Sequence and structure of ncRNA operation elements

• Project Area: Neo-taxonomy of noncoding RNAs
• Project/Area Number: 26113002
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Hokkaido University
• Principal Investigator: Hirose Tetsuro 北海道大学, 遺伝子病制御研究所, 教授 (30273220)
• Co-Investigator(Kenkyū-buntansha): 富田 耕造 東京大学, 大学院新領域創成科学研究科, 教授 (00345274)
• Project Period (FY): 2014-07-10 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥232,440,000 (Direct Cost: ¥178,800,000、Indirect Cost: ¥53,640,000); Fiscal Year 2018: ¥44,200,000 (Direct Cost: ¥34,000,000、Indirect Cost: ¥10,200,000); Fiscal Year 2017: ¥46,410,000 (Direct Cost: ¥35,700,000、Indirect Cost: ¥10,710,000); Fiscal Year 2016: ¥45,110,000 (Direct Cost: ¥34,700,000、Indirect Cost: ¥10,410,000); Fiscal Year 2015: ¥46,280,000 (Direct Cost: ¥35,600,000、Indirect Cost: ¥10,680,000); Fiscal Year 2014: ¥50,440,000 (Direct Cost: ¥38,800,000、Indirect Cost: ¥11,640,000)
• Keywords: noncoding RNA / 核内構造 / 液相分離 / ゲノム機能 / RNP複合体 / ノンコーディング RNA / RNAドメイン / 液体相分離 / 核内構造体 / RNAプロセシング / 生体分子 / 核酸 / 発現制御 / 細胞 / ゲノム / ノンコーディングRNA / RNA結合タンパク質 / RNA-タンパク質相互作用 / タンパク質構造 / ゲノム編集 / 遺伝子

Outline of Final Research Achievements

This study investigated the operating elements and machinery of arcRNAs that build massive intracellular structures. NEAT1 was employed as a model arcRNA. The operating elements were identified by the analyses using genome editing technology and revealed that ncRNA is comprised of modular domain structure such as those in polypeptides. It also revealed that multiple prion-like proteins bind the operating elements and induce liquid-liquid phase separation that eventually form a massive structure. A new method for searching arcRNAs has been developed and showed that the human genome produces numerous arcRNAs, suggesting that arcRNA can be a distinct taxon of ncRNAs. Furthermore, the structural analysis of the ncRNA processing factors revealed the detail molecular process at the atomic level.

Academic Significance and Societal Importance of the Research Achievements

本研究は、ncRNA配列中の作動エレメントと作動装置の解析を、世界に先駆けて詳細に行ったものであり、ncRNAの機能構造の理解に大きく貢献した。また一方で、ncRNA作動エレメントの機能として、プリオン様タンパク質を介した液相分離の誘発という作動原理を明確に示すことができ、ncRNA研究と相分離研究の接点を見いだしたことにより分子細胞生物学分野に大きなインパクトを与えた。また新規arcRNA探索法の開発によって、上記arcRNA機能の一般性が示され、arcRNAをncRNAの独立タクソンとして提唱するに至った。

Research Products

• [Int'l Joint Research] University of Western Australia(オーストラリア)
• [Int'l Joint Research] CNRS(フランス)
• [Int'l Joint Research] Francis Crick Institute(英国)
• [Int'l Joint Research] Rochester University/Stanford University/Augusta University(米国)
• [Int'l Joint Research] VIB(ベルギー)
• [Int'l Joint Research] University of Western Australia(オーストラリア)
• [Int'l Joint Research] CNRS(フランス)
• [Int'l Joint Research] KAUST(サウジアラビア)
• [Int'l Joint Research] Francis Crick Institute(英国)
• [Int'l Joint Research] Helmholtz Zentrum(ドイツ)
• [Int'l Joint Research] CNRS(フランス)
• [Int'l Joint Research] 西オーストラリア大(オーストラリア)
• [Int'l Joint Research] KAUST(サウジアラビア)
• [Int'l Joint Research] CNRS(フランス)
• [Int'l Joint Research] 西オーストラリア(オーストラリア)
• [Int'l Joint Research] CNRS(フランス)
• [Int'l Joint Research] 西オーストラリア大学(オーストラリア)
• [Int'l Joint Research] VIB(ベルギー)
• [Journal Article] The expression of long noncoding RNA NEAT1 is reduced in schizophrenia and modulates oligodendrocytes transcription. (2019)
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• [Journal Article] Long noncoding RNA NEAT1 modulates immune cell functions and is suppressed in early onset myocardial infarction patients. (2019)
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  • Peer Reviewed
• [Journal Article] Functional Domains of NEAT1 Architectural lncRNA Induce Paraspeckle Assembly through Phase Separation (2018)
  • Author(s): Yamazaki Tomohiro、Souquere Sylvie、Chujo Takeshi、Kobelke Simon、Chong Yee Seng、Fox Archa H.、Bond Charles S.、Nakagawa Shinichi、Pierron Gerard、Hirose Tetsuro
  • Journal Title: Molecular Cell Volume: 70 Issue: 6 Pages: 1038-1053
  • DOI: 10.1016/j.molcel.2018.05.019
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Long noncoding RNA NEAT1 (nuclear paraspeckle assembly transcript 1) is critical for phenotypic switching of vascular smooth muscle cells. (2018)
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  • Journal Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 115 Issue: 37
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• [Journal Article] CRISPRa-mediated NEAT1 lncRNA upregulation induces formation of intact paraspeckles. (2018)
  • Author(s): Yamazaki T, Fujikawa C, Kubota A, Takahashi A, Hirose T.
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• [Journal Article] Molecular dissection of nuclear paraspeckles: towards understanding the emerging world of the RNP milieu. (2018)
  • Author(s): Nakagawa S, Yamazaki T, Hirose T.
  • Journal Title: Open Biology Volume: 8 Issue: 10 Pages: 180150-180150
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• [Journal Article] Function and Regulation of Human Terminal Uridylyltransferases. (2018)
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• [Journal Article] Acetate-dependent tRNA acetylation required for decoding fidelity in protein synthesis (2018)
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• [Journal Article] Human BCDIN3D is a cytoplasmic tRNAHis -specific 5'-monophosphate methyltransferase. (2018)
  • Author(s): Tomita K & Liu Y.
