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Membrane topogenesis and quality control of tail-anchored proteins (TAs)

Planned Research

Project AreaNascent-chain Biology
Project/Area Number 26116007
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKyushu University

Principal Investigator

Fujiki Yukio  九州大学, 生体防御医学研究所, 特任教授 (70261237)

Co-Investigator(Kenkyū-buntansha) 田村 茂彦  九州大学, 基幹教育院, 教授 (90236753)
Research Collaborator OKUMOTO kanji  九州大学, 理学研究院
HONSHO masanori  九州大学, 生体防御医学研究所
Project Period (FY) 2014-07-10 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥109,200,000 (Direct Cost: ¥84,000,000、Indirect Cost: ¥25,200,000)
Fiscal Year 2018: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2017: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2016: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2015: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2014: ¥33,410,000 (Direct Cost: ¥25,700,000、Indirect Cost: ¥7,710,000)
Keywords新生鎖 / テイルアンカー型タンパク質 / オルガネラ選別輸送 / 膜挿入機構 / 品質管理機構 / オルガネラ恒常性 / 酸化ストレス応答 / オルガネラへの選別輸送 / オルガネラ / 機能発現制御 / 蛋白質 / 脂質 / 脳神経疾患
Outline of Final Research Achievements

Peroxisome homeostasis involving regulation of the number and metabolic functions is maintained by coordinating biogenesis, division, and degradation. Tail-anchored (TA) proteins localized by a single C-terminal transmembrane domain are found in all cellular membranes. Peroxisomal TAs were investigated in this research. A number of outcomes include 1) TA proteins to peroxisomes are targeted via the Pex19p- and Pex3p-dependent Class-I pathway. 2) VDAC2 was identified as restoring ZP114, a CHO cell mutant lacking peroxisome. We also discovered that the catalase released from peroxisomes via BAK pore eliminates H2O2, a toxic and major causative of the oxidative stress, in the cytosol for cell survival. 3) We discovered that the 17-kDa nucleoside diphosphate kinase-like protein, DYNAMO1, locally generates GTP in mitochondrial division and peroxisome-dividing machineries. These outstanding contributions to organelle homeostasis in molecular cell biology are highly appreciated.

Academic Significance and Societal Importance of the Research Achievements

細胞機能の発現は、新生タンパク質の細胞内小器官への選別輸送・局在化により実現される。TA膜タンパク質は細胞総膜タンパク質の3~5%を占め300~400種が存在、物質輸送や細胞内情報伝達などの生命活動を担う。本研究では、ペルオキシソームTAの膜標的化とペルオキシソーム機能制御の分子機構解明に取り組んだ。代表的成果として、細胞死因子BAKによる細胞死防御戦略の発見、ペルオキシソームやミトコンドリアの分裂に必須なGTP供給因子Dynamo1の発見がある。多くの新知見は他のオルガネラ局在性TA輸送だけでなく、オルガネラ膜タンパク質や可溶性タンパク質の輸送・品質管理機構の解明に大きな波及効果を有する。

Report

(6 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report

Research Products

(136 results)

All 2019 2018 2017 2016 2015 2014 Other

All Int'l Joint Research (2 results) Journal Article (35 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 35 results,  Open Access: 22 results,  Acknowledgement Compliant: 20 results) Presentation (79 results) (of which Int'l Joint Research: 24 results,  Invited: 13 results) Book (18 results) Remarks (2 results)

  • [Int'l Joint Research] Columbia大学/Stanford大学(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Wien医科大学(オーストリア)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Dynamics of the nucleoside diphosphate kinase protein DYNAMO2 correlates with the changes in the global GTP level during the cell cycle of <i>Cyanidioschyzon merolae</i>2019

    • Author(s)
      Imoto, Y., Abe, Y., Okumoto, K., Ohnuma, M., Kuroiwa, H., Kuroiwa, T., and Fujiki, Y.
    • Journal Title

      Proceedings of the Japan Academy, Series B

      Volume: 95 Issue: 2 Pages: 75-85

    • DOI

      10.2183/pjab.95.007

    • NAID

      130007591938

    • ISSN
      0386-2208, 1349-2896
    • Year and Date
      2019-02-08
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Peroxisomes control mitochondrial dynamics and the mitochondrion-dependent pathway of apoptosis.2019

    • Author(s)
      Tanaka, H., *Okazaki, T., Aoyama, S., Yokota, M., Koike, M., Okada, Y., Fujiki, Y., and Gotoh, Y.
    • Journal Title

      J. Cell Sci.

      Volume: -

    • DOI

      10.1242/jcs.224766

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A newly identified mutation in the PEX26 gene is associated with a milder form of Zellweger spectrum disorder.2019

    • Author(s)
      Tanaka, A. J., Okumoto, K., Tamura, S., Abe, Y., Hirsch, Y., Deng, L., Ekstein, J., Chung, W. K., and Fujiki Y.
    • Journal Title

      Cold Spring Harb. Mol. Case Stud.

      Volume: 5 Issue: 1 Pages: 1-16

    • DOI

      10.1101/mcs.a003483

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The cytosolic peroxisome-targeting signal (PTS)-receptors, Pex7p and Pex5pL, are sufficient to transport PTS2 proteins to peroxisomes2019

    • Author(s)
      Mukai Satoru、Matsuzaki Takashi、Fujiki Yukio
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

      Volume: 1866 Issue: 3 Pages: 441-449

    • DOI

      10.1016/j.bbamcr.2018.10.006

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regulation of peroxisome homeostasis and functions2018

    • Author(s)
      本庄 雅則、藤木 幸夫
    • Journal Title

      生化学

      Volume: 90 Issue: 1 Pages: 5-13

    • DOI

      10.14952/SEIKAGAKU.2018.900005

    • ISSN
      0037-1017
    • Year and Date
      2018-02-25
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Onsite GTP fuelling via DYNAMO1 drives division of mitochondria and peroxisomes2018

    • Author(s)
      Imoto Yuuta、Abe Yuichi、Honsho Masanori、Okumoto Kanji、Ohnuma Mio、Kuroiwa Haruko、Kuroiwa Tsuneyoshi、Fujiki Yukio
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 1-12

