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Formation and regulation of ligand signals associated with accepting and activating molecular oxygen

Planned Research

Project AreaOxygen biology: a new criterion for integrated understanding of life
Project/Area Number 26111011
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokyo (2016-2019)
Nagoya University (2014-2015)

Principal Investigator

UCHIDA Koji  東京大学, 大学院農学生命科学研究科(農学部), 教授 (40203533)

Co-Investigator(Kenkyū-buntansha) 西田 基宏  大学共同利用機関法人自然科学研究機構(新分野創成センター、アストロバイオロジーセンター、生命創成探究, 生命創成探究センター, 教授 (90342641)
居原 秀  大阪府立大学, 理学(系)研究科(研究院), 教授 (60254447)
柴田 貴広  名古屋大学, 生命農学研究科, 准教授 (80447838)
Project Period (FY) 2014-07-10 – 2019-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥113,750,000 (Direct Cost: ¥87,500,000、Indirect Cost: ¥26,250,000)
Fiscal Year 2018: ¥22,230,000 (Direct Cost: ¥17,100,000、Indirect Cost: ¥5,130,000)
Fiscal Year 2017: ¥22,230,000 (Direct Cost: ¥17,100,000、Indirect Cost: ¥5,130,000)
Fiscal Year 2016: ¥22,490,000 (Direct Cost: ¥17,300,000、Indirect Cost: ¥5,190,000)
Fiscal Year 2015: ¥22,360,000 (Direct Cost: ¥17,200,000、Indirect Cost: ¥5,160,000)
Fiscal Year 2014: ¥24,440,000 (Direct Cost: ¥18,800,000、Indirect Cost: ¥5,640,000)
Keywords活性酸素種 / ケミカルバイオロジー / タンパク質修飾 / リモデリング / レドックス
Outline of Final Research Achievements

(1) We identified a novel lysine adduct as an oxidative stress-related biomarker candidate. We also unambiguously detected 2-oxo-histidine-containing dipeptides in mouse tissue homogenates. In addition, an enhanced S-thiolation of HSA in the hyperlipidemia patients was observed.(2) We identified complement component C1q as a novel AGE-binding protein. We also discovered that the EGCG could be an endogenous source of the electrically-transformed proteins that could be recognized by the natural antibodies. In addition, lactate dehydrogenase was identified as a novel a mammalian PQQ-binding protein.(3) We found that the filamin A acted as a guanine nucleotide exchange factor for Drp1 and mediated mitochondrial fission-associated myocardial senescence in mice after myocardial infarction. We also demonstrate that TRPC3 acts as a positive regulator of ROS that stabilizes Nox2 activity through physical interaction, leading to amplification of maladaptive signaling in cardiomyocytes.

Academic Significance and Societal Importance of the Research Achievements

新規リジン付加体や2-オキソイミダゾールジペプチドに関する成果は、酸化ストレス関連疾患のメカニズム解明や予防・治療法開発が期待される新たな基盤となりうるものである。ポリフェノール類修飾タンパク質による生体防御機構に関する知見は、人類誕生より食されてきた植物成分の意義と人類進化のプロセスを解明する手がかりになりうる。
心筋組織におけるリモデリング機構に関する一連の研究成果は、病態マーカーの開発やリモデリング制御可能な医薬品などの応用開発に資することが期待される。また、慢性心不全の予後改善を可能とする既承認薬を同定したことで、ヒト健康社会の実現に寄与しうる臨床応用への糸口を見出した。

Report

(6 results)
  • 2019 Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (95 results)

All 2019 2018 2017 2016 2015 2014 Other

All Int'l Joint Research (2 results) Journal Article (58 results) (of which Int'l Joint Research: 25 results,  Open Access: 50 results,  Peer Reviewed: 50 results,  Acknowledgement Compliant: 9 results) Presentation (28 results) (of which Int'l Joint Research: 6 results,  Invited: 19 results) Book (6 results) Patent(Industrial Property Rights) (1 results)

  • [Int'l Joint Research] Mahidol大学薬学部(タイ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Sabah大学医学部(マレーシア)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] A unique mechanism for thiolation of serum albumins by disulphide molecules2019

    • Author(s)
      Nakashima Fumie、Shibata Takahiro、Uchida Koji
    • Journal Title

      The Journal of Biochemistry

      Volume: 167 Pages: 165-171

    • DOI

      10.1093/jb/mvz084

    • Related Report
      2018 Annual Research Report
    • Open Access
  • [Journal Article] Ibudilast attenuates doxorubicin‐induced cytotoxicity by suppressing formation of TRPC3 channel and NADPH oxidase 2 protein complexes2019

    • Author(s)
      Nishiyama Kazuhiro、Numaga‐Tomita Takuro、Fujimoto Yasuyuki、Tanaka Tomohiro、Toyama Chiemi、Nishimura Akiyuki、Yamashita Tomohiro、Matsunaga Naoya、Koyanagi Satoru、Azuma Yasu‐Taka、Ibuki Yuko、Uchida Koji、Ohdo Shigehiro、Nishida Motohiro
    • Journal Title

