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Technology for pathway-selective manipulation and control of neural circuit

Planned Research

Project AreaMechanisms underlying the functional shift of brain neural circuitry for behavioral adaptation
Project/Area Number 26112002
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionFukushima Medical University

Principal Investigator

Kobayashi Kazuto  福島県立医科大学, 医学部, 教授 (90211903)

Research Collaborator Kato Shigeki  
Fukabori Ryoji  
Nishizawa Kayo  
Iguchi Yoshio  
Setogawa Susumu  
Project Period (FY) 2014-07-10 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥137,280,000 (Direct Cost: ¥105,600,000、Indirect Cost: ¥31,680,000)
Fiscal Year 2018: ¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2017: ¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2016: ¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2015: ¥24,180,000 (Direct Cost: ¥18,600,000、Indirect Cost: ¥5,580,000)
Fiscal Year 2014: ¥40,170,000 (Direct Cost: ¥30,900,000、Indirect Cost: ¥9,270,000)
Keywords高頻度逆行性遺伝子導入 / 光遺伝学 / 化学遺伝学 / 刺激弁別学習 / 皮質基底核回路 / 機能シフト / 経路選択的操作 / 基底核回路 / オペラント学習
Outline of Final Research Achievements

Here we applied our new strategy to manipulate specific neural types and pathways and to characterize dynamic changes of the neural circuit and aimed to elucidate the mechanisms underlying the development and transition of neural circuit during learning processes and the functional compensation of the circuit against neural injury. To achieve this purpose, our planned group focused on the development of the technology for the neural circuit control, in particular, through the application of optogenetic and chemogenetic approaches with viral vector system. In addition, we investigated the roles of specific cell types or neural pathways constituting the cortico-basal ganglia-thalamic network in behavioral acquisition, performance, and switching, and challenged to identify the brain regions in which the activity changes during the learning processes to elucidate the mechanisms underlying the functional shift of neural circuit.

Academic Significance and Societal Importance of the Research Achievements

神経回路機能の障害は、さまざまな精神・神経疾患の発病や病態に深く関与するため、本領域で取り組む神経回路の機能シフトの研究成果は、学術的な重要性ばかりでなく、臨床医学的にも重要な意義を持つ。これらの研究成果は、高次脳機能障害の病態を発現するメカニズムについて神経回路レベルでの理解に結び付く。詳細な回路動態の解明は、特に、発達や学習の脳内機序の理解は、効果的な教育・訓練法の開発につながる可能性がある。さらに、特定の神経回路を操作する技術は、脳機能障害において変化する細胞種や神経路の活動を制御することによって、疾患や病態の改善を目指す新たなストラテジーの開発に繋がる可能性を持つ。

Report

(6 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report

Research Products

(101 results)

All 2019 2018 2017 2016 2015 2014 Other

All Int'l Joint Research (4 results) Journal Article (38 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 38 results,  Open Access: 27 results,  Acknowledgement Compliant: 9 results) Presentation (58 results) (of which Int'l Joint Research: 9 results,  Invited: 21 results) Book (1 results)

  • [Int'l Joint Research] University of Kansas Medical Center(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Rostock University(Germany)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Navarra University(Spain)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Basel University(スイス)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Enhancement of the transduction efficiency of a lentiviral vector for neuron-specific retrograde gene delivery through the point mutation of fusion glycoprotein type E.2019

    • Author(s)
      Kato S; Sugawara M; Kobayashi K; Kimura K; Inoue K; Takada M; Kobayashi K
    • Journal Title

      J Neurosci Methods

      Volume: 311 Pages: 147-155

    • DOI

      10.1016/j.jneumeth.2018.10.023

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ipsilateral-dominant control of limb movements in rodent posterior parietal cortex.2019

    • Author(s)
      1.Soma S, Yoshida J, Kato S, Takahashi Y, Nonomura S, Sugimura YK, Ríos A, Kawabata M, Kobayashi K, Kato F, Sakai Y, Isomura Y.
    • Journal Title

      J Neurosci.