  • Journal Title: Front. Genet Volume: - Pages: 305-310
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  • Peer Reviewed / Open Access
• [Journal Article] ノンコーディングRNAによる相転移を介した核内構造構築機構 (2018)
  • Author(s): 廣瀬哲郎
  • Journal Title: 科研費ＮＥＷＳ Volume: 2 Pages: 15-15
  • Open Access
• [Journal Article] 長鎖非コードRNAであるNEAT1の機能ドメインは相分離を介して核内構造体であるパラスペックルの形成をひき起こす (2018)
  • Author(s): 山崎智弘、廣瀬哲郎
  • Journal Title: First Author's Volume: - Pages: 070
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  • Open Access
• [Journal Article] 超解像顕微鏡で長鎖ncRNAの機能解析 (2018)
  • Author(s): 廣瀬哲郎、中川真一
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• [Journal Article] Paraspeckles: Where Long Noncoding RNA Meets Phase Separation. (2017)
  • Author(s): Fox AH, Nakagawa S, Hirose T, Bond CS.
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• [Journal Article] Nuclear bodies built on architectural long noncoding RNAs: unifying principles of their construction and function (2017)
  • Author(s): Chujo T, Hirose T.
  • Journal Title: Mol Cells. Volume: 31;40(12) Pages: 889-896
  • Peer Reviewed
• [Journal Article] Neat1 is a p53-inducible lincRNA essential for transformation suppression. (2017)
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• [Journal Article] Unusual semi‐extractability as a hallmark of nuclear body‐associated architectural noncoding RNAs (2017)
  • Author(s): Chujo T, Yamazaki T, Kawaguchi T, Kurosaka S, Takumi T, Nakagawa S, Hirose T
  • Journal Title: The EMBO Journal Volume: - Issue: 10 Pages: 861-868
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  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] RNase Sensitivity Screening for Nuclear Bodies with RNA Scaffolds in Mammalian Cells (2017)
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  • Journal Title: Bio-protocol Volume: 7 Issue: 8
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• [Journal Article] A possible link between specific transfer RNA methylation and tumorigenic phenotype of breast cancer. (2017)
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• [Journal Article] Human BCDIN3D Monomethylates Cytoplasmic Histidine Transfer RNA. (2017)
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• [Journal Article] Crystal structures of U6 snRNA-specific terminal uridylyltransferase (2017)
  • Author(s): Yamshita S, Takagi Y, Nagaike T, Tomita K.
  • Journal Title: Nature Communications Volume: -
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Synthetic mRNA devices that detect endogenous proteins and distinguish mammalian cells (2017)
  • Author(s): Kawasaki S, Fujita Y, Nagaike T, Tomita K, Saito H.
  • Journal Title: Nucleic Acids Res. Volume: -
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  • Peer Reviewed
• [Journal Article] p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity. (2016)
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  • Journal Title: Nat. Med. Volume: 22 Issue: 8 Pages: 861-868
  • DOI: 10.1038/nm.4135
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The Sam68 nuclear body is composed of two RNase-sensitive substructures joined by the adaptor HNRNPL (2016)
  • Author(s): Mannen T, Yamashita S, Tomita K, Goshima G, Hirose T
  • Journal Title: J Cell Biol. Volume: 214 Issue: 1 Pages: 45-59
  • DOI: 10.1083/jcb.201601024
  • NAID: 120005828468
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Control of the heat stress-induced alternative splicing of a subset of genes by hnRNP K. (2016)
  • Author(s): Yamamoto K, Furukawa M, Fukumura K, Kawamura A, Yamada T, Suzuki H, Hirose T, Sakamoto H, Inoue K.
  • Journal Title: Genes Cells. Volume: 21 Issue: 9 Pages: 1006-1014
  • DOI: 10.1111/gtc.12400
  • Peer Reviewed
• [Journal Article] Regulation of membrane KCNQ1/KCNE1 channel density by sphingomyelin synthase 1. (2016)
  • Author(s): Wu M, Takemoto M, Taniguchi M, Takumi T, Okazaki T, Song WJ
  • Journal Title: Am J Physiol Cell Physiol Volume: 311 Issue: 7 Pages: 817-830
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  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Paraspeckles modulate the intranuclear distribution of paraspeckle-associated Ctn RNA. (2016)
  • Author(s): Anantharaman A, Jadaliha M, Tripathi V, Nakagawa S, Hirose T, Jantsch MF, Prasanth SG, Prasanth KV.
  • Journal Title: Sci Rep Volume: 6 Issue: 1 Pages: 34043-34043
  • DOI: 10.1038/srep34043
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Simultaneous multicolor detection of RNA and proteins using super-resolution microscopy. (2016)
  • Author(s): Mito M, Kawaguchi T, Hirose T, Nakagawa S.
  • Journal Title: Methods Volume: 98 Pages: 158-165
  • DOI: 10.1016/j.ymeth.2015.11.007
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Architectural RNAs (arcRNAs): A class of long noncoding RNAs that functions as the scaffold of nuclear bodies (2016)
  • Author(s): Takeshi Chujo, Tomohiro Yamazaki, Tetsuro Hirose
  • Journal Title: Biochim Biophys Acta Volume: 1859 Issue: 1 Pages: 139-146
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  • Peer Reviewed
• [Journal Article] Mechanism of 3′-matured tRNA discrimination from 3′-immature tRNA by class-II CCA-adding enzyme. (2016)
  • Author(s): Yamashita S, Tomita K
  • Journal Title: Structure Volume: 24
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] SWI/SNF chromatin-remodeling complexes function in noncoding RNA-dependent assembly of nuclear bodies. (2015)
  • Author(s): Kawaguchi T, Tanigawa A, Naganuma T, Ohkawa Y, Souquere S, Pierron G, Hirose T.
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 112 Issue: 14 Pages: 4304-4309
  • DOI: 10.1073/pnas.1423819112
  • NAID: 120005661435
  • Peer Reviewed / Open Access
• [Journal Article] Prion-like domains in RNA binding proteins are essential for building subnuclear paraspeckles. (2015)
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  • Journal Title: J. Cell Biol. Volume: 210 Issue: 4 Pages: 3529-539
  • DOI: 10.1083/jcb.201504117
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Genome-wide co-localization screening of nuclear body components using a fluorescently tagged FLJ cDNA clone library. (2015)
  • Author(s): Hirose, T., Goshima, N.
  • Journal Title: Methods Mol. Biol. Volume: 1262 Pages: 155-163
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• [Journal Article] Chromatin remodeling complexes in the assembly of long noncoding RNA-dependent nuclear bodies. (2015)
  • Author(s): Kawaguchi T, Hirose T.
  • Journal Title: Nucleus Volume: 6 Issue: 6 Pages: 462-467
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  • NAID: 120005905615
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Clues to long noncoding RNA taxonomy. (2015)
  • Author(s): Hirose T, Nakagawa S.
