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Mechanisms underlying Src and Wnt-mediated cell competition and their roles in tumorigenesis

Planned Research

Project AreaCell competition: a mechanism for survival of the fittest in the multi-cellular community
Project/Area Number 26114006
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionGunma University (2017-2018)
Kyushu University (2014-2016)

Principal Investigator

Ishitani Tohru  群馬大学, 生体調節研究所, 教授 (40448428)

Co-Investigator(Kenkyū-buntansha) 岡田 雅人  大阪大学, 微生物病研究所, 教授 (10177058)
Research Collaborator Shimizu Nobuyuki  
Sakuma Megumi  
Ishitani Shizuka  
Haraoka Yukinari  
Akieda Yuki  
Ogamino Shohei  
Zou Juqi  
Furuie Hironobu  
Kajiwara Kentaro  
Kitano Kisuke  
Ookura Hiroya  
Kawase Naoyuki  
Chen Ping-Kuan  
Project Period (FY) 2014-07-10 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥163,930,000 (Direct Cost: ¥126,100,000、Indirect Cost: ¥37,830,000)
Fiscal Year 2018: ¥28,470,000 (Direct Cost: ¥21,900,000、Indirect Cost: ¥6,570,000)
Fiscal Year 2017: ¥28,470,000 (Direct Cost: ¥21,900,000、Indirect Cost: ¥6,570,000)
Fiscal Year 2016: ¥28,470,000 (Direct Cost: ¥21,900,000、Indirect Cost: ¥6,570,000)
Fiscal Year 2015: ¥28,340,000 (Direct Cost: ¥21,800,000、Indirect Cost: ¥6,540,000)
Fiscal Year 2014: ¥50,180,000 (Direct Cost: ¥38,600,000、Indirect Cost: ¥11,580,000)
KeywordsWnt / Src / ゼブラフィッシュ / がん / 初期発生 / Wntシグナル / 細胞競合 / 発生・分化 / 癌 / シグナル伝達 / Wnt経路
Outline of Final Research Achievements

In this study, we have tried to make clear the mechanisms of Src- and Wnt signaling-driven cell competition and their roles in physiological development and tumor progression. We firstly succeeded to establish the in vivo imaging systems for cell competition processes in zebrafish. Using this, we revealed that Wnt signaling-driven cell competition supports developmental robustness. Wnt signaling-driven cell competition senses and eliminates accidentally generated defective cells during zebrafish embryos, whereas inhibition of the cell competition induces the distortion of embryonic patterning.
On the other hand, we discovered that Src-activated cells are basally extruded from MDCK-I cell sheet, whereas, they are basally extruded from MDCK-II cell sheet. We also made clear part of the mechanisms underlying this difference.

Academic Significance and Societal Importance of the Research Achievements

細胞競合による発がん抑制とその破綻による腫瘍形成のプロセスをゼブラフィッシュをモデルに明らかにした。また、これまで細胞競合の生理機能としてはがん抑制機構が注目されてきたが、生理的な発生過程において、健康な体の構築に寄与することを初めて解明した。この成果は、発生生物学、腫瘍学の理解を大きく進めるだけでなく、将来的には、不良細胞の除去によるがんや疾患の予防法など、新たな医療技術にも繋がるだろう。

Report

(6 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (174 results)

All 2019 2018 2017 2016 2015 2014 Other

All Int'l Joint Research (7 results) Journal Article (22 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 22 results,  Open Access: 15 results,  Acknowledgement Compliant: 4 results) Presentation (141 results) (of which Int'l Joint Research: 21 results,  Invited: 30 results) Remarks (3 results) Funded Workshop (1 results)

  • [Int'l Joint Research] UCL(英国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] IST Austria(オーストリア)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Georgetown University/NIH/Harvard University(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] マラヤ大学(マレーシア)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] ソガン大学/ソウル大学/蔚山大学校(韓国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] University College London(英国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Cleveland Clinic(米国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Pharmacological enhancement of retinoid-related orphan receptor α function mitigates spinocerebellar ataxia type 3 pathology.2019

    • Author(s)
      Watanave M, Hoshino C, Konno A, Fukuzaki Y, Matsuzaki Y, Ishitani T, Hirai H.
    • Journal Title

      Neurobiol Dis.

      Volume: 121 Pages: 263-273

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Horizontal Boundary Cells, a Special Group of Somitic Cells, Play Crucial Roles in the Formation of Dorsoventral Compartments in Teleost Somite2019

    • Author(s)
      Kota Abe,Atsuko Shimada,Sayaka Tayama,Hotaka Nishikawa,Takuya Kaneko, Sachiko Tsuda,Akari Karaiwa,Takaaki Matsui,Tohru Ishitani,Hiroyuki Takeda
    • Journal Title

      Cell Reports

      Volume: 27 Issue: 3 Pages: 928-939

    • DOI

      10.1016/j.celrep.2019.03.068

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Src mediates TGF-β-induced intraocular pressure elevation in glaucoma.2019

    • Author(s)
      Tsukamoto T, Kajiwara K, Nada S, Okada M
    • Journal Title

      J Cell Physiol.

      Volume: 234 Issue: 2 Pages: 1730-1744

    • DOI

      10.1002/jcp.27044

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of sonic hedgehog and notch signaling in regenerative neurogenesis in adult zebrafish optic tectum after stab injury2018

    • Author(s)
      Ueda Y, Shimizu Y, Shimizu N, Ishitani T, Ohshima T.
    • Journal Title

      Journal of Comparative Neurology

      Volume: 526 Issue: 15 Pages: 2360-2372

    • DOI

      10.1002/cne.24489

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of Lamtor1 in Macrophages, CD4+ T-cells, and Regulatory T-cells.2018

    • Author(s)
      Kimura T, Kumanogoh A, Okada M
    • Journal Title

      Critical reviews in immunology

      Volume: 38 Issue: 5 Pages: 403-414

    • DOI

      10.1615/critrevimmunol.2018028252

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lysosomal Protein Lamtor1 Controls Innate Immune Responses via Nuclear Translocation of Transcription Factor EB.2018

    • Author(s)
      Hayama Y, Kimura T, Takeda Y, Nada S, Koyama S, Takamatsu H, Kang S, Ito D, Maeda Y, Nishide M, Nojima S, Sarashina-Kida H, Hosokawa T, Kinehara Y, Kato Y, Nakatani T, Nakanishi Y, Tsuda T, Koba T, Okada M, Kumanogoh A.
    • Journal Title

      J Immunol.