      Volume: 39 Issue: 3 Pages: 485-502

    • DOI

      10.1523/jneurosci.1584-18.2018

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] [Na+] increases in body fluids sensed by central Nax induce sympathetically mediated blood pressure elevations via H+-dependent activation of ASIC1a.2019

    • Author(s)
      Nomura, K., Hiyama, T.Y., Sakuta, H., Matsuda, T., Lin, C.H., Kobayashi, K., Kobayashi, K., Kuwaki, T., Takahashi, K., Matsui, S., and Noda, M.
    • Journal Title

      Neuron

      Volume: 101 Issue: 1 Pages: 60-75

    • DOI

      10.1016/j.neuron.2018.11.017

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Motor skills mediated through cerebellothalamic tracts projecting to the central lateral nucleus2019

    • Author(s)
      Sakayori Nobuyuki、Kato Shigeki、Sugawara Masateru、Setogawa Susumu、Fukushima Hotaka、Ishikawa Rie、Kida Satoshi、Kobayashi Kazuto
    • Journal Title

      Molecular Brain

      Volume: 12 Issue: 13 Pages: 13-13

    • DOI

      10.1186/s13041-019-0431-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dissecting the circuit for blindsight to reveal the critical role of pulvinar and superior colliculus2019

    • Author(s)
      Kinoshita M, Kato R, Isa K, Kobayashi K, Kobayashi K, Onoe H, Isa T
    • Journal Title

      Nat Commun

      Volume: 10 Issue: 1 Pages: 135-135

    • DOI

      10.1038/s41467-018-08058-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A note on retrograde gene transfer efficiency and inflammatory response of lentiviral vectors pseudotyped with FuG-E vs. FuG-B2 glycoproteins.2019

    • Author(s)
      Tanabe S; Uezono S; Tsuge H; Fujiwara M; Miwa M; Kato S; Nakamura K; Kobayashi K; Inoue K; Takada M
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 3567-3567

    • DOI

      10.1038/s41598-019-39535-1

    • NAID

      120006818701

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Targeted expression of step-function opsins in transgenic rats for optogenetic studies2018

    • Author(s)
      Igarashi Hiroyuki、Ikeda Keiko、Onimaru Hiroshi、Kaneko Ryosuke、Koizumi Kyo、Beppu Kaoru、Nishizawa Kayo、Takahashi Yukari、Kato Fusao、Matsui Ko、Kobayashi Kazuto、Yanagawa Yuchio、Muramatsu Shin-Ichi、Ishizuka Toru、Yawo Hiromu
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 5435-5435

    • DOI

      10.1038/s41598-018-23810-8

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Monitoring and updating of action selection for goal-directed behavior through the striatal direct and indirect pathways2018

    • Author(s)
      Nonomura S, Nishizawa K, Sakai Y, Kawaguchi Y, Kato S, Uchigashima M, Watanabe M, Yamanaka K, Enomoto K, Chiken S, Sano H, Soma S, Yoshida J, Samejima K, Ogawa M, Kobayashi K, Nambu A, Isomura Y, Kimura M
    • Journal Title

      Neuron

      Volume: 99(6) Issue: 6 Pages: 1302-1314

    • DOI

      10.1016/j.neuron.2018.08.002

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] In vivo observation of structural changes in neocortical catecholaminergic projections in response to drugs of abuse2018

    • Author(s)
      Morimoto, M. Tanaka, S., Mizutani, S., Urata, S., Kobayashi, K., Okae, S.
    • Journal Title

      eNeuro

      Volume: 6 Issue: 1 Pages: 1-1

    • DOI

      10.1523/eneuro.0071-17.2018

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Action selection and flexible switching controlled by the intralaminar thalamic neurons2018

    • Author(s)
      Kato, S., Fukabori, R., Nishizawa, K., Okada, K., Yoshioka, N., Sugawara, M., Maejima, Y., Shimomura, K., Okamoto, M., Eifuku, S., and Kobayashi, K.
    • Journal Title

      Cell Rep.

      Volume: 22 Pages: 2370-2382

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Spatial distribution of synapse on tyrosine hydroxylase expressing juxtaglomerular cells in the mouse olfactory glomerulus.2017

    • Author(s)
      Kiyokage E, Kobayashi K, Toida K.
    • Journal Title

      The Journal of Comparative Neurology

      Volume: 525 Issue: 5 Pages: 1059-1074

    • DOI

      10.1002/cne.24147

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Dopamine D1 Receptor Immunoreactivity on Fine Processes of GFAP-Positive Astrocytes in the Substantia Nigra Pars Reticulata of Adult Mouse2017

    • Author(s)
      Katsuhiro Nagatomo, Sechiko Suga, Masato Saitoh, Masahito Kogawa, Kazuto Kobayashi, Yoshio Yamamoto, Katsuya Yamada
    • Journal Title

      Frontiers in Neuroanatomy

      Volume: 11 Pages: 1-11

    • DOI

      10.3389/fnana.2017.00003

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The use of an optimized chimeric envelope glycoprotein enhances the efficiency of retrograde gene transfer of a pseudotyped lentiviral vector in the primate brain.2017

