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Elucidatio of neural network disruption mechanisms by protein specific PET imaging

Planned

Project AreaPrevention of brain protein aging and dementia
Project/Area Number 26117003
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionTohoku University

Principal Investigator

Yanai Kazuhiko  東北大学, 医学系研究科, 教授 (50192787)

Co-Investigator(Kenkyū-buntansha) 田代 学  東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (00333477)
Research Collaborator Okamura Nobuyuki  
Furumoto Shozo  
Harada Ryuichi  
Project Period (FY) 2014-07-10 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥130,390,000 (Direct Cost: ¥100,300,000、Indirect Cost: ¥30,090,000)
Fiscal Year 2018: ¥23,660,000 (Direct Cost: ¥18,200,000、Indirect Cost: ¥5,460,000)
Fiscal Year 2017: ¥23,660,000 (Direct Cost: ¥18,200,000、Indirect Cost: ¥5,460,000)
Fiscal Year 2016: ¥23,790,000 (Direct Cost: ¥18,300,000、Indirect Cost: ¥5,490,000)
Fiscal Year 2015: ¥23,660,000 (Direct Cost: ¥18,200,000、Indirect Cost: ¥5,460,000)
Fiscal Year 2014: ¥35,620,000 (Direct Cost: ¥27,400,000、Indirect Cost: ¥8,220,000)
Keywords老化 / 脳神経疾患 / 認知症 / トランスレーショナルリサーチ / イメージング
Outline of Final Research Achievements

We performed the investigation of clinical utility of [18F]THK-5351 in neurodegenerative diseases such as tauopathies and validation studies of PET images such as imaging-pathology correlations. Recent validation studies revealed that dominant off-target substrate of [18F]THK-5351 was monoamine oxidase-B (MAO-B), suggesting that [18F]THK-5351 PET has limited utility for selective detection of tau pathology.The aim of study was to develop next generation of selective tau PET tracers, which showed no off-target binding. We synthesized about 200 compounds and screened using the binding assay for tau aggregates from AD and recombinant MAO-B. After identifying candidates for further evaluation of F-18 labeled compounds, we performed in vitro autoradiography using human brain tissues, led to the discovery of F-18 labeled compounds, a promising tau PET tracer candidate that was shown to have a selective binding profile to tau without off-target binding and suitable pharmacokinetics.

Academic Significance and Societal Importance of the Research Achievements

研究期間の間にタウ病変を画像化するためのPETプローブが開発され、世界中で研究が進められている。PET画像が真にタウの病理を反映しているのを検証するのは、その後の研究を進めていく上で特に重要な課題である。本研究では、3名の画像病理相関の症例を蓄積し、[18F]THK-5351の画像の意味を明らかにした。その結果、より選択的なタウPETプローブの必要性、そして神経変性疾患において神経炎症が局所的にダイナミックに変化していることが明らかとなった。より選択的なPETプローブを開発することでより詳細な現象を捉えられることが期待される。

Report

(5 results)
  • 2018 Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report

Research Products

(111 results)

All 2018 2017 2016 2015 2014 Other

All Int'l Joint Research Journal Article Presentation Patent(Industrial Property Rights)

  • [Int'l Joint Research] McGil University(カナダ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Karolinska Institutet(スウェーデン)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] University of Wisconsin-Madison/New York University School of Medicine(アメリカ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Gachon University(韓国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] The University of Melbourne(オーストラリア)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] メルボルン大学(オーストラリア)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] ハバナ大学(キューバ)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] ガチョン大学(韓国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] メルボルン大学(オーストラリア)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] ハバナ大学(キューバ)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Correlations of (18)F-THK5351 PET with Postmortem Burden of Tau and Astrogliosis in Alzheimer Disease2018

    • Author(s)
      Brendel M, Furukawa K, et al.
    • Journal Title

      J. Nucl. Med.

      Volume: 24 Pages: 130-136

    • DOI

      10.2967/jnumed.117.197426

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] [18F]-THK5351 PET Imaging in Patients With Semantic Variant Primary Progressive Aphasia.2018

    • Author(s)
      Kang JM, Lee SY, Seo S, Jeong HJ, Woo SH, Lee H, Lee YB, Yeon BK, Shin DH, Park KH, Kang H, Okamura N, Furumoto S, Yanai K, Villemagne VL, Seong JK, Na DL, Ido T, Cho J, Lee KM, Noh Y
    • Journal Title

      Alzheimer Dis Assoc Disord.

