|Budget Amount *help
¥127,530,000 (Direct Cost: ¥98,100,000、Indirect Cost: ¥29,430,000)
Fiscal Year 2018: ¥24,700,000 (Direct Cost: ¥19,000,000、Indirect Cost: ¥5,700,000)
Fiscal Year 2017: ¥24,570,000 (Direct Cost: ¥18,900,000、Indirect Cost: ¥5,670,000)
Fiscal Year 2016: ¥24,700,000 (Direct Cost: ¥19,000,000、Indirect Cost: ¥5,700,000)
Fiscal Year 2015: ¥24,570,000 (Direct Cost: ¥18,900,000、Indirect Cost: ¥5,670,000)
Fiscal Year 2014: ¥28,990,000 (Direct Cost: ¥22,300,000、Indirect Cost: ¥6,690,000)
|Outline of Final Research Achievements
Sever cell and tissue damages are observed in lung, kidney, skin, and blood vessels of a-klotho deficient mouse in association with the occurrence of multiple aging related disorders.
We found that increased stem cell growth and followed exhaustion of stem cells were induced to compensate sever cell and tissue damages. We next analyzed metabolic abnormalities and great activation of calpain-1 observed in a-klotho deficient mouse caused cell and tissue damages and followed compensatory responses of stem cells. In addition, we analyzed the abnormality of NAD metabolism in a-klotho deficient mouse and discovered the remarkable acceleration of secondary (usually minor) pathway of NAD metabolism.