    • Author(s)
      Tanabe S, Inoue K, Tsuge H, Uezono S, Nagaya K, Fijiwara M, Kato S, Kobayashi K, Takada M
    • Journal Title

      Neurosci Res

      Volume: 印刷中 Pages: 45-52

    • DOI

      10.1016/j.neures.2017.02.007

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Optimisation of murine organotypic slice culture preparation for a novel sagittal-frontal co-culture system2017

    • Author(s)
      Joost, S., Kobayashi, K., Wree, A., and Haas, S.J.
    • Journal Title

      J. Neurosci. Methods

      Volume: 285 Pages: 49-57

    • DOI

      10.1016/j.jneumeth.2017.05.003

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Neuronal cytoskeletal gene dysregulation and mechanical hypersensitivity in a rat model of Rett Syndrome.2017

    • Author(s)
      Bhattacherjee, A., Mu, Y., Winter, M., Knapp, J., Eggiman, L., Gunewardena, S., Kobayashi, K., Kato, S., Krizsan-Agbas, D. and Smith, P.
    • Journal Title

      PNAS

      Volume: 114 Issue: 33

    • DOI

      10.1073/pnas.1618210114

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Segregated Excitatory?Inhibitory Recurrent Subnetworks in Layer 5 of the Rat Frontal Cortex2017

    • Author(s)
      Morishima Mieko、Kobayashi Kenta、Kato Shigeki、Kobayashi Kazuto、Kawaguchi Yasuo
    • Journal Title

      Cerebral Cortex

      Volume: 27 Issue: 12 Pages: 5846-5857

    • DOI

      10.1093/cercor/bhx276

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Light/dark phase-dependent spontaneous activity is maintained in dopamine-deficient mice.2017

    • Author(s)
      3.Fujita M, Hagino Y, Takeda T, Kasai S, Tanaka M, Takamatsu Y, Kobayashi K, Ikeda K.
    • Journal Title

      Mol Brain

      Volume: 10 Issue: 1 Pages: 49-49

    • DOI

      10.1186/s13041-017-0329-4

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] In Vivo Spiking Dynamics of Intra- and Extratelencephalic Projection Neurons in Rat Motor Cortex.2017

    • Author(s)
      Saiki A, Sakai Y, Fukabori R, Soma S, Yoshida J, Kawabata M, Yawo H, Kobayashi K, Kimura M, Isomura Y.
    • Journal Title

      Cereb Cortex.

      Volume: 印刷中 Issue: 3 Pages: 1-15

    • DOI

      10.1093/cercor/bhx012

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contribution of propriospinal neurons to recovery of hand dexterity after corticospinal tract lesions in monkeys.2017

    • Author(s)
      Tohyama, T., Kinoshita, M., Kobayashi, K., Isa, K., Watanabe, D., Kobayashi, K., Liu, M., and Isa, T.
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 114 Issue: 3 Pages: 604-609

    • DOI

      10.1073/pnas.1610787114

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Distinct neural mechanisms for the control of thirst and salt appetite in the subfornical organ.2017

    • Author(s)
      Matsuda, T., Hiyama, T.Y., Nimura, F., Matsusaka, T., Fukamizu, A., Kobayashi, K., Kobayashi, K., and Noda, M.
    • Journal Title

      Nat. Neurosci.

      Volume: 20 Issue: 2 Pages: 230-241

    • DOI

      10.1038/nm.4463

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic manipulation of specific neural circuits by use of a viral vector system.2017

    • Author(s)
      Kobayashi, K., Kato, S., and Kobayashi, K.
    • Journal Title

      J. Neural Transm.

      Volume: in press Issue: 1 Pages: 67-75

    • DOI

      10.1007/s00702-016-1674-7

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gene therapy approaches in the non-human primate model of Parkinson’s disease.2017

    • Author(s)
      Pignataro, D., Sucunza, D., Rico, A.J., Dopeso-Reyes, I.G., Roda, E., Rodríguez-Perez, A.I., Labandeira-Garcia, J.L., Broccoli, V., Kato,S., Kobayashi, K., and Lanciego, J.L.
    • Journal Title

      J. Neural Transm.

      Volume: in press Issue: 3 Pages: 575-589

    • DOI

      10.1007/s00702-017-1681-3

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Using a novel PV-Cre rat model to characterize pallidonigral cells and their terminations.2016

    • Author(s)
      Oh Y-M, Karube F, Takahashi S, Kobayashi K, Takada M, Uchigashima M, Watanabe M, Nishizawa K, Kobayashi K, *Fujiyama F
    • Journal Title

