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物質情報計測における分子認識と精密分離

Research Project

Project/Area Number 01307014
Research Category

Grant-in-Aid for Co-operative Research (B)

Allocation TypeSingle-year Grants
Research Field Physical pharmacy
Research InstitutionTohoku University

Principal Investigator

南原 利夫  東北大学, 薬学部, 教授 (30004534)

Co-Investigator(Kenkyū-buntansha) 四ツ柳 隆夫  東北大学, 工学部, 教授 (00001199)
高木 誠  九州大学, 工学部, 教授 (90037739)
辻 章夫  昭和大学, 薬学部, 教授 (80053784)
大倉 洋甫  九州大学, 薬学部, 教授 (00037574)
戸田 昭三  東京大学, 農学部, 教授 (40011845)
Project Period (FY) 1989
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1989: ¥1,900,000 (Direct Cost: ¥1,900,000)
Keywords物質情報計測 / 分子認識 / 化学情報変換 / 精密分離 / 分離科学 / 金属イオン / 非イオン性化学種 / 生体関連物質
Research Abstract

近年、科学技術はめざましい発展をとげており、物質に関する情報を生み出す計測科学と物質の分離科学の発達は、それを支える基礎技術として多大の貢献をしてきた。21世紀をめざす先端技術の分野では、物質情報の計測において、識別と分離の技術に格段の進歩が求められている。これらの創造を目指す研究は、先導的基礎的研究として高い価値を有するばかりでなく、先端科学領域の進展に対して広範な新しいアプロ-チを可能とするものであり、学術的、社会的要請の強い研究分野として重点的に推進する必要があることはいうまでもない。わが国では、分子認識と精密分離を志向した基礎研究が盛んであり、個々には国際的にも第一級のレベルを有している。この背景を生かし、社会的ニ-ズの強い物質情報計測の視点から、研究者間の討論と研鑽の場を持つことが強く望まれている。本研究は、分子認識に関する第一線の研究者を中心とし、これに分離科学を専門とする研究者を加えた組織をつくり、この領域の基礎研究の進展と体系化を図る準備のための場を持つことを目的とした。また、その結果を踏まえ将来重点研究領域として発展させ、この分野の研究に大きく寄与することを目標とした。
本研究では、1)イオンの分子認識と精密分離、2)非イオン性化学種の分子認識と精密分離、3)生体関連物質の分子認識と精密分離、4)化学計測における情報変換と分子認識、5)分離科学における理論と新しい方法の5研究項目を設定し、各研究者間の緊密な研究連絡を行なうとともに、本研究分野の将来に向けての展望を模索した。すなわち、各研究者の研究成果を踏まえた活発な討論により、次年度以降重点研究領域としての充実、発展を期すため重点とする研究項目の設定および分担、研究体制の確立等を中心に具体的内容について討議を進め、吟味を重ねて研究計画のアウトラインを策定した。

Report

(1 results)
  • 1989 Annual Research Report
  • Research Products

    (54 results)

All Other

All Publications (54 results)