    • DOI

      10.1038/s41467-018-07009-z

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Peroxisome biogenesis deficiency attenuates the BDNF-TrkB pathway-mediated development of the cerebellum2018

    • Author(s)
      Abe Yuichi、Honsho Masanori、Itoh Ryota、Kawaguchi Ryoko、Fujitani Masashi、Fujiwara Kazushirou、Hirokane Masaaki、Matsuzaki Takashi、Nakayama Keiko、Ohgi Ryohei、Marutani Toshihiro、Nakayama Keiichi I、Yamashita Toshihide、Fujiki Yukio
    • Journal Title

      Life Science Alliance

      Volume: 1 Issue: 6 Pages: 1-17

    • DOI

      10.26508/lsa.201800062

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A newly isolated Pex7-binding, atypical PTS2 protein P7BP2 is a novel dynein-type AAA+ protein.2018

    • Author(s)
      Niwa, H., Miyauchi-Nanri, Y., Okumoto, K., Mukai, S., Noi, K., Ogura, T., and Fujiki Y.
    • Journal Title

      J. Biochem.

      Volume: 164 Pages: 437-447

    • DOI

      10.1093/jb/mvy073

    • NAID

      40021789527

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] New splicing variants of mitochondrial Rho GTPase-1 (Miro1) transport peroxisomes.2018

    • Author(s)
      Okumoto, K., Ono, T., Toyama, R., Shimomura, A., Nagata, A., and Fujiki Y.
    • Journal Title

      J. Cell Biol.

      Volume: 217 Issue: 2 Pages: 619-633

    • DOI

      10.1083/jcb.201708122

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reduction of ether-type glycerophospholipids, plasmalogens, by NF-κB signal leading to microglial activation2017

    • Author(s)
      Hossain, Md. S., Abe, Y., Ali, F., Youssef, M., Honsho, M., Fujiki, Y., and *Katafuchi, T.
    • Journal Title

      J. Neurosci.

      Volume: 37 Issue: 15 Pages: 4074-4092

    • DOI

      10.1523/jneurosci.3941-15.2017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] BAK regulates catalase release from peroxisomes.2017

    • Author(s)
      *Fujiki, Y., Miyata, N., Mukai, S., Okumoto, K., Cheng, E. H.
    • Journal Title

      Mol. Cell. Oncol.

      Volume: - Issue: 3 Pages: e1306610-e1306610

    • DOI

      10.1080/23723556.2017.1306610

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Functional complementation(version 3.0).2017

    • Author(s)
      *Fujiki, Y.
    • Journal Title

      Encyclopedia of Life Sciences

      Volume: - Pages: 1-6

    • DOI

      10.1002/9780470015902.a0005676.pub3

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Plasmalogen homeostasis - regulation of plasmalogen biosynthesis and its physiological consequence in mammals2017

    • Author(s)
      Honsho Masanori、Fujiki Yukio
    • Journal Title

      FEBS Letters

      Volume: 591 Issue: 18 Pages: 2720-2729

    • DOI

      10.1002/1873-3468.12743

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Peroxisome biogenesis: a novel inducible PEX19 splicing variant is involved in early stages of peroxisome proliferation.2017

    • Author(s)
      Kinoshita, N., Matsuura, A., and *Fujiki, Y.
    • Journal Title

      J. Biochem.

      Volume: 161 Issue: 3 Pages: 297-308

    • DOI

      10.1093/jb/mvw075

    • NAID

      40021162100

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Deficiency of a retinal dystrophy protein, acyl-CoA binding domain-containing 5 (ACBD5), impairs peroxisomal β-oxidation of very-long-chain fatty acids.2017

    • Author(s)
      Yagita, Y., Shinohara, K., Liu, Y., and *Fujiki, Y.
    • Journal Title

      J. Biol. Chem.

      Volume: 292 Issue: 2 Pages: 691-705

    • DOI

      10.1074/jbc.m116.760090

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The VDAC2-BAK axis regulates peroxisomal membrane permeability.2017

    • Author(s)
      Hosoi, K., Miyata, N., Mukai, S., Furuki, S., Okumoto, K., Cheng, E. H., and *Fujiki, Y.
    • Journal Title

      J. Cell Biol.

      Volume: 216 Issue: 3 Pages: 709-722

    • DOI

      10.1083/jcb.201605002

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Defining dynamin-based ring organizing center on the peroxisome-dividing machinery isolated from Cyanidioschyzon merolae.2017

    • Author(s)
      Imoto, Y., Abe, Y., Okumoto, K., Honsho, M., Kuroiwa, H., Kuroiwa, T., and *Fujiki, Y.
    • Journal Title

      J. Cell Sci.

      Volume: 130 Pages: 853-867

    • DOI

      10.1242/jcs.199182

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Localization of protein kinase NDR2 to peroxisomes and its role in ciliogenesis.2017

    • Author(s)
      Abe, S., Nagai, T., Masukawa, M., Okumoto, K., Homma, Y., Fujiki, Y., and Mizuno, K.
    • Journal Title

      J. Biol. Chem.

      Volume: 292 Issue: 10 Pages: 4089-4098

    • DOI

      10.1074/jbc.m117.775916

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Plasmalogen synthesis is spatiotemporally regulated by sensing plasmalogens in the inner leaflet of plasma membrane.2017

    • Author(s)
      Honsho, M., Abe, Y., and *Fujiki, Y.
    • Journal Title

      Sci. Rep.

      Volume: 7 Issue: 1 Pages: 43936-43936

    • DOI

      10.1038/srep43936

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Peroxisome homeostasis: mechanisms of division and selective degradation of peroxisomes in mammals.2016

    • Author(s)
      Honsho, M., Yamashita,S., and Fujiki, Y.
    • Journal Title

      Biochim. Biophys. Acta- Mol. Cell Res.