      Brain Struct Funct

      Volume: 印刷中 Issue: 5 Pages: 2359-2378

    • DOI

      10.1007/s00429-016-1346-2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dopamine synapse is a neuroligin-2–mediated contact between dopaminergic presynaptic and GABAergic postsynaptic structures.2016

    • Author(s)
      Uchigashima, M., Ohtsuka, T., Kobayashi, K., Watanabe, M.
    • Journal Title

      PNAS

      Volume: - Issue: 15 Pages: 4206-4211

    • DOI

      10.1073/pnas.1514074113

    • NAID

      120005849913

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Ionic Basis for Membrane Potential Resonance in Neurons of the Inferior Olive.2016

    • Author(s)
      Matsumoto-Makidono, Y., Nakayama, H., Yamasaki, M., Miyazaki, T., Kobayashi, K., Watanabe, M., Kano, M., Sakimura, K., Hashimoto, K.
    • Journal Title

      Cell Reports

      Volume: 16 Issue: 4 Pages: 994-1004

    • DOI

      10.1016/j.celrep.2016.06.053

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Survival of corticostriatal neurons by Rho/Rho-kinase signaling pathway.2016

    • Author(s)
      Kobayashi K, Sano H, Kato S, Kuroda K, Nakamuta S, Isa T, Nambu A, Kaibuchi K, Kobayashi K.
    • Journal Title

      Neurosci Lett.

      Volume: 630 Pages: 45-52

    • DOI

      10.1016/j.neulet.2016.07.020

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Involvement of mesolimbic dopaminergic network in neuropathic pain relief by treadmill exercise: A study for specific neural control with gi-dreadd in mice.2016

    • Author(s)
      Wakaizumi K, Kondo T, Hamada Y, Narita M, Kawabe R, Narita H, Watanabe M, Kato S, Senba E, Kobayashi K, Kuzumaki N, Yamanaka A, Morisaki H, *Narita M
    • Journal Title

      Mol Pain

      Volume: 12 Pages: 1-11

    • DOI

      10.1177/1744806916681567

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neuronal circuits and physiological roles of the basal ganglia in terms of transmitters, receptors and related disorders. The Journal of Physiological Sciences.2016

    • Author(s)
      Yamada K, Takahashi S, Karube F, Fujiyama F, Kobayashi K, Nishi A, Momiyama T
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 0 Issue: 6 Pages: 1-12

    • DOI

      10.1007/s12576-016-0445-4

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Causal Link between the Cortico-Rubral Pathway and Functional Recovery through Forced Impaired Limb Use in Rats with Stroke.2016

    • Author(s)
      Ishida A, Isa K, Umeda T, Kobayashi K, Kobayashi K, Hida H, Isa T.
    • Journal Title

      J Neurosci.

      Volume: 36 Issue: 2 Pages: 455-455

    • DOI

      10.1523/jneurosci.2399-15.2016

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Altering Entry Site Preference of Lentiviral Vectors into Neuronal Cells by Pseudotyping with Envelope Glycoproteins.2016

    • Author(s)
      Kobayashi K, Kato S, Inoue K, Takada M, Kobayashi K.
    • Journal Title

      Methods Mol Biol.

      Volume: 1382: Pages: 175-86

    • DOI

      10.1007/978-1-4939-3271-9_12

    • ISBN
      9781493932702, 9781493932719
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Differential roles of the nucleus accumbens shell neurons containing dopamine D1 and D2 receptors in behavioral sensitization.2015

    • Author(s)
      Kai N, Nishizawa K, Tsutsui Y, Ueda S, Kobayashi K.
    • Journal Title

      Journal of Neurochemistry

      Volume: 135(6) Issue: 6 Pages: 1232-1241

    • DOI

      10.1111/jnc.13380

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distinct roles of basal forebrain cholinergic neurons in spatial and object recognition memory.2015

    • Author(s)
      Okada K, Nishizawa K, Kobayashi T, Sakata S, Kobayashi K.
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 13158-13158

    • DOI

      10.1038/srep13158

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Double virus vector infection to the prefrontal network of the macaque brain.2015

    • Author(s)
      Oguchi, M., Okajima, M., Tanaka, S., Koizumi, M., Kikusui, T., Ichihara, N., Kato, S., Kobayashi, K., and Sakagami, M.
    • Journal Title

      PLoS One

      Volume: 10

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differential contribution of Ih to the integration of excitatory synaptic inputs in substantia nigra pars compacta and ventral tegmental area dopaminergic neurons.2015

    • Author(s)
      Masi, A., Narducci, R., Resta, F., Carbone, C., Kobayashi, K., and Mannaioni, G.
    • Journal Title

      Eur. J. Neurosci.