  • [Publications] Junichi Goto: "Separation of C-25 Epimers of 5β-Cholestanoic Acids by High-Performance Liquid Chromatography with Precolumn Fluorescence Labeling" Anal.Sci.5. 19-22 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Junichi Goto: "Studies on Steroids.CCXXXXIV.Separation and Characterization of C-25 Epimers of Unconjugated and Conjugated Trihydroxycholestanoic Acids in Urine from a Patient with Zellweger Syndrome by High-Performance Liquid Chromatography" J.Liquid Chromatogr.12. 1075-1084 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Junichi Goto: "Studies on Steroids.CCXXXXV.Determination of 5β-Cholestanoic Acids in Human Urine by Gas Chromatography-Mass Spectrometry with Negative Ion Chemical Ionization Detection" J.Chromatogr.493. 245-255 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Masatoshi Oue: "Sylver Ion-Selective Polymeric Membrane Electrode Based on Lipophilic Monothiacrown Ether" Anal.Sci.5. 165-169 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Masatoshi Oue: "Lipophilic Thiacrown Ether Derivatives as Neutral Silver-Ion Selective Carriers" J.Chem.Soc.Perkin Trans.I.1675-1678 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Hidefumi Sakamoto: "Selective Lithium Ion Transport through Hollow-Fiber Membrane Containing Easily-Dissociable 14-Crown-4 Derivative" Bull.Chem.Soc.Jpn.62. 3394-3396 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Kensaku Haraguchi: "Solvent Extraction of Some Metal Ions with Alkylcarbonyl-Substituted N-phenylhydroxylamines" Anal.Sci.5. 735-738 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Etsuro Yoshimura: "Circulating Solvent Extraction System for Trace Metals in Aqueous Solution" Trace and Microprobe Tech.7. 103-110 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Harumi Suzuki: "Lignosulfonate from Waste Liquor of Pulping Process Activates Murine Macrophages and Causes Proliferatin of Bone Marrow Cells" Agric.Biol.Chem.53. 1197-1199 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Harumi Suzuki: "Lignosulfate,a Water-Solubilized Lignin from the Waste Liquor of Pulping Process,Inhibits the Infectivity and Cytopathic Effects of Human Immunodeficiency Virus in Vitro" Agric.Biol.Chem.53. 3369-3372 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Masayasu Akiyama: "N-Hydroxy Amides.Part 8.Synthesis and Iron(III)-holding Properties of Di-and Tri-hydroxamic Acids Extending from Benzene-di-and-tri-carbonyl Units through Oligo(ethyleneoxy)Arms" J.Chem.Soc.Perkin Trans.2. 1213-1218 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Masayasu Akiyama: "N-Hydroxy Amides.Part 6.Synthesis and Spectroscopic Properties of 1-Hydroxypiperazine-2,5-diones" J.Chem.Soc.Perkin Trans.1. 235-239 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Yoshinobu Yokomori: "Structure of Cyclo(-N-Hydroxyglycyl-L-alanyl)" Acta Cryst.C45. 1084-1086 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Koji Kano: "Monolayers of 1-Sterarylpyrene-6-sulfonate and 1-Stearylpyrene-8-sulfonate" Langmuir. 5. 927-932 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Koji Kano: "Chiral Recognition of Binaphthyls by Permethylated β-Cyclodextrin" J.Chem.Soc.,Chem.Commun.1278-1279 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Koji Kano: "Molecular Recognition by Saccharides.Asymmetric Complexation between Bilirubin and Nucleosides" Chem.Lett.21-24 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Yasuhiro Aoyama: "Molecular Recognition.5.Molecular Recognition of Sugars via Hydrogen Bonding Interaction with a Synthetic Polyhydroxy Macrocycle" J.Am.Chem.Soc.111. 5397-5404 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Yasutaka Tanaka: "Selective Sugar Binding with a Synthetic Polyhydroxy Macrocycle.A Remarkable Selectivity for Fructose over Glucose" Chem.Lett.1905-1908 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Yasutaka Tanaka: "Two-Point Hydrogen Bonding Interaction:A Remarkable Chain-Length Selectivity in the Binding of Diacids with Resorcinol-Aldehyde Cyclotetramer as a Multidentate Host" J.Am.Chem.Soc.

