katoh M, Nakagama Y, Isagawa T, Komuro I
  • Organizer: European society of cardiology, ESC congress 2017
  • Int'l Joint Research
• [Presentation] The roles of hypoxia or inflammatory signals in cardiovascular remodeling (2017)
  • Author(s): Takeda N.
  • Organizer: Special Research Seminar at 神戸女子薬科大学
  • Invited
• [Presentation] The roles of lactate metabolism in cardiac function (2017)
  • Author(s): Takeda N.
  • Organizer: Consortium of Biological Sciences 2017
  • Invited
• [Presentation] マクロファージ活性化における細胞内グルコース代謝の役割 (2016)
  • Author(s): 武田憲彦
  • Organizer: 第20回日本適応医学会学術集会
  • Place of Presentation: 東京コンベンションホール、東京
  • Year and Date: 2016-12-16
  • Invited
• [Presentation] Perivascular accumulation of M1 macrophages elicits the development of immature vascular formation. (2016)
  • Author(s): 武田憲彦
  • Organizer: 第24回日本血管生物医学会学術集会
  • Place of Presentation: 長崎ブリックホール、長崎
  • Year and Date: 2016-12-10
  • Invited
• [Presentation] Oxygen biology in the kidney. (2016)
  • Author(s): Nangaku M.
  • Organizer: 2nd NTU-UTokyo Joint Conference
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2016-12-01
  • Int'l Joint Research / Invited
• [Presentation] Novel therapeutic targets in PKD, DKD, and CKD: mitochondria, ER, and oxygen metabolism. (2016)
  • Author(s): Nangaku M.
  • Organizer: Yale University Nephrology Seminar
  • Place of Presentation: New Haven, USA
  • Year and Date: 2016-11-21
  • Invited
• [Presentation] Hypoxia-inducible factors in diabetic nephropathy. (2016)
  • Author(s): Nangaku M.
  • Organizer: 50th American Society of Nephrology
  • Place of Presentation: Chicago, USA
  • Year and Date: 2016-11-19
  • Int'l Joint Research / Invited
• [Presentation] 低酸素応答システムが拓く代謝性疾患の新しい病態理解 (2016)
  • Author(s): 合田亘人
  • Organizer: 第20回酸素ダイナミクス研究会
  • Place of Presentation: 東京
  • Year and Date: 2016-11-19
  • Invited
• [Presentation] HIF-1alpha-PDK1経路を介した代謝リプログラミングはマクロファージ遊走能を促進する (2016)
  • Author(s): 武田憲彦
  • Organizer: 第37回日本肥満学会
  • Place of Presentation: 東京ファッションタウン、東京
  • Year and Date: 2016-10-08
  • Invited
• [Presentation] Metabolic diseases and HIF-1 (2016)
  • Author(s): Goda N.
  • Organizer: 第89回生化学会大会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2016-09-26
  • Invited
• [Presentation] Switching of two HIF-alpha; isforms regulates inflammatory processes and cardiac remodeling (2016)
  • Author(s): 武田憲彦
  • Organizer: 第52回高血圧関連疾患モデル学会
  • Place of Presentation: 秋葉原UDX、東京
  • Year and Date: 2016-09-22
  • Invited
• [Presentation] Anemia management update. (2016)
  • Author(s): Nangaku M.
  • Organizer: 15th Asian Pacific Congress of Nephrology
  • Place of Presentation: Perth, Australia
  • Year and Date: 2016-09-17
  • Int'l Joint Research / Invited
• [Presentation] 心血管リモデリングにおける炎症細胞・低酸素シグナルの役割 (2016)
  • Author(s): 武田憲彦
  • Organizer: 第48回日本動脈硬化学会総会学術集会
  • Place of Presentation: 京王プラザホテル、東京
  • Year and Date: 2016-07-14
  • Invited
• [Presentation] HIF-1alpha-PDK1 axis induced active glycolysis plays an essential role in macrophage migratory capacity. (2016)
  • Author(s): Takeda N.
  • Organizer: 2016 HDRC International Symposium
  • Place of Presentation: Incheon, Korea
  • Year and Date: 2016-06-17
  • Int'l Joint Research / Invited
• [Presentation] Development of novel drugs targeting renal hypoxia and anaemia. (2016)
  • Author(s): Nangaku M.
  • Organizer: 53rd European Renal Association/European Dialysis and Transplantation Association
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2016-05-24
  • Int'l Joint Research / Invited
• [Presentation] Hypoxia and persistent inflammation in CKD. (2016)
  • Author(s): Nangaku M.