      British Journal of Pharmacology

      Volume: 176 Issue: 18 Pages: 3723-3738

    • DOI

      10.1111/bph.14777

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protein adductomics: A comprehensive analysis of protein modifications by electrophiles2019

    • Author(s)
      Shibata Takahiro、Uchida Koji
    • Journal Title

      Free Radical Biology and Medicine

      Volume: 144 Pages: 218-222

    • DOI

      10.1016/j.freeradbiomed.2019.02.034

    • Related Report
      2018 Annual Research Report
    • Open Access
  • [Journal Article] 2-Alkenal modification of hemoglobin: Identification of a novel hemoglobin-specific alkanoic acid-histidine adduct2019

    • Author(s)
      Yoshitake Jun、Shibata Takahiro、Shimayama Chihiro、Uchida Koji
    • Journal Title

      Redox Biology

      Volume: 23 Pages: 101115-101115

    • DOI

      10.1016/j.redox.2019.101115

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mitochondrial dynamics in exercise physiology.2019

    • Author(s)
      Tanaka T, Nishimura A, Nishiyama K, Goto T, Numaga-Tomita T, Nishida M.
    • Journal Title

      Pflugers Archiv European Journal of Physiology

      Volume: 印刷中 Issue: 2 Pages: 1-17

    • DOI

      10.1007/s00424-019-02258-3

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Current topics in prostaglandin D2 metabolites2018

    • Author(s)
      柴田 貴広、内田 浩二
    • Journal Title

      生化学

      Volume: 90 Issue: 5 Pages: 711-714

    • DOI

      10.14952/SEIKAGAKU.2018.900711

    • ISSN
      0037-1017
    • Year and Date
      2018-10-25
    • Related Report
      2018 Annual Research Report
    • Open Access
  • [Journal Article] 2-Oxo-histidine-containing dipeptides are functional oxidation products2018

    • Author(s)
      Ihara Hideshi、Kakihana Yuki、Yamakage Akane、Kai Kenji、Shibata Takahiro、Nishida Motohiro、Yamada Ken-ichi、Uchida Koji
    • Journal Title

      Journal of Biological Chemistry

      Volume: 294 Issue: 4 Pages: 1279-1289

    • DOI

      10.1074/jbc.ra118.006111

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structural and functional insights into S-thiolation of human serum albumins.2018

    • Author(s)
      Nakashima F, Shibata T, Kamiya K, Yoshitake J, Kikuchi R, Matsushita T, Ishii I, Gimenez-Bastida JA, Schneider C, Uchida K
    • Journal Title

      Sci Rep.

      Volume: 8(1) Issue: 1 Pages: 932-932

    • DOI

      10.1038/s41598-018-19610-9

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prolonged stimulation of β2-adrenergic receptor with β2-agonists impairs insulin actions in H9c2 cells2018

    • Author(s)
      Parichatikanond Warisara、Nishimura Akiyuki、Nishida Motohiro、Mangmool Supachoke
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 138 Issue: 3 Pages: 184-191

    • DOI

      10.1016/j.jphs.2018.09.007

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence.2018

    • Author(s)
      Nishimura A, Shimauchi T, Tanaka T, Shimoda K, Toyama T, Kitajima N, Ishikawa T, Shindo N, Numaga-Tomita T, Yasuda S, Sato Y, Kuwahara K, Kumagai Y, Akaike T, Ide T, Ojida A, Mori Y, Nishida M.
    • Journal Title

      Sci Signal

      Volume: 11 Issue: 556 Pages: 5185-5195

    • DOI

      10.1126/scisignal.aat5185

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TRPC5-eNOS Axis Negatively Regulates ATP-Induced Cardiomyocyte Hypertrophy.2018

    • Author(s)
      Sunggip C, Shimoda K, Oda S, Tanaka T, Nishiyama K, Mangmool S, Nishimura A, Numaga-Tomita T and Nishida M
    • Journal Title

      Front. Pharmacol.