    • Related Report
      1989 Annual Research Report
  • [Publications] Fumio Toda: "Optical Resolution of Pantolactone by Inclusion Crystallization with(R,R)-(-)-trans-2,3-Bis(diphenylhydrxymethyl)-1,4-dioxaspiro[4.5]decane,and Crystal Structure of the Resulting 1:1 Complex" Chem.Lett.873-876 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Fumio Toda: "Optical Resolution of Amine N-Oxide by Diastereomeric Complex Formation with Optically Active Host Compound" Tetrahedron Lett.30. 1841-1844 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Fumio Toda: "Resolution of Bicyclo[2.2.1]heptanone,Bicyclo[2.2.2]octanone,and Bicyclo[3.2.1]octanone Derivatives by Complexation with Optically Active Host Compounds" Chem.Exp.4. 439-442 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Yoshihiko Umegae: "meso-1,2-Bis(4-methoxyphenyl)ethylenediamine as fluorogenic Reagent for reducing carbohydrates" Anal.Chim.Acta. 217. 263-270 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Masahiro Ohno: "High-Performance Liquid Chromatographic Determination of substance P-like Peptide in Rat Brain by on-line Post-Column Fluorescence Derivatization with Benzoin" J.Chromatogr.490. 301-310 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Hitoshi Nohta: "Measurement of Catecholamines,Their precursor and Metabolites in Human Urine and Plasma by Solid-Phase Extraction Followed by HPLC with Fluorescence Derivatization" J.Chromatogr.493. 15-26 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Masako Maeda: "Chemiluminescent Assay of Various Enzyme Activities and Its Application to Enzyme Immunoassays" J.Biolumi.Chemilumi.4. 140-148 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Hidetoshi Arakawa: "Highly Sensitive Biotin-Labelled Hybridization Probe" Chem.Pharm.Bull. 37. 1831-1833 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Yoshinori Uji: "Chemiluminescent Determination of Nonesterified Fatty Acids in Serum" Clin.Chem.35. 325-326 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Kazuhiro Imai: "Dynamic Analytical Chemistry:A Trial Study of The Interaction of Fluorogenic Reagents with Living Chinese Hamster Ovary Cells" Anal.Chim.Acta. 223. 299-308 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Toshimasa Toyo'oka: "Fluorogenic Reagent for Thiols:4-(N,N-Dimethylaminosulphonyl)-7-fluoro-2,1,3-benzoxadiazole" Analyst.114. 413-419 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Toshimasa Toyo'oka: "Determination of Thiols and Disulfides in Normal Rat Tissues and Hamster Pancreas Treated with N-Nitrosobis(2-oxopropyl)amine using 4-(Aminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole and Ammonium 7-Fluoro-2,1,3-benzoxadiaole-sulfonate" Biomed.Chromatogr.3. 166-172 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] A.Ohki: "Extraction of Organic Dianionic Species with Dicationic Extractans and Their Application to Anionic Selective Electrode" Chem.Lett.95-98 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] S.Ida: "Synergistic Extraction of Heavy Metal Ions with 1,2-Bis(octanesulfonamido)benzene in Chlorobenzene" Anal.Sci.5. 351-354 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] A.Ohki: "Solvent Extraction of D-and L-Dibenzoyltartrate Anions with Dicationic Ion-Pair Extractions Featuring Chirality Recognition and Shape Recognition" Chem.Lett.1551-1554 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] James C.Bigelow: "Separation of B and T Lymphocytes by a Hybrid Field-Flow Fractionation/Adhesion Chromatography Technique" J.Immunol.Methods. 117. 289-293 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Atsushi Maruyama: "Elimination of Cellular Active Adhesion on Microdomain Strutured Surface of Polyamine Graft Copolymers" Biomaterials. 10. 291-298 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Atsushi Maruyama: "Separation of B and T Lymphocytes by Cellular Adsorption Chromatography with Polyamine Graft Copolymers as Column Matrices II.Recovery of Adsorbed B Cell Enriched Populations from the Column" Biomaterials. 10. 393-399 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Atsushi Yoshinaga: "Laser Induced Photoacoustic Spectrometry with Single Particle Sample" Anal.Sci.5. 147-149 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Jun Kawai: Phys.Rev.A. 39. 3686-3689 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Kenji Sakamaki: Bull.Chem.Soc.Jpn.62. 2890-2896 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Kouhei Uosaki: "Crystal-Face-Specific Response of a Single-Crystal Cadmium Sulfide Based Ion-Selective Electrode" Anal.Chem.61. 1980-1983 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Masamitsu Kataoka: "Potentiometric Liquid Membrane Sensors that Discriminate Linear Homologs and Geometrical/Positional Isomers of Dicarboxylates" Anal.Lett.22. 1089-1105 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Shinobu Nagase: "Anion Responsive Ion-Channel Type Sensors Based on Langmuir-Blodgett Membrane Assemblies Containing Synthetic Anion Receptors" Anal.Chem.

    • Related Report
      1989 Annual Research Report
  • [Publications] Yasushi Hasebe: "Photo-Excitable Membranes.Ion-Selective Photoresponse of poly(Vinyl Chloride)/Spirobenzopyrane Membranes Doped with Nonactin and Valinomycin" Chem.Pharm.Bull.37. 1307-1310 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Chien-Wu Chen: "Photo-Switchable Ion and Enzyme Sensors.Photoinduced Potentiometric Response of Glassy Carbon Electrode Coated with Polymer or Polymer/Enzyme Dual Membrane" Chem.Pharm.Bull.37. 3316-3319 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Shin Tsuge: J.High Res.Chromatogr.12. 727-731 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Toyohide Takeuchi: "Temperature Effects in Microcolumn Size Exclusion Chromatography" J.Liquid Chromatogr.12. 987-996 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Toyohide Takeuchi: "New Approach to the GC Separation of Hydrocarbons by Using LC-like Microcolumns" Chromatographia. 27. 182-184 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Tohru Saito: "Separation of 4-(2-Pyridylazo)resorcinolato Metal Chelates by Micellar Electrokinetic Capillary Chromatography" J.Chromatogr.469. 175-181 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Nobuo Uehara: "An Ion-Pair Reversed-Phase HPLC-Fluorimetric system for Ultratrace Determination of Aluminum with Salicylaldehydebenzoylhydrazone" Talanta. 36. 1031-1035 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Hideki Obi: "Ion-Associate Solvent Extraction of Gallium(III)from Aqueous Sodium Hydroxide Solution" Chem.Lett.547-550 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Shigeru Terabe: "Band Broadening in Electrokinetic Chromatography with Micellar Solution and Open-Tubular Capillary" Anal.Chem.61. 251-260 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Shigeru Terabe: "Electrokinetic Chromatography:An Interface between Electrophoresis and Chromatography" Trends Anal.Chem.8. 129-134 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Shigeru Terabe: "Chiral Separation by Electrokinetic Chromatography with Bile Salt Micells" J.Chromatogr.480. 403-411 (1989)

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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