| Project/Area Number |
01480400
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Keio University |
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Principal Investigator |
MAKINO Tsunehisa Keio University, Dept. of OB/GY, 医学部・構講 (30085758)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAI Atsushi Keio University, Dept. of OB/GY, 医学部, 助手 (00196031)
TOYOSIMA Kiwamu Keio University, Dept. of OB/GY, 医学部, 助手 (00197964)
SUGI Toshitaka Keio University, Dept. of OB/GY, 医学部, 助手 (70196707)
HARA Takabumi Keio University, Dept. of OB/GY, 医学部, 助手 (30189683)
OKA Chikahiro Keio University, Dept. of OB/GY, 医学部, 助手 (20185408)
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| Project Period (FY) |
1989 – 1990
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| Project Status |
Completed (Fiscal Year 1990)
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| Budget Amount *help |
¥5,500,000 (Direct Cost: ¥5,500,000)
Fiscal Year 1990: ¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 1989: ¥2,900,000 (Direct Cost: ¥2,900,000)
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| Keywords | Habitual abortion / Infertility / Uterine anomaly / Immunotherapy / Chemical abortion / Anti-phospholipid antibody / 自然流産 / 抗カルジオリピン抗体 / 抗リン脂質抗体症候群 / 抗リン脂肪抗体症候群 / Chemical Abortion / 先天性子宮奇形 |
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| Research Abstract |
One thousand, three hundreds and seventeen women with a history of repeated reproductive wastages were analyzed for their possible causes of early pregnancy failure by using histological, immunological, hormonal as well as biochemical techniques.
We demonstrated that the number of blood vessels were less in the septum of the uterus than in the other site of normal uterus. It is presumed that the lack of blood supply for embryonal implants in septate uterus may cause early pregnancy failure.
Unexplained recurrent spontaneous abortions are generally agreed to be related with immunological factors. It has been partially supported by the beneficial effect of immunotherapy for these patients. We founded that changes in a Mixed Lymphocyte Culture (MLC), T-cell subsets and generation of anti-idiotypic antibodies were induced after immunotherapy as compared to pre-immunization values. This suggests that the maternal immunosuppresion was induced by the immunotherapy in both humoral and cell-mediated immune response.
It is also demonstrated that the incidence of detected chemical abortions was higher in habitually aborting women than in nonhabitual abortion group. This suggests that numerous periimplantaional losses may include clinical abortion.
We elucidated that diagnosis of antiphospholipid syndrome evaluated by the standard serum and its application for recurrent fetal loss were very essential and beneficial for investigation of the mechanism of various autoantibodies to pregnancy and appropriate treatment for recurrent fetal wastages.
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