      Volume: 1863 Issue: 5 Pages: 984-991

    • DOI

      10.1016/j.bbamcr.2015.09.032

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Assembly of Peroxisomal Membrane Proteins via the Direct Pex19p-Pex3p Pathway2016

    • Author(s)
      Yuqiong Liu, Yuichi Yagita, and Yukio Fujiki
    • Journal Title

      Traffic

      Volume: 17(4) Issue: 4 Pages: 433-455

    • DOI

      10.1111/tra.12376

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peroxisome biogenesis and human peroxisome-deficiency disorders2016

    • Author(s)
      Fujiki, Y.
    • Journal Title

      Proceedings of the Japan Academy, Series B

      Volume: 92 Issue: 10 Pages: 463-477

    • DOI

      10.2183/pjab.92.463

    • NAID

      130005179419

    • ISSN
      0386-2208, 1349-2896
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The peroxin Pex14p is the key component for coordinated autophagic degradation of mammalian peroxisomes by direct binding to LC3-II2015

    • Author(s)
      Jiang, L., Hara-Kuge, S., Yamashita, S., and *Fujiki, Y.
    • Journal Title

      Genes to Cells

      Volume: 20 Issue: 1 Pages: 36-49

    • DOI

      10.1111/gtc.12198

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Pex11p mediates peroxisomal proliferation by promoting deformation of the lipid membrane.2015

    • Author(s)
      Yoshida, Y., Niwa, H., Honsho, M., Itoyama, A., and Fujiki,Y.
    • Journal Title

      Biology Open

      Volume: 4 Issue: 6 Pages: 910-721

    • DOI

      10.1242/bio.201410801

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Dysregulation of plasmalogen homeostasis impairs cholesterol biosynthesis.2015

    • Author(s)
      Honsho, M., Abe, Y., and Fujiki, Y
    • Journal Title

      J. Biol. Chem.

      Volume: 290 Issue: 48 Pages: 28822-28833

    • DOI

      10.1074/jbc.m115.656983

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Pex11p mediates peroxisomal proliferation by promoting deformation of the lipid membrane2015

    • Author(s)
      Yoshida, Y., Niwa, H., Honsho, M., Itoyama, A., and *Fujiki,Y.
    • Journal Title

      Biology Open

      Volume: ―

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Molecular basis for peroxisome biogenesis disorders2014

    • Author(s)
      *Fujiki, Y., Okumoto, K., Mukai, S., and Tamura, S.
    • Journal Title

      In: Brocard, C. and Hartig, A. (eds) Molecular machines involved in peroxisome biogenesis and maintenance, Springer-Verlag, Wien, Austria

      Volume: ― Pages: 91-110

    • DOI

      10.1007/978-3-7091-1788-0_5

    • ISBN
      9783709117873, 9783709117880
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Molecular complex coordinating peroxisome morphogenesis2014

    • Author(s)
      *Fujiki, Y., Itoyama, A., Abe, Y., and Honsho, M.
    • Journal Title

      In: Brocard, C. and Hartig, A. (eds) Molecular machines involved in peroxisome biogenesis and maintenance, Springer-Verlag, Wien, Austria

      Volume: ― Pages: 391-401

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Very-long-chain polyunsaturated fatty acids accumulate in phosphatidylcholine of fibroblasts from patients with Zellweger syndrome and acyl-CoA oxidase1 deficiency2014

    • Author(s)
      Yuichi Abe, Masanori Honsho, Hiroki Nakanishi, Ryo Taguchi, Yukio Fujiki
    • Journal Title

      BBA - Molecular and Cell Biology of Lipids

      Volume: 1841 Issue: 4 Pages: 610-619

    • DOI

      10.1016/j.bbalip.2014.01.001

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Distinct modes of ubiquitination of peroxisome-targeting signal type 1 (PTS1)-receptor Pex5p regulate PTS1 protein import2014

    • Author(s)
      Okumoto, K., Noda, H., and *Fujiki, Y.
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 289 Issue: 20 Pages: 14089-14108

    • DOI

      10.1074/jbc.m113.527937

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Mild reduction of plasmalogens causes rhizomelic chondrodysplasia punctata: Functional characterization of a novel mutation2014

    • Author(s)
      Noguchi, M., Honsho, M., Abe, Y., Toyama, R., Niwa, H., Sato, Y., Ghaedi, K., Rahmanifar, A., Shafeghati, Y., and *Fujiki, Y.
    • Journal Title

      Journal of Human Genetics

      Volume: 59 Issue: 7 Pages: 387-392

    • DOI

      10.1038/jhg.2014.39

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The membrane peroxin PEX3 induces peroxisome-ubiquitination-linked pexophagy2014

    • Author(s)
      Yamashita, S., Abe, K., Tatemichi, Y., and *Fujiki, Y.
    • Journal Title

      Autophagy

      Volume: 10 Issue: 9 Pages: 1549-1564

    • DOI

      10.4161/auto.29329

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Peroxisome biogenesis in mammalian cells2014

    • Author(s)
      *Fujiki, Y., Okumoto, K., Mukai, S., Honsho, M., and Tamura, S.
    • Journal Title

      Frontiers in Physiology

      Volume: 5 Pages: 307-315

    • DOI

      10.3389/fphys.2014.00307

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Cul4A-DDB1-Rbx1 E3 ligase controls the quality of the PTS2 receptor Pex7p2014

    • Author(s)
      Miyauchi-Nanri, Y., Mukai, S., Kuroda, K., and *Fujiki, Y.
    • Journal Title

      Biochemical Journal

      Volume: 463 Issue: 1 Pages: 65-74

    • DOI

      10.1042/bj20130861

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] AAA peroxins and their recruiter Pex26p modulate the interactions of peroxins involved in peroxisomal protein import2014

    • Author(s)
      Tamura, S., Matsumoto, N., Takeba, R., and *Fujiki, Y.
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 289 Issue: 35 Pages: 24336-24346

    • DOI

      10.1074/jbc.m114.588038

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Peroxisome homeostasis: Tightly regulated import and export of matrix enzyme, catalase2019

    • Author(s)
      Yukio Fujiki
    • Organizer
      EMBO Workshop “Current advances in protein translocation across membranes”
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Pathological mechanism of peroxisome biogenesis disorders2019

