| Budget Amount *help |
¥57,590,000 (Direct Cost: ¥44,300,000、Indirect Cost: ¥13,290,000)
Fiscal Year 2018: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Fiscal Year 2017: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Fiscal Year 2016: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Fiscal Year 2015: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2014: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
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| Outline of Final Research Achievements |
In this study, we considered the process of epithelial cell remodeling in Drosophila during metamorphosis as an example of physiological cell competition, and searched for factors that induce non-autonomous cell death by using genetic screening. Pvf1, a Drosophila homolog of vascular endothelial growth factor, was identified as a factor on the winner cell side. As a loser-side factor, myosin VI involved in vesicle transport endocytosis was identified. In addition, we also analyzed cell competition-like phenomena in other epithelial cell populations. We established an experimental material that enables analysis of cell competition in epithelial rearrangement and published it.
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