      Volume: 59 Pages: 210-219

    • DOI

      10.1097/wad.0000000000000216

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain2017

    • Author(s)
      Ng KP, Pascoal TA, Mathotaarachchi S, Therriault J, Kang MS, Shin M, Guiot MC, Guo Q, Harada R, Comley RA, Massarweh G, Soucy JP, Okamura N, Gauthier S, Rosa-Neto P.
    • Journal Title

      Alzheimer's Research & Therapy

      Volume: 9:25 Pages: 25-25

    • DOI

      10.1186/s13195-017-0253-y

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comparative binding properties of the tau PET tracers THK5117, THK5351, PBB3, and T807 in postmortem Alzheimer brains2017

    • Author(s)
      Lemoine L, Gillberg PG, Svedberg M, Stepanov V, Jia Z, Huang J, Nag S, Tian H, Ghetti B, Okamura N, Higuchi M, Halldin C, Nordberg A.
    • Journal Title

      Alzheimer's Research & Therapy

      Volume: 9 Pages: 96-96

    • DOI

      10.1186/s13195-017-0325-z

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Characterization of the radiosynthesis and purification of [18F]THK-5351, a PET ligand for neurofibrillary tau.2017

    • Author(s)
      Betthauser Tobey J.、Ellison Paul A.、Murali Dhanabalan、Lao Patrick J.、Barnhart Todd E.、Furumoto Shozo、Okamura Nobuyuki、Johnson Sterling C.、Engle Jonathan W.、Nickles Robert J.、Christian Bradley T.
    • Journal Title

      Appl Radiat Isot.

      Volume: 130 Pages: 230-237

    • DOI

      10.1016/j.apradiso.2017.10.002

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Regional tau deposition and subregion atrophy of medial temporal structures in early Alzheimer's disease: A combined positron emission tomography/magnetic resonance imaging study.2017

    • Author(s)
      Sone Daichi、Imabayashi Etsuko、Maikusa Norihide、Okamura Nobuyuki、Furumoto Shozo、Kudo Yukitsuka、Ogawa Masayo、Takano Harumasa、Yokoi Yuma、Sakata Masuhiro、Tsukamoto Tadashi、Kato Koichi、Matsuda Hiroshi
    • Journal Title

      Alzheimers Dement (Amst)

      Volume: 9 Pages: 35-40

    • DOI

      10.1016/j.dadm.2017.07.001

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biodistribution and Radiation Dosimetry for the Tau Tracer 18 F-THK-5351 in Healthy Human Subjects2017

    • Author(s)
      Hsiao IT, Lin KJ, Huang KL, Huang CC, Chen HS, Wey SP, Yen TC, Okamura N, Hsu JL.
    • Journal Title

      Journal of Nuclear Medicine

      Volume: - Pages: 1498-1503

    • DOI

      10.2967/jnumed.116.189126

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Applications of tau PET imaging2017

    • Author(s)
      Okamura N, Yanai K.
    • Journal Title

      Nature Reviews Neurology

      Volume: 13 Pages: 197-198

    • DOI

      10.1038/nrneurol.2017.38

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Prediction of the clinical SUV ratio in amyloid PET imaging using a biomathematical modeling approach towards the efficient development of a radioligand.2017

    • Author(s)
      Arakawa Y, Nai Y, Shidahara M, Furumoto S, Seki C, Okamura N, Tashiro M, Kudo Y, Yanai K, Gonda K, Watabe H.
    • Journal Title

      Journal of Nuclear Medicine

      Volume: - Pages: 1285-1292

    • DOI

      10.2967/jnumed.116.183566

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Cerebrospinal Fluid Clearance in Alzheimer Disease Measured with Dynamic PET.2017

    • Author(s)
      de Leon MJ, Li Y, Okamura N, Tsui WH, Saint Louis LA, Glodzik L, Osorio RS, Fortea J, Butler T, Pirraglia E, Fossati S, Kim HJ, Carare RO, Nedergaard M, Benveniste H, Rusinek H.
    • Journal Title

      J Nucl Med.

      Volume: - Pages: 1471-1476

    • DOI

      10.2967/jnumed.116.187211

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A report of the automated radiosynthesis of the tau positron emission tomography radiopharmaceutical, [18F]-THK-5351.2017

    • Author(s)
      Neelamegam R, Yokell DL, Rice PA, Furumoto S, Kudo Y, Okamura N, El Fakhri G.
    • Journal Title

      J Labelled Comp Radiopharm.

      Volume: 60 Pages: 140-146

    • DOI

      10.1002/jlcr.3482

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] In vivo comparison of tau radioligands 18F-THK-5351 and 18F-THK-5317.2017

    • Author(s)
      Betthauser T, Lao PJ, Murali D, Barnhart TE, Furumoto S, Okamura N, Stone CK, Johnson SC, Christian BT.
    • Journal Title

      J Nucl Med.

      Volume: - Pages: 996-1002

    • DOI

      10.2967/jnumed.116.182980

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Tau imaging with [(18) F]THK-5351 in progressive supranuclear palsy.2017

    • Author(s)
      Ishiki A, Harada R, Okamura N, Tomita N, Rowe CC, Villemagne VL, Yanai K, Kudo Y, Arai H, Furumoto S, Tashiro M, Furukawa K.
    • Journal Title

      Eur J Neurol

      Volume: 24 Pages: 130-136

    • DOI

      10.1111/ene.13164

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Development of [11C]/[3H]THK-5351 - A potential novel carbon-11 tau imaging PET radioligand.2017

    • Author(s)
      Stepanov V, Svedberg M, Jia Z, Krasikova R, Lemoine L, Okamura N, Furumoto S, Mitsios N, Mulder J, Langstrom B, Nordberg A, Halldin C.
    • Journal Title

      Nucl Med Biol.

      Volume: 46 Pages: 50-53

    • DOI

      10.1016/j.nucmedbio.2016.12.004

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 18F-Labeled 2-arylquinoline derivatives for tau imaging: chemical, radiochemical, biological and clinical features.2017

    • Author(s)
      Furumoto S, Tago T, Harada R, Kudo Y, Okamura N.
    • Journal Title

      Curr Alzheimer Res.

