|Budget Amount *help
¥163,930,000 (Direct Cost: ¥126,100,000、Indirect Cost: ¥37,830,000)
Fiscal Year 2018: ¥28,470,000 (Direct Cost: ¥21,900,000、Indirect Cost: ¥6,570,000)
Fiscal Year 2017: ¥28,470,000 (Direct Cost: ¥21,900,000、Indirect Cost: ¥6,570,000)
Fiscal Year 2016: ¥28,470,000 (Direct Cost: ¥21,900,000、Indirect Cost: ¥6,570,000)
Fiscal Year 2015: ¥28,340,000 (Direct Cost: ¥21,800,000、Indirect Cost: ¥6,540,000)
Fiscal Year 2014: ¥50,180,000 (Direct Cost: ¥38,600,000、Indirect Cost: ¥11,580,000)
|Outline of Final Research Achievements
In this study, we have tried to make clear the mechanisms of Src- and Wnt signaling-driven cell competition and their roles in physiological development and tumor progression. We firstly succeeded to establish the in vivo imaging systems for cell competition processes in zebrafish. Using this, we revealed that Wnt signaling-driven cell competition supports developmental robustness. Wnt signaling-driven cell competition senses and eliminates accidentally generated defective cells during zebrafish embryos, whereas inhibition of the cell competition induces the distortion of embryonic patterning.
On the other hand, we discovered that Src-activated cells are basally extruded from MDCK-I cell sheet, whereas, they are basally extruded from MDCK-II cell sheet. We also made clear part of the mechanisms underlying this difference.