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  • Peer Reviewed
• [Journal Article] Measurement of acceptor-TΨC helix length of tRNA for terminal A76-addition by A-adding enzyme (2015)
  • Author(s): Yamashita S, Martinez A, Tomita K
  • Journal Title: Structure Volume: 23 Issue: 5 Pages: 830-842
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• [Journal Article] Rapid and Efficient Elimination of Specific Nuclear Noncoding RNAs in Mammalian Cells with Antisense Oligonucleotides. (2015)
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  • Journal Title: Methods Mol. Biol. Volume: 1206 Pages: 149-156
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• [Journal Article] The lncRNA Neat1 is required for corpus luteum formation and the establishment of pregnancy in a subpopulation of mice. (2014)
  • Author(s): Nakagawa S, Shimada M, Yanaka K, Mito M, Arai T, Takahashi E, Fujita Y, Fujimori T, Standaert L, Marine JC, Hirose T.
  • Journal Title: Development Volume: 141 Issue: 23 Pages: 4618-27
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  • Peer Reviewed / Open Access
• [Journal Article] The long noncoding RNA Neat1 is required for mammary gland development and lactation. (2014)
  • Author(s): Standaert, L., Adriaens, C., Radaelli, E., Van Keymeulen, A., Blanpain, C., Hirose, T., Nakagawa, S. & Marine, J.C.
  • Journal Title: RNA Volume: 20 Issue: 12 Pages: 1844-1849
  • DOI: 10.1261/rna.047332.114
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The Estrogen receptor alpha regulated lncRNA NEAT1 is a critical modulator of prostate cancer. (2014)
  • Author(s): Chakravarty, D., Sboner, A., Nair, S., Giannopoulou, E., Li, R., Hennig, S., Mosquera, J.M., Pauwels, J., Park, K., Kossai, M., MacDonald, T., Fontugne, J., Erho, N., Vergara, I., Ghadessi, M., Davicioni, E., Jenkins, R., Palanisamy, N., Chen, Z., Nakagawa, S., Hirose, T., et al.
  • Journal Title: Nat. Commun. Volume: 5 Issue: 1 Pages: 5383-5383
  • DOI: 10.1038/ncomms6383
  • Peer Reviewed
• [Journal Article] Molecular insights into replication initiation by Qβ replicase using ribosomal protein S1 (2014)
  • Author(s): Takeshita D, Yamashita S Tomita K
  • Journal Title: Nucleic Acids Res. Volume: 42 Issue: 16 Pages: 10823-10831
  • DOI: 10.1093/nar/gku745
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Structures and Functions of Qβ Replicase: Translation factors beyond protein synthesis. (2014)
  • Author(s): Tomita K
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  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Nuclear Architecture by Long Noncoding RNAs (2018)
  • Author(s): Tetsuro Hirose
  • Organizer: 北大-中国医薬大ジョイントシンポジウム
  • Int'l Joint Research / Invited
• [Presentation] Molecular Mechanism of Nuclear Body Formation by Architectural Noncoding RNAs (2018)
  • Author(s): 廣瀬哲郎
  • Organizer: SILエキスパートシンポジウム “RNA-Binding Proteins in Neuroscience”
  • Invited
• [Presentation] Ancient and Modern RNA Worlds (2018)
  • Author(s): Tetsuro Hirose
  • Organizer: The 2nd GI-CoRE GSQ, GSB, & IGM Joint Symposium
  • Int'l Joint Research / Invited
• [Presentation] ノンコーディングRNAによる核内構造体構築 (2018)
  • Author(s): 廣瀬哲郎
  • Organizer: 第12回日本エピジェネティックス研究会年会
  • Invited
• [Presentation] Formation and function of phase separated nuclear bodies with architectural noncoding RNAs (2018)
  • Author(s): Tetsuro Hirose
  • Organizer: Japan-Australia Joint RNA meeting 2018
  • Int'l Joint Research / Invited
• [Presentation] HSATIII lncRNA-based nuclear stress bodies control pre-mRNA splicing in post-stress recovery phase (2018)
  • Author(s): Kensuke Ninomiya, Shungo Adachi, Tohru Natsume, Junichi Iwakiri, Goro Terai, Kiyoshi Asai, and Tetsuro Hirose
  • Organizer: Japan-Australia Joint RNA meeting 2018
  • Int'l Joint Research
• [Presentation] Multiple NEAT1 modular RNA domains cooperatively construct phase-separated, distinct, highly ordered paraspeckle nuclear bodies (2018)
  • Author(s): Tomohiro Yamazaki, Souquere Sylvie, Hiro Takakuwa, Hyura Yoshino, Takeshi Chujo, Archa H fox, Charles S Bond, Shinichi Nakagawa, Gerard Pierron, Tetsuro Hirose
  • Organizer: Japan-Australia Joint RNA meeting 2018
  • Int'l Joint Research
• [Presentation] Molecular mechanisms of the paraspeckle formation as distinct nuclear bodies (2018)
  • Author(s): Hiro Takakuwa, Tomohiro Yamazaki, Sylvie Souquere, Gerard Pierron, and Tetsuro Hirose
  • Organizer: Japan-Australia Joint RNA meeting 2018
  • Int'l Joint Research
• [Presentation] Stress-Induced Transient Recruitment of m6A RNAs to HSATIII lncRNA Based Nuclear Stress Bodies (2018)
  • Author(s): Mahmoud Khamis Aly, Kensuke Ninomiya, Shungo Adachi, Tohru Natsume and Tetsuro Hirose
  • Organizer: Japan-Australia Joint RNA meeting 2018
  • Int'l Joint Research
• [Presentation] The functional analysis of liver-specific long noncoding RNA Hep-ncR1 in hepatocarcinoma cells (2018)
  • Author(s): Midori Dannoura, Tomohiro Yamazaki, Kimihiro Hino, and Tetsuro Hirose
