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Effects of low-powered He-Ne laser irradiation on biological membranes and nerve transmission.

Research Project

Project/Area Number 01570858
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 麻酔学
Research InstitutionChiba University

Principal Investigator

IIJIMA Kazuhiko  Chiba Univ., Sch. of Med., Dept. of Anesthesiology, Associate Professor, 医学部・麻酔学教室, 助教授 (70009596)

Co-Investigator(Kenkyū-buntansha) FUKUDA Yasuichirou  Chiba Univ., Sch. of Med., Dept. of Physiology 2nd, Associate Professor, 医学部・第2生理学教室, 助教授 (10009649)
SHIMOYAMA Naohito  Chiba Univ., Sch. of Anesthesiology, Staff, 医学部・麻酔学教室, 助手 (40196572)
下山 恵美  千葉大学, 医学部・麻酔学教室, 研究生 (10206253)
Project Period (FY) 1989 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1991: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1990: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1989: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywordslow power laser / hypotonic hemolysis / membrane stability / red cell deformability / membrane potential / synaptic transmission / threshold of pain / cutaneous blood flow / 低出力HeーNeレ-ザ- / 刺激閾値 / 複合活動電位 / ホメオスタシス / 生体膜 / 星状神経節 / シナプス電位 / 末梢血流 / 末梢皮膚温 / 赤血球膜 / 低張性溶血
Research Abstract

1)The hypotonic hemolysis in human red cells was investigated before and during 30 minute irradiation of low power He-Ne lasers(8.5mW in power). Low power laser beams have a protective effect on damaged red cell membranes from hypotonic hemolysis and stabilize the red cell membrane.
2)The deformability of human red cells was researched using a filter-filtration method with and without irradiation of the lasers. The laser beams improve the function of cytoskeltal proteins in damaged human red cells.
3)Postsynaptic compound action potentials and firing rates in rat cervical ganglions decreased after irradiation of the lasers.
4)Postsynaptic resting membrane potentials were hyperpolarized and electrically stabilized with irradiation of the lasers.
5)Thresholds of electrical stimulation on presynaptic neurons to make firings on postsynaptic neurons were elevated after irradiation of the lasers on sympathetic ganglions.
6)The laser beams recover jaw blood flow during presynaptic stimulations on cervical sympathetic ganglion and depress in sympathetic ganglion transmission.
These results suggest that low power laser beams weaken painful stimulation and suppress firings in peripheral area and normalize the sympathetic tone and biophysical conditions.
Biophotostimulations of low power laser beams appear to maintain homeostasis in living things.

Report

(4 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • 1989 Annual Research Report
  • Research Products

    (48 results)

All Other

All Publications (48 results)

  • [Publications] 飯島 一彦,下山 直人,下山 恵美,水口 公信: "低出力HeーNeレ-ザ-の赤血球低張性溶血に及ぼす影響" 日本レ-ザ-医学会誌. 10. 419-422 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 飯島 一彦,下山 直人,下山 恵美,水口 公信: "低出力HeーNeレ-ザ-の照射部位による局所皮膚温,疼痛閾値の変化" 日本レ-ザ-医学会誌. 10. 383-384 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K.Iijima,.N.Shimoyama,M.shimoyama,T.Mizuguchi: "The effect of low power He-Ne laser on hypotonic hemolysis of human srythrocytes." J. of Bloodless medicine and Sungery. 8. 17-19 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K.Iijima,N.Shimoyama,M.shimoyama,T.Mizuguchi: "Effects of red and green He-Ne lasers on hypotonic hemolysis of human erythrocytes." Surgical and Medical Lasers. 3. 158-159 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 飯島 一彦,下山 直人,下山 恵美,萩谷 雅人,水口 公信: "合谷および手三里への低出力HeーNeレ-ザ-照射の末梢皮膚温,痛覚閾値に及ぼす影響" ペインクリニック. 11. 369-372 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 飯島 一彦,下山 直人,下山 恵美,水口 公信,田辺 恵美子: "星状神経節近傍への低出力HeーNeレ-ザ-照射の皮膚温,痛覚閾値、指尖血流への影響" 第11回日本レ-ザ-医学会大会論文集. 525-528 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 飯島 一彦,下山 直人,下山 恵美,水口 公信: "帯状疱疹後神経痛に対する低出力HeーNeレ-ザ-の効果、ー50回照射後の判定ー" 第11回日本レ-ザ-医学会大会論文集. 541-544 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 飯島 一彦,下山 直人,下山 恵美, 萩谷 雅人,水口 公信: "星状神経筋近傍への低出力HeーNeレ-ザ-照射の影影" 麻酔. 39. S220-S220 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 飯島 一彦,水口 公彦: "低出力HeーNeレ-ザ-の生体膜への影響" 日本臨床生理学会誌. 20増刊. 109-109 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 下山 恵美,飯島 一彦,水口 公信,福田 康一郎: "ラット上頚神経節に対する低出力HeーNeレ-ザ-照射の効果" 麻酔. 40. S480-S480 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K.Iijima,N.Shimoyama,M.Shimoyama,T.Mizuguchi: "Evaluation of analgesic effect of low-powered He:Ne laser on postherpetic neuralgia using VAS and modified McGill Pain Questionnaire." J.of Clinical Laser Medicine & Surgery. 9. 121-126 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K.Iijima,N.Shimoyama,M.Shimoyama,T.Mizuguchi: "Red and green low-powered He-Ne laser protect human erythrocytes from hypotonic hemolysis." J of Clinical Laser Medicine & Surgery.9. 385-389 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 飯島 一彦: "低出力レ-ザ-治療" 看護技術. 38. 189-192 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 飯島 一彦,下山 直人,下山 恵美,杉森 邦夫,野村 明,水口 公信: "赤血球変形態に対する低出力HeーNeーレ-ザ-の効果" 第12回日本レ-ザ-医学会大会論文集.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M.Shimoyama,N.Shimoyama,K.Iijima,T.Mizuguchi,Y.Fuhuda: "Effects of He-Ne laser irradiation on sympathetic ganglion trans-misson." J.of Clinical Laser Medicine & surgery.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K.Ijima,N.shimoyama,M.Shimoyama,T.Mizuguchi: "The effect of low-powered laser on red cell deformability" J.of Clinical Laser Medicine & Surgery.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K.Iijima,N.Shimoyama,M.Shimoyama,T.Mizuguchi: "The Second World Congress of Low Power Lasers in Medicine '90 Tokyo:Effects of red and green He-Ne lasers on hypotonic hemolysis of human erythrocytes." Pargamon Press,