  • Organizer: XVIII International Congress on Nutrition and Metabolism in Renal Disease
  • Place of Presentation: Okinawa, Japan
  • Year and Date: 2016-04-22
  • Int'l Joint Research / Invited
• [Presentation] HIF-1α - Pdk1 axis induced metabolic reprogramming critically regulates macrophage function in inflammatory conditions (2016)
  • Author(s): Semba H, Takeda N, Isagawa T, Wake M, Abe H, Soma K, Koyama K, Katoh M, Manabe I, Nagai R, Takeshi Yamashita, Komuro I
  • Organizer: 第80回日本循環器学会総会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-18
• [Presentation] HIF-1α - PDK1 axis induced active glycolysis plays an essential role in macrophage migratory capacity (2016)
  • Author(s): Takeda N, Semba H, Isagawa T, Abe H, Sugiura Y, Honda K, Wake M, Kim JW, Soma K, Koyama K, Katoh M, Johnson RS, Manabe I, Nagai R, Komuro I
  • Organizer: Keystone symposium; Immunometabolism in immune function and inflammatory disease
  • Place of Presentation: Alberta, Canada
  • Year and Date: 2016-02-24
  • Int'l Joint Research
• [Presentation] Roles of Ly6Chi monocytes hypoxia signaling in cardiac remodeling (2016)
  • Author(s): Abe H, Takeda N, Semba H, Soma K, Koyama K, Wake M, Katoh M, Manabe I, Nagai R, Komuro I
  • Organizer: Keystone symposium; Immunometabolism in immune function and inflammatory disease
  • Place of Presentation: Alberta, Canada
  • Year and Date: 2016-02-22
  • Int'l Joint Research
• [Presentation] M1マクロファージの集積遷延は腫瘍内血管の未熟化を引き起こす (2015)
  • Author(s): 相馬桂 武田憲彦 砂河孝行 安部元 仙波宏章 小山雄広 和氣正樹 加藤愛巳 真鍋一郎 永井良三 小室一成
  • Organizer: 第23回日本血管生物医学会学術集会
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2015-12-12
• [Presentation] Roles of macrophages hypoxia signaling in pressure overload-induced cardiac remodeling (2015)
  • Author(s): Abe H, Takeda N, Semba H, Soma K, Koyama K, Wake M, Katoh M, Manabe I, Nagai R, Komuro I
  • Organizer: 第32回国際心臓研究学会日本部会
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2015-12-10
• [Presentation] りん光寿命測定を用いた腎臓尿細管細胞内分圧の測定 (2015)
  • Author(s): 平川陽亮、吉原利忠、神谷真子、三村維真理、田中真司、田中哲洋、浦野泰照、飛田成史、南学正臣
  • Organizer: 第３８回日本分子生物学会年会・第８８回日本生化学会大会合同大会
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2015-12-04
• [Presentation] HIF-1α;-PDK1を介する解糖系代謝シフトがマクロファージ遊走能を促進する (2015)
  • Author(s): 武田憲彦
  • Organizer: 第３８回日本分子生物学会年会・第８８回日本生化学会大会合同大会
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2015-12-04
  • Invited
• [Presentation] 低酸素とTGF-βは、下流にある IGFBP3 を介して、尿細管上皮細胞に apoptosis を誘導する． (2015)
  • Author(s): 串田夏樹、野村征太郎、藤田隆教、三村維真理、南学正臣、油谷浩幸
  • Organizer: 第３８回日本分子生物学会年会・第８８回日本生化学会大会合同大会
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2015-12-01
• [Presentation] 炎症プロセスにおけるマクロファージ細胞内代謝調節機構の役割 (2015)
  • Author(s): 武田憲彦
  • Organizer: 脳心血管抗加齢研究会2015
  • Place of Presentation: 大阪梅田スカイビル（大阪府大阪市）
  • Year and Date: 2015-11-25
  • Invited
• [Presentation] Quantitating Intracellular Oxygen Tension in Kidney by Phosphorescence Lifetime Measurement. (2015)
  • Author(s): Yosuke Hirakawa, Imari Mimura, Toshitada Yoshihara, Mako Kamiya, Yasuteru Urano, Seiji Tobita, Masaomi Nangaku.
  • Organizer: The 49th Annual Meeting of the American Society of Nephrology
  • Place of Presentation: San Diego, USA
  • Year and Date: 2015-11-07
  • Int'l Joint Research
• [Presentation] Oxidative Stres and Kidney Injury. (2015)
  • Author(s): Nangaku M.
  • Organizer: The 49th Annual Meeting of the American Society of Nephrology
  • Place of Presentation: San Diego, USA
  • Year and Date: 2015-11-06
  • Int'l Joint Research / Invited
• [Presentation] Palmitate Exacerbates Renal Anemia: Suppression of Renal Erythropoietin Production via Endoplasmic Reticulum Stress. (2015)
  • Author(s): Reiko Inagi, Thitinun Anusornvongchai, Yu Ishimoto, Akira Okada, Norio Suzuki, Masayuki Yamamoto, Masaomi Nangaku.
  • Organizer: The 49th Annual Meeting of the American Society of Nephrology
  • Place of Presentation: San Diego, USA
  • Year and Date: 2015-11-06
  • Int'l Joint Research
• [Presentation] Estimation of intracellular oxygen concentration in diabetic kidney by phosphorescence lifetime measurement. (2015)
  • Author(s): Hirakawa Y, Mimura I, Yoshihara T, Kamiya M, Tanaka S, Tanaka T, Inagi R, Urano Y, Tobita S, Nangaku M.