      Volume: 14 Pages: 178-185

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] In vivo visualization of tau deposits in corticobasal syndrome by 18F-THK5351 PET2016

    • Author(s)
      Kikuchi A, Okamura N, Hasegawa T, Harada R, Watanuki S, Funaki Y, Kobayashi M, Tano O, Baba T, Sugeno N, Oshima R, Yoshida S, Kobayashi J, Ezura M, Hiraoka K, Mugikura S, Takase K, Iwata R, Taki Y, Furukawa K, HArai H, Furumoto S, Tashiro M, Yanai K, Kudo Y, Takeda A,Aoki M.
    • Journal Title

      Neurology.

      Volume: 87 Pages: 2309-2316

    • DOI

      10.1212/wnl.0000000000003375

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Applied multimodal diagnostics in a case of presenile dementia.2016

    • Author(s)
      Schonecker S, Brendel M, Huber M, Vollmar C, Huppertz HJ, Teipel S, Okamura N, Levin J, Rominger A, Danek A.
    • Journal Title

      BMC Neurol.

      Volume: 16 Pages: 131-131

    • DOI

      10.1186/s12883-016-0647-7

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Untangling tau imaging.2016

    • Author(s)
      Villemagne VL, Okamura N, Rowe CC.
    • Journal Title

      Alzheimers Dement (Amst).

      Volume: 4 Pages: 39-42

    • DOI

      10.1016/j.dadm.2016.05.001

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Characterization of the radiolabeled metabolite of tau PET tracer 18F-THK53512016

    • Author(s)
      Harada R, Furumoto S, Tago T, Furukawa K, Ishiki A, Tomita N, Iwata R, Tashiro M, Arai H, Yanai K, Kudo Y, Okamura N.
    • Journal Title

      European Journal of Nuclear Medicine and Molecular Imaging

      Volume: 43 Pages: 2211-2218

    • DOI

      10.1007/s00259-016-3453-y

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Dynamic PET Measures of Tau Accumulation in Cognitively Normal Older Adults and Alzheimer's Disease Patients Measured Using [18F] THK-53512016

    • Author(s)
      Lockhart SN, Baker SL, Okamura N, Furukawa K, Ishiki A, Furumoto S, Tashiro M, Yanai K, Arai H, Kudo Y, Harada R, Tomita N, Hiraoka K, Watanuki S, Jagust WJ.
    • Journal Title

      PLoS One

      Volume: 11

    • DOI

      10.1371/journal.pone.0158460

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] タウイメージングの現状と将来展望.2016

    • Author(s)
      岡村信行,古川勝敏.
    • Journal Title

      臨床放射線

      Volume: 61 Pages: 1635-1640

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 18F-THK5351 PETによるタウイメージング2016

    • Author(s)
      原田龍一、岡村信行
    • Journal Title

      JSMI Report

      Volume: 10 Pages: 12-14

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 認知症鑑別診断へのタウイメージングの応用2016

    • Author(s)
      岡村信行,石木愛子,古川勝敏.
    • Journal Title

      老年精神医学雑誌

      Volume: 27 Pages: 957-962

    • Related Report
      2016 Annual Research Report
  • [Journal Article] タウPETによるアルツハイマー病の評価2016

    • Author(s)
      岡村信行,原田龍一
    • Journal Title

      医学のあゆみ

      Volume: 257 Pages: 489-493

    • Related Report
      2016 Annual Research Report
  • [Journal Article] アルツハイマー病の最新診断法2016

    • Author(s)
      岡村信行
    • Journal Title

      Isotope News

      Volume: 747 Pages: 28-29

    • Related Report
      2016 Annual Research Report
  • [Journal Article] タウイメージングプローブの開発と臨床応用2016

    • Author(s)
      岡村信行
    • Journal Title

      山形ニューロサイエンス・医工学研究会会誌

      Volume: 16 Pages: 1-4

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 病的タンパク質の可視化から見た認知症2016

    • Author(s)
      岡村信行
    • Journal Title

      Bio Clinica

      Volume: 31 Pages: 28-32

    • Related Report
      2016 Annual Research Report
  • [Journal Article] microPET Imaging of Tau Pathology with [18F]THK5117 in two Transgenic Mouse Models.2016

    • Author(s)
      Brendel M, Jaworska A, Probst F, Overhoff F, Korzhova V, Lindner S, Carlsen J, Bartenstein P, Harada R, Kudo Y, Haass C, van Leuven F, Okamura N, Herms J, Rominger A.
    • Journal Title

      Journal of Nuclear Medicine

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Advances in the development of tau PET radiotracers and their clinical applications2016

    • Author(s)
      Okamura N, Harada R, Furukawa K, Furumoto S, Tago T, Yanai K, Arai H, Kudo Y.
    • Journal Title

      Ageing Research Reviews

      Volume: - Pages: 107-113

    • DOI

      10.1016/j.arr.2015.12.010

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Introduction and overview of the special issue "Brain imaging and aging": The new era of neuroimaging in aging research.2016

    • Author(s)
      Furukawa K, Ishiki A, Tomita N, Onaka Y, Saito H, Nakamichi T, Hara K, Kusano Y, Ebara M, Arata Y, Sakota M, Miyazawa I, Totsune T, Okinaga S, Okamura N, Kudo Y, Arai H.
    • Journal Title

      Ageing Res Rev.