      Volume: 9 Pages: 523-523

    • DOI

      10.3389/fphar.2018.00523

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] TRPC channels in exercise-mimetic therapy.2018

    • Author(s)
      Numaga-Tomita T, Oda S, Nishiyama K, Tanaka T, Nishimura A, Nishida M.
    • Journal Title

      Pflugers Archiv European Journal of Physiology

      Volume: 471 Issue: 3 Pages: 507-517

    • DOI

      10.1007/s00424-018-2211-3

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 心臓リモデリングを制御するGタンパク質/受容体シグナリング2018

    • Author(s)
      西田基宏、西村明幸、西山和宏
    • Journal Title

      日本臨牀増刊「心不全(第2版) 上巻-最新の基礎・臨床研究の進歩-」

      Volume: 76(9) Pages: 155-161

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 8-Nitro-cGMP attenuates the interaction between SNARE complex and complexin through S-guanylation of SNAP-252018

    • Author(s)
      Kishimoto Y, Kunieda K, Kitamura A, Kakihana Y, Akaike T, Ihara H.
    • Journal Title

      ACS Chem Neurosci

      Volume: 9 Issue: 2 Pages: 217-223

    • DOI

      10.1021/acschemneuro.7b00363

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of nitric oxide/reactive oxygen species signaling via 8-nitro-cGMP formation in 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in PC12 cells and rat cerebellar granule neurons2018

    • Author(s)
      Masuda Kumiko、Tsutsuki Hiroyasu、Kasamatsu Shingo、Ida Tomoaki、Takata Tsuyoshi、Sugiura Kikuya、Nishida Motohiro、Watanabe Yasuo、Sawa Tomohiro、Akaike Takaaki、Ihara Hideshi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 495 Issue: 3 Pages: 2165-2170

    • DOI

      10.1016/j.bbrc.2017.12.088

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Adductome-based identification of biomarkers for lipid peroxidation.2017

    • Author(s)
      Shibata T, Shimizu K, Hirano K, Nakashima F, Kikuchi R, Matsushita T, Uchida K.
    • Journal Title

      J Biol Chem.

      Volume: 292(20) Issue: 20 Pages: 8223-8235

    • DOI

      10.1074/jbc.m116.762609

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Roles of 5-lipoxygenase and cyclooxygenase-2 in the biosynthesis of hemiketals E2 and D2 by activated human leukocytes2017

    • Author(s)
      Gimenez-Bastida JA, Shibata T, Uchida K, Schneider C.
    • Journal Title

      FASEB J.

      Volume: 31 Issue: 5 Pages: 1867-1878

    • DOI

      10.1096/fj.201601136r

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of polyphenol-specific innate epitopes originated from a resveratrol analogue.2017

    • Author(s)
      Furuhashi, M., Hatasa, Y., Kawamura, S., Shibata, T., Akagawa, M., Uchida, K.
    • Journal Title

      Biochemistry

      Volume: 56 Issue: 35 Pages: 470-4712

    • DOI

      10.1021/acs.biochem.7b00409

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] TRPC3-Nox2 complex mediates doxorubicin-induced myocardial atrophy2017

    • Author(s)
      Shimauchi Tsukasa、Numaga-Tomita Takuro、Ito Tomoya、Nishimura Akiyuki、Matsukane Ryosuke、Oda Sayaka、Hoka Sumio、Ide Tomomi、Koitabashi Norimichi、Uchida Koji、Sumimoto Hideki、Mori Yasuo、Nishida Motohiro
    • Journal Title

      The JCI insight

      Volume: 2 Issue: 15 Pages: 93358-93358

    • DOI

      10.1172/jci.insight.93358

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice2017

    • Author(s)
      Oda Sayaka、Numaga-Tomita Takuro、Kitajima Naoyuki、Toyama Takashi、Harada Eri、Shimauchi Tsukasa、Nishimura Akiyuki、Ishikawa Tatsuya、Kumagai Yoshito、Birnbaumer Lutz、Nishida Motohiro
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 7511-7511

    • DOI

      10.1038/s41598-017-07903-4

    • NAID

      120007128849

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics2017

    • Author(s)
      Akaike Takaaki、、、Nishida Motohiro(4)、、、、、、Fujii Shigemoto(20)、、、Motohashi Hozumi(26)
    • Journal Title

      Nature Communications

      Volume: 8 Issue: 1 Pages: 1177-1177

    • DOI

      10.1038/s41467-017-01311-y

    • NAID

      120007134656

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Exposure to Electrophiles Impairs Reactive Persulfide-Dependent Redox Signaling in Neuronal Cells2017

    • Author(s)
      Ihara Hideshi、Kasamatsu Shingo、Kitamura Atsushi、Nishimura Akira、Tsutsuki Hiroyasu、Ida Tomoaki、Ishizaki Kento、Toyama Takashi、Yoshida Eiko、Abdul Hamid Hisyam、Jung Minkyung、Matsunaga Tetsuro、Fujii Shigemoto、Sawa Tomohiro、Nishida Motohiro、Kumagai Yoshito、Akaike Takaaki
    • Journal Title

      Chem. Res. Toxicol

      Volume: 30 Issue: 9 Pages: 1673-1684

    • DOI

      10.1021/acs.chemrestox.7b00120

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] TRPC3 participates in angiotensin II type 1 receptor-dependent stress-induced slow increase in intracellular Ca2+ concentration in mouse cardiomyocytes2017

    • Author(s)
      Yamaguchi Y, Iribe G, Kaneko T, Takahashi K, Numaga-Tomita T, Nishida M, Birnbaumer L, Naruse K.
    • Journal Title