  • Organizer: Japan-Australia Joint RNA meeting 2018
  • Int'l Joint Research
• [Presentation] Nuclear architecture by long noncoding RNAs through phase separation (2018)
  • Author(s): Tetsuro Hirose
  • Organizer: 2018 China Nucleic Acid Forum
  • Int'l Joint Research / Invited
• [Presentation] 核内ストレス体によるストレス回復期のスプライシング制御 (2018)
  • Author(s): 二宮賢介、足達俊吾、夏目徹、岩切淳一、寺井悟朗、浅井潔、廣瀬哲郎
  • Organizer: 第20回日本RNA学会年会
• [Presentation] NEAT1 lncRNA 機能ドメイン上での NONO オリゴマー化が相 分離した核内構造体パラスペックル形成を誘導する (2018)
  • Author(s): 山崎智弘、Sylvie Souquere、吉野彪羅、高桑 央、 中條岳志、Archa H. Fox、Charles S. Bond、中川真一、 Gerard Pierron、廣瀬哲郎
  • Organizer: 第20回日本RNA学会年会
• [Presentation] 核内構造体パラスペックル独立性維持のための分子機構の解明 (2018)
  • Author(s): 高桑央，山崎智弘，Sylvie Souquere, Gerard Pierron, 廣瀬哲郎
  • Organizer: 第20回日本RNA学会年会
• [Presentation] ノンコーディングRNAによる核内構造体の形成機構 (2018)
  • Author(s): 廣瀬哲郎
  • Organizer: 第59回日本神経学会学術大会シンポジウム
  • Invited
• [Presentation] Formation and Function of Phase Separated Nuclear Bodies with Architectural Noncoding RNAs (2018)
  • Author(s): Tetsuro Hirose
  • Organizer: 第41回日本分子生物学会年会
• [Presentation] 核内構造体パラスペックルはNEAT1 lncRNAの複数のモジュールドメインの協調した機能により構築される (2018)
  • Author(s): 山崎智弘, Sylvie Souquere, 吉野彪羅, 高桑央, 中條岳志, Archa H. Fox, Charles S. Bond, 中川真一, Gerard Pierron, 廣瀬哲郎
  • Organizer: 第41回日本分子生物学会年会
• [Presentation] 核内構造体パラスペックル独立性維持のための分子機構の解明 (2018)
  • Author(s): 高桑央, 山崎 智弘, Sylvie Souquere, Gerard Pierron, 廣瀬哲郎
  • Organizer: 第41回日本分子生物学会年会
• [Presentation] 腸管出血性大腸菌におけるAtaT-AtaRトキシン-アンチトキシン複合体の立体構造の決定 (2018)
  • Author(s): 八代悠歌、富田 耕造
  • Organizer: 第41回日本分子生物学会年会
• [Presentation] ヒトTUT4によるLin28依存的なlet7 miRNA抑制の分子構造基盤 (2018)
  • Author(s): 山下征輔、富田 耕造
  • Organizer: 第41回日本分子生物学会年会
• [Presentation] Crystal structure of enterohemorrhagic Escherichia coli AtaT-AtaR toxin-antitoxin complex (2018)
  • Author(s): Yuka Yashiro, Kozo Tomita
  • Organizer: 27th tRNA Conference
  • Int'l Joint Research
• [Presentation] Dissection of elements and machinery of architectural noncoding RNAs (2018)
  • Author(s): Tetsuro Hirose
  • Organizer: Keystone symposium Noncoding RNAs: Form, Function, Physiology
  • Int'l Joint Research / Invited
• [Presentation] 核内構造体アーキテクチュラルRNAの探索手法の開発：難溶性RNA-seqとFABS法 (2018)
  • Author(s): 中條岳志、田中くみ子、山崎智弘、萬年太郎、川口哲哉、黒坂哲、内匠透、中川真一、廣瀬哲郎
  • Organizer: 第3回北海道大学・部局横断シンポジウム
• [Presentation] Sat III lncRNAを足場とする核内ストレス体の構成変化とストレス回復期における役割 (2018)
  • Author(s): 二宮賢介 足達俊吾 夏目徹 廣瀬哲郎
  • Organizer: 第３回北大部局間横断シンポジウム
• [Presentation] 核内構造体パラスペックルはNEAT1 lncRNAの複数の機能RNAドメインが協働することにより構築される (2018)
  • Author(s): 山崎 智弘、 Sylvie Souquere、 吉野 彪羅、 高桑 央、 中條 岳志、 Archa H. Fox、 中川 真一、 Gerard Pierron、 廣瀬 哲郎
  • Organizer: 第３回北大部局横断シンポジウム
• [Presentation] Dissection of NEAT1 lncRNA domains to establish distinct, highly ordered, phase-separated paraspeckle nuclear body (2018)
  • Author(s): 山崎 智弘, Sylvie Souquere, 吉野 彪羅, 高桑 央, 木立 尚孝, Archa H. Fox, Charles S. Bond, 中川 真一, Gerard Pierron、廣瀬 哲郎
  • Organizer: Keystone symposium Noncoding RNAs: Form, Function, Physiology
  • Int'l Joint Research
• [Presentation] NEAT1 lncRNAに潜むパラスペックル構築を司るRNAエレメント (2017)
  • Author(s): 山崎智弘Sylvie Souquere、木立尚孝、Archa H. Fox, 中川真一, Gerard Pierron, 廣瀬哲郎
  • Organizer: 第２回北大・部局横断シンポジウム「免疫・癌・感染」
  • Place of Presentation: 北海道大学工学部鈴木章記念ホール ポスター発表
  • Year and Date: 2017-03-14
• [Presentation] Novel functional insights into Sat III lncRNA-dependent nuclear stress bodies in post-stress recovery phase. (2017)
  • Author(s): 二宮 賢介、Mahmoud Khamis Aly、廣瀬 哲郎
  • Organizer: 第２回北大・部局横断シンポジウム「免疫・癌・感染」
  • Place of Presentation: 北海道大学工学部鈴木章記念ホール ポスター発表
  • Year and Date: 2017-03-14
• [Presentation] Unusual semi-extractability as the hallmark of nuclear body-;associated architectural long noncoding RNAs (2017)
  • Author(s): 中條岳志，山崎智弘，川口哲哉，黒坂哲，内匠透，中川真一，廣瀬哲郎
  • Organizer: 第２回北大・部局横断シンポジウム「免疫・癌・感染」
  • Place of Presentation: 北海道大学工学部鈴木章記念ホール ポスター発表
  • Year and Date: 2017-03-14
• [Presentation] Distinct RNA polymerase transcripts competitively function as scaffold of the DBC1 nuclear bodies in specific cancer cell lines. (2017)
  • Author(s): Taro Mannen, Seisuke Yamashita, Kozo Tomita, Naoki Goshima, Tetsuro Hirose.
  • Organizer: 第２回北大・部局横断シンポジウム「免疫・癌・感染」
  • Place of Presentation: 北海道大学工学部鈴木章記念ホール ポスター発表
  • Year and Date: 2017-03-14
• [Presentation] Unravelling The Architectural Organization of The SAT III lncRNA- Dependent Nuclear Stress Bodies (2017)
  • Author(s): Mahmoud Khamis Aly, Kensuke Ninomiya, Shungo Adachi, Tohru Natsume and Tetsuro Hirose
  • Organizer: 第２回北大・部局横断シンポジウム「免疫・癌・感染」
  • Place of Presentation: 北海道大学工学部鈴木章記念ホール
  • Year and Date: 2017-03-14
• [Presentation] Architectural lncRNAの機能解明 (2017)
  • Author(s): 廣瀬哲郎
  • Organizer: 第三回バイオシグナル研究会
  • Place of Presentation: 神戸大学（兵庫県神戸市）
  • Year and Date: 2017-03-08
  • Invited
• [Presentation] Liquid-liquid phase separation induced by NEAT1 lncRNA that builds paraspeckle nuclear body. (2017)
  • Author(s): Tomohiro Yamazaki、Sylvie Souquere, Archa H. Fox, Shinichi Nakagawa, Gerard Pierron, Tetsuro Hirose.