      Volume: 200 Issue: 11 Pages: 3790-3800

    • DOI

      10.4049/jimmunol.1701283

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rheb localized on the Golgi membrane activates lysosome-localized mTORC1 at the Golgi lysosome contact site2018

    • Author(s)
      Feike Hao, Kazuhiko Kondo, Takashi Itoh, Sumiko Ikari, Shigeyuki Nada, Masato Okada, Takeshi Noda
    • Journal Title

      J cell Science

      Volume: 131 Issue: 3 Pages: 208017-208017

    • DOI

      10.1242/jcs.208017

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structural basis for the assembly of the Ragulator-Rag GTPase complex.2017

    • Author(s)
      Yonehara R, Nada S, Nakai T, Nakai M, Kitamura A, Ogawa A, Nakatsumi H, Nakayama KI, Li S, Standley DM, Yamashita E, Nakagawa A, Okada M.
    • Journal Title

      Nat Commun.

      Volume: 8 Issue: 1 Pages: 1625-1625

    • DOI

      10.1038/s41467-017-01762-3

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Induction of intrinsic apoptosis in leukaemia stem cells and in vivo zebrafish model by betulonic acid isolated from Walsura pinnata Hassk (Meliaceae).2017

    • Author(s)
      Leong KH, Mahdzir MA, Din MF, Awang K, Tanaka Y, Kulkeaw K, Ishitani T, Sugiyama D.
    • Journal Title

      Phytomedicine

      Volume: 26 Pages: 11-21

    • DOI

      10.1016/j.phymed.2016.12.018

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Wip1 directly dephosphorylates NLK and increases Wnt activity during germ cell development.2017

    • Author(s)
      Cho SJ, Cha BS, Kwon OS, Lim J, Shin DM, Han DW, Ishitani T, Jho EH, Fornace AJ, Cha HJ.
    • Journal Title

      Biochim Biophys Acta.

      Volume: 1863 Issue: 4 Pages: 1013-1022

    • DOI

      10.1016/j.bbadis.2017.01.028

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Context-dependent regulation of the β-catenin transcriptional complex supports diverse functions of Wnt/β-catenin signaling.2017

    • Author(s)
      Masuda T, Ishitani T.
    • Journal Title

      J Biochem.

      Volume: 161 Issue: 1 Pages: 9-17

    • DOI

      10.1093/jb/mvw072

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Hippo signaling interactions with Wnt/β-catenin and Notch signaling repress liver tumorigenesis.2017

    • Author(s)
      Kim W, Khan SK, Gvozdenovic-Jeremic J, Kim Y, Dahlman J, Kim H, Park O, Ishitani T, Jho EH, Gao B, Yang Y.
    • Journal Title

      J Clin Invest.

      Volume: 127 Issue: 1 Pages: 137-152

    • DOI

      10.1172/jci88486

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals2016

    • Author(s)
      Kimura T, Nada S, Takegahara N, OkunoT, NojimaS, Kang S, Ito D, Morimoto K, Morimoto K, Hosokawa T, Hayama Y, Mitsui Y, Sakurai N, Sarashina-Kida H, Nishide M, Maeda Y, Takamatsu H, Okuzaki D, Yamada M, Okada M, Kumanogoh A.
    • Journal Title

      Nat Commun.

      Volume: 7 Issue: 1 Pages: 13130-13130

    • DOI

      10.1038/ncomms13130

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] P53- and mevalonate pathway-driven malignancies require Arf6 for metastasis and drug resistance.2016

    • Author(s)
      Hashimoto, A., Oikawa, T., Hashimoto, S., Sugino, H., Yoshikawa, A., Otsuka, Y., Handa, H., Onodera, Y., Nam, J.M., Oneyama, C., Okada, M., Fukuda M. and Sabe, H.
    • Journal Title

      J Cell Biol.

      Volume: 213 Issue: 1 Pages: 81-95

    • DOI

      10.1083/jcb.201510002

    • NAID

      120005763128

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The Rho guanine nucleotide exchange factor ARHGEF5 promotes tumor malignancy via epithelial-mesenchymal transition2016

    • Author(s)
      Komiya Y, Onodera Y, Kuroiwa M, Nomimura S, Kubo Y, Nam JM, Kajiwara K, Nada S, Oneyama C, Sabe H, Okada M.
    • Journal Title

      Oncogenesis

      Volume: 5 Issue: 9 Pages: e258-e258

    • DOI

      10.1038/oncsis.2016.59

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] miR-27b suppresses tumor progression by regulating ARFGEF1 and the focal adhesion signaling.2016

    • Author(s)
      Matsuyama, R., Okuzaki, D., Okada, M., Oneyama, C.
    • Journal Title

      Cancer Science

      Volume: 107 Issue: 1 Pages: 28-35

    • DOI

      10.1111/cas.12834

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] In vivo RNAi screen identifies NLK as a negative regulator of mesenchymal activity in glioblastoma.2015

    • Author(s)
      Sa JK, Yoon Y, Kim M, Kim Y, Cho HJ, Lee JK, Kim GS, Han S, Kim WJ, Shin YJ, Joo KM, Paddison PJ, Ishitani T, *Lee J, *Nam DH.
    • Journal Title

      Oncotarget

      Volume: 6 Issue: 24 Pages: 20145-20159

    • DOI

      10.18632/oncotarget.3980

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] mLST8 promotes mTOR-mediated tumor progression.2015

    • Author(s)
      Kakumoto, K., Ikeda, J., Okada, M., Morii, E., Oneyama, C.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 4 Pages: e0119015-e0119015

    • DOI

      10.1371/journal.pone.0119015

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fer tyrosine kinase oligomer mediates and amplifies Src-induced tumor progression2015

    • Author(s)
      Oneyama C, Yoshikawa Y, Ninomiya Y, Iino T, Tsukita S, Okada M
    • Journal Title

      Oncogene

      Volume: 35 Issue: 4 Pages: 501

    • DOI

      10.1038/onc.2015.110

    • URL

      https://pure.teikyo.jp/en/publications/5eab79ca-728b-4573-acd2-1630ccbeab92

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] MicroRNAs as the fine-tuners of Src oncogenic signaling.2015

    • Author(s)
      Oneyama, C., Okada, M.
    • Journal Title

      J Biochem

      Volume: 157 Issue: 6 Pages: 431-438

    • DOI

      10.1093/jb/mvv036

    • NAID

      40020489200

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] mLST8 promotes mTOR-mediated tumor progression.2015

    • Author(s)
      Kakumoto K, Ikeda J, Okada M, Morii E, Oneyama C
    • Journal Title

      PLos One

      Volume: 未定

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hipk2 and PP1c cooperate to maintain Dvl protein levels required for Wnt signal transduction.2014