      Volume: - Pages: 1-3

    • DOI

      10.1016/j.arr.2016.02.005

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Characteristics of Tau and Its Ligands in PET Imaging.2016

    • Author(s)
      Ryuichi Harada, Nobuyuki Okamura, Shozo Furumoto, Tetsuro Tago, Kazuhiko Yanai, Hiroyuki Arai, Yukitsuka Kudo
    • Journal Title

      Biomolecules.

      Volume: 6 Pages: 1-15

    • DOI

      10.3390/biom6010007

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Synthesis and Characterization of 18F-Interleukin-8 Using a Cell-Free Translation System and 18F-Fluoro-L-Proline.2016

    • Author(s)
      Ryuichi Harada, Shozo Furumoto, Takeo Yoshikawa, Yoichi Ishikawa, Katsutoshi Shibuya, Nobuyuki Okamura, Kiichi Ishiwata, Ren Iwata, Kazuhiko Yanai
    • Journal Title

      J. Nucl. Med. Mol. Imag.

      Volume: 57(4) Pages: 634-639

    • DOI

      10.2967/jnumed.115.162602

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure-activity relationship of 2-arylquinolines as PET imaging tracers for tau pathology in Alzheimer’s disease.2016

    • Author(s)
      Tetsuro Tago, Shozo Furumoto, Nobuyuki Okamura, Ryuichi Harada, Hajime Adachi, Yoichi Ishikawa, Kazuhiko Yanai, Ren Iwata, and Yukitsuka Kudo
    • Journal Title

      J. Nucl. Med. Mol. Imag.

      Volume: 57(4) Pages: 608-614

    • DOI

      10.2967/jnumed.115.166652

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Characterization of the radiolabeled metabolite of tau PET tracer 18F-THK5351.2016

    • Author(s)
      Harada R, Okamura N, Furumoto S, Furukawa K, Ishiki A, Tomita N, Tago T, Hiraoka K, Watanuki S, Shidahara M, Miyake M, Ishikawa Y, Matsuda R, Inami A, Yoshikawa T, Funaki Y, Iwata R, Tashiro M, Yanai K, Arai H, Kudo Y
    • Journal Title

      Eur. J. Nucl. Med. Mol. Imag.

      Volume: 57 Pages: 208-214

    • DOI

      10.2967/jnumed.115.164848

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Preclinical Evaluation of [(18)F]THK-5105 Enantiomers: Effects of Chirality on Its Effectiveness as a Tau Imaging Radiotracer.2016

    • Author(s)
      Tago T., Furumoto S., Okamura N., Harada R., Adachi H., Ishikawa Y., Yanai K., Iwata R., Kudo Y.
    • Journal Title

      Mol Imaging Biol.

      Volume: 未定 Pages: 258-166

    • DOI

      10.1007/s11307-015-0879-8

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Tau imaging in the study of ageing, Alzheimer's disease, and other neurodegenerative conditions.2016

    • Author(s)
      Villemagne VL, Okamura N.
    • Journal Title

      Curr Opin Neurobiol

      Volume: 36 Pages: 43-51

    • DOI

      10.1016/j.conb.2015.09.002

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Longitudinal Assessment of Tau Pathology in Patients with Alzheimer’s Disease Using [18F]THK-5117 Positron Emission Tomography2015

    • Author(s)
      Ishiki, Aiko Okamura, Nobuyuki Furukawa, Katsutoshi Furumoto, Shozo Harada, Ryuichi Tomita, Naoki Hiraoka, Kotaro Watanuki, Shoichi Ishikawa, Yoichi Tago, Tetsuro Funaki, Yoshihito Iwata, Ren Tashiro, Manabu Yanai, Kazuhiko Kudo, Yukitsuka Arai, Hiroyuki
    • Journal Title

      PLoS One.

      Volume: 10 Pages: 1-9

    • DOI

      10.1371/journal.pone.0140311

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Amyloid deposits and response to shunt surgery in idiopathic normal-pressure hydrocephalus.2015

    • Author(s)
      Hiraoka, Kotaro Narita, Wataru Kikuchi, Hirokazu Baba, Toru Kanno, Shigenori Iizuka, Osamu Tashiro, Manabu Furumoto, Shozo Okamura, Nobuyuki Furukawa, Katsutoshi Arai, Hiroyuki Iwata, Ren Mori, Etsuro Yanai, Kazuhiko
    • Journal Title

      Journal of the Neurological Sciences

      Volume: 356 Pages: 124-128

    • DOI

      10.1016/j.jns.2015.06.029

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Quantitative kinetic analysis of PET amyloid imaging agents [11C]BF227 and [18F]FACT in human brain2015

    • Author(s)
      Shidahara M, Watabe H, Tashiro M, Okamura N, Furumoto S, Watanuki S, Furukawa K, Arakawa Y, Funaki Y, Iwata R, Gonda K, Kudo Y, Arai H, Ishiwata K, Yanai K.
    • Journal Title

      Nucl Med Biol

      Volume: 42 Pages: 734-44

    • DOI

      10.1016/j.nucmedbio.2015.05.001

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Visualization of regional tau deposits using (3)H-THK5117 in Alzheimer brain tissue.2015

    • Author(s)
      Lemoine L, Saint-Aubert L, Marutle A, Antoni G, Eriksson JP, Ghetti B, Okamura N, Nennesmo I, Gillberg PG, Nordberg A
    • Journal Title

      Acta Neuropathol Commun.