      J. Physiol. Sci.

      Volume: 印刷中 Issue: 2 Pages: 1-12

    • DOI

      10.1007/s12576-016-0519-3

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] MiR30-GALNT1/2 Axis-Mediated Glycosylation Contributes to the Increased Secretion of Inactive Human Prohormone for Brain Natriuretic Peptide (proBNP) From Failing Hearts.2017

    • Author(s)
      Nakagawa Y, Nishikimi T, Kuwahara K, Fujishima A, Oka S, Tsutamoto T, Kinoshita H, Nakao K, Cho K, Inazumi H, Okamoto H, Nishida M, Kato T, Fukushima H, Yamashita JK, Wijnen WJ, Creemers EE, Kangawa K, Minamino N, Nakao K, Kimura T.
    • Journal Title

      J Am Heart Assoc.

      Volume: 6 Issue: 2

    • DOI

      10.1161/jaha.116.003601

    • NAID

      120007100125

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Redox regulation of electrophilic signaling by reactive persulfides in cardiac cells2017

    • Author(s)
      Nishida M, Nishimura A, Matsunaga T, Motohashi H, Kasamatsu S, Akaike T.
    • Journal Title

      Free Radic Biol Med.

      Volume: 印刷中 Pages: 30033-3

    • DOI

      10.1016/j.freeradbiomed.2017.01.024

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] プリン作動性シグナルの心血管系における役割2017

    • Author(s)
      西村明幸、西田基宏
    • Journal Title

      日本薬理学雑誌

      Volume: 149 Pages: 84-90

    • NAID

      130005306336

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Identification of C1q as a binding protein for advanced glycation end products2016

    • Author(s)
      Chikazawa, M., Shibata, T., Hatasa, Y., Hirose, S., Otaki, N., Nakashima, F., Ito, M., Machida, S., Maruyama, S., Uchida, K.
    • Journal Title

      Biochemistry

      Volume: 55 Issue: 3 Pages: 435-446

    • DOI

      10.1021/acs.biochem.5b00777

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Oxidative deamination of serum albumins by (-)-epigallocatechin-3-O-gallate: A potential eechanism for the formation of innate antigens by antioxidants2016

    • Author(s)
      Hatasa, Y., Chikazawa, M., Furuhashi, M., Nakashima, F., Shibata, T., Kondo, T., Akagawa, M., Hamagami, H., Tanaka, H., Tachibana, H., Uchida, K.
    • Journal Title

      PLoS One

      Volume: 11 Issue: 4 Pages: e0153002-e0153002

    • DOI

      10.1371/journal.pone.0153002

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of lactate dehydrogenase as a mammalian pyrroloquinoline quinone (PQQ)-binding protein2016

    • Author(s)
      Akagawa, M., Minematsu, K., Shibata, T., Kondo, T., Ishii, T., and Uchida, K.
    • Journal Title

      Sci. Rep.

      Volume: 6 Issue: 1 Pages: 26723-26723

    • DOI

      10.1038/srep26723

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Membrane lipid peroxidation in neurodegeneration: Role of thrombin and proteinase-activated receptor-12016

    • Author(s)
      Citron, B. A., Ameenuddin, S., Uchida, K., Suo, W. Z., SantaCruz, K., and Festoff, B. W.
    • Journal Title

      Brain Res.

      Volume: 1643 Pages: 10-17

    • DOI

      10.1016/j.brainres.2016.04.071

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis2016

    • Author(s)
      Nokin, M. J., Durieux, F., Peixoto, P., Chiavarina, B., Peulen, O., Blomme, A., Turtoi, A., Costanza, B., Smargiasso, N., Baiwir, D., De Tullio, P., Bianchi, E., Thiry, M., Uchida, K., Spiegel, D. A., Hutton, C. A., De Pauw, E., Delvenne, P., Belpomme, D., Castronovo, D., and Bellahcène, A.
    • Journal Title

      eLife

      Volume: 5

    • DOI

      10.7554/elife.19375

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The purinergic P2Y6 receptor heterodimerizes with the angiotensin AT1 receptor to promote angiotensin II-induced hypertension2016

    • Author(s)
      A. Nishimura, C. Sunggip, H. Tozaki-Saitoh, T. Shimauchi, T. Numaga-Tomita, K. Hirano, T. Ide, J-M. Boeynaems, H. Kurose, M. Tsuda, B. Robaye, K. Inoue and M. Nishida
    • Journal Title

      Science Signaling

      Volume: Jan 19;9(411) Issue: 411

    • DOI

      10.1126/scisignal.aac9187

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compounds2016

    • Author(s)
      S. Sawamura, M. Hatano, Y. Takada, K. Hino, T. Kawamura, J. Tanikawa, H. Nakagawa, H. Hase, A. Nakao, M. Hirano, R. Rotrattanadumrong, S. Kiyonaka, M.X. Mori, M. Nishida, Y. Hu, R. Inoue, R. Nagata and Y. Mori
    • Journal Title

      Mol Pharmacol

      Volume: 89(3) Issue: 3 Pages: 348-363

    • DOI

      10.1124/mol.115.102863

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sustained betaAR stimulation mediates cardiac insulin resistance in a PKA-dependent manner2016

    • Author(s)
      S. Mangmool, T. Denkaew, S. Phosri, D. Pinthong, W. Parichatikanond, T. Shimauchi and M. Nishida
    • Journal Title

      Mol. Endocrinol.