    • Author(s)
      Shimizu N, Ishitani S, Sato A, Shibuya H, Ishitani T.
    • Journal Title

      Cell Reports

      Volume: 8 Issue: 5 Pages: 1391-1404

    • DOI

      10.1016/j.celrep.2014.07.040

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 組織の正確なパターン形成を支える、細胞競合を介したWntシグナル勾配修復機構2019

    • Author(s)
      龝枝 佑紀
    • Organizer
      Wnt研究会 2018-2019
    • Related Report
      2018 Annual Research Report
  • [Presentation] がん進展制御におけるSrcおよびmTORシグナルの役割2019

    • Author(s)
      岡田 雅人
    • Organizer
      がん進展制御研究所セミナーにて特別講演
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 膜貫通タンパク質Rsp1はHGF依存性のがん細胞の浸潤を制御する2019

    • Author(s)
      河瀬 直之、梶原 健太郎、岡田 雅人
    • Organizer
      第12回若手研究フォーラム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 魚が切り拓く疾患・老化研究2019

    • Author(s)
      石谷 太
    • Organizer
      群馬大学最先端生命科学セミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Src時空間的制御による上皮細胞層からの細胞逸脱の方向性決定2018

    • Author(s)
      梶原 健太郎、岡田 雅人
    • Organizer
      第6回がんと代謝研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ゼブラフィッシュ可視化解析により見えてきた、発生ロバストネスを支える細胞競合を介したシグナル補正機構2018

    • Author(s)
      石谷 太
    • Organizer
      第70回細胞生物学会・第51回日本発生生物学会 合同大会 NBRP サテライトワークショップ
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Oncogenic Ras and p53 mutations cooperate to prime the initial step of tumorigenesis.2018

    • Author(s)
      Yukinari Haraoka, Yuki Akieda, Tohru Ishitani
    • Organizer
      第70回細胞生物学会・第51回日本発生生物学会 合同大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] NFκB controls dorsal-ventral patterning of vertebrate embryos through negative regulation of Wnt/β-catenin signaling2018

    • Author(s)
      Juqi Zou, Satoshi Anai, Takamasa Masuda, Satoshi Ota, Tohru Ishitani
    • Organizer
      第70回細胞生物学会・第51回日本発生生物学会 合同大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Smad signaling and ROS are involved in the “noise-cancelling system” of Wnt/β-catenin signaling.2018

    • Author(s)
      Shohei Ogamino, Yuki Akieda, Jumpei Nogami, Yasuyuki Ohkawa, Tohru Ishitani
    • Organizer
      第70回細胞生物学会・第51回日本発生生物学会 合同大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ノイズキャンセリングシステム: 動物組織の正確なパターン形成を支える、細胞競合を介したシグナルノイズ除去2018

    • Author(s)
      龝枝 佑紀、小神野 翔平、石谷 太
    • Organizer
      新学術領域研究―細胞競合― 第6回領域班会議
    • Related Report
      2018 Annual Research Report
  • [Presentation] イズキャンセリングシステム: 動物組織の正確なパターン形成を支える、細胞競合を介したシグナルノイズ除去2018

    • Author(s)
      龝枝 佑紀、小神野 翔平、石谷 太
    • Organizer
      新学術領域『細胞競合』 第5回領域班会議
    • Related Report
      2018 Annual Research Report
  • [Presentation] 細胞競合によるSrc変異細胞の排除機構2018

    • Author(s)
      岡田雅人
    • Organizer
      第6回領域班会議
    • Related Report
      2018 Annual Research Report
  • [Presentation] 上皮細胞層におけるSrc活性化細胞の振る舞い2018

    • Author(s)
      梶原 健太郎、Ping-Kuan Chen、岡田 雅人
    • Organizer
      第6回領域班会議
    • Related Report
      2018 Annual Research Report
  • [Presentation] Apoptotic elimination of unfit cells shapes up the Wnt/β-catenin morphogen gradient.2018

    • Author(s)
      Tohru Ishitani
    • Organizer
      2018 International Zebrafish Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Apoptotic elimination of unfit cells shapes up the Wnt/β-catenin morphogen gradient.2018

    • Author(s)
      Tohru Ishitani
    • Organizer
      2018 Nothobranchius symposium.
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 上皮細胞層におけるSrc活性化細胞の振る舞い2018

    • Author(s)
      梶原 健太郎
    • Organizer
      第10回シグナルネットワーク研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Oncogenic Ras and p53 mutations cooperate to prime the initial step of tumorigenesis.2018

    • Author(s)
      Yukinari Haraoka, Yuki Akieda, Tohru Ishitani
    • Organizer
      International Zebrafish Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 組織変性を防ぐモルフォゲン勾配修復機構 ~魚が切り拓く疾患・老化研究~2018

    • Author(s)
      石谷 太
    • Organizer
      大阪大学微生物病研究所セミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] RasV12は変異型p53と協調して初期の腫瘍形成を促進する2018

    • Author(s)
      原岡 由喜也、龝枝 佑紀、石谷 太
    • Organizer
      第 17 回生体機能研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Mutant p53 switches the fate of senescent RasV12 cells from apical elimination to tumor priming2018

    • Author(s)
      Yukinari Haraoka, Yuki Akieda, Tohru Ishitani
    • Organizer
      National Health Research Institutes 台湾
    • Related Report
      2018 Annual Research Report
  • [Presentation] NFκB controls dorsal-ventral patterning of vertebrate embryos through negative regulation of Wnt/β-catenin signaling2018

    • Author(s)
      Juqi Zou, Satoshi Anai, Satoshi Ota, Masayuki Oginuma, Tohru Ishitani
    • Organizer
      National Health Research Institutes 台湾
    • Related Report
      2018 Annual Research Report
  • [Presentation] The short-lived African turquoise killifish: a novel model for aging2018

    • Author(s)
      Shohei Ogamino, Masayuki Oginuma, Kota Abe, Chihiro Mogi, Tohru Ishitani
    • Organizer
      National Health Research Institutes 台湾
    • Related Report
      2018 Annual Research Report
  • [Presentation] 魚で解き明かす、未知のがん初期発生機構と生体防御システム2018

    • Author(s)
      石谷 太
    • Organizer
      第13回Basic Urology Research Seminar
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] How cellular senescence causes individual aging?2018

    • Author(s)
      Shohei Ogamino, Masayuki Oginuma, Kota Abe, Chihiro Mogi, Tohru Ishitani
    • Organizer
      第24回小型魚類研究会(The 24th Japanese medaka and zebrafish meeting)
    • Related Report
      2018 Annual Research Report
  • [Presentation] Understanding homeostatic mechanism of tissue pattering during whole life2018