      Volume: 3 Pages: 40-40

    • DOI

      10.1186/s40478-015-0220-4

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] [(18)F]THK-5117 PET for assessing neurofibrillary pathology in Alzheimer's disease2015

    • Author(s)
      Harada R, Furukawa K, et al.
    • Journal Title

      European Journal of Nuclear Medicine and Molecular Imaging

      Volume: 42 Pages: 1052-1061

    • DOI

      10.1007/s00259-015-3035-4

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] [18F]THK-5117 PET for assessing neurofibrillary pathology in Alzheimer's disease.2015

    • Author(s)
      Harada R, Okamura N, Furumoto S, Furukawa K, Ishiki A, Tomita N, Hiraoka K, Watanuki S, Shidahara M, Miyake M, Ishikawa Y, Matsuda R, Inami A, Yoshikawa T, Tago T, Funaki Y, Iwata R, Tashiro M, Yanai K, Arai H, Kudo Y.
    • Journal Title

      Eur J Nucl Med Mol Imaging

      Volume: -

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Role of histamine H3 receptor in glucagon-secreting αTC1.6 cells2015

    • Author(s)
      Tadaho Nakamura, Takeo Yoshikawa, Fumito Naganuma, Attyeb Mohsen, Tomomitsu iida, Yamato Miura, Akira Sugawara and Kazuhiko Yanai
    • Journal Title

      FEBS Open Bio.

      Volume: 5 Pages: 36-41

    • DOI

      10.1016/j.fob.2014.12.001

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Insufficient intake of L-histidine reduces brain histamine and causes anxiety-like behaviors in male mice.2015

    • Author(s)
      Takeo Yoshikawa, Tadaho Nakamura, Testuro Shibakusa, Mayu Sugita, Fumito Naganuma, Tomomitsu Iida, Yamato Miura, Attayeb Mohsen, Ryuichi Harada, and Kazuhiko Yanai
    • Journal Title

      J Nutr.

      Volume: 144 Pages: 1637-1641

    • DOI

      10.3945/jn.114.196105

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Brain histamine H1 receptor occupancy measured by PET after oral administration of levocetirizine, a non-sedating antihistamine.2015

    • Author(s)
      Hiraoka K, Tashiro M, Grobosch T, Maurer M, Oda K, Toyohara J, Ishii K, Ishiwata K, Yanai K.
    • Journal Title

      Expert Opin Drug Saf.

      Volume: 14 Pages: 199-206

    • DOI

      10.1517/14740338.2015.989831

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tau PET imaging in Alzheimer's disease.2014

    • Author(s)
      Nobuyuki Okamura, Ryuichi Harada, Shozo Furumoto, Hiroyuki Arai, Kazuhiko Yanai, Yukistsuka Kudo,
    • Journal Title

      Curr Neurol Neurosci Rep.

      Volume: 14 Pages: 500-500

    • DOI

      10.1007/s11910-014-0500-6

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Pitfalls of voxel-based amyloid PET analyses for diagnosis of Alzheimer's disease: artifacts due to non-specific uptake in the white matter and the skull.2014

    • Author(s)
      Arai A, Kaneta T, Okamura N, Tashiro M, Iwata R, Takanami K, Fukuda H, Takahashi S, Yanai K, Kudo Y, Arai H.
    • Journal Title

      Tohoku J Exp Med

      Volume: 234 Pages: 175-181

    • NAID

      130004694506

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Non-invasive assessment of Alzheimer's disease neurofibrillary pathology using 18F-THK5105 PET.2014

    • Author(s)
      Nobuyuki Okamura, Shozo Furumoto, Michelle T. Fodero-Tavoletti, Rachel S. Mulligan, Ryuichi Harada, Paul Yates, Svetlana Pejoska, Yukitsuka Kudo, Colin L. Masters, Kazuhiko Yanai, Christopher C. Rowe, Victor L. Villemagne
    • Journal Title

      Brain

      Volume: 137 Pages: 1762-1771

    • DOI

      10.1093/brain/awu064

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mechanism of the histamine H(3) receptor-mediated increase in exploratory locomotor activity and anxiety-like behaviours in mice.2014

    • Author(s)
      Mohsen A, Yoshikawa T, Miura Y, Nakamura T, Naganuma F, Shibuya K, Iida T, Harada R, Okamura N, Watanabe T, Yanai K.
    • Journal Title

      Neuropharmacology.

