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Basic study on pharmacological treatment of patent ductus arteriosus in premature infants.

Research Project

Project/Area Number 01570552
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionTokyo Women's Medical College

Principal Investigator

MOMMA Kazuo  Tokyo Women's Medical College, Dept, of Pediatric Cardiology, Professor, 医学部, 教授 (80075233)

Co-Investigator(Kenkyū-buntansha) TAKAO Atsuyoshi  Tokyo Women's Medical College, Dept. of Pediatric Cardiology, Professor Emeritus, 医学部, 名誉教授 (70075167)
Project Period (FY) 1989 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1991: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1990: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1989: ¥1,000,000 (Direct Cost: ¥1,000,000)
Keywordsductus arteriosus / fetus / neonate / prostaglandin / indomethacin / betamethasone / sulindac / rat / スリンダク, / 胎児, / ベ-タメサゾン
Research Abstract

To find a better treatment for patent ductus arteriosus of preterm infants, we studied the combined effect of indomethacin and betamethasone on -the fetal ductus in rats. We used a rapid whole-body freezing technique, and the ratio of the inner diameter of the ductus to the main pulmonary artery, which was 1.0 in controls, was used as an index of constriction. Indices of ductal constriction 4 h after administration of indomethacin (1 mg/kg) alone, betamethasone (1 mg/kg) alone or in combination in near-term rats were 0.56 <plus-minus> 0.05 (mean <plus-minus> SEM), 0.76 <plus-minus> 0.06, and 0.17 <plus-minus> 0.03, respectively. In preterm rats too, a marked increase in fetal ductus constriction was observed with the combined administration of these two drugs. Study of the dose effect of betamethasone revealed that maximal effects were obtained with 1 mg/kg of betamethasone combined with indomethacin in both preterm and near-term fetal rats. Increased constriction of the fetal ductus with combination treatment persisted from 1 to 8 h after administration. Administration of betamethasone 24 h before the rat was killed did not augment constriction of the fetal ductus by indomethacin administered 4 h before they were killed. Fetal ductus constriction by sulindac, another nonsteroidal antiinflammatory drug with little inhibitory effect on renal function, also was augmented by combined use with betamethasone (1 mg/kg). In conclusion, ductal constriction was markedly increased by combined administration of indomethacin and betamethasone in near-term and preterm fet

Report

(4 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • 1989 Annual Research Report
  • Research Products

    (32 results)

All Other

All Publications (32 results)

  • [Publications] Momma,K.and Takao,A.: "Increased constriction of the ductus arteriosus with combined administration of indomethacin and betamethasone in fetal rat." Pediatric Research. 25. 69-75 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Momma,K.and Takao,A.: "Right ventricular concentric hypertrophy and left ventricular dilatation by ductal constriction in fetal rat." Circulation Research. 64. 1137-1146 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Momma,K.and Takao,A.: "Transplacental cardiovascular effects of four popular analgesics in rats." Americal Journal Obstetrics and Gynecology. 162. 1304-1310 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 門間 和夫: "動脈管の薬物治療の基礎と臨床." 日本発達薬理研究会雑誌. 3. 1-11 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 門間 和夫,富松 宏文: "薬剤による動脈管閉鎖・開存。" 小児内科. 22. 1303-1306 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 門間 和夫: "プロスタグランディンの基礎と臨床" 日本小児科学会雑誌. 94. 1721-1724 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 門間 和夫: "鎮痛解熱消炎剤.松田一郎監修:妊婦への投薬." ミクス,東京, 7 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 門間 和夫: "胎生期血行動態と出生時変化.他 高尾篤良編集:臨床発達心臓病学." 中外医学社,東京., 105 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Momma, K. and Takao, A.: "Increased constriction of the ductus arteriosus with combined administration of indomethacin and betamethasone in fetal rat." Pediatric Research. 25. 69-75 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Momma, K. and Takao, A.: "Right ventricular concentric hypertrophy and left ventricular dilatation by ductal constriction in fetal rat." Circulation Research. 64. 1137-1146 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 門間 和夫: "動脈管の薬物治療の基礎と臨床" 発達薬理誌. 3. 1-11 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] 門間 和夫,森 善樹,山村 英司: "胎生期心不全の心臓断面形態ーラット全身急速凍結法による研究ー" 日本新生児学会雑誌. 23. 626-631 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 門間 和夫: "1,000g 未満の超未熟児動脈管開存症に対する外科治療の検討への討論" 胸部外科. 44. 450-451 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 門間 和夫: "動脈管依存性先天性心疾患薬の上手な使い方ー1991" クリニカ. 18. 293-297 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 門間 和夫,富松 宏文: "薬剤による動脈管閉鎖・開存" 小児内科. 22. 1303-1306 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] Momma,K,Ando,M,Takao,A.and Tomita,S.: "Fetal cardiovascular morphology of truncus arteriosus with or without truncal valve insufficiency in the rat." Circulation. 83. 2094-2100 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 門間 和夫: "動脈管の薬物治療の基礎と臨床" 発達薬理誌. 3. 1-11 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 門間 和夫: "胎生期心不全の心臓断面形態:ラット全身急速凍結法による研究" 日本小児循環器学会雑誌. 6. 422-423 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Momma K,Ando M,Takao A.: "Fetal cardiac morphology of tetralogy of Fallot with absent pulmonary valve." Circulation. 82. 1343-1351 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Momma.K.,Takao A.: "Transplacental cardiovascular effects of four popular analgesics in rats." American Journal of Obstetrics and Gynecology. 162. 1304-1310 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 門間 和夫,富松 宏文: "薬剤による動脈管閉鎖・開存" 小児医学. 22. 1303-1306 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 門間 和夫: "プロスタグランディンの基礎と臨床" 日本小児科学会雑誌. 94. 1721-24 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 門間 和夫: "新小児医学大系 年刊版90B (動脈管の薬物動態)" 中山書店,東京., 9 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Momma,K.,Takao A.,Nishikawa T.: "Developmental Cardiology:Morphogenesis and Function.(Ed.Clark EB,Takao A) Hypertrophy and failure of the fetal heart following pharmacological constriction of the ductus arteriosus in rats." Futura,Mount Kisco, 12 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Momma,K and Takao,A.:"Increased constriction of the ductus arteriosus with combined administration of indomethacin and betamethasone in fetal rats." Pe diatr.Res.25. 69-75 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Momma,K and Takao,A.:"Right ventricular concentric hypertrophy and left vent-ricular dilatation by ductal constriction in fetal rats." Circulation Research. 64. 1137-1146 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Momma,K and Takao,A.:"Fetal cardiovascular effects of nifedipine in rats" Pediatric Res.26. 442-447 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 門間和夫: "インドメサシンとベ-タ-メサゾンの併用による動脈管収縮" 日本心臓血圧研究振興会・昭和62年度研究業績集. 3-5 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 門間和夫: "薬剤による動脈管収縮の研究" 循環器病研究振興財団,大阪,研究助成業績報告集1987年度. 55-60 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 門間和夫: "薬剤による動脈管収縮の研究" 昭和63年度厚生省心身障害研究・新生児管理における諸問題の総合的研究. 189-193 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 門間和夫: "松田一郎監修:妊婦への投薬,解熱鎮痛消炎剤" ミスク,東京, 7 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 門間和夫: "梶原長雄ほか編集:循環器科診断治療大系1:心室中隔欠損症,動脈管開存症,三心房心,部分肺動脈還流異常症" 講談社,東京, 6 (1989)

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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