    • Author(s)
      Masayuki Oginuma, Shohei Ogamino, Kota Abe, Chihiro Mogi, Tohru Ishitani
    • Organizer
      第24回小型魚類研究会(The 24th Japanese medaka and zebrafish meeting)
    • Related Report
      2018 Annual Research Report
  • [Presentation] 上皮細胞層におけるSrc活性化細胞の振る舞い2018

    • Author(s)
      梶原 健太郎
    • Organizer
      新学術領域研究「数理シグナル」第2回若手ワークショップ
    • Related Report
      2018 Annual Research Report
  • [Presentation] ノイズキャンセリングシステム: 動物組織の正確なパターン形成を支える、細胞死 を介したシグナルノイズ除去2018

    • Author(s)
      石谷 太
    • Organizer
      【第91回日本生化学会大会】シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] がん発展におけるSrcチロシンキナーゼの立ち位置2018

    • Author(s)
      岡田 雅人
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] ゼブラフィッシュin vivoイメージングにより明らかになる、がん初期発生におけるがん原細胞の未知の挙動と変異蓄積の新たな意義2018

    • Author(s)
      石谷 太
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Mutant p53 switches the fate of senescent RasV12 cells from apical elimination to tumor priming.2018

    • Author(s)
      Yukinari Haraoka, Yuki Akieda, Tohru Ishitani
    • Organizer
      The 4th IMCR Symposium on Endocrine and Metabolism
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] How cellular senescence causes individual aging?2018

    • Author(s)
      Shohei Ogamino, Masayuki Oginuma, Kota Abe, Chihiro Mogi, Tohru Ishitani
    • Organizer
      The 4th IMCR Symposium on Endocrine and Metabolism
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Apoptotic elimination of unfit cells corrects noisy Wnt morphogen gradients to achieve robust patterning2018

    • Author(s)
      Yuki Akieda, Shohei Ogamino, Hironobu Furuie, Shizuka Ishitani, Ryutaro Akiyoshi, Jumpei Nogami, Yasuyuki Ohkawa, and Tohru Ishitani
    • Organizer
      IMCR Young Researcher Development Program, 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 「モルフォゲン勾配ノイズキャンセリング」: 組織の細胞配置パターンがあべこべになるのを防ぐシステム2018

    • Author(s)
      石谷 太
    • Organizer
      国立循環器病研究センター セミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 細胞競合が支える、正確なモルフォゲン勾配形成とロバストな組織パターニング2018

    • Author(s)
      石谷 太
    • Organizer
      第41回日本分子生物学会年会 シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Ras変異細胞の細胞老化による排除と、多重変異によるその破綻2018

    • Author(s)
      原岡 由喜也、龝枝 佑紀、石谷 太
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 細胞競合を介した不適応細胞の除去は正確なWntシグナル勾配とロバストなパターンの形成に必須である2018

    • Author(s)
      龝枝 佑紀、小神野 翔平、古家 博信、石谷 閑、石谷 太
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] NFκB controls dorsal-ventral patterning of vertebrate embryos through negative regulation of Wnt/β-catenin signaling2018

    • Author(s)
      Juqi Zou, Satoshi Anai, Satoshi Ota, Masayuki Oginuma, Tohru Ishitani
    • Organizer
      The 41st Annual Meeting of the Molecular Biology Society of Japan
    • Related Report
      2018 Annual Research Report
  • [Presentation] Srcの時空間的制御によるがん細胞の運命決定2018

    • Author(s)
      梶原 健太郎、Ping-Kuan Chen、岡田 雅人
    • Organizer
      第41回日本分子生物学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 「モルフォゲン勾配ノイズキャンセリング」: 組織の細胞配置パターンがあべこべになるのを防ぐシステム2018

    • Author(s)
      石谷 太
    • Organizer
      鹿児島大学セミナー
    • Related Report
      2018 Annual Research Report
  • [Presentation] Rsp1は腎臓の再生とがん進展のふたつの顔をもつ2018

    • Author(s)
      梶原 健太郎、岡田 雅人
    • Organizer
      第2回がんと代謝研究会 若手の会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ノイズキャンセリングシステム:動物組織の正確なパターン形成を支える細胞死を介したシグナルノイズ除去2018

    • Author(s)
      龝枝 佑紀、古家 博信、小神野 翔平、石谷 閑、石谷 太
    • Organizer
      新学術領域「幹細胞老化と疾患」「細胞競合」合同若手の会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ゼブラフィッシュをモデルとした、がん原細胞排除システムとその破綻2018

    • Author(s)
      原岡由喜也・穐枝佑紀・石谷太
    • Organizer
      新学術領域「幹細胞老化と疾患」「細胞競合」合同若手の会
    • Related Report
      2017 Annual Research Report
  • [Presentation] The noise-cancelling system supporting precise Wnt/β-catenin signaling-mediated vertebrate tissue patterning.2018

    • Author(s)
      Tohru Ishitani
    • Organizer
      International Symposium: Cell competition in Develeopment and Cancer
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 小型魚類イメージング解析により明らかになる、未知のがん初期発生機構2018

    • Author(s)
      石谷 太
    • Organizer
      日本薬学会第138年会 シンポジウム モデル生物が拓く“がん治療イノベーション”:創薬と診断のパラダイムシフト
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 上皮細胞層におけるSrc活性化細胞の振る舞い2018

    • Author(s)
      梶原健太郎、岡田雅人
    • Organizer
      新学術領域「幹細胞老化と疾患」「細胞競合」総括班主催「若手の会」
    • Related Report
      2017 Annual Research Report
  • [Presentation] 正常組織およびがん細胞集団内におけるSrc活性化細胞の解析2018

    • Author(s)
      大倉寛也、梶原健太郎、岡田雅人
    • Organizer
      新学術領域「幹細胞老化と疾患」「細胞競合」総括班主催「若手の会」
    • Related Report
      2017 Annual Research Report
  • [Presentation] 上皮細胞層におけるSrc活性化細胞の振る舞い2018

    • Author(s)
      梶原健太郎、Ping-Kuan Chen、岡田雅人
    • Organizer
      第7回細胞競合コロキウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] ゼブラフィッシュを用いた、がん原細胞の振る舞いのイメージング解析2017

    • Author(s)
      原岡由喜也、穐枝佑紀、古家 博信、石谷 閑、岡田 雅人、 石谷 太
    • Organizer
      第6回細胞競合コロキウム
    • Place of Presentation
      北海道大学医学部学友会館フラテ
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] 細胞競合におけるβ-catenin活性化の役割の解析2017