    • Author(s)
      Yuichi Abe, Masanori Honsho, Ryota Itoh, Ryoko Kawaguchi, Masashi Fujitani, Kazushirou Fujiwara, Masaaki Hirokane, Takashi Matsuzaki, Keiko Nakayama, Ryohei Ohgi, Toshihiro Marutani, Keiichi I. Nakayama, Toshihide Yamashita, and Yukio Fujiki
    • Organizer
      EMBO Workshop “Current advances in protein translocation across membranes”
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Peroxisome homeostasis: Tightly regulated import and export of matrix enzyme, catalase2018

    • Author(s)
      Yukio Fujiki
    • Organizer
      International Symposium on “Proteins; from the Cradle to the Grave”
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Biogenesis of peroxisomal tail-anchored membrane proteins, new splicing variants of Miro1, acyl-CoA binding domain containing protein 5 (ACBD5), and peroxin Pex26p2018

    • Author(s)
      Kanji Okumoto, Yuichi Yagita, Masanori Honsho, Yukio Fujiki
    • Organizer
      International Symposium on “Proteins; from the Cradle to the Grave”
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Maintenance and de novo formation of mammalian peroxisomes in the absence of membrane assembly peroxin, Pex16p2018

    • Author(s)
      Yuichi Yagita, Yukio Fujiki
    • Organizer
      International Symposium on “Proteins; from the Cradle to the Grave”
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Peroxisome homeostasis and human disorders2018

    • Author(s)
      Yukio Fujiki
    • Organizer
      BIT's 8th Annual World Congress of Molecular & Cell Biology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Peroxisome biogenesis, dysfunctions, and disorders2018

    • Author(s)
      Yukio Fujiki
    • Organizer
      International Conference on Plasmalogen 2018 (ICP 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Local GTP fueling via nucleoside diphosphate kinase like protein DYNAMO1 drives division of peroxisome and mitochondrion2018

    • Author(s)
      Yukio Fujiki, Yuuta Imoto, Yuichi Abe, Masanori Honsho, Kanji Okumoto, Mio Ohnuma, Haruko Kuroiwa, Tsuneyoshi Kuroiwa
    • Organizer
      ASCB/EMBO 2018 Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ペルオキシソームの細胞内移動の制御機構2018

    • Author(s)
      奥本寛治
    • Organizer
      「新生鎖の生物学」第5回若手ワークショップ
    • Related Report
      2018 Annual Research Report
  • [Presentation] Pex14欠損マウスにおける小脳形態異常の分子機構2018

    • Author(s)
      阿部雄一 、本庄雅則 、藤木幸夫
    • Organizer
      平成30年度日本生化学会九州支部例会
    • Related Report
      2018 Annual Research Report
  • [Presentation] テイルアンカー型タンパク質 ACBD5 の翻訳速度とペルオキシソームへの 輸送・局在化効率の関連性の検討2018

    • Author(s)
      小山桂恵奈、奥本寛治、田村茂彦、藤木幸夫
    • Organizer
      平成30年度日本生化学会九州支部例会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ペルオキシソーム形成因子 Pex14p の細胞周期依存的なリン酸化による機能制御2018

    • Author(s)
      山下昂一郎、田村茂彦、藤木幸夫
    • Organizer
      平成30年度日本生化学会九州支部例会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ペルオキシソームの構成酵素および膜タンパク質の局在性と生理機能制御2018

    • Author(s)
      藤木幸夫
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] シンポジウム:New aspects of lipid homeostasis: Regulation of cholesterol and plasmalogen homeostasis and physiological consequences. コレステロールとプラスマローゲンのホメオスタシス機構と疾患2018

    • Author(s)
      藤木幸夫、佐藤隆一郎
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] プラスマローゲン依存的なコレステロール生合成調節とその障害による病態2018

    • Author(s)
      本庄 雅則、藤木 幸夫
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ペルオキシソーム形成因子 Pex14p の細胞周期依存的なリン酸化による機能制御メカニズムの解析2018

    • Author(s)
      山下昂一郎、田村茂彦、藤木幸夫
    • Organizer
      第94回日本生化学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 過酸化水素分解酵素カタラーゼの細胞内局在制御による酸化ストレス応答の分子機構2018

    • Author(s)
      藤木 幸夫、奥本 寛治、宮田 暖、Emily Cheng
    • Organizer
      第13回臨床ストレス応答学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 新しく単離したPex7結合PTS2タンパク質P7BP2は新規ダイニンタイプAAA+である2018

    • Author(s)
      藤木 幸夫、丹羽 一、宮内(南里) 康弘、奥本 寛治、向井 悟、野井 健太郎、小椋 光、遠藤 斗志也
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ペルオキシソーム局在性テイルアンカー型膜タンパク質の輸送局在化機構2018

    • Author(s)
      奥本 寛治、田村 茂彦、八木田 悠一、本庄 雅則、藤木 幸夫
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ワークショップ: 新生鎖オルガネラ膜タンパク質局在化と品質管理2018

    • Author(s)
      藤木幸夫、川原 裕之
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Lab overview; Drawer data2018

    • Author(s)
      Yukio Fujiki
    • Organizer
      New Horizons in Peroxisome Biology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Pex5-Ub化によるTraffic制御とストレス応答2018

    • Author(s)
      藤木 幸夫
    • Organizer
      第1回ユビキチン研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Core components of peroxisomal membrane translocator of matrix proteins2017

    • Author(s)
      Yukio Fujiki, Yuko Kawamura, and Shigehiko Tamura
    • Organizer
      EMBO Conference: Protein translocation and cellular homeostasis
    • Place of Presentation
      Hotel Valamar Lacroma, Dubrovnik, Croatia
    • Year and Date
      2017-03-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Peroxisomal matrix protein transport requires a series of constitutional changes of Pex14p homo-oligomers.2017

    • Author(s)
      Yukio Fujiki, Yuko Kawamura, and Shigehiko Tamura
    • Organizer
      EMBO Conference: Protein translocation and cellular homeostasis
    • Place of Presentation
      Hotel Valamar Lacroma, Dubrovnik, Croatia
    • Year and Date
      2017-03-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Peroxisome Homeostasis、 Dysfunctions、 and Disorders2017