      Volume: 42 Pages: 2699-2706

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Enhanced flexibility of place discrimination learning by targeting of striatal cholinergic interneurons.2014

    • Author(s)
      Okada, K., Nishizawa, K., Fukabori, R., Kai, N., Shiota, A., Ueda, S., Tsutsui, Y., Sakata, S., Matsushita, N., and Kobayashi, K.
    • Journal Title

      Nat. Commun.

      Volume: 5 Issue: 1 Pages: 3778-3778

    • DOI

      10.1038/ncomms4778

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Lesions of the nucleus accumbens core modulate development of matching behavior2014

    • Author(s)
      Kai N, Tsusui Y, Kobayashi K
    • Journal Title

      BMC Neuroscience 2014

      Volume: 15 Issue: 1 Pages: 55-55

    • DOI

      10.1186/1471-2202-15-55

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simultaneous visualization of extrinsic and intrinsic axon collaterals in Golgi-like detail for mouse corticothalamic and corticocortical cells: a double viral infection method2014

    • Author(s)
      Watakabe, A., Takaji, M., Kato, S., Kobayashi, K., Mizukami, H., Ozawa, K., Ohsawa, S., Matsui, R., Watanabe, D., and Yamamori, T.
    • Journal Title

      Frontiers in neural circuits

      Volume: 8 Pages: 110-110

    • DOI

      10.3389/fncir.2014.00110

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of Cholinergic System in Hyperactivity in Dopamine-Deficient Mice2014

    • Author(s)
      Hagino Y., Kasai S, Masayo F, Setogawa S, Yamaura H,Yanagihara D, Hashimoto M, Kobayashi K, Meltzer H, Ikeda K
    • Journal Title

      Neuropsychopharmacology

      Volume: - Issue: 5 Pages: 1-10

    • DOI

      10.1038/npp.2014.295

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 神経回路の遺伝子操作による動物モデル研究2018

    • Author(s)
      小林 和人
    • Organizer
      第29回東北動物実験研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 視床線条体路を介する行動選択と切り替えの調節2018

    • Author(s)
      小林 和人
    • Organizer
      遺伝学研究所研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 行動選択および行動柔軟性の制御を担う神経基盤の機能解明2018

    • Author(s)
      加藤 成樹
    • Organizer
      生理学研究所研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 「適応回路シフト」研究の成果のまとめ2018

    • Author(s)
      小林和人
    • Organizer
      適応回路シフト研究成果報告会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Behavioral selection and switching flexibility regulated by thalamustriatal circuit2018

    • Author(s)
      Shigeki Kato, Kazuto Kobayashi
    • Organizer
      The 41st Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2018 Annual Research Report
  • [Presentation] Identification of indirect pathway neurons and dopaminergic innervation in the rat dorsomedial striatum2018

    • Author(s)
      Satoshi Nonomura, Shigeki Kato, Yoshio Iguchi, Kayo Nishizawa, Yutaka Sakai, Yasuo Kawaguchi, Atsushi Nambu, Masahiko Watanabe, Kazuto Kobayashi, Yoshikazu Isomura, Minoru Kimura
    • Organizer
      The 41st Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2018 Annual Research Report
  • [Presentation] Lentiviral vectors pseudotyped with FuG-E and FuG-E2 glycoprotein suitable for retrograde gene transfer into neural networks involveing cerebral cortical areas in nonhuman primates and rodents2018

    • Author(s)
      Yukio Otsuka, Hitomi Tsuge, Shiori Uezono, Soshi Tanabe, Maki Fujiwara, Miki Miwa, Shigeki Kato, Katsuki Nakamura, Kazuto Kobayashi, Ken-ichi Inoue, Masahiko Takada
    • Organizer
      The 41st Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2018 Annual Research Report
  • [Presentation] 線条体における学習依存的な神経回路シフトの解明2018

    • Author(s)
      瀬戸川将、加藤成樹、小林和人
    • Organizer
      第33回日本大脳基底核研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] The functional shift of striatal circuits during an acquisition of auditory discrimination2018

    • Author(s)
      Susumu Setogawa
    • Organizer
      平成30年度第2回大脳基底核機能研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 視床線条体路における行動選択と行動柔軟性2018

    • Author(s)
      加藤成樹
    • Organizer
      次世代脳プロジェクト冬のシンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 視覚弁別行動の獲得過程における線条体内の機能シフト2018

