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Studies on the neuronal mechanisms of the memory functions in the amygdala and the uippocampus of monkeys

Research Project

Project/Area Number 01570063
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Neurophysiology and muscle physiology
Research InstitutionKyoto University

Principal Investigator

MIKAMI Akichika  Kyoto University, Primate Research Institute Associate Professor, 霊長類研究所, 助教授 (40027503)

Project Period (FY) 1989 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1991: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1990: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1989: ¥900,000 (Direct Cost: ¥900,000)
KeywordsAmygdala / Hippocampus / Monkey / Visual short-term memory / Visual Discrimination / Neuron / Temporal Association Corbex / 学習課題 / 短期記憶 / 視覚刺激
Research Abstract

The memory functions in the amygdala and the hippocampus has been studied in the human patient and non-human primates. In these experiments, psychological tests to find the deficits of memory functions were performed after the surgical or ishemic lesion of the brain tissues. There were two kinds of contradictory results have been presented by these experiments. Mishkin's group are emphasizing the importance of both structures. On the other hand, Zola-Morgan's group are emphasizing the role of hippocampus. Because neuronal activities were never recorded in these structures related to the memory task, it was not clear which is correct. In this study, the neuronal activities were recorded from the amygdala and hippocampus of the rhesus monkeys during the performance of visual short-term memory task. We found the selective memory neurons which fired i n response to particular photograph-and throughout the subseqtrent memory periods in the amygdala but not in the hippocampus. In addition to these neurons, we found the non-selective delay neurons which showed increase of their discharge rates gradually during the delay period and the discharge rate decreased after the next stimulus in both of structures. We concluded that the amygdala was involved in the retention of the visual short-term memory, but the hippocampus was not directly involved in the retention of the visual memory.

Report

(4 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • 1989 Annual Research Report
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] Nakamura,K.: "The activity of single neurons in the monkey amygdala during performance of a visual discrimiuation task." J.Neurophysiol.(1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Nakamura,K.: "Neuronal activities in the amygdala of rhesus monkey during a sequential visual discrimination kask with delay." Neurosic.Research. 9. 79 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Nakamura,K.: "Stimulus selective meuronal responses to colored photographs in the amygdala of the rhesus monkey" Jpn.J.Physiol.39. 166 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Nakamura,K.: "Stimulus selectivoty correlated with temporal characteristics in amygdala visual neu rons in the rhesus monkey" Jpn.J.Physiol.40. 183 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Iwai,E.: "Vision,Memory and Temporal Loke" Elsevier, (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ono,T.: "Brain Mechanisus of Perception and Memory" Cambridge Univ Press, (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Nakamura, K., Mikami, A. and Kubota, K.: "The activity of single neurons in the monkey amygdala during performance of a visual discrimination task." J. Neurophysiology.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Nakamura, K., Mikami, A. and Kubota, K: "Neuronal activities in the amygdala of rhesus monkey during a sequential visual discrimination task with delay." Neurosci. Research,. 9. 79 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Nakamura, K., Mikami, A. and Kubota, K: "Stimulus selective neuranal responses to colored photographs in the amygdala of the rhesus monkey." Jpn. J. Physiol.39. 166 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Nakamura, K., Mikami, A. and Kubota, K.: "Stimulus selectivity correlated with temporal characteristics in amygdala visual neurons of the rhesus monkey." Jpn. J. Physiol. 40. 183 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Mikami, A. Nakamura, K. and Kubota, K.: "Visual short-term memory in the superior temporal sulcus and the amygdala of the rhesus monkey." Vision, Memory and Temporal Lobe. Elsevier,. 123-127 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Mikami, A. Nakamura, K. and Kubota, K: "Comparisons of single neuronal activities in the temporal cortex and the amygdala of the rhesus monkey during a discrimination and memory task." Brain Mechanisms of Perception and Memory. Cambridge Univ. Press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Katsuki Nakamura: "The activity of single neurons in the monkey anygdala during performance of a visual discrimination task" J.Neurophysilogy.

    • Related Report
      1991 Annual Research Report
  • [Publications] T.Ono: "Brain Mechanisms of Perception and Memory(in press)" Combridge Univ.Press,

    • Related Report
      1991 Annual Research Report
  • [Publications] Katsuki Nakamura: "Stimulus selectivity correlated with temporal characteristics in amygdala visual neurons of the rhesus monkey" Jap.J.Physiol.40. 184 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Katsuki Nakamura: "Low frequency oscillatory activity of single neurons in the temporal pole of the rhesus monkey" Neuroscience Abst.16. 760 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Eiichi Iwai: "Vision,Memory and the Temporal Labe" Elsevier Science Publishing Co., 453 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Akichika Mikami: "Visual short-term memory in the superior temporal sulcus and the amygdala of the rhesus monkey" “Vision Memory and Temporal Lobe"edited by E.Iwai. (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Nakamura,K.,: "Stinulus Selective neuronal responses to colored photographs in the amygdaga of the rhesus monkey" Jpn.J.Physiol.39. 139 (1989)

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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