  • Organizer: Phase Separation and RNA Processing as Drivers of Cancer and Neurodegenerative Disease.
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2017-02-24
• [Presentation] Dissection of architectural noncoding RNA elements and machinery (2017)
  • Author(s): Tetsuro Hirose
  • Organizer: Simon Fraser Univ MBB seminar
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2017-02-10
  • Int'l Joint Research / Invited
• [Presentation] Liquid-liquid phase separation and paraspeckle formation induced by the specific region of NEAT1 lncRNA (2017)
  • Author(s): Tetsuro Hirose
  • Organizer: Keystone Symposia
  • Place of Presentation: Banff, Canada
  • Year and Date: 2017-02-07
  • Int'l Joint Research
• [Presentation] Remarkable semi-extractability as the hallmark of nuclear body-associated architectural long ncRNAs (2017)
  • Author(s): Takeshi Chujo, Tomohiro Yamazaki, Tetsuya Kawaguchi, Satoshi Kurosaka,Toru Takumi, Shinichi Nakagawa, and Tetsuro Hirose.
  • Organizer: Keystone Symposia Protein-RNA Interactions: Scale, Mechanisms, Structure and Function of Coding and Noncoding RNPs
  • Place of Presentation: Banff （Canada）
  • Year and Date: 2017-02-07
• [Presentation] Distinct RNA polymerase transcripts competitively function as scaffold of the DBC1 nuclear bodies in specific cancer cell lines. (2017)
  • Author(s): Taro Mannen, Seisuke Yamashita, Kozo Tomita, Naoki Goshima, Tetsuro Hirose.
  • Organizer: 第11回研究所ネットワーク国際シンポジウム
  • Place of Presentation: 徳島大学藤井節郎記念ホール（徳島県蔵本町）
  • Year and Date: 2017-01-26
• [Presentation] ノンコーディング RNAによる細胞内構造構築機構 (2017)
  • Author(s): 廣瀬 哲郎
  • Organizer: 第69回日本細胞生物学会
  • Invited
• [Presentation] Molecular Dissection of Architectural Noncoding RNA Elements and Machinery (2017)
  • Author(s): 廣瀬 哲郎
  • Organizer: 第43回内藤コンファレンス
  • Int'l Joint Research / Invited
• [Presentation] Nuclear Architecture by Long Noncoding RNAs (2017)
  • Author(s): 廣瀬 哲郎
  • Organizer: 日韓(HU-KSMCB)ジョイントシンポジウム
  • Int'l Joint Research / Invited
• [Presentation] Noncoding RNA-dependent Nuclear Body Formation through Liquid-liquid Phase Separation (2017)
  • Author(s): 廣瀬 哲郎
  • Organizer: 第40回日本神経科学会
  • Invited
• [Presentation] Molecular Dissection of Architectural Noncoding RNA Elements and Machinery, (2017)
  • Author(s): 廣瀬 哲郎
  • Organizer: Symposium on Multidisciplinary insights into higher order biological complexes
  • Int'l Joint Research / Invited
• [Presentation] Architectural Function of Noncoding RNA for Subcellular Structures (2017)
  • Author(s): 廣瀬 哲郎
  • Organizer: 第40回日本分子生物学会（ConBio2017）
  • Invited
• [Presentation] Nuclear Architecture by Long Noncoding RNAs (2017)
  • Author(s): 廣瀬 哲郎
  • Organizer: 11th International Symposium on Nanomedicine (ISNM2017)
  • Invited
• [Presentation] Crystal Structure of U6 snRNA-specific terminal uridylyltransferase (2017)
  • Author(s): Seisuke Yamashita & Kozo Tomita
  • Organizer: The 43rd Naito Conference on "Noncoding RNA：Biology, Chemistry, & Diseases"
  • Int'l Joint Research
• [Presentation] A possible link between specific transfer RNA methylation and tumorigenic phenotype of breast cancer (2017)
  • Author(s): Kozo Tomita
  • Organizer: The 43rd Naito Conference on "Noncoding RNA：Biology, Chemistry, & Diseases"
  • Int'l Joint Research / Invited
• [Presentation] tRNAのメチル化と乳がん転移の相関 (2017)
  • Author(s): Kozo Tomita
  • Organizer: 第76回 日本癌学会学術総会 シンポジウム 「がん研究につながるRNA生物学の新展開」
  • Invited
• [Presentation] ADPリボシル化によるRNAポリウリジル化の制御機構 (2017)
  • Author(s): 永池崇、富田 耕造
  • Organizer: 生命科学系学会合同年次大会（ConBio2017）
• [Presentation] The specific domains of architectural NEAT1 lncRNA induces the formation of the distinct phase-separated paraspeckle nuclear body (2017)
  • Author(s): Tomohiro Yamazaki, Taro Mannen, Sylvie Souquere, Hisanori Kiryu, Archa H. Fox, Shinichi Nakagawa, Gerard Pierron and Tetsuro Hirose
  • Organizer: RNA Society Meeting 2017
  • Int'l Joint Research
• [Presentation] Unusual semi-extractability as a hallmark of nuclear body-associated architectural long noncoding RNAs (2017)
  • Author(s): Takeshi Chujo, Tomohiro Yamazaki, Tetsuya Kawaguchi, Satoshi Kurosaka, Shinichi Nakagawa, and Tetsuro Hirose
  • Organizer: RNA Society Meeting 2017
  • Int'l Joint Research
• [Presentation] Unusual semi-extractability as a hallmark of nuclear body-associated architectural long noncoding RNAs (2017)
  • Author(s): Takeshi Chujo and Tetsuro Hirose
  • Organizer: 2nd International Symposium for Noncoding RNA Neo-Taxonomy in conjunction with Tokyo RNA Club 23rd Meeting
  • Int'l Joint Research / Invited
• [Presentation] The specific region of architectural NEAT1 lncRNA induces the formation of the phase-separated paraspeckle nuclear body (2017)
