| Budget Amount *help |
¥85,930,000 (Direct Cost: ¥66,100,000、Indirect Cost: ¥19,830,000)
Fiscal Year 2018: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2017: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2016: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2015: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2014: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
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| Outline of Final Research Achievements |
We have developed a primary three dimensional culture method for cancer. Using the method, we revealed the molecular mechanism of cancer cell dormancy, under which cancer cells suppress the oncogenic pathway and their activity in hypoxia. The dormant cells are resistant to the molecular targeting drugs. In addition, we revealed that cells of common origin exist in a mixed tumor, in which distinct pathological types co-exist in a tumor, and the differentiation is dominated by oxygen levels. We also revealed that the mucosal cells in the colon reside in hypoxic microenvironment and the hypoxia inducible factor is critical for the development of colon tumor using mouse model of colon cancer.
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