    • Author(s)
      河瀬直之、梶原健太郎、石谷太、岡田雅人
    • Organizer
      第6回細胞競合コロキウム
    • Place of Presentation
      北海道大学医学部学友会館フラテ
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] Cell Competition between normal and Src transformed cells2017

    • Author(s)
      Ping-Kuan Chen、北野圭介、梶原健太郎、岡田雅人
    • Organizer
      第6回細胞競合コロキウム
    • Place of Presentation
      北海道大学医学部学友会館フラテ
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] シグナル可視化解析から明らかになる、新たな組織構築システム2017

    • Author(s)
      石谷 太
    • Organizer
      神戸大学医学部セミナー
    • Place of Presentation
      神戸大学医学部
    • Year and Date
      2017-03-03
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 脊椎動物の胚発生を支える、モルフォゲンシグナルのノイズ除去システム2017

    • Author(s)
      古家 博信、穐枝佑紀、石谷 太
    • Organizer
      細胞競合・ダイイングコード合同若手WS
    • Place of Presentation
      ホテルコスモスクエア国際交流センター
    • Year and Date
      2017-01-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] Analysis of Src activated cells within the cancer cell population2017

    • Author(s)
      大倉寛也、梶原健太郎、岡田雅人
    • Organizer
      細胞競合・ダイイングコード合同若手WS
    • Place of Presentation
      ホテルコスモスクエア国際交流センター
    • Year and Date
      2017-01-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] ゼブラフィッシュをモデルとした、がん原性細胞排除システムの解析2017

    • Author(s)
      原岡由喜也、穐枝佑紀、古家 博信、石谷 閑、岡田 雅人、 石谷 太
    • Organizer
      細胞競合・ダイイングコード合同若手WS
    • Place of Presentation
      ホテルコスモスクエア国際交流センター
    • Year and Date
      2017-01-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] Cellular competition in MDCK with induced Src activation2017

    • Author(s)
      Ping-Kuan Chen、北野圭介、梶原健太郎、岡田雅人
    • Organizer
      細胞競合・ダイイングコード合同若手WS
    • Place of Presentation
      ホテルコスモスクエア国際交流センター
    • Year and Date
      2017-01-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] ノイズキャンセリングシステム:動物組織の正確なパターン形成を支える、細胞競合を介したシグナルノイズ除去2017

    • Author(s)
      龝枝 佑紀・古家 博信・石谷 閑・石谷 太
    • Organizer
      第69回日本細胞生物学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Cell competition supports robustness of embryonic patterning: a new system correcting distortion of the Wnt/β-catenin signaling activity gradient2017

    • Author(s)
      Tohru Ishitani
    • Organizer
      Japanese Society ofDevelopmental Biologists 50th
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] The noise-cancelling system supporting precise Wnt/β-catenin signaling-mediated vertebrate tissue patterning.2017

    • Author(s)
      Tohru Ishitani
    • Organizer
      International Symposium of Cell Competition
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The noise-cancelling system supporting precise Wnt/β-catenin signaling-mediated vertebrate tissue patterning2017

    • Author(s)
      Tohru Ishitani
    • Organizer
      Gordon Research Conference Wnt signaling
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In vivo imaging analysis of the initial tumorigenic processes using zebrafish.2017

    • Author(s)
      原岡由喜也・穐枝佑紀・・石谷太
    • Organizer
      International Symposium of Cell Competition
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 動物組織の前後軸パターンニングを支えるWnt シグナルノイズシグナルノイズキャンセリングシステムの分子実体の解析2017

    • Author(s)
      小神野翔平・龝枝佑紀・野上順平・大川恭行・石谷太
    • Organizer
      Conbio2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] ゼブラフィッシュin vivoイメージングを用いた、がんの初期発生過程の解析2017

    • Author(s)
      原岡由喜也・穐枝佑紀・石谷太
    • Organizer
      Conbio2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] The noise-cancelling system supporting precise Wnt/β-catenin signaling-mediated vertebrate tissue patterning.2017

    • Author(s)
      Tohru Ishitani
    • Organizer
      Conbio2017
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 緑内障とSrc2017

    • Author(s)
      塚本晃久、岡田雅人
    • Organizer
      第9回シグナルネットワーク研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 上皮細胞の形態形成における活性化Srcの時空間的制御2017

    • Author(s)
      梶原健太郎、岡田雅人
    • Organizer
      第69回日本細胞生物学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] mTORC1栄養シグナル制御の分子基盤解析2017

    • Author(s)
      岡田雅人
    • Organizer
      「数理シグナル」領域推進会議
    • Related Report
      2017 Annual Research Report
  • [Presentation] Analysis of the role of β-catenin activity in mammalian cell competition2017

    • Author(s)
      河瀬直之、梶原健太郎、石谷太、岡田雅人
    • Organizer
      3rd International Symposium on Cell Competition “Cell Competition in Development and Cancer”
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cell competition between normal and Src transformed cells2017

    • Author(s)
      Ping-Kuan Chen, Kentaro Kajiwara, Keisuke Kitano, Masato Okada
    • Organizer
      3rd International Symposium on Cell Competition “Cell Competition in Development and Cancer
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 上皮形態形成における活性化Srcの時空間的制御2017

    • Author(s)
      梶原健太郎
    • Organizer
      第9回若手研究フォーラム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 上皮形態形成における活性化Srcの時空間的制御2017

    • Author(s)
      梶原健太郎、松本邦夫、岡田雅人
    • Organizer
      金沢大学がん進展制御研究所 共同利用・共同研究拠点シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Src活性化による細胞競合現象2017

    • Author(s)
      梶原健太郎、大倉寛也、河瀬直之、Ping-Kuan Chen、岡田雅人
    • Organizer
      Conbio2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 上皮形態形成における活性化Srcの時空間的制御2017

    • Author(s)
      梶原健太郎、松本邦夫、岡田雅人
    • Organizer
      Conbio2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] Identification of new target proteins involved in Src-mediated tumor progression2017

    • Author(s)
      Shuchismita Basu、梶原健太郎、阿部雄一、朝長毅、岡田雅人
    • Organizer
      Conbio2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 小胞膜輸送を介したがん原遺伝子産物Srcの制御機構2017

    • Author(s)
      田中健太郎、阿部雄一、梶原健太郎、名田茂之、岡田雅人
    • Organizer
      Conbio2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] The structural basis for the assembly of the Ragulato-RagGTPase complex2017

