|Budget Amount *help
¥2,100,000 (Direct Cost : ¥2,100,000)
Fiscal Year 1990 : ¥700,000 (Direct Cost : ¥700,000)
Fiscal Year 1989 : ¥1,400,000 (Direct Cost : ¥1,400,000)
The effect of noxious or innocuous mechanical stimulation of cutaneous areas (face, forelimb and paw, back, hind limb and paw) on cerebral blood flow in cortex was examined with laser Doppler flowmeter in anesthetized rats. Pinching of the face, forpaw and hindpaw for 15 s produced significant increases of systemic blood pressure and of cortical blood flow, whereas pinching of the back or brushing of any cutaneous area produced no significant changes in either parameter. Following spinal transaction at the first thoracic level, the blood pressure response to forepaw pinching was suppressed, whereas the increase in cortical blood flow still took place. Thus the results suggest that the increase in cortical blood flow following cutaneous noxious stimulation is, in part at least, independent of changes in blood pressure and of any concomitant vasodilatation.