    • Author(s)
      Yukio Fujiki
    • Organizer
      8th International Conference and Exhibition on Metabolomics & Systems Biology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Peroxisome homeostasis: Protein translocation and quality control2017

    • Author(s)
      Yukio Fujiki
    • Organizer
      2017 Nascent Chain Biology International Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] VDAC2-BAK axis regulates peroxisomal membrane permeability and catalase release2017

    • Author(s)
      Yukio Fujiki、 Non Miyata、 Satoru Mukai、 Kenichiro Hosoi、 Kanji Okumoto、 and Emily H. Cheng
    • Organizer
      Gordon Research Conference on Organellar Channels & Transporters
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Bcl-2 ファミリータンパク質 BAK を介したペルオキシソーム膜透過性制御2017

    • Author(s)
      細井謙一郎、 宮田暖、 向井悟、 奥本寛治、 Emily Cheng、 藤木幸夫
    • Organizer
      平成29年度生化学会九州支部例会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 過酸化水素分解酵素カタラーゼによる新たな酸化ストレス応答機構の発見 - アポトーシス因子BAKの標的膜依存的な死と生の振り分け -2017

    • Author(s)
      Yukio Fujiki、 Non Miyata、 Satoru Mukai、 Kanji Okumoto、 and Emily H. Cheng
    • Organizer
      第69回日本細胞生物学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] プラスマローゲン生合成機構:acyl/alkyl dihydroxyacetonephosphate還元酵素(DHRS7B)のペルオキシソームと小胞体への標的化機構2017

    • Author(s)
      田中恵美、 本庄雅則、 藤木幸夫
    • Organizer
      第69回日本細胞生物学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] NDR2 のペルオキシソーム膜への局在と一次繊毛形成における役割2017

    • Author(s)
      増川萌瑛 、 阿部彰子、 永井友朗、 奥本寛治、 本間悠太、 藤木幸夫、 水野健作
    • Organizer
      第69回日本細胞生物学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] エーテルリン脂質プラスマローゲンの生合成を制御するセンシング機構2017

    • Author(s)
      本庄雅則、 阿部雄一、 藤木幸夫
    • Organizer
      第59回日本脂質生化学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ペルオキソソームの恒常性:膜およびマトリックスタンパク質輸送の分子基盤2017

    • Author(s)
      Yukio Fujiki、 Kanji Okumoto、 Yuichi Yagita、 and Shigehiko Tamura
    • Organizer
      第17回日本蛋白質科学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 過酸化水素分解酵素カタラーゼによる新たな酸化ストレス応答機構の発見2017

    • Author(s)
      藤木幸夫、 細井謙一郎、 宮田暖、 向井悟、 奥本寛治、 Emily Cheng.
    • Organizer
      第12回臨床ストレス応答学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ペルオキシソームの機能と細胞内配置・運動性の新たな制御機構2017

    • Author(s)
      奥本 寛治、小野 立晃、外山 隆介、細井 謙一郎、宮田 暖、向井 悟、Emily H. Cheng、藤木 幸夫
    • Organizer
      2017年度 生命科学系学会合同年次大会ConBio2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] エーテルリン脂質プラスマローゲンの恒常性維持機構とその生理的意義2017

    • Author(s)
      本庄 雅則、藤木 幸夫
    • Organizer
      2017年度 生命科学系学会合同年次大会ConBio2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] PEX14障害マウスにおける小脳形態異常2017

    • Author(s)
      阿部 雄一、本庄 雅則、大城 遼平、藤木 幸夫
    • Organizer
      2017年度 生命科学系学会合同年次大会ConBio2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] ペルオキシソーム膜透過装置複合体の同定と輸送メカニズムの解明2017

    • Author(s)
      田村 茂彦、河村 優子、藤木 幸夫
    • Organizer
      2017年度 生命科学系学会合同年次大会ConBio2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] Biogenesis of peroxisome: assembly of nascent membrane proteins2016

    • Author(s)
      Yuqiong Liu, Yuichi Yagita, Kanji Okumoto, Kyoko Shinohara, Aiko Nagata, and Yukio Fujiki
    • Organizer
      2016 ASCB Annual Meeting
    • Place of Presentation
      Moscone Center, San Fransisco,California, USA
    • Year and Date
      2016-12-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Peroxisome biogenesis: Import of nascent membrane and matrix proteins2016

    • Author(s)
      Yuqiong Liu, Shigehiko Tamura, Kanji Okumoto, Yuichi Yagita, Yuko Kawamura, Aiko Nagata, and Yukio Fujiki
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      横浜パシフィコ、横浜市
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] Plasmalogen synthesis is spatiotemporally regulated by sensing plasmalogens in the inner leaflet of plasma membrane2016

    • Author(s)
      Masanoi Honsho, Yuichi Abe, and Yukio Fujiki
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      横浜パシフィコ、横浜市
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] ペルオキシソーム膜透過輸送にはPex14p複合体の動的な構成変化が必要である2016

    • Author(s)
      河村優子, 田村茂彦, 藤木幸夫
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      横浜パシフィコ、横浜市
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] アストロサイトにおけるペルオキシソーム形成障害による神経軸索形成異常2016

    • Author(s)
      阿部雄一, 川口怜子, 廣兼正明, 藤原一志郎, 本庄雅則, 松崎高志, 藤谷昌司, 山下俊英, 藤木幸夫
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      横浜パシフィコ、横浜市
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] Peroxisome Homeostasis, Dysfunctions, and Disorders2016

    • Author(s)
      Yukio Fujiki
    • Organizer
      The 1st INTERNATIONAL PLASMALOGEN SYMPOSIUM
    • Place of Presentation
      Centennial Hall Kyushu University School of Medicine, Fukuoka
    • Year and Date
      2016-11-07
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Plasmalogen Synthesis Is Spatiotemporally Regulated by Sensing Plasmalogens in the Inner Leaflet of Plasma Membrane2016