    • Author(s)
      中井 昌弘、米原 涼、名田 茂之、中井 友和、北村 彩佳、小川 輝、山下 栄樹、中山 敬一、中津海 洋一、中川 敦史、岡田 雅人
    • Organizer
      Conbio2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] がん進展におけるSrc局在化タンパク質とc-Metの機能解析2017

    • Author(s)
      杉原充哉、梶原健太郎、松本邦夫、岡田雅人
    • Organizer
      Conbio2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] がん細胞集団内におけるSrc活性化細胞の解析2017

    • Author(s)
      大倉寛也、梶原健太郎、岡田雅人
    • Organizer
      Conbio2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] ゼブラフィッシュをモデルとした、がん原性細胞排除システムの解析2016

    • Author(s)
      原岡 由喜也、龝枝 佑紀, 古家 博信, 石谷 太
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-12-01
    • Related Report
      2016 Annual Research Report
  • [Presentation] Analysis of Src activated cells within the cancer cell population2016

    • Author(s)
      大倉寛也、梶原健太郎、石谷太、藤田恭之、岡田雅人
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-12-01
    • Related Report
      2016 Annual Research Report
  • [Presentation] Cell competition supports robustness of embryonic patterning: a new system correcting distortion of the Wnt/β-catenin signaling activity gradient.2016

    • Author(s)
      Tohru Ishitani
    • Organizer
      第39回日本分子生物学会年会 指定シンポジウム「細胞競合が切り拓く新たな概念・領域」
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ゼブラフィッシュを用いた、動物初期胚における細胞死の動態解析2016

    • Author(s)
      龝枝 佑紀, 古家 博信, 石谷 太
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 発生ロバストネスを支えるWnt/β-cateninシグナルの活性パターンの補正システム2016

    • Author(s)
      古家 博信, 石谷 太
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] Identification of new target proteins involved in Src-mediated tumor progression2016

    • Author(s)
      Shuchismita Basu、梶原健太郎、阿部雄一、朝長毅、岡田雅人
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] Apoptosis-mediated elimination of "Wnt/β-catenin signaling noise" supports precise embryonic patterning2016

    • Author(s)
      Yuki Akieda, Tohru Ishitani
    • Organizer
      The 26th Hot Spring Harbor International Symposium -Trans-Omics: New Approaches in Biology and Medicine
    • Place of Presentation
      九州大学
    • Year and Date
      2016-11-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cell competition corrects distortion of the Wnt/β-catenin signaling activity gradient in vertebrate embryonic patterning2016

    • Author(s)
      Tohru Ishitani
    • Organizer
      International Symposium Cell competition, apoptosis, cancer
    • Place of Presentation
      Madrid
    • Year and Date
      2016-10-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Apoptotic elimination of cells lacking the harmony of Wnt/β-catenin signaling.2016

    • Author(s)
      Tohru Ishitani
    • Organizer
      発生生物学会 秋季シンポジウム
    • Place of Presentation
      三島市
    • Year and Date
      2016-10-19
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Immune cell-independent defense system against Wnt signaling-hyperactivation in animal tissues.2016

    • Author(s)
      Tohru Ishitani
    • Organizer
      ZDM9
    • Place of Presentation
      マリーナベイサンズ、シンガポール
    • Year and Date
      2016-10-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cells with unfit levels of β-catenin are actively eliminated from animal tissues to make certain of Wnt/β-catenin signaling-mediated morphogenesis.2016

    • Author(s)
      Tohru Ishitani
    • Organizer
      the 7th Asia Oceania Zebrafish Meeting
    • Place of Presentation
      シンガポール国立大学
    • Year and Date
      2016-10-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Unfit cells with abnormal levels of β-catenin are actively eliminated from animal tissues to make certain of Wnt/β-catenin signaling-mediated morphogenesis.2016

    • Author(s)
      Yuki Akieda, Hironobu Furuie, Tohru Ishitani
    • Organizer
      EMBO conference Wnt meeting 2016
    • Place of Presentation
      マサリク大学、チェコ
    • Year and Date
      2016-09-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 組織中のWnt/β-cateninシグナルの活性パターンの”乱れ”を補正するシステム2016

    • Author(s)
      龝枝 佑紀, 古家 博信, 石谷 太
    • Organizer
      第4回新学術領域「細胞競合」班会議
    • Place of Presentation
      東京大学薬学部
    • Year and Date
      2016-08-31
    • Related Report
      2016 Annual Research Report
  • [Presentation] Srcによる細胞競合2016

    • Author(s)
      岡田雅人
    • Organizer
      第4回新学術領域「細胞競合」班会議
    • Place of Presentation
      東京大学薬学部
    • Year and Date
      2016-08-31
    • Related Report
      2016 Annual Research Report
  • [Presentation] がん細胞集団内におけるSrc活性化細胞の逸脱現象の解析2016

    • Author(s)
      大倉寛也、梶原健太郎、岡田雅人
    • Organizer
      第4回新学術領域「細胞競合」班会議
    • Place of Presentation
      東京大学薬学部
    • Year and Date
      2016-08-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 正常細胞と異常細胞のせめぎ合い ~イメージング解析から明らかになる細胞の社会性~2016

    • Author(s)
      石谷 太
    • Organizer
      国立がん研究センター セミナー
    • Place of Presentation
      国立がん研究センター
    • Year and Date
      2016-08-29
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 動物のからだを作り維持する、形態形成シグナルとその制御システム ~小型魚類イメージング解析から明らかになる意外な細胞間連携~2016

    • Author(s)
      石谷 太
    • Organizer
      東京大学薬学部セミナー
    • Place of Presentation
      東京大学薬学部
    • Year and Date
      2016-07-25
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Immune cell-independent elimination of signaling-perturbed cells supports robustness of early vertebrate embryogenesis2016

    • Author(s)
      石谷 太
    • Organizer
      the 12th International Conference on Zebrafish Development and Genetics
    • Place of Presentation
      オーランド
    • Year and Date
      2016-07-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 動物組織は、Wntシグナル異常活性化細胞を免疫細胞非依存的に排除するシステムを備えている2016

    • Author(s)
      龝枝 佑紀, 古家 博信, 石谷 太
    • Organizer
      第68回日本細胞生物学会大会
    • Place of Presentation
      京都テルサ
    • Year and Date
      2016-06-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] ゼブラフィッシュをモデルとした、がん原性細胞排除システムの解析2016

    • Author(s)
      龝枝 佑紀, 古家 博信, 石谷 太
    • Organizer
      第68回日本細胞生物学会大会
    • Place of Presentation
      京都テルサ
    • Year and Date
      2016-06-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] Immune cell-independent elimination of signaling-perturbed cells supports robustness of early vertebrate embryogenesis2016