      Volume: 30(1) Issue: 1 Pages: 118-132

    • DOI

      10.1210/me.2015-1201

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Synthesis of radioiodinated probes to evaluate the biodistribution of a potent TRPC3 inhibitor2016

    • Author(s)
      M. Hagimori, T. Murakami, K. Shimizu, M. Nishida, T. Ohshima, T. Mukai
    • Journal Title

      MedChemComm

      Volume: 7 Issue: 5 Pages: 1003-1006

    • DOI

      10.1039/c6md00023a

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Methylmercury, an environmental electrophile capable of activation and disruption of the Akt/CREB/Bcl-2 signal transduction pathway in SH-SY5Y cells2016

    • Author(s)
      Unoki T, Abiko Y, Toyama T, Uehara T, Tsuboi K, Nishida M, Kaji T, Kumagai Y.
    • Journal Title

      Sci Rep.

      Volume: 6 Issue: 1 Pages: 28944-28944

    • DOI

      10.1038/srep28944

    • NAID

      120007135346

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling.2016

    • Author(s)
      Kitajima N., Numaga-Tomita T., Watanabe M., Kuroda T., Nishimura A., Miyano K., Yasuda S., Kuwahara K., Sato Y., Ide T., Birnbaumer L., Sumimoto H., Mori Y. and Nishida M
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 37701-37701

    • DOI

      10.1038/srep37001

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis.2016

    • Author(s)
      Numaga-Tomita T., Kitajima N., Kuroda T., Nishimura A., Miyano K., Yasuda S., Kuwahara K., Sato Y., Ide T., Birnbaumer L., Sumimoto H., Mori Y. and Nishida M.
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 39383-39383

    • DOI

      10.1038/srep39383

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Redox signaling regulated by electrophiles and reactive sulfur species2016

    • Author(s)
      Nishida M, Kumagai Y, Ihara H, Fujii S, Motohashi H, Akaike T.
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 58 Issue: 2 Pages: 91-98

    • DOI

      10.3164/jcbn.15-111

    • NAID

      130005132519

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] アダクトーム解析法を用いた疾患バイオマーカーの探索2016

    • Author(s)
      柴田貴広、内田浩二
    • Journal Title

      バイオサイエンスとインダストリー

      Volume: 74 Pages: 26-29

    • NAID

      40020705853

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Redox signaling regulated by an electrophilic cyclic nucleotide and reactive cysteine persulfides2016

    • Author(s)
      Fujii S, Sawa T, Nishida M, Ihara H, Ida T, Motohashi H, Akaike T.
    • Journal Title

      Arch Biochem Biophys.

      Volume: 595 Pages: 140-146

    • DOI

      10.1016/j.abb.2015.11.008

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TRPC3 amplifies B cell receptor-induced ERK signaling via protein kinase D-dependent Rap1 activation2016

    • Author(s)
      T. Numaga-Tomita, M. Nishida, J.W. Jr. Putney and Y. Mori
    • Journal Title

      Biochem J

      Volume: 473(2) Issue: 2 Pages: 201-210

    • DOI

      10.1042/bj20150596

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Recent progress in studies on the health benefits of pyrroloquinoline quinone2015

    • Author(s)
      Akagawa, M., Nakano, M., Ikemoto, K.
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 80 Issue: 1 Pages: 13-22

    • DOI

      10.1080/09168451.2015.1062715

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Abnormal myofiber morphology and limb dysfunction in claudication.2015

    • Author(s)
      Koutakis, P., Myers, S. A., Cluff, K., Ha, D. M., Haynatzki, G., McComb, R. D., Uchida, K., Miserlis, D., Papoutsi, E., Johanning, J. M., Casale, G. P., and Pipinos, I. I.
    • Journal Title

      J. Surg. Res.

      Volume: J. Surg. Res. Issue: 1 Pages: 172-179

    • DOI

      10.1016/j.jss.2015.02.011

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Generation of adducts of 4-hydroxy-2-nonenal with heat shock 60kDa protein 1 in human promyelocytic HL-60 and monocytic THP-1 cell lines.2015

    • Author(s)
      Arcaro, A., Daga, M., Paolo Cetrangolo, G., Ciamporcero, E., Lepore, A., Pizzimenti, A., Petrella, C., Graf, M., Uchida, U., Mamone, G., Ferranti, P., Julian Ames, R., Palumbo, G., BarreraG., and Gentile, F.
    • Journal Title

      Oxid Med. Cell. Longev.