      Volume: 81 Pages: 188-194

    • DOI

      10.1016/j.neuropharm.2014.02.003

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Synthesis and preliminary evaluation of 2-arylhydroxyquinoline derivatives for tau imaging.2014

    • Author(s)
      Villemagne L. Victor, Shozo Furumoto, Michelle T. Fodero-Tavoletti, Rachel S. Mulligan, John Hodges, Ryuichi Harada, Paul Yates, Oliver Piguet, Svetlana Pejoska, Vincent Doré, Kazuhiko Yanai, Colin L. Masters, Yukitsuka Kudo, Christopher C. Rowe, Nobuyuki Okamura.
    • Journal Title

      Eur J Nucl Med Mol Imaging.

      Volume: 41 Pages: 18-24

    • DOI

      10.1007/s00259-013-2681-7

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Predominant role of plasma membrane monoamine transporters in monoamine transport in 1321N1, a human astrocytoma-derived cell line2014

    • Author(s)
      Fumito Naganuma, Takeo Yoshikawa, Tadaho Nakamura, Tomomistu Iida, Ryuichi Harada, Attayeb S. Mohsen, Yamato Miura and Kazuhiko Yanai.
    • Journal Title

      J Neurochem.

      Volume: 129 Pages: 591-601

    • DOI

      10.1111/jnc.12665

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Imaging-autopsy correlation of 18F-THK5351 in typical and atypical cases of progressive supranuclear palsy.2018

    • Author(s)
      Harada R, Ishiki A, Kai H, Furukawa K, Furumoto S, Tashiro M, Kitamoto T, Kudo Y, Yanai K, Arai H, Okamura N.
    • Organizer
      The 11th Human Amyloid Imaging (HAI) meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Structure-binding relationship of quinoline derivatives on monoamine oxidase B.2018

    • Author(s)
      Okamura N, Harada R, Furumoto S, Arai H, Yanai K, Kudo Y.
    • Organizer
      The 11th Human Amyloid Imaging (HAI) meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Characterizing the “off-target” binding of 18F-THK5351 in Alzheimer’s disease: correlation between ante-mortem and post-mortem findings.2017

    • Author(s)
      Harada R, Ishiki A, Furumoto S, Furukawa K, Tashiro M, Arai H, YanaiK, Kudo Y, Okamura N
    • Organizer
      11th Human Amyloid Imaging
    • Place of Presentation
      Miami, USA
    • Year and Date
      2017-01-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Successful reduction of off-target binding of quinoline derivatives as tau-selective PET tracers.2017

    • Author(s)
      Harada R, Hayakawa Y, Ezura M, Furumoto S, Iwata R, Arai H, Yanai K, Kudo Y, Okamura N.
    • Organizer
      AAIC 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Amyloid and Tau Imaging in Neurodegenerative Diseases.2017

    • Author(s)
      Okamura N
    • Organizer
      XXIII World Congress of Neurology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Imaging tau and astrocyte with 18F-THK5351 - analysis of autopsy cases -.2017

    • Author(s)
      Okamura N
    • Organizer
      Society of Nuclear Medicine and Molecular Imaging
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] [18F]THK-5351のoff-target bindingの解析:画像病理相関症例を含めて2017

    • Author(s)
      原田龍一、石木愛子、甲斐英朗、佐藤直美、古川勝敏、冨田尚希、古本祥三、笹野公伸、工藤幸司、北本哲之、谷内一彦 、荒井啓行 、岡村信行
    • Organizer
      第36回日本認知症学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] [18F]THK-5351のアルツハイマー病患者における画像病理相関解析2017

    • Author(s)
      原田龍一、石木愛子、甲斐英朗、佐藤直美、古本祥三、笹野公伸、工藤幸司、北本哲之、谷内一彦、荒井啓行、岡村信行
    • Organizer
      第57回 日本核医学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] タウイメージング18F-THK5351 PETの画像病理相関解析2017

    • Author(s)
      原田龍一、石木愛子、甲斐英朗、佐藤直美、古川勝敏、冨田尚希、谷内一彦、岡村信行、工藤幸司、荒井啓行
    • Organizer
      第28回日本老年医学会東北地方会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Novel tracer development and potential application for movement disorders.2017

    • Author(s)
      Okamura N
    • Organizer
      3rd Taiwan International Congress of Parkinson's Disease and Movement Disorders
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] CHARACTERIZATION OF 18F-BF227 IN A MOUSE MODEL VIA STEREOTAXIC INJECTION OF α-SYNUCLEIN AGGREGATES2017

    • Author(s)
      Michael E.J. Stouthandel, Ryuichi Harada, Yoshimi Hayakawa, Takeo Yoshikawa, Shozo Furumoto, Yukitsuka Kudo, Nobuyuki, Okamura, Kazuhiko Yanai
    • Organizer
      第90回日本薬理学会
    • Place of Presentation
      長崎新聞文化ホール(長崎)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 時間分解蛍光法用ランタニド錯体標識βシートリガンドの開発2017

    • Author(s)
      原田龍一、岡村信行、古本祥三、吉川雄朗、工藤幸司、谷内一彦
    • Organizer
      第90回日本薬理学会
    • Place of Presentation
      長崎新聞文化ホール(長崎)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 認知症のPETイメージング2017

    • Author(s)
      岡村信行
    • Organizer
      日本神経学会東北地方会
    • Place of Presentation
      フォレスト仙台 (仙台)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] アミロイド / タウ PET 基礎から最新のトピックスまで2017

