| Project/Area Number |
01570643
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
内分泌・代謝学
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| Research Institution | Shimane Medical University |
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Principal Investigator |
KATO Yuzuru Shimane Medical University Professor, 医学部, 教授 (90030965)
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| Co-Investigator(Kenkyū-buntansha) |
NOTSU Kazumi Shimane Medical University Instructor, 医学部, 助手 (50144697)
FURUYA Hiroshi Shimane Medical University Instructor, 医学部, 助手 (30181465)
TANIGAWA Keiichiro Shimane Medical University Assistant Prof., 医学部, 講師 (20171837)
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| Project Period (FY) |
1989 – 1990
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| Project Status |
Completed (Fiscal Year 1990)
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| Budget Amount *help |
¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1990: ¥600,000 (Direct Cost: ¥600,000)
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| Keywords | Growth hormone / Prolactin / VIP / Serotonin / Galanin / Somatostatin / Neuropeptide / Pituitary tumor / 薬物療法 / ド-パミン / オピオイドペプチド / α受容体 |
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| Research Abstract |
The secretion of Growth Hormone (GH) and prolactin (PRL) from the pituitary is regulated by a variety of hypothalamic factors, which are mostly neuropeptides and biogenic amines. We found that GH and PRL secretion induced by serotonin is mediated by hypothalamic GRF and VIP. Galanin stimulates both GH and PRL secretion in the rat. We found that alpha-adrenergic and opioidergic mechanisms are involved in PRL release induced by galanin. Furthermore, the interaction of galanin with serotonin in PRL secretion was also demonstrated. GH secretion induced by galanin is mediated by hypothalamic GRF. On the other hand, PRL and GH secretion is inhibited by endogenous dopamine and somatostatin. GRP stimulates both dopamine and somatostatin release from the hypothalamus. These findings indicate an important and complicated role of neuropeptides in regulating pituitary hormones and suggest a possible therapeutic use of a potent and long-actinf analogue of such neuropeptides in cosistently modulating the function of pituitary tumors.
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