  • Organizer: Keystone Symposia: Diabetes: New insights into molecular mechanisms and therapeutic strategies.
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2015-10-26
  • Int'l Joint Research
• [Presentation] Palmitate suppresses EPO production via ER stress in renal EPO producing cells. (2015)
  • Author(s): Anusomvongchai T, Tanaka S, Hirakawa Y, Suzuki n, Yamamoto M, Nangaku M, Inagi R.
  • Organizer: Keystone Symposia: Diabetes: New insights into molecular mechanisms and therapeutic strategies.
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2015-10-26
  • Int'l Joint Research
• [Presentation] 腎不全に至る共通経路と高血圧の役割 (2015)
  • Author(s): 南学正臣
  • Organizer: 第３８回日本高血圧学会総会
  • Place of Presentation: 愛媛県県民文化会館（愛媛県松山市）
  • Year and Date: 2015-10-11
  • Invited
• [Presentation] HIF-1αを介する解糖系代謝シフトはマクロファージ遊走能を促進する (2015)
  • Author(s): 武田憲彦
  • Organizer: 第19回酸素ダイナミクス研究会
  • Place of Presentation: 東京女子医科大学 健保会館（東京都新宿区）
  • Year and Date: 2015-09-12
• [Presentation] Perivascular accumulation of M1 macrophages elicits the development of immature vascular formation. (2015)
  • Author(s): Soma K, Takeda N, Isagawa T, Abe H, Semba H, Koyama K, Wake M, Manabe I, Nagai R, Komuro I
  • Organizer: ESC Congress2015
  • Place of Presentation: London, UK
  • Year and Date: 2015-09-01
  • Int'l Joint Research
• [Presentation] Hypoxia induced metabolic reprograming in macrophages. (2015)
  • Author(s): Takeda N.
  • Organizer: An International Symposium on Oxygen Biology
  • Place of Presentation: 早稲田大学 先端生命医科学センター/TWIns（東京都新宿区）
  • Year and Date: 2015-07-24
  • Int'l Joint Research
• [Presentation] 低酸素シグナルを介する心血管病態治療の可能性 (2015)
  • Author(s): 武田憲彦
  • Organizer: 第47回日本動脈硬化学会総会学術集会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2015-07-09
  • Invited
• [Presentation] AKI-to-CKD: epidemiology and pathogenesis. (2015)
  • Author(s): Nangaku M.
  • Organizer: Shanghai International AKI-CRRT Forum
  • Place of Presentation: Shanghai, China
  • Year and Date: 2015-07-04
  • Int'l Joint Research / Invited
• [Presentation] 腎性貧血とHIF (2015)
  • Author(s): 南学正臣
  • Organizer: 第60回日本透析医学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2015-06-27
  • Invited
• [Presentation] Hypoxia as a new therapeutic target in CKD. (2015)
  • Author(s): 南学正臣
  • Organizer: 第５８回日本腎臓学会学術総会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-06-06
  • Invited
• [Presentation] Development of novel drugs targeting CKD: hypoxia, oxidative stress, and epigenetics. (2015)
  • Author(s): Nangaku M.
  • Organizer: 52nd European Renal Association/European Dialysis and Transplantation Association
  • Place of Presentation: London, UK
  • Year and Date: 2015-05-30
  • Int'l Joint Research / Invited
• [Presentation] Roles of Macrophages Hypoxia Signaling in Pressure Overload Induced Cardiac Remodeling (2015)
  • Author(s): Abe H, Takeda N, Semba H, Soma K, Koyama K, Wake M, Manabe I, Nagai R, Komuro I.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24
• [Presentation] Hypoxia and Renal Disease (2015)
  • Author(s): Nangaku M
  • Organizer: 第８回国際腎臓学会
  • Place of Presentation: Cape Town, South Africa
  • Year and Date: 2015-03-15
  • Invited
• [Presentation] マクロファージの代謝リプログラミングにおける細胞内低酸素センサー (2014)
  • Author(s): 仙波宏章, 武田憲彦, 砂河孝行, 杉浦悠毅, 安部元, 相馬桂, 小山雄広, 和氣正樹, 真鍋一郎, 小室一成, 永井良三
  • Organizer: 第37回日本分子生物学会年会ワークショップ
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-11-26
• [Presentation] 慢性腎臓病の進展とエピゲノム~低酸素刺激によるクロマチン立体構造変化 (2014)
  • Author(s): 三村維真理
  • Organizer: 第37回日本分子生物学会年会ワークショップ
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-11-26
• [Presentation] Hypoxic HIF, Fibrosis, and CKD. (2014)
  • Author(s): Nangaku M
  • Organizer: 第４７回アメリカ腎臓学会
  • Place of Presentation: Philadelphia, U.S.A.
  • Year and Date: 2014-11-15
  • Invited
• [Funded Workshop] 国際低酸素シンポジウム（CARPEDIEMと共催） (2015)
  • Place of Presentation: 東京
  • Year and Date: 2015-07-29