  • Author(s): Tomohiro Yamazaki, Taro Mannena, Sylvie Souquereb, Hisanori Kiryu, Archa H. Foxc,d, Shinichi Nakagawae, Gerard Pierronb and Tetsuro Hirose
  • Organizer: 第４３回内藤コンファレンス 非コードRNA：生物学、化学、そして疾患
  • Int'l Joint Research
• [Presentation] Novel functional insights into Sat III lncRNA-dependent nuclear stress bodies in post-stress recovery phase. (2017)
  • Author(s): Kensuke Ninomiya, Mahmoud Khamis Aly and Tetsuro Hirose
  • Organizer: 第４３回内藤コンファレンス 非コードRNA：生物学、化学、そして疾患
  • Int'l Joint Research
• [Presentation] The specific regions of architectural NEAT1 lncRNA induce the formation of the phase-separated paraspeckle nuclear body (2017)
  • Author(s): 山崎智弘、萬年太郎、Sylvie Souquere、木立尚孝、Archa H. Fox、中川真一、Gerard Pierron、廣瀬哲郎
  • Organizer: 第54回日本生化学会北海道支部例会
• [Presentation] 核内構造体形成のアーキテクチュラル長鎖ncRNAの共通特性としての難抽出性 (2017)
  • Author(s): 中條岳志、山崎智弘、黒坂哲、内匠透、中川真一、廣瀬哲郎
  • Organizer: 第54回日本生化学会北海道支部例会
• [Presentation] NEAT1長鎖ノンコーディングRNAは液相分離を誘導することで核内構造体パラスペックルを構築する (2017)
  • Author(s): 山崎 智弘、Sylvie Souquere 、木立 尚孝、Archa H. Fox 、中川 真一、Gerard Pierron 、廣瀬 哲郎
  • Organizer: 第19回日本RNA学会年会
• [Presentation] 核内ストレス体の構成変化とストレス回復期におけるスプライシング制御 (2017)
  • Author(s): 二宮賢介 足達俊吾 夏目徹 廣瀬哲郎
  • Organizer: 第19回日本RNA学会年会
• [Presentation] Unusual semi-extractability as a hallmark of nuclear body-associated architectural long noncoding RNAs (2017)
  • Author(s): Takeshi Chujo, Tomohiro Yamazaki, Tetsuya Kawaguchi, Satoshi Kurosaka, Shinichi Nakagawa, and Tetsuro Hirose
  • Organizer: 第19回日本RNA学会年会
• [Presentation] 核内構造体パラスペックル内のNEAT1lncRNAの空間的配置を規定する分子メカニズムの解明 (2017)
  • Author(s): 吉野彪羅、山崎智弘、廣瀬哲郎
  • Organizer: 第19回日本RNA学会年会
• [Presentation] Sat III lncRNAを足場とする核内ストレス体の構成変化とストレス回復期における役割 (2017)
  • Author(s): 二宮賢介 足達俊吾 夏目徹 廣瀬哲郎
  • Organizer: RNAフロンティアミーティング2017
• [Presentation] Molecular mechanisms to determine spatial organization of NEAT1 lncRNA within the paraspeckles (2017)
  • Author(s): Hyura Yoshino, Tomohiro Yamazaki, Tetsuro Hirose
  • Organizer: RNAフロンティアミーティング2017
• [Presentation] 核内構造体パラスペックルが独立した構造体として存在するための分子メカニズムの解明 (2017)
  • Author(s): 高桑 央、山崎 智弘、Sylvie Souquere、 Gerard Pierron、 廣瀬 哲郎
  • Organizer: RNAフロンティアミーティング2017
• [Presentation] 核内構造体パラスペックルはNEAT1 lncRNAの複数の機能ドメインにより構築される (2017)
  • Author(s): 山崎智弘、Sylvie Souquere、木立 尚孝、Archa H. Fox、中川 真一、Gerard Pierron、廣瀬 哲郎
  • Organizer: 第40回日本分子生物学会（ConBio2017）
• [Presentation] Characterization of architectural lncRNA elements using genome-editing technology. (2016)
  • Author(s): 廣瀬哲郎
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-12-01
• [Presentation] RNA elements in NEAT1 lncRNA for the architectural role of the paraspeckle. (2016)
  • Author(s): 山崎 智弘、Sylvie Souquere、木立尚孝、馬場由貴、麦倉一樹、Archa H. Fox、Charles S. Bond、中川 真一、Gerard Pierron、廣瀬 哲郎
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-11-30
• [Presentation] SatIII lncRNAと核内ストレス体のストレス回復期における新規機能 (2016)
  • Author(s): 二宮 賢介、Mahmoud Khamis Aly、廣瀬 哲郎
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-11-30
• [Presentation] Sam68核内構造体は、HNRNPLアダプターを介して2つのRNase感受性サブ構造体が融合してつくられる (2016)
  • Author(s): 萬年太郎, 山下征輔, 富田耕造, 五島直樹, 廣瀬哲郎
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-11-30
• [Presentation] Remarkable semi-extractability as a hallmark of architectural long noncoding RNAs associated with nuclear bodies. (2016)
  • Author(s): Takeshi Chujo, Tomohiro Yamazaki, Tetsuya Kawaguchi, Satoshi Kurosaka, Toru Takumi, Shinichi Nakagawa, Tetsuro Hirose
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-11-30
• [Presentation] Dissection of architectural noncoding RNA elements and machinery. (2016)
  • Author(s): 廣瀬哲郎
  • Organizer: Cold Spring Harbor Aisa meeting
  • Place of Presentation: World Hotel Grand Dushulake Suzhou（中国 蘇州）
  • Year and Date: 2016-11-17
  • Int'l Joint Research / Invited
• [Presentation] Elements and machinery of architectural long noncoding RNAs. (2016)
  • Author(s): 廣瀬哲郎
  • Organizer: Shanghai Institutes for Biological Sciences Seminar series
  • Place of Presentation: Shanghai Institute for Biological Science（中国 上海）
  • Year and Date: 2016-11-14
  • Int'l Joint Research / Invited
• [Presentation] ノンコーディングRNAによる核内アーキテクチャ制御 (2016)
  • Author(s): 廣瀬哲郎
  • Organizer: 富山大学薬学部大学院講義「遺伝情報制御学特論」
  • Place of Presentation: 富山大学（富山県富山市）
  • Year and Date: 2016-11-08
  • Invited
• [Presentation] プリオン様RNA結合タンパク質の機能制御を担うnon-coding RNA作動エレメントの解析 (2016)
  • Author(s): 廣瀬哲郎
  • Organizer: 「筋萎縮性側索硬化症（ALS）新規治療法開発をめざした病態解明」 平成28年度ワークショップ
  • Place of Presentation: 都市センターホテル（東京都千代田区）
  • Year and Date: 2016-09-30
  • Invited
• [Presentation] Architectural noncoding RNAs controlling subnuclear organization and gene expression. (2016)
  • Author(s): 廣瀬哲郎
  • Organizer: Mini-symposium on ncRNA
  • Place of Presentation: Academia Sinica （台湾台北市）