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kazukiko Iijima: "The Second World Congress of Low Power Lasers in Medicine '90 Tokyo:A Review;Low power lasers for the treetment of pain in Japan." Pargamon Press,

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K. Iijima, N. Shimoyama, M. Shimoyama, T. Mizuguchi: "The effect of low power He-Ne laser on hypotonic hemolysis in human red cells." J. of Japan Society for Laser Medicine.10(3). 419-422 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K. Iijima, N. Shimoyama, M. Shimoyama, T. Mizuguchi: "Changes in the skin temperature and pain threshold after irradiation of low power He-Ne laser on different spots in the radialnerve supplying field." Pain Clinic. 11(3). 369-372 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K. Iijima, N. Shimoyama, M. Shimoyama, T. Mizuguchi: "The effect of low power He-Ne laser on hypotonic hemolysis in human red cells." J. of Bloodless Medicine and Surgery.8(1). 17-19 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K. Iijima, N. Shimoyama, M. Shimoyama, T. Mizuguchi, E. Tanabe: "Changes in the skin temperature, pain threshold and finger blood flow after irradiation of low-power He-Ne laser on the area near stellate ganglion." The Proceedings on 11th Cong. of Japan Society for Laser Medicine.525-528 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M. Shimoyama, K. Iijima, T. Mizuguchi, Y. Fukuda: "Effects of low-power He-Ne laser irradiation on sympathetic ganglion transmission." Masui. 40(9). S480 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K. Iijima, N. Shimoyama, M. Shimoyama, T. Mizuguschi: "Evaluation of analogesic effect of low-powered He : Ne laser on postherpetic neuralgia using VAS and modified McGill Pain Questionnaire." J. of Clinical Laser Medicine & Surgery.9. 121-126 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K. Iijima, N. Shimoyama, M. Shimoyama, T. Mizuguschi: "Red and green low-powered He-Ne laser protect human erythrocytes from hypotonic hemolysis." J. of Clinical Laser Medicine & Surgery.9. 385-389 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K. Iijima, N. Shimoyama, M. Shimoyama, T. Mizuguschi: "The Second World Congress of Low Power Lasers in Medicine '90, Tokyo" The effects of red and green He-Ne lasers on hypotonic hemolysis of human erythrocytes.Pargamon Press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K. Iijima, N. Shimoyama, M. Shimoyama, T. Mizuguschi: "The Second World Congress of Low Power Lasers In Medicine '90, Tokyo" A Review ; Low power lasers for the treatment of pain in Japan.Pargamon Press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M. Shimoyama, K. Iijima, T. Mizuguchi, Y. Fukuda: "Effects of low-power He-Ne laser irradiation on sympathetic ganglion transmission." J. of Clinical Laser Medicine & Surgery.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K. Iijima, N. Shimoyama, M. Shimoyama, T. Mizuguchi: "The effect of low-powered laser on red cell deformability." J. of Clinical Laser Medicine & Surgery.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K.Iijima,N.Shimoyam,M.Shimoyama,T.Mizuguchi: "Evaluation of Analgisic effect of lowーpower He:Ne Laser on postーherpetic Neuralgia Llsing VAS and Modified Mc Gill Pain Questionraire" Journal of Clinical Laser Medicine & Surgery. 