    • Author(s)
      Masanori Honsho, Yuichi Abe, and Yukio Fujiki
    • Organizer
      The 1st INTERNATIONAL PLASMALOGEN SYMPOSIUM
    • Place of Presentation
      Centennial Hall Kyushu University School of Medicine, Fukuoka
    • Year and Date
      2016-11-07
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Lipidomic Analysis of Fibroblasts from Patients with Peroxisome Biogenesis Deficiency and PEX Gene-Knockout Mouse2016

    • Author(s)
      Yuichi Abe, Masanori Honsho, and Yukio Fujiki
    • Organizer
      The 1st INTERNATIONAL PLASMALOGEN SYMPOSIUM
    • Place of Presentation
      Centennial Hall Kyushu University School of Medicine, Fukuoka
    • Year and Date
      2016-11-07
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] DHRS7B Targets to Peroxisomes by a PEX19-dependent Class I Pathway2016

    • Author(s)
      Megumi Tanaka, Masanori Honsho, and Yukio Fujiki
    • Organizer
      The 1st INTERNATIONAL PLASMALOGEN SYMPOSIUM
    • Place of Presentation
      Centennial Hall Kyushu University School of Medicine, Fukuoka
    • Year and Date
      2016-11-07
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of core components of peroxisomal membrane translocator2016

    • Author(s)
      Shigehiko Tamura, Yuko Kawamura, and Yukio Fujiki
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター/東北大学川内北キャンパス、仙台市
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 超分子ナノマシンPeroxisome-dividing ringの形成起点同定とGTP濃度依存的伸長機構の解明2016

    • Author(s)
      井元祐太, 阿部雄一, 奥本寛治, 本庄雅則, 黒岩晴子, 黒岩常祥, 藤木幸夫
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター/東北大学川内北キャンパス、仙台市
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] ペルオキシソーム局在型Miro1バリアントによるペルオキシソームの細胞内移動制御2016

    • Author(s)
      奥本寛治, 小野立晃, 下村紋子, 外山隆介, 藤木幸夫
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター/東北大学川内北キャンパス、仙台市
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] ペルオキシソーム分裂装置の構造と機能解析2016

    • Author(s)
      井元祐太, 阿部雄一, 奥本寛治, 本庄雅則, 黒岩晴子, 黒岩常祥, 藤木幸夫
    • Organizer
      第80回大会日本植物学会
    • Place of Presentation
      沖縄コンベンションセンター、宜野湾市
    • Year and Date
      2016-09-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] Plasmalogen synthesis is spatiotemporally regulated by sensing plasmalogens in plasma membrane2016

    • Author(s)
      Masanori Honsho, Yuichi Abe, and Yukio Fujiki
    • Organizer
      5th Open European Peroxisome Meeting 2016
    • Place of Presentation
      Medical University of Vienna,Vienna, Austria
    • Year and Date
      2016-09-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] オルガネラ恒常性とその障害の分子基盤2016

    • Author(s)
      藤木幸夫
    • Organizer
      H28年度日本生化学会九州支部例会
    • Place of Presentation
      鹿児島大学、 鹿児島市
    • Year and Date
      2016-05-14
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Homeostasis of peroxisome biogenesis and functions2016

    • Author(s)
      Yukio Fujiki, Yuqiong Liu, Yuuta Imoto, and Masanori Honsho
    • Organizer
      Peroxisystem: Understanding peroxisomes as a complete biological system
    • Place of Presentation
      Rehovot, Israel
    • Year and Date
      2016-02-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Ultrastructure and molecular mechanism of Ring-shaped Supramolecular Nanomachinery for Peroxisome Division Revealed by Single Organelle EM Analysis2016

    • Author(s)
      Yuuta Imoto, Yuichi Abe, Masaki Yoshida, Masanori Honsho, Kanji Okumoto, Mio Ohnuma, Haruko Kuroiwa, Tsuneyoshi Kuroiwa, and Yukio Fujiki
    • Organizer
      1st Cyanidioschyzon merolae Symposium
    • Place of Presentation
      東京大学、東京都
    • Related Report
      2016 Annual Research Report
  • [Presentation] Regulation of peroxisome biogenesis by mitochondrial proteins2015

    • Author(s)
      Non Miyata, Satoru Mukai, Emily H. Cheng, and Yukio Fujiki
    • Organizer
      2015 ASCB Annual Meeting
    • Place of Presentation
      San Diego, California, USA
    • Year and Date
      2015-12-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of ultrastructure and molecular mechanism of the peroxisome-dividing (POD) machinery2015

    • Author(s)
      Yuuta Imoto, Haruko Kuroiwa, Tsuneyoshi Kuroiwa, and Yukio Fujiki
    • Organizer
      2015 ASCB Annual Meeting
    • Place of Presentation
      San Diego, California, USA
    • Year and Date
      2015-12-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Bcl-2ファミリータンパク質を介したペルオキシソーム形成制御2015

    • Author(s)
      細井謙一郎、宮田暖、向井悟、古木聡美、Emily H. Cheng、藤木 幸夫
    • Organizer
      BMB2015、第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド【神戸市】
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] エーテルリン脂質プラスマローゲンの恒常性の生理的意義2015

    • Author(s)
      本庄 雅則、阿部雄一、藤木幸夫
    • Organizer
      BMB2015、第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド【神戸市】
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Analysis of ultrastructure and molecular mechanism of the mitochondrion and peroxisome dividing machineries2015

    • Author(s)
      Yuuta Imoto, Yuichi Abe, Masanori Honsho, Kanji Okumoto, Masaki Yoshida, Haruko Kuroiwa, Tsuneyoshi Kuroiwa, Yukio Fujiki
    • Organizer
      BMB2015、第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド【神戸市】
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Direct targeting of membrane proteins to peroxisomes in mammals2015

    • Author(s)
      Yuqiong Liu, Yuichi Yagita, and Yukio Fujiki
    • Organizer
      BMB2015、第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド【神戸市】
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] ペルオキシソーム局在性テイルアンカータンパク質Pex26の品質管理と膜局在化機構2015

    • Author(s)
      奥本寛治、永田愛子、藤木幸夫
    • Organizer
      BMB2015、第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド【神戸市】
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Plasmalogen homeostasis and peroxisomal disorders2015

