| Budget Amount *help |
¥138,970,000 (Direct Cost: ¥106,900,000、Indirect Cost: ¥32,070,000)
Fiscal Year 2018: ¥25,350,000 (Direct Cost: ¥19,500,000、Indirect Cost: ¥5,850,000)
Fiscal Year 2017: ¥25,350,000 (Direct Cost: ¥19,500,000、Indirect Cost: ¥5,850,000)
Fiscal Year 2016: ¥25,350,000 (Direct Cost: ¥19,500,000、Indirect Cost: ¥5,850,000)
Fiscal Year 2015: ¥25,220,000 (Direct Cost: ¥19,400,000、Indirect Cost: ¥5,820,000)
Fiscal Year 2014: ¥37,700,000 (Direct Cost: ¥29,000,000、Indirect Cost: ¥8,700,000)
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| Outline of Final Research Achievements |
MSA-syn showed similar seeding activity to the synthetic fibrils, although DLB-syn showed a lower seeding activity (Tarutani et al, Acta Neuropathol Commun 2018). N-terminally 10- or 30-residues-truncated human α-syn fibrils induced more abundant α-syn pathologies than WT fibrils in mice, whereas other truncated fibrils induced less abundant pathologies (Terada et al, J Biol Chem 2018). Abnormal expansion of a hexanucleotide repeat in an intron of C9ORF72 induced aggregation of poly-GA protein, which may be the mechanism to induce TDP-43, but not tau or α-syn (Nonaka et al, Hum Mol Genet 2018).
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