Budget Amount *help |
¥100,360,000 (Direct Cost: ¥77,200,000、Indirect Cost: ¥23,160,000)
Fiscal Year 2018: ¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Fiscal Year 2017: ¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2016: ¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Fiscal Year 2015: ¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2014: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000)
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Outline of Final Research Achievements |
(1) We performed functional analyses of PRL, a redox sensor molecule. We found a novel regulatory mechanism of the complex formation with its target molecule CNNM and a unique role in the regulation of energy metabolism and blood pressure. (2) We also performed functional analyses of another redox sensor molecule KLHDC10. We found its involvement in systemic inflammation by promoting cell death and the importance of ASK1, which functions downstream of KLHDC10, in cell death induced by the accumulation of peroxidized lipids, which is called ferroptosis.
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