    • Author(s)
      Yukio Fujiki, Yuichi Abe, and Masanori Honsho
    • Organizer
      2015 GFPD & ULF International Peroxisome and Leukodystrophy Meeting
    • Place of Presentation
      Omaha, Nebraska,USA
    • Year and Date
      2015-07-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ミトコンドリアとペルオキシソーム分裂リングの収縮機構解明に挑むー原始紅藻シゾンのポストゲノム情報を基盤として2015

    • Author(s)
      井元祐太、本庄雅則、奥本寛治、大沼みお、黒岩晴子、黒岩常祥、藤木幸夫
    • Organizer
      第67回日本細胞生物学会大会
    • Place of Presentation
      タワーホール船堀【東京都】
    • Year and Date
      2015-06-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] 一次繊毛形成制御キナーゼNDR2はC末端GKLモチーフを解してペルオキシソームに局在化する2015

    • Author(s)
      阿部彰子、永井友朗、藤木幸夫、水野健作
    • Organizer
      第67回日本細胞生物学会大会
    • Place of Presentation
      タワーホール船堀【東京都】
    • Year and Date
      2015-06-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] 精巣に高発現するペルオキシソーム局在型Miro1バリアントの機能2015

    • Author(s)
      外山隆介、小野立晃、下村紋子、奥本寛治、藤木幸夫
    • Organizer
      第67回日本細胞生物学会大会
    • Place of Presentation
      タワーホール船堀【東京都】
    • Year and Date
      2015-06-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] エーテルリン脂質プラスマローゲン依存的なコレステロールの生合成制御2015

    • Author(s)
      本庄 雅則 、阿部 雄一 、藤木幸夫
    • Organizer
      第57回日本脂質生化学会
    • Place of Presentation
      一橋大学一橋講堂【東京都】
    • Year and Date
      2015-06-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] ペルオキシソーム分裂装置(POD machinery)の同定と微細構造の解析2015

    • Author(s)
      井元祐太、黒岩常祥、藤木幸夫
    • Organizer
      H27年度日本生化学会九州支部例会
    • Place of Presentation
      九州大学箱崎キャンパス【福岡市】
    • Year and Date
      2015-05-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] Direct targeting of membrane proteins to mammalian peroxisomes2015

    • Author(s)
      Yuqiong Liu, Yuichi Yagita, and Yukio Fujiki
    • Organizer
      H27年度日本生化学会九州支部例会
    • Place of Presentation
      九州大学箱崎キャンパス【福岡市】
    • Year and Date
      2015-05-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] Mechanistic insight into peroxisomal protein import2015

    • Author(s)
      Shigehiko Tamura, Kanji Okumoto, Naomi Matsumoto,Yuri Shirahama, Ryota Takeba, and Yukio Fujiki
    • Organizer
      EMBO Conference: Mechanisms and regulation of protein translocation
    • Place of Presentation
      Hotel Valamar Lacroma,Dubrovnik, Croatia
    • Year and Date
      2015-03-21 – 2015-03-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] The role of peroxisomes in lipid metabolism2015

    • Author(s)
      Yukio Fujiki, Yuichi Abe and Masanori Honsho
    • Organizer
      This 6th international conference on Phospholipase A2 and Lipid Mediators (PLM2015)
    • Place of Presentation
      Keio Plaza Hotel, Tokyo, Japan
    • Year and Date
      2015-02-10 – 2015-02-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ペルオキシソーム局在型Miro1バリアントの同定とその機能解析2014

    • Author(s)
      奥本寛治、小野立晃、下村紋子、外山隆介、藤木幸夫
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] D-アミノ酸酸化酵素(DAO)の細胞内局在異常による細胞毒性2014

    • Author(s)
      福留久美子、阿部雄一、本庄雅則、藤木幸夫
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Molecular complex coordinating peroxisome morphogenesis in mammalian cells2014

    • Author(s)
      Yukio Fujiki, Akinori Itoyama, Yuichi Abe, and Masanori Honsho
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      国立京都国際会館・グランドプリンスホテル京都(京都市)
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 新生鎖テイルアンカー型タンパク質の運命決定・膜局在化機構2014

    • Author(s)
      八木田悠一、劉玉瓊、奥本寛治、藤木幸夫
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      国立京都国際会館・グランドプリンスホテル京都(京都市)
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] エーテルリン脂質プラスマローゲン依存的なコレステロールの生合成2014

    • Author(s)
      本庄雅則, 藤木幸夫
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      国立京都国際会館・グランドプリンスホテル京都(京都市)
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] PEX14欠損マウスにおける大脳皮質の形態とリン脂質の解析2014

    • Author(s)
      阿部雄一、伊藤竜太、中山啓子、丸谷寿裕、本庄雅則、藤谷昌司、山下俊英、中山敬一、藤木幸夫
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      国立京都国際会館・グランドプリンスホテル京都(京都市)
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] ペルオキシソーム膜透過装置複合体の同定とマトリックスタンパク質輸送の分子メカニズム解明2014

    • Author(s)
      小川智大、田村茂彦、藤木幸夫
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      国立京都国際会館・グランドプリンスホテル京都(京都市)
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] The peroxin Pex14p is the key component for coordinating autophagic degradation of mammalian peroxisomes by directly binding to LC3-II2014

    • Author(s)
      Li Jiang, Sayuri Kuge, Shun-ichi Yamashita, Yukio Fujiki
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      国立京都国際会館・グランドプリンスホテル京都(京都市)
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Book] Encyclopedia of Food Chemistry2019

    • Author(s)
      Honsho, M. and Fujiki, Y.
    • Total Pages
      16
    • Publisher
      Elsevier Inc.
    • ISBN
      9780128140451
    • Related Report
      2018 Annual Research Report
  • [Book] 生化学 特集:オルガネラの生物機能と疾患における破綻機構2018

    • Author(s)
      本庄雅則、藤木幸夫
    • Total Pages
      9
    • Publisher
      公益社団法人日本生化学会
    • Related Report
      2018 Annual Research Report
  • [Book] 医学のあゆみ 蛋白質代謝医学-構造・機能の研究から臨床応用まで2018