  • Year and Date: 2016-09-29
  • Int'l Joint Research / Invited
• [Presentation] Functional characterization of architectural RNA species toward noncoding RNA taxonomy. (2016)
  • Author(s): 廣瀬哲郎
  • Organizer: RNA2016 Symposium
  • Place of Presentation: 国立成功大学（台湾台南市）
  • Year and Date: 2016-09-27
  • Int'l Joint Research / Invited
• [Presentation] 核内構造体の機能構築に必要なlncRNA機能ドメインの解析 (2016)
  • Author(s): 廣瀬哲郎
  • Organizer: 第89回日本生化学会大会シンポジウム
  • Place of Presentation: 東北大学（宮城県仙台市）
  • Year and Date: 2016-09-25
  • Invited
• [Presentation] Methylation of 5′-phosphate of cytoplasmic tRNAHis in human (2016)
  • Author(s): Kozo Tomita
  • Organizer: 26th tRNA Conference
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2016-09-04
  • Int'l Joint Research / Invited
• [Presentation] Recognition of tRNAHis by tRNAHis specific methyltransferase, ThMTase (2016)
  • Author(s): Anna Martinez & Kozo Tomita
  • Organizer: 26th tRNA Conference
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2016-09-04
• [Presentation] Mechanism of 3′-matured tRNA discrimination from 3′-immature tRNA by class-II CCA-adding enzyme (2016)
  • Author(s): Seisuke Yamashita & Kozo Tomita
  • Organizer: 26th tRNA Conference
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2016-09-04
• [Presentation] Remarkable semi-extractability as a hallmark of architectural long noncoding RNAs associated with nuclear bodies (2016)
  • Author(s): Takeshi Chujo, Tomohiro Yamazaki, Tetsuya Kawaguchi, Satoshi Kurosaka, Toru Takumi, Shinichi Nakagawa, Tetsuro Hirose
  • Organizer: RNAフロンティアミーティング2016
  • Place of Presentation: いこいの湯宿いろは（北海道ニセコ町）
  • Year and Date: 2016-08-31
• [Presentation] 非コードRNAの配列と機能の連関 (2016)
  • Author(s): 廣瀬哲郎
  • Organizer: 日本進化学会第18回大会
  • Place of Presentation: 東京工業大学（東京都目黒区）
  • Year and Date: 2016-08-25
  • Invited
• [Presentation] Noncoding RNA (2016)
  • Author(s): 廣瀬哲郎
  • Organizer: RNA2016
  • Place of Presentation: 京都国際会館（京都府京都市）
  • Year and Date: 2016-06-29
  • Invited
• [Presentation] Decoding “architectural” RNA elements in NEAT1 lncRNA, (2016)
  • Author(s): Tomohiro Yamazaki, Sylvie Souquere, Archa H. Fox, Gerard Pierron, Shinichi Nakagawa, Tetsuro Hirose
  • Organizer: RNA 2016 (The 21st Annual Meeting of the RNA Society)
  • Place of Presentation: 国立京都国際会館（京都府京都市）
  • Year and Date: 2016-06-28
• [Presentation] The Sam68 nuclear body is composed of two RNase-sensitive substructures with the adaptor HNRNPL (2016)
  • Author(s): Taro Mannen, Naoki Goshima, and Tetsuro Hirose
  • Organizer: RNA2016(The 21st Annual Meeting of the RNA Society)
  • Place of Presentation: 国立京都国際会館（京都府京都市）
  • Year and Date: 2016-06-28
• [Presentation] Regulation of Poly(U) Polymerase by Poly(ADP-ribose) (2016)
  • Author(s): Takashi Nagaike & Kozo Tomita
  • Organizer: 21st Annual meeting of the RNA Society
  • Place of Presentation: 国立京都国際会館（京都府京都市）
  • Year and Date: 2016-06-28
• [Presentation] Semi-extractable feature as the hallmark of nuclear body-associated architectural long ncRNAs (2016)
  • Author(s): 廣瀬哲郎
  • Organizer: 国際シンポジウム「Clues to Non-coding RNA Taxonomy」
  • Place of Presentation: 東京大学（東京都文京区）
  • Year and Date: 2016-06-27
  • Invited
• [Presentation] Re-quantification of paraspeckle architectural components and an exploratory search for novel nuclear RNA bodies by using an improved RNA extraction method. (2016)
  • Author(s): Takeshi Chujo, Tomohiro Yamazaki, Shinichi Nakagawa, Tetsuya Kawaguchi, Chikako Fujikawa, Ayaka Kubota, Toru Takumi, Tetsuro Hirose
  • Organizer: Keystone symposia
  • Place of Presentation: Santa Fe, USA
  • Year and Date: 2016-02-21
  • Int'l Joint Research
• [Presentation] CRISPR/Cas9-mediated dissection of NEAT1 lncRNA to identify “architectural” RNA elements. (2016)
  • Author(s): Tomohiro Yamazaki and Tetsuro Hirose
  • Organizer: Keystone symposia
  • Place of Presentation: Santa Fe, USA
  • Year and Date: 2016-02-21
  • Int'l Joint Research
• [Presentation] CRISPR/Cas9システムを用いたNEAT1 lncRNAに潜む構造構築エレメントの探索 (2015)
  • Author(s): 山崎智弘、廣瀬哲郎
  • Organizer: RNAフロンティアミーティング2015
  • Place of Presentation: ﾀｶﾐﾔﾋﾞﾚｯｼﾞﾎﾃﾙ樹林（山形県山形市）
  • Year and Date: 2015-12-08
• [Presentation] NEAT1 lncRNAの難溶性を考慮したパラスペックル構造因子の再定量と構造構築原理の探究 (2015)
  • Author(s): 中條 岳志、中川 真一、川口哲哉、内匠 透、廣瀬 哲郎
  • Organizer: 日本分子生物学会
  • Place of Presentation: 神戸ﾎﾟｰﾄｱｲﾗﾝﾄﾞ（兵庫県神戸市）
  • Year and Date: 2015-12-01
• [Presentation] RNase感受性スクリーニングにより同定された核内RNA顆粒の形成機構の解析 (2015)
  • Author(s): 萬年 太郎、五島 直樹、廣瀬 哲郎
  • Organizer: 日本分子生物学会
  • Place of Presentation: 神戸ﾎﾟｰﾄｱｲﾗﾝﾄﾞ（兵庫県神戸市）
  • Year and Date: 2015-12-01
• [Presentation] CRISPR/Cas9-mediated dissection of NEAT1 lncRNA to identify “architectural” RNA elements (2015)
