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Clinical significance of oncogene expression for patients with a colorectal cancer

Research Project

Project/Area Number 01570762
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionOita Medical University

Principal Investigator

MIYAHARA Masaki  Oita Medical Univ. Instructor., 医学部, 講師 (10183641)

Co-Investigator(Kenkyū-buntansha) SAITO Takao  Oita Medical Univ. Associate Prof., 医学部, 助教授 (20037443)
KUWAHARA Akihiko  Oita Medical Univ. Instructor., 医学部, 講師 (10161811)
Project Period (FY) 1989 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1991: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1990: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1989: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywordscolorectal cancer / c-myc mRNA / c-fos mRNA / c-Ki-ras mRNA / ras p21 / Northern blotting / clinicopathologic findings / malignant potential / cーmyc / cーfos / cーkiーras / ノ-ザンブロット法 / 核DNA ploidy pattern / 癌遺伝子 / Kiーras / 免疫組織染色 / 癌遺伝子蛋白 / 免疫組織学的検索 / 臨床病理学的諸因子
Research Abstract

The expression of c-myc, c-fos and c-Ki-ras mRNAs and ras p21 protein in the primary lesion were analyzed in patients with a colorectal cancer. Correlation of overexpression of these oncogene products and clinicopathologic findings, Dukes classification and prognoses were studied.
1. c-myc mRNA expression: The overexpression of c-myc mRNA was recognized in 25 of 35 patients(71%). Tumors with overexpression had a significantly higher frequency of lymphatic vessel invasion and lymph node metastasis and Dukes C and D patients than those without it(p 0.05). All the 4 patients with liver metastasis had positive overexpression. The 2 year survival rates were 79% in patients with overexpression and 100% in those without it(p=0.073).
2. c-fos and c-Ki-ras mRNA expression: The overexpression of c-fos and c-Ki-ras mRNAs were recognized in 16(46%) and 18(51%) of 35 patients. There was no correlation between overexpression and clinicopathologic findings, Dukes classification and prognoses.
3. ras p21 expression: ras p21 overexpression was recognized in 20 of 68 patients(28%). Tumors with overexpression had a significantly higher frequency of lymphatic vessel and venous invasion than those without it(p 0.01, p 0.05). Patients with overexpression had also higher frequency of lymph node and hepatic metastasis(p=0.06).
Thus, the overexpressions of c-myc mRNA and ras p21 protein in the primary lesion of the colorectal cancer were important in cancer progression. Detection of overexpression of these oncogenes seemed to be beneficial as a predictive indicator of prognoses in the patients with a colorectal cancer.

Report

(4 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • 1989 Annual Research Report
  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Masaki Miyahara: "Clinical significance of ras p21 overexpression for patients with an advanced colorectal cancer" Dis Colon Rectum. 34. 1097-1102 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Koichi Sato: "Clinical significance of c-myc,c-fos and c-Ki-ras mRNA overexpressions in patients with colorectal cancer" J Jpn Soc Cancer Ther. 28. 215- (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Koichi Sato: "Clinical significance of DNA ploidy pattern and c-myc expression in patients with colorectal cancer" Japanese Society for Genetic Aspects of Malignancy-Commemorative Issue of the 10th Annual Meeting,1992-. 85- (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Koichi Sato: "c-myc mRNA overexpression is associated with lymph node metastasis in colorectal cancer" Br J Surg.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Masaki Miyahara.: "Clinical significance of ras p21 overexpression for patients with an advanced colorectal cancer" Dis Colon Rectum. 34. 1097-1102 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Koichi Sato.: "Clinical significance of c-myc, c-fos and c-Ki-ras mRNA overexpressions in patients with colorectal cancer." J Jpn Soc Cancer Ther. 28. 215 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Koichi Sato.: "Clinical significance of DNA ploidy pattern and c-myc expression in patients with colorectal cancer." Japanese Society for Genetic Aspects of Human Malignancy-Commemorative Issue of the 10th Annual Meeting. 1992-. 85 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Koichi Sato.: "c-myc mRNA overexpression is associated with lymph node metastasis in colorectal cancer." Br J Surg.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M.Miyahara,T.Saito,K.Kaketani,K.Sato,A.Kuwahara,K.Shimoda,M.Kobayashi: "Clinical significance of ras p21 overexpression for patients with an advanced colorectal cancer" Dis Colon Rectum. 34. 1097-1102 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 宮原 正樹,佐藤 浩一,掛谷 和俊,下田 勝広,桑原 亮彦,斉藤 貴生,小林 迪夫: "大腸癌におけるras遺伝子発現と核DNA ploidy patternの臨床的意義に関する検討" 日本外科学会雑誌. 臨時増刊. 210 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 佐藤 浩一,宮原 正樹,村重 光哉,筑波 貴与根,下田 勝広,斉藤 貴生,小林 迪夫: "癌遺伝子発現からみた大腸癌の悪性度" 日本消化器外科学会雑誌. 25. 495 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 佐藤 浩一,宮原 正樹,村重 光哉,下田 勝広,斉藤 貴生,小林 迪夫: "癌遺伝子発現と核DNA ploidy patternからみた大腸癌の悪性度" 日本外科学会雑誌. 臨時増刊. 197 (1992)

    • Related Report
      1991 Annual Research Report

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Published: 1989-04-01   Modified: 2018-02-02  

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