    • Author(s)
      瀬戸川 将
    • Organizer
      次世代脳プロジェクト冬のシンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 報酬学習の履歴とストレス反応性::行動と結果の随伴性の学習によるレジリエンス生起2018

    • Author(s)
      井口善生
    • Organizer
      次世代脳プロジェクト冬のシンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Dynamic shifts of striatal activation pattern during acquisition of an auditory discrimination task2018

    • Author(s)
      Susumu Setogawa, Okauchi Takashi, Di Hu, Mika Shigeta, Emi Hayashinaka, Kayo Onoe, Yasuhiro Wada, Keigo Hikishima, Hirotaka Onoe, Yilong Cui, Kazuto Kobayashi
    • Organizer
      Society for Neuroscience 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 特定神経回路の機能制御を可能とする高頻度逆行性導入ウイルスベクターの開発2018

    • Author(s)
      菅原正晃,小林和人
    • Organizer
      京大霊長類研究所共同利用研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 背内側線条体コリン作動性介在神経細胞の行動柔軟性における双方向的制御2018

    • Author(s)
      岡田佳奈、西澤佳代、瀬戸川将、橋本浩一、小林和人
    • Organizer
      先端モデル動物支援プラットフォーム成果発表会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 皮質線条体路による意思決定の制御メカニズムの解析2017

    • Author(s)
      吉岡望、加藤成樹、小林和人
    • Organizer
      第122回日本解剖学会
    • Place of Presentation
      長崎
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] Coordinated expression of learned motor behavior through striatofugal pathways2017

    • Author(s)
      Kazuto Kobayashi, Yoshio Iguchi, Kayo Nishizawa.
    • Organizer
      26th Annual Meeting for International Behavioral Neuroscience Society
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Controlling stimulus-response learning through striatal direct and indirect pathways2017

    • Author(s)
      Kazuto Kobayashi.
    • Organizer
      40th Annual Meeting of the Society Japan Neuroscience Society
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 脳神経ネットワークにおける経路選択的な機能操作技術2017

    • Author(s)
      小林和人
    • Organizer
      第4回包括的緩和医療科学学術研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 選択的経路標的法による回路機能の解析2017

    • Author(s)
      小林和人
    • Organizer
      平成29年度日本アルコール・薬物依存関連学会合同学術総会・第52回日本アルコール・アディクション医学会学術総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 経路選択的な回路操作技術の応用:行動制御機構の解明に迫る2017

    • Author(s)
      加藤成樹、小林 和人
    • Organizer
      生理研研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Noradrenergic control of emotional memory retrieval2017

    • Author(s)
      Kazuto Kobayashi
    • Organizer
      適応回路シフト国際シンポジウム
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Action-specific reinforcement and update by direct- and indirect- pathway striatal projection neurons2017

    • Author(s)
      Nonomura, S., Nishizawa, K.,Kobayashi, K., Sakai, Y., Kawaguchi, Y., Nambu, A., Yamanaka, K., Enomoto, K., Isomura, Y., Kimura, M.
    • Organizer
      Society for Neuroscience 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Differences in retrograde gene transfer efficiency and cytotoxicity between lentiviral vectors pseudotyped with FuG-E and FuG-B2 glycoprotein in rodent and primate brains.2017

    • Author(s)
      Tanabe, S., Tsuge, H., Uezono, S., Fujiwara, M., Miwa, M., Konoike, N., Kato, S., Nakamura, K., Kobayashi, K., Inoue, K., and Takada, M.
    • Organizer
      Society for Neuroscience 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Differential involvement of direct- and indirect-pathway spiny projection neuron in action valuation and update in the dorsomedial striatum2017

    • Author(s)
      Kimura, M., Nonomura, S., Nishizawa, K., Kobayashi, K., Sakai, Y., Kawaguchi, Y., Nambu, A., Yamanaka, K., Isomura, Y.
    • Organizer
      40th Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2017 Annual Research Report
  • [Presentation] AMPA density is homogeneneous across striatal synapses irrespective of cell types and input pathways2017

    • Author(s)
      Yamasaki, M., Song, X., Kobayashi, K., and Watanabe, M.
    • Organizer
      40th Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2017 Annual Research Report
  • [Presentation] Optogenetic analysis of neuronal network of medullary respiratory center in transgenic rats expressing channelrhodopsin in Phox2b expressing cells2017

    • Author(s)
      Onimura, H., Ikeda, K., Igarashi, H., Yao, H., Kobayashi, K., Kawakami, K.
    • Organizer
      40th Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2017 Annual Research Report
  • [Presentation] Responses in the basal ganglia induced by cortico-striatal neurons2017