      Volume: 2015 Pages: 296146-296146

    • DOI

      10.1155/2015/296146

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Divergent Roles of CAAX Motif-signaled Posttranslational Modifications in the Regulation and Subcellular Localization of Ral GTPases2015

    • Author(s)
      LR Gentry, A. Nishimura, A.D. Cox, T.D. Martin, D. Tsygankov, M. Nishida, T.C. Elston and C.J. Der
    • Journal Title

      J Biol Chem.

      Volume: 290(37) Issue: 37 Pages: 22851-22861

    • DOI

      10.1074/jbc.m115.656710

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Reactive sulfur species-mediated activation of the Keap1-Nrf2 pathway by 1,2-napthoquinone through sulfenic acids formation under oxidative stress.2015

    • Author(s)
      Shinkai Y, Abiko Y, Ida T, Miura T, Kakehashi H, Ishii I, Nishida M, Sawa T, Akaike T, Kumagai Y.
    • Journal Title

      Chem Res Toxicol.

      Volume: 印刷中 Issue: 5 Pages: 838-847

    • DOI

      10.1021/tx500416y

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Measurement of Glucose Uptake in Cultured Cells2015

    • Author(s)
      Yamamoto N., Ueda-Wakagi M., Sato T., Kawasaki K., Sawada K., Kawabata K., Akagawa M., Ashida H.
    • Journal Title

      Current Protocols in Pharmacology

      Volume: 12.14 Issue: 1 Pages: 1-26

    • DOI

      10.1002/0471141755.ph1214s71

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Production of hypoallergenic cocoa beans by a pregermination treatment method2015

    • Author(s)
      Handoyo, T., Akagawa, M., Kim, K.
    • Journal Title

      J. Plant Biotechnol.

      Volume: 42 Issue: 2 Pages: 123-128

    • DOI

      10.5010/jpb.2015.42.2.123

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Aldehyde adducts generated during lipid peroxidation modification of proteins.2015

    • Author(s)
      Uchida K
    • Journal Title

      Free Radic Res.

      Volume: 49 Issue: 7 Pages: 896-904

    • DOI

      10.3109/10715762.2015.1036052

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Special issue on "Recent progress in lipid peroxidation based on novel approaches2015

    • Author(s)
      Yin H, Niki E, Uchida K.
    • Journal Title

      Free Radic Res.

      Volume: 49 Issue: 7 Pages: 813-815

    • DOI

      10.3109/10715762.2015.1021697

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 15-Deoxy-Δ12, 14-prostaglandin J2 as an electrophilic mediator2015

    • Author(s)
      Shibata T.
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 79 Issue: 7 Pages: 1044-1049

    • DOI

      10.1080/09168451.2015.1012149

    • Related Report
      2015 Annual Research Report
    • Open Access
  • [Journal Article] 内因性抗原としての陰性荷電分子の生成と制御2015

    • Author(s)
      近澤未歩、内田浩二
    • Journal Title

      生化学

      Volume: 87 Pages: 776-780

    • NAID

      40020687514

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Palmitate induces insulin resistance in human HepG2 hepatocytes by enhancing ubiquitination and proteasomal degradation of key insulin signaling molecules2015

    • Author(s)
      Ishii M, Maeda A, Tani S, Akagawa M.
    • Journal Title

      Arc.h Biochem. Biophys

      Volume: 566 Pages: 26-35

    • DOI

      10.1016/j.abb.2014.12.009

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Elastin modification by 4-hydroxynonenal in hairless mice exposed to UV-A. Role in photoaging and actinic elastosis.2014

    • Author(s)
      Larroque-Cardoso, P., Camaré, C., Nadal-WollboldF., Grazide, M. H., Pucelle, M., Garoby-Salom, S., Bogdanowicz, P., Josse, G., Schmitt, A. M., Uchida, K., Zarkovic, K., Salvayre, R., and Nègre-Salvayre, A.
    • Journal Title

      J. Invest. Dermatol.

      Volume: 135 Issue: 7 Pages: 1873-1881

    • DOI

      10.1038/jid.2015.84

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Toll-like receptors as a target of food-derived anti-Inflammatory compounds.2014

    • Author(s)
      Shibata, T., Nakashima, F., Honda, K., Lu, Y. J., Kondo, T., Ushida, Y., Aizawa, K., Suganuma, H., Oe, S., Tanaka, H., Takahashi, T. and Uchida, K.
    • Journal Title

      J. Biol. Chem.

      Volume: 289 Issue: 47 Pages: 32757-32772

    • DOI

      10.1074/jbc.m114.585901

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Functional interaction between cyclooxygenase-2 and p53 in response to an endogenous electrophile2014

    • Author(s)
      Kumagai, T., Usami, H., Matsukawa, N., Nakashima, F., Chikazawa, M., Shibata, T., Noguchi, N., and Uchida, K.
    • Journal Title

      Redox Biol.

