| Budget Amount *help |
¥73,060,000 (Direct Cost: ¥56,200,000、Indirect Cost: ¥16,860,000)
Fiscal Year 2018: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2017: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2016: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2015: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2014: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Outline of Final Research Achievements |
In this study, by interspecies comparison between naked mole rats (NMRs) and mice, we identified the upregulated or downregulated metabolic pathways, possibly contributing to the senescence-resistance of the NMR. Next, we succeeded to generate NMR-iPS cells and revealed that NMR-iPS cells have tumor-resistance. Interestingly, NMR-fibroblasts failed to reprogram in a hypoxic condition. Thus, the response of the NMR cells to oxygen condition during the reprogramming process seems to be unique. Additionally, we identified the social context-dependent brown adipose tissues thermogenesis in the NMRs.
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