    • Author(s)
      藤木幸夫、奥本寛治
    • Total Pages
      6
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2018 Annual Research Report
  • [Book] 生体の科学 特集:細胞高次機能をつかさどるオルガネラコミュニケーション2018

    • Author(s)
      藤木幸夫、奥本寛治、本庄雅則
    • Total Pages
      5
    • Publisher
      医学書院
    • Related Report
      2018 Annual Research Report
  • [Book] 実験医学 2017年7月号2017

    • Author(s)
      藤木幸夫, 山下俊一, 奥本寛治, 本庄雅則
    • Total Pages
      8
    • Publisher
      羊土社
    • ISBN
      9784758101653
    • Related Report
      2017 Annual Research Report
  • [Book] Analysis of plasmalogen synthesis in cultured cells. In: Schrader, M. (ed.) Peroxisomes: Methods and Protocols, Methods in Molecular Biology (Series Ed.: Walker, J.M.)2017

    • Author(s)
      Honsho, M., and Fujiki, Y.
    • Total Pages
      7
    • Publisher
      Springer, Humana Press, New York, USA
    • Related Report
      2016 Annual Research Report
  • [Book] Experimental systems to study yeast pexophagy. In: Schrader, M. (ed.) Peroxisomes: Methods and Protocols, Methods in Molecular Biology (Series Ed.: Walker, J.M.)2017

    • Author(s)
      Yamashita, S., Oku, M., Sakai, Y., and Fujiki, Y.
    • Total Pages
      7
    • Publisher
      Springer, Humana Press, New York, USA
    • Related Report
      2016 Annual Research Report
  • [Book] In vitro PMP import analysis using cell-free synthesized PMP and isolated peroxisomes. In: Schrader, M. (ed.) Peroxisomes: Methods and Protocols, Methods in Molecular Biology (Series Ed.: Walker, J.M.)2017

    • Author(s)
      Liu,Y., Honsho, M., and Fujiki, Y.
    • Total Pages
      6
    • Publisher
      Springer, Humana Press, New York, USA
    • Related Report
      2016 Annual Research Report
  • [Book] Generation of peroxisome-deficient somatic animal cell mutants. In: Schrader, M. (ed.) Peroxisomes: Methods and Protocols, Methods in Molecular Biology (Series Ed.: Walker, J.M.)2017

    • Author(s)
      Okumoto, K., and Fujiki, Y.
    • Total Pages
      9
    • Publisher
      Springer, Humana Press, New York, USA
    • Related Report
      2016 Annual Research Report
  • [Book] Peroxisomal membrane and matrix protein import using a semi-intact mammalian cell system. In: Schrader, M. (ed.) Peroxisomes: Methods and Protocols, Methods in Molecular Biology (Series Ed.: Walker, J.M.)2017

    • Author(s)
      Okumoto, K., Honsho, M., Liu, Y., and Fujiki, Y.
    • Total Pages
      7
    • Publisher
      Springer, Humana Press, New York, USA
    • Related Report
      2016 Annual Research Report
  • [Book] Assessing pexophagy in mammalian cells. In: Schrader, M. (ed.) Peroxisomes: Methods and Protocols, Methods in Molecular Biology (Series Ed.: Walker, J.M.)2017

    • Author(s)
      Yamashita, S., and Fujiki, Y.
    • Total Pages
      6
    • Publisher
      Springer, Humana Press, New York, USA
    • Related Report
      2016 Annual Research Report
  • [Book] Blue-Native PAGE: Applications to study on peroxisome biogenesis. In: Schrader, M. (ed.) Peroxisomes: Methods and Protocols, Methods in Molecular Biology (Series Ed.: Walker, J.M.)2017

    • Author(s)
      Okumoto, K., Tamura, S., and Fujiki, Y.
    • Total Pages
      9
    • Publisher
      Springer, Humana Press, New York, USA
    • Related Report
      2016 Annual Research Report
  • [Book] 別冊・医学のあゆみ ストレスシグナルと疾患―細胞恒常性維持機構の破綻と病態 『ペルオキシソーム形成異常と疾患』2016

    • Author(s)
      藤木幸夫, 奥本寛治, 本庄雅則
    • Total Pages
      5
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2016 Annual Research Report
  • [Book] 機能性食品と薬理栄養 Vol.9 【通巻53号】2016

    • Author(s)
      藤木幸夫、本庄雅則
    • Total Pages
      6
    • Publisher
      インフォノーツパブリッシング
    • Related Report
      2015 Annual Research Report
  • [Book] 小児科診療  第79巻増刊号:小児の症候群2016

    • Author(s)
      藤木幸夫
    • Total Pages
      2
    • Publisher
      診断と治療社
    • Related Report
      2015 Annual Research Report
  • [Book] Encyclopedia of Life Sciences, Protein Import into Peroxisomes: the principles and methods of studying (version 2.0)2015

    • Author(s)
      Fujiki, Y., Okumoto, K., and Honsho, M.
    • Publisher
      John Wiley & Sons, Chichester, UK
    • Related Report
      2015 Annual Research Report
  • [Book] 医学のあゆみ Vol.2542015

    • Author(s)
      藤木幸夫、奥本寛治、本庄雅則
    • Total Pages
      5
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2015 Annual Research Report
  • [Book] Encyclopedia of Life Sciences: Protein Import into Peroxisomes: the principles and methods of studying (version 2.0).2015

    • Author(s)
      *Fujiki, Y., Okumoto, K., and Honsho, M.
    • Publisher
      John Wiley & Sons, Chichester, UK
    • Related Report
      2014 Annual Research Report
  • [Remarks] オルガネラホメオスタシス研究室

    • URL

      http://www.organelle.kyushu-u.ac.jp/lab/organellestasis/top.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] 生体防御医学研究所 オルガネラホメオスタシス研究室

    • URL

      http://www.organelle.kyushu-u.ac.jp/lab/organellestasis/index.html

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report

URL: 

Published: 2014-11-20   Modified: 2023-03-16  

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