    • Author(s)
      岡村信行
    • Organizer
      第46回日本神経放射線学会
    • Place of Presentation
      ソラシティカンファレンスセンター(東京)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 認知症のPET分子イメージング:最近の進歩2017

    • Author(s)
      岡村信行
    • Organizer
      第7回山口Brain Imaging
    • Place of Presentation
      ANAクラウンプラザホテル宇部(宇部)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] タウイメージングの現状と課題2017

    • Author(s)
      原田龍一
    • Organizer
      第4回東北認知症画像診断研究会
    • Place of Presentation
      アークホテル仙台青葉通り(仙台)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Development of THK tau tracers.2016

    • Author(s)
      Okamura N.
    • Organizer
      Tau PET Futures Meeting
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2016-10-13
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] [F-18]THK5351 retention is associated with the progression of brain atrophy in patients with Alzheimer’s disease.2016

    • Author(s)
      Okamura N, Ishiki A, Furukawa K, Harada R, Tomita N, Furumoto S, Tashiro M, Yanai K, Arai H, Kudo Y.
    • Organizer
      AAIC2016
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2016-07-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of wavelength-dependent compounds for imaging Lewy pathology2016

    • Author(s)
      Harada R, Okamura N, Furumoto S, Iwata R, Arai H, Yanai K, Kudo Y
    • Organizer
      AAIC2016
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2016-07-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Tau imaging.2016

    • Author(s)
      Okamura N
    • Organizer
      AONeuro Symposium - Neurotrauma
    • Place of Presentation
      仙台市立病院講堂(宮城県・仙台市)
    • Year and Date
      2016-02-28
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Tau PET Imaging. Current status and future directions.2016

    • Author(s)
      Okamura N.
    • Organizer
      Mind Brain Conference "From Molecules to the Universe: Advancing Biomedical Sciences and Engineering"
    • Place of Presentation
      グランドホテル浜松(静岡県・浜松市)
    • Year and Date
      2016-02-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Distinct patterns of [18F]THK-5351 retention in AD and non-AD tauopathies.2016

    • Author(s)
      Okamura N, Kikuchi A, Furukawa K, Ishiki A, Harada R, Hasegawa T, Takeda A, Furumoto S, Iwata R, Tashiro M, Yanai K, Aoki M, Arai H, Kudo Y.
    • Organizer
      The 10th Human Amyloid Imaging (HAI) meeting
    • Place of Presentation
      Miami, USA
    • Year and Date
      2016-01-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Metabolite analysis of tau PET tracer [18F]THK-5351.2016

    • Author(s)
      Harada R, Okamura N, Furumoto S, Tago T, Furukawa K, Ishiki A, Iwata R, Tashiro M, Arai H, Yanai K, Kudo Y.
    • Organizer
      The 10th Human Amyloid Imaging (HAI) meeting
    • Place of Presentation
      Miami, USA
    • Year and Date
      2016-01-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Longitudinal analysis of [18F]THK5351 tau PET images in patients with Alzheimer’s disease and corticobasal syndrome2016

    • Author(s)
      kamura N, Harada R, Ishiki A, Furukawa K, Kikuchi A, Hasegawa T, Aoki M, Furumoto S, Tashiro M, Yanai K, Arai H, Kudo Y
    • Organizer
      CTAD 2016
    • Place of Presentation
      San Diego, USA
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Novel PET Probes for Imaging of Tau in Alzheimer’s Disease.2016

    • Author(s)
      Okamura N
    • Organizer
      Symposium of Medical Imaging, PET/MR and Molecular Images
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Recent clinical studies with THK tau tracers.2016

    • Author(s)
      Okamura N
    • Organizer
      SNMMI 2016 Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] タウPETプローブの開発研究2016

    • Author(s)
      原田龍一
    • Organizer
      第5回物理・分析系若手研究者セミナー
    • Place of Presentation
      東北医科薬科大学 (仙台)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] タウPETイメージングの現状と可能性2016

    • Author(s)
      岡村信行、原田龍一
    • Organizer
      第35回日本認知症学会学術集会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 認知症患者における神経原線維変化の画像化に関する研究2016

    • Author(s)
      岡村信行
    • Organizer
      第35回日本認知症学会学術集会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Impact of tau PET on dementia research2016

    • Author(s)
      岡村信行
    • Organizer
      第56回日本核医学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 東北大学におけるタウPETプローブの基礎開発について2016

    • Author(s)
      原田龍一
    • Organizer
      第6回日本認知症予防学会
    • Place of Presentation
      東北大学(仙台)
    • Related Report
      2016 Annual Research Report
  • [Presentation] タウPETトレーサーによる診断マーカー開発2016

    • Author(s)
      原田龍一
    • Organizer
      2016タウ研究ミーティング
    • Place of Presentation
      学習院大学(東京)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] アルツハイマー病の分子イメージング2016

    • Author(s)
      岡村信行、長沼史登、中村正帆
    • Organizer
      第32回日本DDS学会学術集会
    • Place of Presentation
      静岡県コンベンションアーツセンター(静岡)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 認知症におけるタウPETイメージング2016

    • Author(s)
      岡村信行
    • Organizer
      第12回認知症ファイヤーカンファレンス
    • Place of Presentation
      大手町サンケイプラザ(東京)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] アルツハイマー病のPET診断2016