  • Author(s): Tomohiro Yamazaki and Tetsuro Hirose
  • Organizer: 日本分子生物学会ワークショップ
  • Place of Presentation: 神戸ﾎﾟｰﾄｱｲﾗﾝﾄﾞ（兵庫県神戸市）
  • Year and Date: 2015-12-01
  • Invited
• [Presentation] Decoding noncoding RNA code: 細胞内構造構築機能を中心に (2015)
  • Author(s): 廣瀬哲郎
  • Organizer: 国際医療センター転写研究会セミナー
  • Place of Presentation: 国立国際医療ｾﾝﾀｰ（東京都新宿区）
  • Year and Date: 2015-11-18
  • Invited
• [Presentation] Long noncoding RNA による核内構造の動態制御 (2015)
  • Author(s): 廣瀬哲郎
  • Organizer: 臨床ストレス応答学会大会
  • Place of Presentation: 東京農工大学（東京都小金井市）
  • Year and Date: 2015-11-07
  • Invited
• [Presentation] Molecular mechanism of template-independent CCA-addition (2015)
  • Author(s): 富田耕造
  • Organizer: Joint Australa and Japan RNA meeting 2014
  • Place of Presentation: Sydney, Australia
  • Year and Date: 2015-11-03
  • Int'l Joint Research / Invited
• [Presentation] Regulation of Poly (U) Polymerase by ADP-ribosylation (2015)
  • Author(s): 長永池崇、富田 耕造
  • Organizer: Joint Australa and Japan RNA meeting 2014
  • Place of Presentation: Sydney, Australia
  • Year and Date: 2015-11-03
  • Int'l Joint Research
• [Presentation] Exploration of the functional code for architectural noncoding RNAs (2015)
  • Author(s): 廣瀬哲郎
  • Organizer: 国際シンポジウム「RNA regulation and Neuroscience」
  • Place of Presentation: 東北大学（宮城県仙台市）
  • Year and Date: 2015-10-29
  • Int'l Joint Research / Invited
• [Presentation] Molecular Basis of A-addition by Aquifex aeolicus A-adding enzyme (2015)
  • Author(s): Seisuke Yamashita, Kozo Tomita
  • Organizer: 10th International Symposium on Aminoacyl-tRNA Synthetases 2015AARS
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2015-10-17
  • Int'l Joint Research
• [Presentation] Molecular basis for CC-addition by Aquifex aeolicus CC-adding enzyme (2015)
  • Author(s): 山下征輔、富田 耕造
  • Organizer: 25th tRNA Conference
  • Place of Presentation: Kyllini Pelopponese, Greece
  • Year and Date: 2015-09-21
  • Int'l Joint Research
• [Presentation] U6 snRNA特異的TUTase (TUT1)によるU6 snRNA認識機構 (2015)
  • Author(s): 高木悠友子、山下征輔、富田 耕造
  • Organizer: 日本RNA学会年会
  • Place of Presentation: ﾎﾃﾙﾗｲﾌｫｰﾄ札幌（北海道札幌市）
  • Year and Date: 2015-07-15
• [Presentation] Aquifex aeolicus A付加酵素によるA付加反応の分子基盤 (2015)
  • Author(s): 山下征輔、富田 耕造
  • Organizer: 日本RNA学会年会
  • Place of Presentation: ﾎﾃﾙﾗｲﾌｫｰﾄ札幌（北海道札幌市）
  • Year and Date: 2015-07-15
• [Presentation] ノンコーディングRNAによる核内アーキテクチュア (2015)
  • Author(s): 廣瀬哲郎
  • Organizer: Aging, Bone and Cnacer Frontline Forum
  • Place of Presentation: 庭のﾎﾃﾙ（東京都千代田区）
  • Year and Date: 2015-05-25
  • Invited
• [Presentation] RNA機能と神経変性 (2015)
  • Author(s): 廣瀬哲郎
  • Organizer: 日本神経学会北海道地区生涯教育講演会
  • Place of Presentation: 北海道大学医学部（北海道札幌市）
  • Year and Date: 2015-03-08
  • Invited
• [Presentation] Search for RNA-dependent subnuclear structures in mammalian cells (2014)
  • Author(s): 廣瀬哲郎
  • Organizer: Tokyo RNA Club
  • Place of Presentation: 東京大学武田ﾎｰﾙ（東京都文京区）
  • Year and Date: 2014-11-28
  • Int'l Joint Research / Invited
• [Presentation] The possible common mechanism underlying assembly of the nuclear bodies on architectural long noncoding RNAs (2014)
  • Author(s): 廣瀬哲郎
  • Organizer: Joint Australa and Japan RNA meeting 2014
  • Place of Presentation: Sydney, Australia
  • Year and Date: 2014-11-03
  • Int'l Joint Research / Invited
• [Presentation] The common mechanism underlying assembly of the nuclear granules on the architectural noncoding RNAs (2014)
  • Author(s): 廣瀬哲郎
  • Organizer: ESF/EMBO Conference
  • Place of Presentation: Polonia Castle, Poland
  • Year and Date: 2014-09-13
  • Int'l Joint Research
• [Presentation] 細胞内構造構築を担うlncRNAの作用機序と関連疾患 (2014)
  • Author(s): 廣瀬哲郎
  • Organizer: 第157回日本獣医学会学術集会（シンポジウム）
  • Place of Presentation: 北海道大学高等教育推進機構（北海道札幌市）
  • Year and Date: 2014-09-09
  • Invited
• [Presentation] Architectural noncoding RNAによる細胞内構造構築の分子機構とその意義 (2014)
  • Author(s): 廣瀬哲郎
  • Organizer: 第５１回日本生化学会北海道支部例会
  • Place of Presentation: 北海道大学百年記念会館（北海道札幌市）
  • Year and Date: 2014-07-18
  • Invited
• [Book] 核内ボディの骨格として働く構造構築RNA(arcRNA) ノンコーディングRNA～RNA分子の全体像を俯瞰する～ (2016)
  • Author(s): 中條岳志、廣瀬哲郎
  • Total Pages: 372
  • Publisher: 化学同人
• [Book] Long Noncoding RNAs: Structures and Functions (2015)
  • Author(s): Mannen, T., Chujo, T., Hirose, T.
  • Total Pages: 22
  • Publisher: Springer
• [Remarks] ノンコーディング RNA の新暗号を解読 ~ゲノム機能に必要な新しい配列ルールの理解に貢献~
  • URL: https://www.hokudai.ac.jp/news/180622_pr2.pdf
• [Remarks] プレスリリース：「抽出しにくいRNA」から核内顆粒形成に関わる癌関連ノンコーディングRNAを発見
  • URL: https://www.hokudai.ac.jp/news/170413_pr.pdf
• [Remarks] 研究成果：「抽出しにくいRNA」から核内顆粒形成に関わる癌関連ノンコーディングRNAを発見
  • URL: http://www.igm.hokudai.ac.jp/achievements/20170413EMBO.php
• [Remarks] 特定の癌細胞でRNA顆粒が融合して核内構造体を形成するメカニズムを発見
  • URL: http://www.hokudai.ac.jp/news/160705.igm_pr.pdf