9. 121-126 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] K.Iijima,N.Shimoyama,M.Shimoyama,T.Mizuguchi: "Red and Green Lowーpowered He^-Ne Lasers protect Human Erythrocytes from Hypotonic Hemolysis" Journal of Clinical Laser Medicine & Surgery. 9. 385-359 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 下山 恵美,飯島 一彦,水口 公信,福田 康一郎: "ラットの上頚神経節に対する低出力レ-ザ-照射の効果." 麻酔(第38回日本麻酔学会総会号). 40. S480-S480 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 飯島 一彦,下山 直人,下山 恵美,野村 明,杉森 邦夫,水口 公信: "赤血球変形能に対する低出力HeーNeレ-ザ-の効果" 第12回日本レ-ザ-医学会大会抄録集. 99-99 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] K.Iijima,N.Shimoyama,M.Shimoyama,A.Nomura,T.Mizuguchi: "The effect of lowーpowered laser on red cell deformability" Proceedings of 9th Congress International Laser Medicine & Surgery.,1991.11.5(Anaheim,U.S.A). (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 飯島 一彦,下山 直人,下山 恵美,野村 明,杉森 邦夫,水口 公信: "第12回日本レ-ザ-医学会大学論文集" 日本レ-ザ-医学会事務局, (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Kazuhiko Iijima et al.: "The effect of lowーpower HeーNe laser on hypotonic hemolysis of human erythrocytes." The Journal of Bloodless Medicine and Surgery. 8. 17-19 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Kazuhiko Iijima et al: "Effect of red and green HeーNe lasers on hypotonic hemolysis of human erythrocytes" Surgical and Medical Lasers(Proceedings of 2nd Congress of low power laser in Medicine '90 Tokyo). 3. 158-159 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 飯島 一彦,下山 直人,下山 恵美,萩谷 雅人: "合谷および手三里への低出力レ-ザ-照射の末梢皮膚温,痛覚閾値に及ぼす影響." ペインクリニック. 11. 369-372 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 飯島 一彦,下山 直人,下山 恵美,萩谷 雅人,水口 公信: "星状神経節近傍への低出力レ-ザ-照射の影響" 麻酔(第37回日本麻酔学会総会号). 39. S220-S220 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 飯島 一彦,下山 直人,下山 恵美,水口 公信: "低出力HeーNeレ-ザ-の光体膜への影響" 日本臨床生理学会誌. 20. 109-109 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 下山 恵美,飯島 一彦,水口 公信,福田 康一郎: "ラット上頚神経節に対する低出力レ-ザ-の照射効果" 麻酔(第38回日本麻酔学会総会号). 40. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] Kazuhiko Iijima et al.: "The effect of low power HeーNe laser on deformability of human erythrocytes." Proceedings of 9th Congress International Society of Laser Surgery and Medicine (Los Angeles). (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 飯島一彦,下山直人,下山恵美,水口公信: "低出力He-Neレ-ザ-照射の赤血球低張性溶血に及ぼす影響" 日本レ-ザ-医学会誌. 10. 419-422 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 飯島一彦,下山直人,下山恵美,水口公信: "低出力レ-ザ-の照射部位による局所皮膚温、疼痛閾値の変化-合谷、手三里照射より-" 日本レ-ザ-医学会誌. 10. 383-384 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 飯島一彦,下山直人,下山恵美,水口公信他: "合谷および手三里への低出力レ-ザ-照射の末梢皮膚温、痛覚閾値に及ぼす影響" ペインクリニック. 11. (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Kazuhiko Iijima,et al.: "The effect of low-power He-Ne laser on hypotonic hemolysis in human red cells." Proceedings of the 8th Congress International Society of laser Surgery and Medicine. 111-111 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Kazuhiko Iijima,et al.: "The effect of low-power He-Ne laser on hypotonic hemolysis of human erythrocytes" Lasers Surg.Med.

    • Related Report
      1989 Annual Research Report
  • [Publications] 飯島一彦,下山直人,下山恵美,萩谷雅人,水口公信: "星状神経節近傍への低出力レ-ザ-照射の影響" 麻酔. 39. (1990)

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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