    • Author(s)
      Sano, H., Kobayashi, K., Kato, S., Chiken, S., Kobayashi, K., and Nambu, A.
    • Organizer
      40th Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2017 Annual Research Report
  • [Presentation] Using a novel PV-Cre rat model to characterize pallidal cells and their terminations2017

    • Author(s)
      Oh, Y.M., Karube, F., Takahashi, S., Kobayashi, K., Kobayashi, K., Fujiyama, F.
    • Organizer
      40th Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2017 Annual Research Report
  • [Presentation] Distinct neural mechanisms for the control of thirst and salt appetite in the subfornical organ2017

    • Author(s)
      Matsuda, T., Hiyama, T.Y., Niimura, F., Matsusaka, T., Fukamizu, A., Kobayashi, K., Kobayashi, K., and Noda, M.
    • Organizer
      40th Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2017 Annual Research Report
  • [Presentation] Functional analysis of Rho/Rho-kinase signaling pathway in corticostriatal neuron survival using a new gene delivery system2017

    • Author(s)
      Kobayashi, K., Sano, H., Kato, S., Kuroda, K., Nakamuta, S., Isa, T., Nambu, A., Kaibuchi, Kobayashi, K.
    • Organizer
      40th Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2017 Annual Research Report
  • [Presentation] Dopamine metabolism and coping behaveors under the tail suspenseon stress2017

    • Author(s)
      Aizawa, H., Cui, W., Aida, T., Ito, H., Kobayashi, K., Wada, Y., Nakano, T., Kato, S., Tanaka, K., Kobayashi, K., and Isa, T.
    • Organizer
      40th Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2017 Annual Research Report
  • [Presentation] Activity of direct- and indirect-pathway striatal projection neurons identified by optogenetics during adaptive choice task with probabilistics reward2017

    • Author(s)
      Nonomura, S., Yamanaka, K., Nishizawa, K., Kobayashi, K., Sakai, Y., Kawaguchi, Y., Nambu, A., Isomura, Y., Kimura, M.
    • Organizer
      40th Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2017 Annual Research Report
  • [Presentation] A chemogenetics approach to elucidate the role of the striatopallidal neurons in the performance of operant auditory discrimination2017

    • Author(s)
      Iguchi, Y., Nishizawa, K., Kato, S., and Kobayashi, K.
    • Organizer
      40th Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2017 Annual Research Report
  • [Presentation] The lentiviral vector pseudotyped with FuG-E glycoprotein is more suitable, compared with the FuG-B2 type, for retrograde gene transfer into the cortical input system of primates2017

    • Author(s)
      Tsuge, H., Uezono, S., Tanabe, S., Fujiwara, M., Nagaya, K., Sugawara, M., Miwa, M., Konoike, N., Kato, S., Nakamura, K., Kobayashi, K., Inoue, K., and Takada, M.
    • Organizer
      40th Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2017 Annual Research Report
  • [Presentation] Dynamic shifts of regional brain activation pattern during acquisition of an auditory discrimination task2017

    • Author(s)
      Setogawa, S., Okauchi, T., Hu, D., Shigeta, M., Hayashinaka, E., Onoe, K., Wada, Y., Hikishima, K., Onoe, H., Cui, Y., and Kobayashi, K.
    • Organizer
      40th Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2017 Annual Research Report
  • [Presentation] 皮質線条体路による意思決定の制御機構-神経回路選択的な操作システムの開発から-2016

    • Author(s)
      吉岡 望、加藤 成樹、小林 和人
    • Organizer
      生理学研究所研究会
    • Place of Presentation
      岡崎
    • Year and Date
      2016-12-09
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Comparative study of gene transduction efficiency for retrograde gene transfer lentiviral vector with novel fusion envelope glycoproteins.2016

    • Author(s)
      Kato, S., and Kobayashi, K.
    • Organizer
      46th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      San Diego
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dorsal striatal indirect pathway modulates the response selection accuracy in performance of an auditory conditional discrimination task2016

    • Author(s)
      Nishizawa, K.,Fukabori, R., Okada, K., Uchigashima, M., Watanabe, M., Shiota, A., Ueda, M., Tsutsui, Y., Kobayashi, K.
    • Organizer
      Dopamine 2016
    • Place of Presentation
      Vienna
    • Year and Date
      2016-09-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Contribution of propriospinal neurons to recovery of hand dexterity after the corticospinal tract lesion in monkeys2016

