| Budget Amount *help |
¥112,840,000 (Direct Cost: ¥86,800,000、Indirect Cost: ¥26,040,000)
Fiscal Year 2018: ¥26,520,000 (Direct Cost: ¥20,400,000、Indirect Cost: ¥6,120,000)
Fiscal Year 2017: ¥26,520,000 (Direct Cost: ¥20,400,000、Indirect Cost: ¥6,120,000)
Fiscal Year 2016: ¥25,090,000 (Direct Cost: ¥19,300,000、Indirect Cost: ¥5,790,000)
Fiscal Year 2015: ¥21,320,000 (Direct Cost: ¥16,400,000、Indirect Cost: ¥4,920,000)
Fiscal Year 2014: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
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| Outline of Final Research Achievements |
In order to elucidate mechanisms underlying formation, sensing, adaptation, and their significance for physiological hypoxia environment in vivo, I investigated how acute hypoxia responses, which are distributed ubiquitously throughout the mammalian body, are integrated as neural outputs in the respiratory regulation. Also, in collaboration with other members of our innovative area, I developed new imaging techniques by combining our own probes for oxygen, ROS, and energy production with multiphoton imaging systems, and succeeded in quantifying their presence in vivo . Moreover, I addressed questions from biological perspectives how oxygen environment in vivo controls signaling cascades and gene transcription.
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