      Volume: 4 Pages: 74-86

    • DOI

      10.1016/j.redox.2014.11.011

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibition of N-type Ca2+ channels ameliorates an imbalance in cardiac autonomic nerve activity and prevents lethal arrhythmias in mice with heart failure.2014

    • Author(s)
      Yamada Y, Kinoshita H, Kuwahara K, Nakagawa Y, Kuwabara Y, Minami T, Yamada C, Shibata J, Nakao K, Cho K, Arai Y, Yasuno S, Nishikimi T, Ueshima K, Kamakura S, Nishida M, Kiyonaka S, Mori Y, Kimura T, Kangawa K, Nakao K.
    • Journal Title

      Cardiovasc Research

      Volume: 104 Issue: 1 Pages: 183-193

    • DOI

      10.1093/cvr/cvu185

    • NAID

      120005619790

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] DNA様構造特性をもつ修飾タンパク質の生成と病態2018

    • Author(s)
      内田浩二
    • Organizer
      「タンパク質のnon-canonical機能:機構と酸素生物学における意義」シンポジウム. 第91回日本生化学会大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 脂質酸化を起点とするタンパク質アダクトーム2018

    • Author(s)
      柴田貴広、内田浩二
    • Organizer
      「脂質酸化を起点とするバイオロジーの新展開」シンポジウム. 第91回日本生化学会大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 酸化イミダゾールジペプチドの検出2018

    • Author(s)
      垣花優希,山陰茜,柴田貴広,内田浩二,居原秀
    • Organizer
      レドックス研究会2018「生命のエネルギー獲得戦略における多様性と共通原
    • Related Report
      2018 Annual Research Report
  • [Presentation] 酸化イミダゾールジペプチド産生の分子メカニズムの解明2018

    • Author(s)
      垣花優希,内田浩二,居原秀
    • Organizer
      第18 回日本NO学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] イミダゾールジペプチドによる抗酸化メカニズムの解明2018

    • Author(s)
      居原 秀
    • Organizer
      第16回レドックス・ライフイノベーションシンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] TRPC3 channels as a key regulator of cardiac plasticity2018

    • Author(s)
      Nishida M.
    • Organizer
      The 18th World Congress of Basic and Clinical Pharmacology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] TRPC3/C6チャネルタンパク質による筋柔軟性制御2018

    • Author(s)
      西田基宏
    • Organizer
      第4回日本筋学会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 酸素由来活性種によるタンパク質多量体化とその意義2018

    • Author(s)
      西田基宏
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] GPCR/Gタンパク質のレドックス修飾に着目した創薬2018

    • Author(s)
      西田基宏
    • Organizer
      レドックス・ライフイノベーション第170委員会/日本におけるケミカルバイオロジーの新展開第189委員会合同シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Cardiovascular Aging Regulated by Heterodimerization of Angiotensin AT1 Receptor with Purinergic P2Y6 Receptor2018

    • Author(s)
      Nishida M.
    • Organizer
      Angiotensin Gordon Research Conference 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] S-チオール化血清アルブミンによる炎症誘導機構の解明2018

    • Author(s)
      中島史恵、柴田貴広、菊地良介、松下正、内田浩二
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 自然抗体エピトープを有する食品成分の探索2018

    • Author(s)
      三輪恭行、今堀夏奈美、古橋麻衣、柴田貴広、内田浩二
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ポリフェノールオキシダーゼによる茶カテキンの自然抗体リガンド生成能の増強2018

    • Author(s)
      今堀夏奈美、三輪恭行、李相美、柴田貴広、内田浩二
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 酸化ストレスに対する細胞内カルノシンの神経保護効果2017

    • Author(s)
      山陰茜、垣花優希、柴田貴広、内田浩二、居原秀
    • Organizer
      第17回日本NO学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 酸化ストレスに依存した酸化イミダゾールジペプチドの産生2017

    • Author(s)
      垣花優希、柴田貴広、内田浩二、居原秀
    • Organizer
      第70回日本酸化ストレス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Detection and quantification of 2-oxo-histidine-containing dipeptides2017

    • Author(s)
      Ihara H, Kakihana Y, Shibata T, Uchida K
    • Organizer
      The Society for Redox Biology and Medicine's (SfRBM) 24th Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脂質異常症に関連した修飾血清アルブミン構造の解析2017

    • Author(s)
      中島史恵、柴田貴広、菊地良介、松下正、内田浩二
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Protein carbonyls as a marker of exposome2017

    • Author(s)
      Koji Uchida
    • Organizer
      第 90 回日本細菌学会総会. レドックス・環境応答-国際シンポジウム(新学術領域「酸素生物学」共催) “Stress responses in environmental and exposure biology”
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Natural antibodies as a sensor of oxidation-specific epitopes2016