    • Author(s)
      石谷 太
    • Organizer
      JSDB Special Symposium: Frontier of Developmental Biology Hosted by JSDB
    • Place of Presentation
      東京大学
    • Year and Date
      2016-06-02
    • Related Report
      2016 Annual Research Report
  • [Presentation] 正常およびがん組織におけるSrc活性化細胞の振る舞い2016

    • Author(s)
      大倉寛也、梶原健太郎、岡田雅人
    • Organizer
      第8回シグナルネットワーク研究会
    • Place of Presentation
      谷口記念講堂
    • Year and Date
      2016-05-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] Cell competition-mediated elimination of signaling-perturbed cells supports robustness of early vertebrate embryogenesis2016

    • Author(s)
      石谷 太
    • Organizer
      2nd Cell Competition International Symposium
    • Place of Presentation
      京都大学
    • Year and Date
      2016-04-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ゼブラフィッシュにおける、細胞競合を介したシグナル異常上皮細胞の排除2016

    • Author(s)
      Yuki Akieda, Furuie Akinobu, Shizuka Ishitani, Tohru Ishitani
    • Organizer
      細胞競合コロキウム
    • Place of Presentation
      北海道大学遺伝性制御研究所
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] ゼブラフィッシュ初期胚で起こるランダムな細胞死の解析2016

    • Author(s)
      古家博信, 石谷 太
    • Organizer
      細胞競合コロキウム
    • Place of Presentation
      北海道大学遺伝性制御研究所
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] c-Srcによって引き起こされる細胞競合機構の解析2016

    • Author(s)
      北野圭介、梶原健太郎、名田茂之、岡田雅人
    • Organizer
      第5回細胞競合コロキウム
    • Place of Presentation
      北海道大学
    • Year and Date
      2016-03-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] がん細胞集団内におけるSrc活性化細胞の逸脱現象の解析2016

    • Author(s)
      大倉寛也、梶原健太郎、岡田雅人
    • Organizer
      第5回細胞競合コロキウム
    • Place of Presentation
      北海道大学
    • Year and Date
      2016-03-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] Ubiquitin-mediated NF-κB degradation directs dorsal-ventral patterning in vertebrate early embryo.2016

    • Author(s)
      Tohru Ishitani, Satoshi Anai, Shizuka Ishitani, Satoshi Ota
    • Organizer
      Keystone Symposia Ubiquitin Signaling
    • Place of Presentation
      Whistler Conference Centre
    • Year and Date
      2016-03-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ゼブラフィッシュ稚魚の皮膚を用いた、がん原細胞の挙動解析2016

    • Author(s)
      石谷太
    • Organizer
      第4回 皮膚の会
    • Place of Presentation
      淡路夢舞台国際会議場
    • Year and Date
      2016-03-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] 動物組織構築を支えるシグナル制御機構の理解を目指して2016

    • Author(s)
      石谷太
    • Organizer
      大阪大学微研セミナー
    • Place of Presentation
      大阪大学微生物学研究所
    • Year and Date
      2016-03-04
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 上皮細胞の形態形成におけるSrc活性化の時空間的制御2016

    • Author(s)
      梶原健太郎、岡田雅人
    • Organizer
      蛋白研セミナーMechanism of Biology on the Membrane生体膜上の生物化学
    • Place of Presentation
      ホテル阪急エキスポパーク
    • Year and Date
      2016-03-03
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Molecular systems that control Wnt/β-catenin signaling during animal tissue development and homeostasis.2016

    • Author(s)
      Tohru Ishitani
    • Organizer
      Seminar
    • Place of Presentation
      Universiti of Malaya, Kuala Lumpur, Malaysia
    • Year and Date
      2016-02-25
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Molecular systems that control Wnt/β-catenin signaling during animal tissue development and homeostasis.2016

    • Author(s)
      Tohru Ishitani
    • Organizer
      Seminar
    • Place of Presentation
      Universiti Putra Malaysia, Selangor, Malaysia
    • Year and Date
      2016-02-24
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] マウス表皮におけるmTORC1シグナルの機能2015

    • Author(s)
      名田茂之、名田真理、長江(相馬)多恵子、北川真理、森俊介、高橋佑介、岡田雅人
    • Organizer
      BMB2015
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2015-12-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] Arhgef5 is upregulated during TGF-β induced epithelial-mesenchymal transition and promotes tumor progression2015

    • Author(s)
      小宮優、呑村優、小野寺康人、黒岩美穂、名田茂之、岡田雅人
    • Organizer
      BMB2015
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2015-12-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] ゼブラフィッシュにおける、細胞競合を介したシグナル異常上皮細胞の排除2015

    • Author(s)
      Yuki Akieda, Furuie Akinobu, Shizuka Ishitani, Tohru Ishitani
    • Organizer
      BMB2015
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2015-12-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] in vivoイメージングを用いた、細胞競合によるがん原性細胞排除システムの解析2015

    • Author(s)
      Yuki Akieda, Furuie Akinobu, Masato Okada, Tohru Ishitani
    • Organizer
      BMB2015
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2015-12-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] TGF-β依存的な上皮間葉転換に伴うSrcの発現誘導2015

    • Author(s)
      久保祐貴、小宮優、梶原健太郎、岡田雅人
    • Organizer
      BMB2015
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2015-12-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] Analysis of interaction between Src-activated cells and normal cells2015

    • Author(s)
      大野理沙、北野圭介、梶原健太郎、岡田雅人
    • Organizer
      BMB2015
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2015-12-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] Srcによって誘導される細胞競合のin vivo解析2015

    • Author(s)
      北野圭介、名田茂之、岡田雅人
    • Organizer
      BMB2015
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] The activation mechanism of ARHGEF5 during tumor progression2015

    • Author(s)
      Choo Jun Jie、小宮優、呑村優、岡田雅人
    • Organizer
      BMB2015
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Analysis of Src-induced cell competition in cancer cells2015

    • Author(s)
      大倉寛也、梶原健太郎、石谷太、藤田恭之、岡田雅人
    • Organizer
      BMB2015
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 動物組織の構築・維持を支えるWnt⁄β-cateninシグナル制御機構2015

    • Author(s)
      石谷太
    • Organizer
      難治疾患共同研究拠点シンポジウム
    • Place of Presentation
      東京医科歯科大学
    • Year and Date
      2015-11-26
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Defense systems against cancer in animal tissues2015

    • Author(s)
      Tohru Ishitani
    • Organizer
      国立遺伝学研究所研究会
    • Place of Presentation
      国立遺伝学研究所
    • Year and Date
      2015-11-25
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Cell competition-mediated elimination of signaling-defective epithelial cells in zebrafish2015