    • Author(s)
      岡村信行
    • Organizer
      第11回日本分子イメージング学会総会・学術集会
    • Place of Presentation
      神戸国際会議場(神戸)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] タウPETイメージングの現状と可能性2016

    • Author(s)
      岡村信行
    • Organizer
      畿大学認知症Core研究 第1回シンポジウム
    • Place of Presentation
      近畿大学医学部付属病院 (大阪)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Experience with Tau PET2015

    • Author(s)
      Okamura N
    • Organizer
      Busan Paik Hospital Neurodegenerative Disease Symposium
    • Place of Presentation
      Busan, South Korea
    • Year and Date
      2015-11-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Tau PET imaging with THK tau tracers.2015

    • Author(s)
      Okamura N.
    • Organizer
      2015 IPA 17th International Congress
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      2015-10-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Molecular PET imaging of tau pathology in Alzheimer disease using THK tracers2015

    • Author(s)
      Yanai K, Okamura N
    • Organizer
      1st International Symposium of Brain Protein Aging and Dementia Control
    • Place of Presentation
      野依記念ホール(愛知県・名古屋市)
    • Year and Date
      2015-10-10
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PET imaging of misfolded proteins in Alzheimer’s disease.2015

    • Author(s)
      Okamura N.
    • Organizer
      Tohoku Forum for Creativity: Frontier of Brain Science Satellite Symposium “Neuroimaging and its impact on our lives”
    • Place of Presentation
      神戸国際会議場(兵庫県・神戸市)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Validation of the binding specificity of tau PET tracer [18F]THK-5351 on postmortem human brain samples.2015

    • Author(s)
      Harada R, Okamura N, Furumoto S, Ishiki A, Furukawa K, Tomita N, Tago T, Iwata R, Yanai K, Arai H, Kudo Y
    • Organizer
      AAIC 2015
    • Place of Presentation
      Washington D.C., USA
    • Year and Date
      2015-07-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Distribution of tau pathology in the patients with mild cognitive impairment and Alzheimer’s disease measured with [18F]THK-5351 PET.2015

    • Author(s)
      Okamura N, Furumoto S, Furukawa K, Ishiki A, Tomita N, Harada R, Tashiro M, Yanai K, Arai H, Kudo Y.
    • Organizer
      AAIC2015
    • Place of Presentation
      Washington D.C., USA
    • Year and Date
      2015-07-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PET imaging of tau pathology in mild cognitive impairment and Alzheimer's disease with [18F]THK-5351.2015

    • Author(s)
      Okamura N, Furumoto S, Furukawa K, Ishiki A, Harada R, Iwata R, Tashiro M, Yanai K, Arai H, Kudo Y.
    • Organizer
      SNMMI 2015 Annual Meeting
    • Place of Presentation
      Baltimore, USA
    • Year and Date
      2015-06-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Tau imaging in dementia.2015

    • Author(s)
      Okamura N.
    • Organizer
      Molecular Imaging of Dementia: Beyond Amyloid PET, SNMMI 2015 Annual Meeting,
    • Place of Presentation
      Baltimore, USA
    • Year and Date
      2015-06-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Preclinical characterization of [18F]THK-5117 enantiomers as a PET tau probe for tau pathology in Alzheimer’s disease2015

    • Author(s)
      Tago T., Furumoto S., Okamura N., Harada R., Adachi H., Ishikawa Y., Yanai Y., Iwata R., Kudo Y.
    • Organizer
      21st International Symposium on Radiopharmaceutical Sciences
    • Place of Presentation
      Columbia, USA
    • Year and Date
      2015-05-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Characterization of [18F]THK-5351, a novel PET tracer for imaging tau pathology in Alzheimer's disease.2014

    • Author(s)
      Okamura N, Furumoto S, Harada R, Tago T, Iwata R, Tashiro M, Furukawa K, Arai H, Yanai K, Kudo Y.
    • Organizer
      EANM 2014
    • Place of Presentation
      Gothenburg, Sweden
    • Year and Date
      2014-10-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] Comparison of 18F-THK5117 and 11C-PiB PET images in the patients with Alzheimer’s disease.2014

    • Author(s)
      Okamura N, Harada R, Furumoto S, Furukawa K, Ishiki A, Tomita N, Tashiro M, Iwata R, Yanai K, Arai H, Kudo Y
    • Organizer
      AAIC 2014
    • Place of Presentation
      Copenhagen, Denmark
    • Year and Date
      2014-07-12 – 2014-07-17
    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] ポジトロン放出核種標識タンパク質合成方法2017

    • Inventor(s)
      原田龍一、谷内一彦、岩田錬、古本祥三、谷内亜衣
    • Industrial Property Rights Holder
      原田龍一、谷内一彦、岩田錬、古本祥三、谷内亜衣
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-219798
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] MONOAMINE OXIDASE B BINDERS2016

    • Inventor(s)
      古本祥三、工藤幸司、岡村信行、原田龍一
    • Industrial Property Rights Holder
      古本祥三、工藤幸司、岡村信行、原田龍一
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-12-18
    • Related Report
      2016 Annual Research Report
    • Overseas

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Published: 2014-11-20   Modified: 2020-03-30  

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