|Budget Amount *help
¥3,700,000 (Direct Cost : ¥3,700,000)
Fiscal Year 1991 : ¥600,000 (Direct Cost : ¥600,000)
Fiscal Year 1990 : ¥900,000 (Direct Cost : ¥900,000)
Fiscal Year 1989 : ¥2,200,000 (Direct Cost : ¥2,200,000)
1. A factor-control study was conducted in Niigata Prefecture to survey the relationship between the use of trichloroethylene(TPI)and the occurrence of gastrointestinal, cutaneous and articular manifestations. The particular symptom complex suggesting PCI, which is characterized by abdominal fullness, flatus, abdominal pain, constipation and diarrhea, and foamy, bloody stool appeared more frequently in the exposed females.
As to scleroderma-like symptoms, a symptom complex consisting of skin-sclerosis of extremities, face and trunk, thickening and tightening of the skin of fingers(scierodactily), Raynaud's phenomenon of fingers was observed more frequently in the exposed workers of both sexes. A similar survey was also conducted in Nagano prefecture, where abdominal fullness and abdominal pain were found to be dose-dependently complained of in TRI-exposed workers.
2. Scrutiny of 19 PCI cases thus far collected by us in Nagano Prefecture revealed that 1)three aroups of patients(7 in total)were working in the same factories, 2)most of the PCI patients were workers in small-scale factories having poor working conditions, and 3)PCI patients were often simultaneously exposed to TRI and methanol at high concentrations. The last finding suggests that co-exposure to TRI and methanol may play a role in the development of primary PCI.
3. TRI and methanol were given orally to rats daily for 3 months either singly or in combination. Although abdominal barium enema examination performed twice during the experiment revealed no abnormality, histological examination at autopsy revealed that rats treated with TRI in combination with methanol had submucosal and/or subserosal edemas in the colon. It remains to be studied whether this change, which was completely absent in the control group rats, is etiologically related to the development of PCI.