    • Author(s)
      Koji Uchida
    • Organizer
      Shanghai Symposium on Lipid Metabolism and Related Diseases
    • Place of Presentation
      Hope Hotel(Shanghai, China)
    • Year and Date
      2016-09-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Electrophiles as a multifunctional molecule2016

    • Author(s)
      Koji Uchida
    • Organizer
      第9回国際NO学会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 親電子修飾によるタンパク質機能活性化2016

    • Author(s)
      内田浩二
    • Organizer
      第89回日本生化学会大会シンポジウム“オルガネラ環境を制御するレドックスシグナル”
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] リジンピロール化によるDNA様蛋白質の生成2015

    • Author(s)
      内田浩二
    • Organizer
      第15回日本蛋白質科学会年会ワークショップ「化学修飾の蛋白質科学と医療への展開」
    • Place of Presentation
      あわぎんホール(徳島県徳島市)
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 小分子酸素センサーによるタンパク質カルボニル化2015

    • Author(s)
      内田浩二
    • Organizer
      第15回日本蛋白質科学会年会ワークショップ「酸素リモデリング・レドックスシグナルとタンパク質修飾の新たな潮流」
    • Place of Presentation
      あわぎんホール(徳島県徳島市)
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ポリフェノールによる自然免疫抗原の生成2015

    • Author(s)
      内田浩二
    • Organizer
      第9回日本ポリフェノール学会年次大会シンポジウム「ポリフェノール研究の将来」
    • Place of Presentation
      奈良女子大学(奈良県奈良市)
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 化学的反応性からみる機能性食品成分の潜在能力2015

    • Author(s)
      内田浩二
    • Organizer
      第38回日本分子生物学会・第88回日本生学会合同大会ワークショップ「食品科学:食品の潜在能力を科学し、活用する」
    • Place of Presentation
      神戸ポートピアホテル(兵庫県神戸市)
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Pyrrolation Is a Naturally-occurring Covalent Protein Modification Involved in the Production of DNA Mimic Proteins2014

    • Author(s)
      Koji Uchida
    • Organizer
      Asian Biological Medicine Summit Forum in Hangzhou
    • Place of Presentation
      Hangzhou, China
    • Year and Date
      2014-11-22 – 2014-11-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Food-derived natural inhibitors of TLR signaling2014

    • Author(s)
      Koji Uchida
    • Organizer
      HNE club/SAS meeting 2014 Lipids, Oxidation, Antioxidants and・・・・・
    • Place of Presentation
      Toulouse, France
    • Year and Date
      2014-09-08 – 2014-09-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 生体防御反応に関わる機能性食品成分2014

    • Author(s)
      内田浩二
    • Organizer
      2014年度 日本生物工学会中部支部例会
    • Place of Presentation
      名古屋大学工学研究科ES総合館(愛知県名古屋市)
    • Year and Date
      2014-08-01
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Book] レドックス疾患学2018

    • Author(s)
      中島史恵、柴田貴広、内田浩二
    • Total Pages
      276
    • Publisher
      羊土社
    • ISBN
      9784758103695
    • Related Report
      2018 Annual Research Report
  • [Book] Japanese Scientists in Science Signaling 2016「シグナリングに載った日本人研究者」 2017 Issue2017

    • Author(s)
      西村明幸、西田基宏
    • Total Pages
      80
    • Publisher
      Science Signaling AAAS, Cosmo Bio Co. Inc.
    • Related Report
      2016 Annual Research Report
  • [Book] Innovative Medicine2015

    • Author(s)
      Nishida M, Kuwahara K, Kozai D, Sakaguchi R, Mori Y.
    • Total Pages
      339
    • Publisher
      Springer Japan
    • Related Report
      2015 Annual Research Report
  • [Book] 別冊医学のあゆみ「レドックスUPDATE:ストレス制御の臨床医学・健康科学」2015

    • Author(s)
      内田浩二
    • Total Pages
      360
    • Publisher
      医歯薬出版
    • Related Report
      2015 Annual Research Report
  • [Book] 細胞工学 Vol.34 No.42015

    • Author(s)
      居原秀、大内雄也
    • Total Pages
      440
    • Publisher
      学研メディカル秀潤社
    • Related Report
      2014 Annual Research Report
  • [Book] 細胞工学 Vol.34 No.42014

    • Author(s)
      熊谷嘉人、内田浩二
    • Total Pages
      440
    • Publisher
      学研メディカル秀潤社
    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] ベンゾイソオキサゾール化合物2018

    • Inventor(s)
      永田龍、森泰生、西田基宏、森誠之、冨田拓郎
    • Industrial Property Rights Holder
      永田龍、森泰生、西田基宏、森誠之、冨田拓郎
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-086929
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report

URL: 

Published: 2014-11-20   Modified: 2023-03-23  

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