    • Author(s)
      Tohru Ishitani
    • Organizer
      1st International Symposium on Cell Competition, Cell Competition in Development and Cancer,
    • Place of Presentation
      京都大学
    • Year and Date
      2015-09-10
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Analysis of interaction between Src-activated cells and normal cells2015

    • Author(s)
      大野理沙、北野圭介、梶原健太郎、岡田雅人
    • Organizer
      1st International Symposium on Cell Competition, Cell Competition in Development and Cancer
    • Place of Presentation
      京都大学芝蘭会館
    • Year and Date
      2015-09-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] Wntシグナルの転写因子TCF4の細胞間連携依存的な分解機構2015

    • Author(s)
      Tohru Ishitani, Megumi Sakuma, Shizuka Ishitani
    • Organizer
      第67回日本細胞生物学会大会
    • Place of Presentation
      タワーホール船堀
    • Year and Date
      2015-07-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Arhgef5は浸潤・増殖を制御し、がんの悪性化に寄与する2015

    • Author(s)
      小宮優、岡田雅
    • Organizer
      第7回シグナルネットワーク研究会
    • Place of Presentation
      沖縄科学技術大学院大学(OIST)
    • Year and Date
      2015-06-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] c-Src活性化による細胞競合モデルマウスの作製2015

    • Author(s)
      北野圭介、名田茂之、岡田雅人
    • Organizer
      平成26年度細胞競合コロキウム
    • Place of Presentation
      北海道大学
    • Year and Date
      2015-03-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Spatiotemporal regulation of Src in epithelial morphogenesis2015

    • Author(s)
      Kentaro Kajiwara, Masato Okada
    • Organizer
      新学術領域研究「修飾シグナル病」第2回国際シンポジウム Protein modifications in pathogenic dysregulation of signaling
    • Place of Presentation
      東京大学医科学研究所
    • Year and Date
      2015-01-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] Wnt/β-cateninシグナルが異常活性化した“がん原性細胞”の挙動解析2015

    • Author(s)
      佐久間 恵、石谷 太
    • Organizer
      第2回新学術領域「細胞競合」研究会議
    • Place of Presentation
      門司港ホテル, 北九州市
    • Year and Date
      2015-01-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Srcによる細胞競合の意義と分子機序解明に向けて2015

    • Author(s)
      岡田 雅人、北野 圭介、大野 理沙、梶原 健太郎、名田 茂之
    • Organizer
      第2回新学術領域「細胞競合」研究会議
    • Place of Presentation
      門司港ホテル, 北九州市
    • Year and Date
      2015-01-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 動物組織の構築・維持を支えるWntシグナルの状況依存的制御2015

    • Author(s)
      石谷 太、清水 誠之、佐久間 恵、石谷 閑
    • Organizer
      第2回新学術領域「細胞競合」研究会議
    • Place of Presentation
      門司港ホテル, 北九州市
    • Year and Date
      2015-01-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Src活性化による上皮細胞の形態変化2015

    • Author(s)
      梶原 健太郎、岡田 雅人
    • Organizer
      第2回新学術領域「細胞競合」研究会議
    • Place of Presentation
      門司港ホテル, 北九州市
    • Year and Date
      2015-01-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] c-Src活性化による細胞競合モデルマウスの作製2015

    • Author(s)
      北野 圭介、名田 茂之、梶原 健太郎、岡田 雅人
    • Organizer
      第2回新学術領域「細胞競合」研究会議
    • Place of Presentation
      門司港ホテル, 北九州市
    • Year and Date
      2015-01-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 上皮細胞の形態形成におけるSrc活性化の時空間的制御2015

    • Author(s)
      梶原健太郎、岡田雅人
    • Organizer
      分子病態医学セミナー
    • Place of Presentation
      愛媛大学大学院医学系研究科
    • Year and Date
      2015-01-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] マウス表皮の正常な発達はリソソーム膜アダプタータンパク質p18に依存している2014

    • Author(s)
      名田真里、名田 茂之、長江 多恵子、森 俊介、岡田 雅人
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 細胞間の協調によるWnt/βカテニンシグナルの制御2014

    • Author(s)
      清水 誠之、石谷 閑、佐久間 恵、石谷 太
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] がん進展におけるEphexin family Rho GEFの機能解析2014

    • Author(s)
      小宮優、呑村優、名田茂之、小根山千歳、岡田雅人
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Function and molecular architecture of the lysosomal mTORC1 anchor: Ragulator2014

    • Author(s)
      Masato Okada, Ayaka Kitamura, Shunsuke Mori, Shigeyuki Nada, Tomokazu Nakai, Hirokazu Nakatsumi, Keiichi I. Nakayama
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Hipk2 and PP1c cooperate to maintain Dvl protein levels required for Wnt signal transduction2014

    • Author(s)
      清水 誠之、石谷 閑、石谷 太
    • Organizer
      第87回日本生化学会大会 シンポジウム
    • Place of Presentation
      京都国際会館
    • Year and Date
      2014-10-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Hipk2 and PP1c-mediated dephosphorylation of Dishevelled sustains Wnt signal transduction2014

    • Author(s)
      Nobuyuki Shimizu, Shizuka Ishitani, Tohru Ishitani
    • Organizer
      EMBO Workshop on Wnt signalling: Stem cells | Development | Disease
    • Place of Presentation
      Blue Seas Resort, Australia
    • Year and Date
      2014-10-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] New mechanisms that regulate Wnt⁄β-catenin signaling and their potential roles in cancer2014

    • Author(s)
      Tohru Ishitani
    • Organizer
      第73回日本癌学会総会 シンポジウム
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] A new system for investigating the function and regulation of cell competition in vivo using zebrafish2014

    • Author(s)
      Megumi Sakuma, Tohru Ishitani
    • Organizer
      第20回小型魚類研究会
    • Place of Presentation
      慶応大学
    • Year and Date
      2014-09-20
    • Related Report
      2014 Annual Research Report
  • [Remarks] http://signal-system.imcr.gunma-u.ac.jp/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 研究室ホームページ

    • URL

      http://www.bioreg.kyushu-u.ac.jp/labo/crs/top.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 石谷研究室のホームページ

    • URL

      http://www.bioreg.kyushu-u.ac.jp/labo/crs/top.html

    • Related Report
      2014 Annual Research Report
  • [Funded Workshop] 第39回日本分子生物学会年会 公募シンポジウム「Wntシグナル:私たちのからだを作る・支えるユーティリティプレイヤー」2016

    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2016 Annual Research Report

URL: 

Published: 2014-11-20   Modified: 2022-02-07  

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