    • Author(s)
      Tohyama, T., Kinoshita, M., Kobayashi,K, Isa, K., Watanabe, D., Kobayashi, K., Liu, M., and Isa, T.
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Yoshioka, N., Kato, S., Sugawara, M., Kato, N., and Kobayashi, K.2016

    • Author(s)
      Subtype-selective Gene Expression System for Cotricostriaral Neurons: Approach from Double Viral Vector Infection
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Cortical spike ensembles of two distinct types of pyramidal neurons and fast-spiking interneurons2016

    • Author(s)
      Saiki, A., Sakai, Y., Fukabori, R., Soma, S., Yoshida, J., Yawo, H., Kobayashi, K., Kimura, M., and Isomura, Y.
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Distinct role of cholinergic neuronal groups in basal forebrain on the spatial/object recognition memory2016

    • Author(s)
      Okada, K., NIshizawa, K., Kobayashi, T., Sakata, S., and Kobayashi, K.
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] The role of cerebellar projections to the centrolateral thalamic nucleus in motor and cognitive functions2016

    • Author(s)
      Sakayori, N., Kato, S., and Kobayashi, K.
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Activity of dopamine D2 receptor-expressing striatal neurons during decision-making task2016

    • Author(s)
      Nonomura, S., Yamanaka, K., Nishizawa, K., Kobayashi, K., Sakai, Y., Kawaguchi, Y., Nambu, A., Isomura, Y., and Kimura, M.
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Use of an optimized chimeric envelope glycoprotein for enhancement of theefficiency of retrogarade gene transfer of a pseudotyped lentiviral vector in the primate brain2016

    • Author(s)
      Inoue, K., Tanabe, S., Tsuge, H., Ueno, T., Nagaya, K., Fujiwara, M., Sugawara, M., Kato, S., Kobayashi, K., and Takada, M.
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Roles of striatal cholinergic interneurons revealed by genetic cell targeting2016

    • Author(s)
      Kobayashi, K.
    • Organizer
      OIST minisymposium ”Cholinergic mechanisms in adaptive behaviour”
    • Place of Presentation
      Okinawa
    • Year and Date
      2016-04-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 行動感作を媒介する神経回路メカニズム2016

    • Author(s)
      西澤佳代、小林和人
    • Organizer
      第89回日本薬理学会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-09
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 脳神経回路における経路選択的な機能操作技術2015

    • Author(s)
      小林 和人
    • Organizer
      第58回日本甲状腺学会
    • Place of Presentation
      福島
    • Year and Date
      2015-11-06
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Thalamostriatal system controls selection and flexibility of motor actions.2015

    • Author(s)
      Kobayashi, K., Kato, S., Okamoto, M., Eifuku, S.
    • Organizer
      45th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      Chicago
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] 環境刺激に適応する大脳基底核回路のメカニズム2015

    • Author(s)
      小林 和人
    • Organizer
      第45回日本神経精神薬理学会
    • Place of Presentation
      船堀
    • Year and Date
      2015-09-24
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Selective elimination of basal ganglia pathways in animal models2015

    • Author(s)
      Kazuto Kobayashi, Shigeki Kato.
    • Organizer
      16th Biennial Meeting of the Spanish Society for Neurosciences
    • Place of Presentation
      Granada
    • Year and Date
      2015-09-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 線条体コリン作動性介在ニューロンを介する行動柔軟性の制御2015

    • Author(s)
      小林 和人
    • Organizer
      解剖学会・生理学会合同大会2015
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] トランスジェニックラット技術による神経回路機構の解明2015

    • Author(s)
      小林 和人
    • Organizer
      第5回新潟大学脳研究所国際シンポジウム
    • Place of Presentation
      新潟
    • Year and Date
      2015-03-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 行動選択における視床線条体路の役割2015

    • Author(s)
      小林 和人
    • Organizer
      生理学研究所研究会
    • Place of Presentation
      岡崎
    • Year and Date
      2015-01-09
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 学習による神経回路のシフト2014

    • Author(s)
      小林 和人
    • Organizer
      マイクロダイアリシス研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-12-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 行動の選択と柔軟性を制御する神経ネットワーク:線条体入力系の役割2014

    • Author(s)
      小林 和人
    • Organizer
      第87回日本生化学大会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 行動の選択と柔軟性を制御する視床線条体システム2014

    • Author(s)
      小林和人、加藤成樹
    • Organizer
      第37回日本神経科学学会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Book] 分子脳科学2015

    • Author(s)
      佐野裕美、小林和人、南部篤
    • Total Pages
      291
    • Publisher
      化学同人
    • Related Report
      2014 Annual Research Report

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Published: 2014-11-20   Modified: 2022-02-28  

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